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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Sil1 (spascer ID:81500)

Gene summary for Sil1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Sil1
	Gene ID	81500
	Gene name	endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
	Synonyms	1810057E01Rik\|AI042831\|wz
	Cytomap	18\|18 B1- B2
	Type of gene	protein-coding
	Description	nucleotide exchange factor SIL1
	Modification date	20220424
	UniProtAcc	Q9EPK6

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for Sil1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Sil1	Mouse	Brain	S3	34413515	2.96e-15
Sil1	Mouse	Brain	S4	34413515	2.43e-15
Sil1	Mouse	Brain	S7	34413515	5.53e-06
Sil1	Mouse	Brain	rep_1	35141374	7.21e-10
Sil1	Mouse	Brain	rep_2	35141374	7.68e-07
Sil1	Mouse	Brain	rep_3	35141374	7.17e-07
Sil1	Mouse	Brain	rep_4	35141374	2.84e-15
Sil1	Mouse	Brain	rep_5	35141374	1.47e-15
Sil1	Mouse	Kidney	CLP	34003797	1.52e-07
Sil1	Mouse	Kidney	IRI	34003797	2.89e-08
Sil1	Mouse	Kidney	Sham	34003797	2.67e-06
Sil1	Mouse	Kidney	rep_5	34853151	7.20e-06
Sil1	Mouse	Brain	rep_1	35027729	1.72e-11
Sil1	Mouse	Brain	rep_2	35027729	2.09e-08
Sil1	Mouse	Brain	rep_3	35027729	1.32e-15
Sil1	Mouse	Brain	rep_5	35027729	3.26e-12
Sil1	Mouse	Intestine	rep_4	35149721	2.30e-15
Sil1	Mouse	Lymph	B1	0	5.96e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Sil1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Sil1	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Sil1	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Sil1	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Sil1	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Sil1	GOBP_Protein_Targeting	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Spinal cord	L7CN45_C1	2.9e-06
Sil1	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Mouse	Spinal cord	L7CN47_C1	7.0e-06
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Spinal cord	L7CN47_D1	5.5e-06
Sil1	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Sil1	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Mouse	Brain	rep_1	2.9e-25
Sil1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Brain	rep_3	1.5e-99
Sil1	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Sil1	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Sil1	GOBP_Protein_Folding	Mouse	Brain	rep_3	5.7e-177
Sil1	GOBP_Protein_Targeting	Mouse	Brain	rep_3	2.9e-187
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Brain	rep_3	1.5e-197
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Embryo	rep_14	6.3e-46
Sil1	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Mouse	Embryo	rep_14	1.7e-10
Sil1	GOBP_Protein_Folding	Mouse	Embryo	rep_14	3.2e-12
Sil1	GOBP_Protein_Targeting	Mouse	Embryo	rep_14	6.3e-09
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Embryo	rep_14	1.4e-25
Sil1	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Sil1	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Sil1	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Kidney	rep_2	8.2e-102
Sil1	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Sil1	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Mouse	Kidney	rep_2	4.7e-11
Sil1	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Sil1	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Sil1	GOBP_Protein_Targeting	Mouse	Kidney	rep_2	1.7e-40
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Kidney	rep_2	2.4e-30
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Liver	CN16-D1	2.3e-09
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Liver	CN16-D2	6.1e-07
Sil1	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Lymph	MS-1	2.5e-14
Sil1	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Sil1	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Mouse	Lymph	MS-1	1.3e-10
Sil1	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Sil1	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Sil1	GOBP_Protein_Folding	Mouse	Lymph	MS-1	1.6e-14
Sil1	GOBP_Protein_Targeting	Mouse	Lymph	MS-1	2.1e-09
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Lymph	MS-1	3.9e-09
Sil1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Sil1	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Mouse	Brain	HP_ad_rep7	2.6e-09
Sil1	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Sil1	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Sil1	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Sil1	GOBP_Protein_Targeting_To_Membrane	Mouse	Brain	HP_ad_rep7	1.1e-09
Sil1	GOBP_Protein_Folding	Mouse	Brain	HP_adpolb_rep1	5.2e-07
Sil1	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Mouse	Brain	HP_polb_rep9	3.1e-10
Sil1	GOBP_Protein_Targeting	Mouse	Brain	HP_polb_rep9	1.8e-11

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Sil1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Sil1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Sil1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Sil1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Sil1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Sil1	C0024814	Marinesco-Sjogren syndrome	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Sil1	C0033578	Prostatic Neoplasms	1	CTD_human
Sil1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Sil1	C3495676	Anorectal Malformations	1	GENOMICS_ENGLAND