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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Mcam (spascer ID:84004)

Gene summary for Mcam

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Mcam
	Gene ID	84004
	Gene name	melanoma cell adhesion molecule
	Synonyms	1-gicerin\|AV025631\|CD146\|CD149\|Muc18\|s-endo\|s-gicerin
	Cytomap	9\|9 A5.1
	Type of gene	protein-coding
	Description	cell surface glycoprotein MUC18gicerinl-gicerin proteinmelanoma adhesion moleculemelanoma-associated antigen MUC18
	Modification date	20220515
	UniProtAcc	Q8R2Y2

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Mcam	GO:0001525	angiogenesis	21873635	Process
Mcam	GO:0005886	plasma membrane	21873635	Component

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Spatial pattern events for Mcam

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Mcam	Mouse	Brain	S1	34413515	2.07e-15
Mcam	Mouse	Brain	S2	34413515	1.56e-15
Mcam	Mouse	Brain	S3	34413515	1.64e-15
Mcam	Mouse	Brain	S4	34413515	1.37e-15
Mcam	Mouse	Brain	S6	34413515	1.46e-15
Mcam	Mouse	Brain	S7	34413515	1.55e-15
Mcam	Mouse	Brain	14B	32637622	1.78e-08
Mcam	Mouse	Brain	29A	32637622	1.75e-07
Mcam	Mouse	Brain	rep_1	35141374	2.02e-15
Mcam	Mouse	Embryo	rep_3	33188776	1.65e-07
Mcam	Mouse	Kidney	CLP	34003797	7.12e-09
Mcam	Mouse	Brain	rep_1	33469025	1.30e-15
Mcam	Mouse	Liver	rep_21	35021063	4.78e-06
Mcam	Mouse	Brain	rep_1	35027729	1.66e-15
Mcam	Mouse	Brain	rep_2	35027729	1.57e-15
Mcam	Mouse	Brain	rep_3	35027729	1.32e-15
Mcam	Mouse	Brain	rep_4	35027729	1.76e-15
Mcam	Mouse	Brain	rep_5	35027729	1.46e-15
Mcam	Mouse	Intestine	rep_1	35149721	1.81e-14
Mcam	Mouse	Intestine	rep_2	35149721	5.49e-15
Mcam	Mouse	Intestine	rep_3	35149721	3.25e-15
Mcam	Mouse	Intestine	rep_4	35149721	2.30e-15
Mcam	Mouse	Lymph	A1	0	3.29e-15
Mcam	Mouse	Lymph	B1	0	3.66e-15
Mcam	Mouse	Lung	rep_1	35290801	4.52e-15
Mcam	Mouse	Lung	rep_2	35290801	1.42e-14
Mcam	Mouse	Lung	rep_3	35290801	5.26e-15
Mcam	Mouse	Lung	rep_4	35290801	3.04e-15
Mcam	Mouse	Brain	rep_1	35210624	1.74e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Kidney_CLP_H&E
Brain_rep_1_H&E
Liver_rep_21_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Mcam envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Mcam	GOBP_Response_To_Wounding	Mouse	Spinal cord	CN94_E1	4.7e-06
Mcam	GOBP_Renal_Filtration	Mouse	Spinal cord	L7bCN01_D2	6.1e-07
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Spinal cord	L7CN45_C1	6.1e-08
Mcam	GOBP_Biological_Adhesion	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	1.0e-07
Mcam	GOBP_Circulatory_System_Development	Mouse	Spinal cord	L7CN45_C1	5.7e-08
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Mcam	GOBP_Renal_System_Process	Mouse	Spinal cord	L7CN45_C1	2.5e-07
Mcam	GOBP_Tube_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Mcam	GOBP_Tube_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Mcam	GOBP_Vasculature_Development	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Mcam	GOBP_Wound_Healing	Mouse	Spinal cord	L7CN47_C1	8.4e-07
Mcam	GOBP_Cell_Migration	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Mcam	GOBP_Locomotion	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Mcam	GOBP_Renal_System_Process	Mouse	Brain	rep_21	5.0e-06
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	rep_3	5.3e-58
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Brain	rep_3	9.4e-12
Mcam	GOBP_Biological_Adhesion	Mouse	Brain	rep_3	4.3e-106
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Brain	rep_3	7.4e-87
Mcam	GOBP_Cell_Migration	Mouse	Brain	rep_3	4.9e-108
Mcam	GOBP_Circulatory_System_Development	Mouse	Brain	rep_3	1.3e-81
Mcam	GOBP_Locomotion	Mouse	Brain	rep_3	5.4e-74
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Brain	rep_3	6.5e-36
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Brain	rep_3	8.2e-109
Mcam	GOBP_Renal_Filtration	Mouse	Brain	rep_3	2.4e-45
Mcam	GOBP_Response_To_Wounding	Mouse	Brain	rep_3	6.2e-112
Mcam	GOBP_Tube_Development	Mouse	Brain	rep_3	9.0e-136
Mcam	GOBP_Tube_Morphogenesis	Mouse	Brain	rep_3	4.7e-120
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Brain	rep_3	6.9e-141
Mcam	GOBP_Vasculature_Development	Mouse	Brain	rep_3	2.6e-82
Mcam	GOBP_Wound_Healing	Mouse	Brain	rep_3	6.2e-109
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Embryo	rep_6	1.3e-12
Mcam	GOBP_Circulatory_System_Development	Mouse	Embryo	rep_6	1.6e-12
Mcam	GOBP_Renal_Filtration	Mouse	Embryo	rep_14	5.5e-25
Mcam	GOBP_Renal_System_Process	Mouse	Embryo	rep_14	1.6e-16
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Embryo	rep_14	3.3e-37
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Embryo	rep_1	2.4e-135
Mcam	GOBP_Biological_Adhesion	Mouse	Embryo	rep_1	2.2e-19
Mcam	GOBP_Cell_Migration	Mouse	Embryo	rep_1	7.4e-36
Mcam	GOBP_Locomotion	Mouse	Embryo	rep_1	1.7e-10
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Embryo	rep_1	1.9e-40
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Embryo	rep_1	2.4e-135
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Embryo	rep_6	3.8e-28
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Embryo	rep_6	1.6e-86
Mcam	GOBP_Vasculature_Development	Mouse	Embryo	rep_6	1.9e-41
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Mcam	GOBP_Cell_Migration	Mouse	Kidney	Nep	5.3e-07
Mcam	GOBP_Circulatory_System_Development	Mouse	Kidney	Nep	5.6e-37
Mcam	GOBP_Locomotion	Mouse	Kidney	Nep	5.3e-07
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Kidney	Nep	5.3e-07
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Kidney	Nep	5.3e-07
Mcam	GOBP_Response_To_Wounding	Mouse	Kidney	Nep	1.6e-16
Mcam	GOBP_Tube_Development	Mouse	Kidney	Nep	5.6e-37
Mcam	GOBP_Tube_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Mcam	GOBP_Vasculature_Development	Mouse	Kidney	Nep	5.6e-37
Mcam	GOBP_Wound_Healing	Mouse	Kidney	Nep	1.6e-16
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	rep_2	5.6e-148
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Kidney	rep_2	1.1e-139
Mcam	GOBP_Biological_Adhesion	Mouse	Kidney	rep_2	1.3e-48
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Kidney	rep_2	3.2e-114
Mcam	GOBP_Cell_Migration	Mouse	Kidney	rep_2	4.7e-40
Mcam	GOBP_Circulatory_System_Development	Mouse	Kidney	rep_2	6.7e-139
Mcam	GOBP_Locomotion	Mouse	Kidney	rep_2	2.1e-43
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Kidney	rep_2	2.1e-54
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Kidney	rep_2	5.4e-74
Mcam	GOBP_Renal_Filtration	Mouse	Kidney	rep_2	7.5e-99
Mcam	GOBP_Renal_System_Process	Mouse	Kidney	rep_2	8.4e-46
Mcam	GOBP_Response_To_Wounding	Mouse	Kidney	rep_2	2.1e-60
Mcam	GOBP_Tube_Development	Mouse	Kidney	rep_2	1.2e-129
Mcam	GOBP_Tube_Morphogenesis	Mouse	Kidney	rep_2	2.1e-134
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Kidney	rep_2	3.3e-61
Mcam	GOBP_Vasculature_Development	Mouse	Kidney	rep_2	2.3e-129
Mcam	GOBP_Wound_Healing	Mouse	Kidney	rep_2	6.5e-45
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Kidney	rep_4	7.0e-04
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Liver	CN65-D1	2.1e-08
Mcam	GOBP_Response_To_Wounding	Mouse	Liver	CN73-C1	1.1e-07
Mcam	GOBP_Wound_Healing	Mouse	Liver	CN73-C1	1.1e-08
Mcam	GOBP_Renal_Filtration	Mouse	Liver	rep_15	2.4e-09
Mcam	GOBP_Biological_Adhesion	Mouse	Liver	rep_16	2.1e-07
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Liver	rep_16	2.3e-09
Mcam	GOBP_Renal_System_Process	Mouse	Liver	rep_16	4.1e-08
Mcam	GOBP_Response_To_Wounding	Mouse	Liver	rep_16	1.3e-13
Mcam	GOBP_Wound_Healing	Mouse	Liver	rep_16	3.5e-11
Mcam	GOBP_Cell_Migration	Mouse	Liver	rep_26	1.6e-10
Mcam	GOBP_Locomotion	Mouse	Liver	rep_26	1.6e-10
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Liver	rep_26	1.6e-10
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Lymph	MS-1	6.4e-13
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Lymph	MS-1	4.9e-21
Mcam	GOBP_Biological_Adhesion	Mouse	Lymph	MS-1	8.0e-14
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Lymph	MS-1	3.6e-10
Mcam	GOBP_Cell_Migration	Mouse	Lymph	MS-1	5.7e-13
Mcam	GOBP_Circulatory_System_Development	Mouse	Lymph	MS-1	1.6e-11
Mcam	GOBP_Locomotion	Mouse	Lymph	MS-1	1.2e-12
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Lymph	MS-1	4.0e-14
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Lymph	MS-1	2.1e-13
Mcam	GOBP_Renal_System_Process	Mouse	Lymph	MS-1	3.1e-12
Mcam	GOBP_Tube_Development	Mouse	Lymph	MS-1	4.6e-09
Mcam	GOBP_Tube_Morphogenesis	Mouse	Lymph	MS-1	9.1e-10
Mcam	GOBP_Vasculature_Development	Mouse	Lymph	MS-1	3.0e-12
Mcam	GOBP_Biological_Adhesion	Mouse	Lung	rep_1	3.0e-22
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Brain	rep_4	2.1e-12
Mcam	GOBP_Cell_Migration	Mouse	Brain	HP_ad_rep7	2.2e-07
Mcam	GOBP_Locomotion	Mouse	Brain	HP_ad_rep7	3.8e-07
Mcam	GOBP_Regulation_Of_Cellular_Component_Movement	Mouse	Brain	HP_ad_rep7	4.0e-07
Mcam	GOBP_Response_To_Wounding	Mouse	Brain	HP_ad_rep7	4.3e-07
Mcam	GOBP_Tube_Development	Mouse	Brain	HP_ad_rep7	2.0e-08
Mcam	GOBP_Vascular_Wound_Healing	Mouse	Brain	HP_ad_rep8	2.0e-13
Mcam	GOBP_Renal_Filtration	Mouse	Brain	HP_adpolb_rep1	6.2e-07
Mcam	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	HP_polb_rep9	6.3e-08
Mcam	GOBP_Angiogenesis_Involved_In_Wound_Healing	Mouse	Brain	HP_polb_rep9	1.5e-10
Mcam	GOBP_Biological_Adhesion	Mouse	Brain	HP_polb_rep9	1.5e-07
Mcam	GOBP_Blood_Vessel_Morphogenesis	Mouse	Brain	HP_polb_rep9	1.0e-11
Mcam	GOBP_Circulatory_System_Development	Mouse	Brain	HP_polb_rep9	3.1e-09
Mcam	GOBP_Positive_Regulation_Of_Locomotion	Mouse	Brain	HP_polb_rep9	6.5e-08
Mcam	GOBP_Renal_System_Process	Mouse	Brain	HP_polb_rep9	4.8e-13
Mcam	GOBP_Tube_Morphogenesis	Mouse	Brain	HP_polb_rep9	4.0e-10
Mcam	GOBP_Vasculature_Development	Mouse	Brain	HP_polb_rep9	3.4e-10

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Mcam function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Mcam function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand	Receptor	LR pair	Tissue	Replication
Ntn1	Mcam	Ntn1_Mcam	Intestine	rep_3

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Transcription factor for Mcam envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Mcam

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Mcam

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Mcam	C0031149	Peritoneal Neoplasms	2	CTD_human
Mcam	C0345967	Malignant mesothelioma	2	CTD_human
Mcam	C0346990	Carcinomatosis of peritoneal cavity	2	CTD_human
Mcam	C0026769	Multiple Sclerosis	1	CTD_human
Mcam	C0600467	Neurogenic Inflammation	1	CTD_human
Mcam	C0751324	Multiple Sclerosis, Acute Fulminating	1	CTD_human
Mcam	C0751871	Autoimmune Diseases of the Nervous System	1	CTD_human
Mcam	C0751872	Immune Disorders, Nervous System	1	CTD_human