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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Cpn1 (spascer ID:93721)

Gene summary for Cpn1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Cpn1
	Gene ID	93721
	Gene name	carboxypeptidase N, polypeptide 1
	Synonyms	0610011F20Rik\|CPN
	Cytomap	19 C3\|19 36.68 cM
	Type of gene	protein-coding
	Description	carboxypeptidase N catalytic chainanaphylatoxin inactivatorcarboxypeptidase N small subunitcarboxypeptidase N, polypeptide 1, 50kDkininase I
	Modification date	20220424
	UniProtAcc	Q9JJN5

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Cpn1	GO:0004181	metallocarboxypeptidase activity	21873635	Function
Cpn1	GO:0005615	extracellular space	21873635	Component
Cpn1	GO:0006518	peptide metabolic process	21873635	Process
Cpn1	GO:0016485	protein processing	21873635	Process

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Spatial pattern events for Cpn1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Cpn1	Mouse	Embryo	rep_1	34489600	3.74e-16
Cpn1	Mouse	Embryo	rep_2	34489600	4.14e-16
Cpn1	Mouse	Embryo	rep_3	34489600	4.04e-16
Cpn1	Mouse	Embryo	rep_4	34489600	3.67e-16
Cpn1	Mouse	Embryo	rep_5	34489600	4.08e-16
Cpn1	Mouse	Embryo	rep_6	34489600	3.64e-16
Cpn1	Mouse	Kidney	rep_1	34853151	2.42e-15
Cpn1	Mouse	Kidney	rep_2	34853151	3.38e-15
Cpn1	Mouse	Kidney	rep_3	34853151	2.94e-15
Cpn1	Mouse	Kidney	rep_4	34853151	4.07e-15
Cpn1	Mouse	Kidney	rep_5	34853151	3.18e-15
Cpn1	Mouse	Intestine	rep_1	35149721	6.08e-15
Cpn1	Mouse	Intestine	rep_2	35149721	3.44e-15
Cpn1	Mouse	Intestine	rep_3	35149721	3.25e-15
Cpn1	Mouse	Intestine	rep_4	35149721	2.30e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E

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Spatial pattern pathway has Cpn1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Cpn1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Spinal cord	CN94_E1	6.6e-06
Cpn1	GOBP_Protein_Maturation	Mouse	Spinal cord	CN94_E1	2.2e-06
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Spinal cord	CN94_E1	1.1e-07
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Spinal cord	CN94_E1	2.6e-08
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Spinal cord	CN94_E1	2.2e-06
Cpn1	GOBP_Response_To_Hormone	Mouse	Spinal cord	CN94_E1	4.8e-06
Cpn1	GOBP_Bradykinin_Catabolic_Process	Mouse	Spinal cord	L7CN41_C2	3.2e-06
Cpn1	GOBP_Activation_Of_Immune_Response	Mouse	Spinal cord	L7CN45_C1	7.8e-08
Cpn1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Spinal cord	L7CN45_C1	1.3e-07
Cpn1	GOBP_Immune_Effector_Process	Mouse	Spinal cord	L7CN45_C1	3.1e-07
Cpn1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.1e-08
Cpn1	GOBP_Peptide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Spinal cord	L7CN45_C1	8.7e-09
Cpn1	GOBP_Protein_Processing	Mouse	Spinal cord	L7CN45_C1	7.1e-07
Cpn1	GOBP_Proteolysis	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Cpn1	GOBP_Regulation_Of_Immune_Effector_Process	Mouse	Spinal cord	L7CN45_C1	6.9e-07
Cpn1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Cpn1	GOBP_Response_To_Corticosteroid	Mouse	Spinal cord	L7CN45_C1	5.7e-06
Cpn1	GOBP_Response_To_Lipid	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Spinal cord	L7CN45_C1	6.3e-07
Cpn1	GOBP_Response_To_Steroid_Hormone	Mouse	Spinal cord	L7CN45_C1	6.8e-08
Cpn1	GOBP_Complement_Activation	Mouse	Spinal cord	L8CN11_C1	4.7e-22
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Spinal cord	L8CN11_C1	4.7e-22
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Brain	rep_19	3.6e-05
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	rep_27	7.5e-06
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Brain	rep_41	1.6e-05
Cpn1	GOBP_Immune_Effector_Process	Mouse	Brain	rep_1	1.5e-12
Cpn1	GOBP_Activation_Of_Immune_Response	Mouse	Brain	rep_3	6.5e-108
Cpn1	GOBP_Bradykinin_Catabolic_Process	Mouse	Brain	rep_3	3.8e-11
Cpn1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Brain	rep_3	2.5e-108
Cpn1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	rep_3	7.1e-166
Cpn1	GOBP_Peptide_Catabolic_Process	Mouse	Brain	rep_3	4.1e-105
Cpn1	GOBP_Peptide_Metabolic_Process	Mouse	Brain	rep_3	1.3e-86
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Brain	rep_3	7.6e-125
Cpn1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Brain	rep_3	6.9e-97
Cpn1	GOBP_Protein_Maturation	Mouse	Brain	rep_3	1.1e-160
Cpn1	GOBP_Protein_Processing	Mouse	Brain	rep_3	2.3e-168
Cpn1	GOBP_Proteolysis	Mouse	Brain	rep_3	1.8e-168
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Brain	rep_3	4.5e-106
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Brain	rep_3	3.1e-79
Cpn1	GOBP_Regulation_Of_Immune_Effector_Process	Mouse	Brain	rep_3	8.0e-182
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	rep_3	1.1e-86
Cpn1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Brain	rep_3	6.4e-111
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Brain	rep_3	6.4e-96
Cpn1	GOBP_Response_To_Hormone	Mouse	Brain	rep_3	8.1e-134
Cpn1	GOBP_Response_To_Lipid	Mouse	Brain	rep_3	7.9e-86
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Brain	rep_3	3.4e-98
Cpn1	GOBP_Response_To_Steroid_Hormone	Mouse	Brain	rep_3	3.0e-66
Cpn1	GOBP_Response_To_Corticosteroid	Mouse	Brain	rep_7	3.1e-23
Cpn1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Cpn1	GOBP_Complement_Activation	Mouse	Embryo	rep_14	4.8e-55
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Embryo	rep_14	6.4e-58
Cpn1	GOBP_Immune_Effector_Process	Mouse	Embryo	rep_14	3.3e-15
Cpn1	GOBP_Peptide_Catabolic_Process	Mouse	Embryo	rep_14	1.8e-13
Cpn1	GOBP_Peptide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Embryo	rep_14	9.6e-07
Cpn1	GOBP_Protein_Maturation	Mouse	Embryo	rep_14	6.3e-10
Cpn1	GOBP_Protein_Processing	Mouse	Embryo	rep_14	4.6e-22
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Embryo	rep_14	4.4e-50
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Embryo	rep_14	1.1e-54
Cpn1	GOBP_Regulation_Of_Immune_Effector_Process	Mouse	Embryo	rep_14	1.0e-29
Cpn1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Embryo	rep_1	5.7e-21
Cpn1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Embryo	rep_1	7.3e-23
Cpn1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Embryo	rep_1	9.5e-143
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Embryo	rep_1	2.5e-19
Cpn1	GOBP_Response_To_Steroid_Hormone	Mouse	Embryo	rep_1	1.9e-50
Cpn1	GOBP_Immune_Effector_Process	Mouse	Embryo	rep_2	1.7e-23
Cpn1	GOBP_Response_To_Hormone	Mouse	Embryo	rep_3	3.6e-133
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Embryo	rep_6	2.0e-17
Cpn1	GOBP_Complement_Activation	Mouse	Kidney	IRI	6.7e-07
Cpn1	GOBP_Protein_Maturation	Mouse	Kidney	IRI	2.5e-33
Cpn1	GOBP_Protein_Processing	Mouse	Kidney	IRI	4.8e-57
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Kidney	IRI	1.3e-81
Cpn1	GOBP_Proteolysis	Mouse	Kidney	Nep	6.8e-23
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Kidney	Nep	6.3e-23
Cpn1	GOBP_Response_To_Hormone	Mouse	Kidney	Nep	6.3e-23
Cpn1	GOBP_Response_To_Lipid	Mouse	Kidney	Nep	6.3e-23
Cpn1	GOBP_Protein_Processing	Mouse	Kidney	rep_1	8.0e-08
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Kidney	rep_1	7.7e-08
Cpn1	GOBP_Activation_Of_Immune_Response	Mouse	Kidney	rep_2	5.4e-134
Cpn1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Cpn1	GOBP_Complement_Activation	Mouse	Kidney	rep_2	1.1e-201
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Kidney	rep_2	7.8e-96
Cpn1	GOBP_Immune_Effector_Process	Mouse	Kidney	rep_2	3.4e-107
Cpn1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Kidney	rep_2	1.2e-14
Cpn1	GOBP_Peptide_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-80
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Kidney	rep_2	8.3e-94
Cpn1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Kidney	rep_2	1.2e-85
Cpn1	GOBP_Protein_Maturation	Mouse	Kidney	rep_2	5.4e-103
Cpn1	GOBP_Proteolysis	Mouse	Kidney	rep_2	6.0e-106
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Kidney	rep_2	1.1e-42
Cpn1	GOBP_Regulation_Of_Immune_Effector_Process	Mouse	Kidney	rep_2	7.0e-98
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Kidney	rep_2	1.3e-91
Cpn1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Kidney	rep_2	2.5e-84
Cpn1	GOBP_Response_To_Corticosteroid	Mouse	Kidney	rep_2	4.3e-09
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Kidney	rep_2	1.1e-44
Cpn1	GOBP_Response_To_Hormone	Mouse	Kidney	rep_2	3.2e-12
Cpn1	GOBP_Response_To_Lipid	Mouse	Kidney	rep_2	1.1e-111
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Kidney	rep_2	1.3e-60
Cpn1	GOBP_Response_To_Steroid_Hormone	Mouse	Kidney	rep_2	4.5e-14
Cpn1	GOBP_Bradykinin_Catabolic_Process	Mouse	Liver	CN16-D1	2.6e-09
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Liver	CN65-D1	3.2e-07
Cpn1	GOBP_Complement_Activation	Mouse	Liver	CN73-C1	3.2e-10
Cpn1	GOBP_Bradykinin_Catabolic_Process	Mouse	Liver	rep_15	2.0e-13
Cpn1	GOBP_Peptide_Catabolic_Process	Mouse	Liver	rep_15	5.0e-07
Cpn1	GOBP_Activation_Of_Immune_Response	Mouse	Liver	rep_16	5.6e-12
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Liver	rep_16	6.6e-21
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Liver	rep_16	2.3e-11
Cpn1	GOBP_Protein_Maturation	Mouse	Liver	rep_16	4.5e-09
Cpn1	GOBP_Protein_Processing	Mouse	Liver	rep_16	3.8e-09
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Liver	rep_16	1.4e-09
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Liver	rep_16	2.0e-24
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Liver	rep_16	2.5e-16
Cpn1	GOBP_Response_To_Corticosteroid	Mouse	Liver	rep_23	7.2e-10
Cpn1	GOBP_Activation_Of_Immune_Response	Mouse	Lymph	MS-1	2.3e-23
Cpn1	GOBP_Bradykinin_Catabolic_Process	Mouse	Lymph	MS-1	1.1e-16
Cpn1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Cpn1	GOBP_Complement_Activation	Mouse	Lymph	MS-1	9.7e-19
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Lymph	MS-1	3.4e-24
Cpn1	GOBP_Immune_Effector_Process	Mouse	Lymph	MS-1	1.6e-18
Cpn1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Cpn1	GOBP_Peptide_Catabolic_Process	Mouse	Lymph	MS-1	4.9e-11
Cpn1	GOBP_Peptide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Lymph	MS-1	1.0e-21
Cpn1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Lymph	MS-1	1.6e-18
Cpn1	GOBP_Protein_Processing	Mouse	Lymph	MS-1	8.5e-10
Cpn1	GOBP_Proteolysis	Mouse	Lymph	MS-1	2.8e-10
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Lymph	MS-1	5.6e-18
Cpn1	GOBP_Regulation_Of_Immune_Effector_Process	Mouse	Lymph	MS-1	2.5e-18
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Lymph	MS-1	2.3e-21
Cpn1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Lymph	MS-1	2.2e-14
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Lymph	MS-1	3.9e-13
Cpn1	GOBP_Response_To_Hormone	Mouse	Lymph	MS-1	7.3e-10
Cpn1	GOBP_Response_To_Lipid	Mouse	Lymph	MS-1	8.6e-10
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Lymph	MS-1	1.9e-09
Cpn1	GOBP_Response_To_Steroid_Hormone	Mouse	Lymph	MS-1	3.7e-08
Cpn1	GOBP_Response_To_Corticosteroid	Mouse	Lymph	PBS	9.1e-07
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Lung	rep_1	2.0e-30
Cpn1	GOBP_Response_To_Hormone	Mouse	Lung	rep_1	1.1e-09
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Lung	rep_1	5.0e-17
Cpn1	GOBP_Immune_Effector_Process	Mouse	Brain	rep_4	7.2e-15
Cpn1	GOBP_Peptide_Catabolic_Process	Mouse	Brain	rep_4	5.1e-22
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Brain	rep_4	3.7e-10
Cpn1	GOBP_Bradykinin_Catabolic_Process	Mouse	Brain	HP_ad_rep3	2.4e-07
Cpn1	GOBP_Peptide_Catabolic_Process	Mouse	Brain	HP_ad_rep3	1.7e-07
Cpn1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Cpn1	GOBP_Complement_Activation	Mouse	Brain	HP_ad_rep7	1.9e-07
Cpn1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.3e-07
Cpn1	GOBP_Peptide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Cpn1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Brain	HP_ad_rep7	4.6e-07
Cpn1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Brain	HP_ad_rep7	5.5e-07
Cpn1	GOBP_Proteolysis	Mouse	Brain	HP_ad_rep7	3.3e-07
Cpn1	GOBP_Regulation_Of_Immune_Effector_Process	Mouse	Brain	HP_ad_rep7	1.6e-08
Cpn1	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	HP_ad_rep7	2.1e-11
Cpn1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Brain	HP_ad_rep7	1.8e-09
Cpn1	GOBP_Response_To_Endogenous_Stimulus	Mouse	Brain	HP_ad_rep7	6.3e-10
Cpn1	GOBP_Response_To_Hormone	Mouse	Brain	HP_ad_rep7	4.0e-10
Cpn1	GOBP_Response_To_Lipid	Mouse	Brain	HP_ad_rep7	3.5e-07
Cpn1	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Brain	HP_ad_rep7	1.4e-09
Cpn1	GOBP_Regulation_Of_Complement_Activation	Mouse	Brain	HP_ad_rep8	9.3e-08
Cpn1	GOBP_Humoral_Immune_Response	Mouse	Brain	HP_adpolb_rep1	2.0e-13
Cpn1	GOBP_Regulation_Of_Humoral_Immune_Response	Mouse	Brain	HP_adpolb_rep1	1.6e-07
Cpn1	GOBP_Activation_Of_Immune_Response	Mouse	Brain	HP_polb_rep9	2.1e-07
Cpn1	GOBP_Immune_Effector_Process	Mouse	Brain	HP_polb_rep9	1.0e-08
Cpn1	GOBP_Protein_Maturation	Mouse	Brain	HP_polb_rep9	9.1e-14
Cpn1	GOBP_Protein_Processing	Mouse	Brain	HP_polb_rep9	1.6e-12

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Cpn1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Cpn1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Cpn1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Cpn1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Cpn1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Cpn1	C0398782	Carboxypeptidase N Deficiency	1	CTD_human;UNIPROT