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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Ppa2 (spascer ID:74776)

Gene summary for Ppa2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Ppa2
	Gene ID	74776
	Gene name	pyrophosphatase (inorganic) 2
	Synonyms	1110013G13Rik\|Sid6306
	Cytomap	3\|3 G3
	Type of gene	protein-coding
	Description	inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphate phospho-hydrolase 2
	Modification date	20220424
	UniProtAcc	Q91VM9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Ppa2	GO:0000287	magnesium ion binding	21873635	Function
Ppa2	GO:0004427	inorganic diphosphatase activity	21873635	Function
Ppa2	GO:0005739	mitochondrion	21873635	Component
Ppa2	GO:0005829	cytosol	21873635	Component
Ppa2	GO:0006796	phosphate-containing compound metabolic process	21873635	Process

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Spatial pattern events for Ppa2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Ppa2	Mouse	Brain	S2	34413515	6.25e-08
Ppa2	Mouse	Brain	S4	34413515	2.43e-15
Ppa2	Mouse	Brain	rep_4	35141374	7.06e-09
Ppa2	Mouse	Kidney	CLP	34003797	2.19e-15
Ppa2	Mouse	Kidney	IRI	34003797	2.29e-15
Ppa2	Mouse	Kidney	Sham	34003797	4.30e-15
Ppa2	Mouse	Kidney	rep_1	34853151	4.13e-15
Ppa2	Mouse	Kidney	rep_2	34853151	7.56e-08
Ppa2	Mouse	Kidney	rep_3	34853151	2.94e-15
Ppa2	Mouse	Kidney	rep_5	34853151	3.18e-15
Ppa2	Mouse	Brain	rep_1	33469025	1.30e-15
Ppa2	Mouse	Intestine	rep_2	35149721	6.06e-10
Ppa2	Mouse	Intestine	rep_3	35149721	3.25e-15
Ppa2	Mouse	Intestine	rep_4	35149721	1.77e-06
Ppa2	Mouse	Lung	rep_1	35290801	1.21e-14
Ppa2	Mouse	Lung	rep_2	35290801	2.97e-06
Ppa2	Mouse	Lung	rep_3	35290801	1.03e-06
Ppa2	Mouse	Lung	rep_4	35290801	5.40e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_4_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_3_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Ppa2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Spinal cord	CN93_D2	5.0e-06
Ppa2	GOBP_Protein_Dephosphorylation	Mouse	Spinal cord	CN94_E1	5.2e-07
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.5e-07
Ppa2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Ppa2	GOBP_Amide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Spinal cord	L7CN45_C1	1.9e-07
Ppa2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Ppa2	GOBP_Dephosphorylation	Mouse	Spinal cord	L7CN45_C1	3.3e-07
Ppa2	GOBP_Ncrna_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.5e-07
Ppa2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Ppa2	GOBP_Peptide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Ppa2	GOBP_Peptide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Ppa2	GOBP_Regulation_Of_Membrane_Potential	Mouse	Spinal cord	L7CN45_C1	3.3e-07
Ppa2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Ppa2	GOBP_Trna_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.6e-07
Ppa2	GOBP_Dephosphorylation	Mouse	Brain	rep_1	1.5e-40
Ppa2	GOBP_Protein_Dephosphorylation	Mouse	Brain	rep_1	1.0e-26
Ppa2	GOBP_Regulation_Of_Membrane_Potential	Mouse	Brain	rep_1	2.5e-34
Ppa2	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	rep_3	2.5e-86
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Brain	rep_3	5.9e-107
Ppa2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_3	8.5e-191
Ppa2	GOBP_Ncrna_Metabolic_Process	Mouse	Brain	rep_3	1.8e-46
Ppa2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Ppa2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Ppa2	GOBP_Peptide_Biosynthetic_Process	Mouse	Brain	rep_3	2.1e-69
Ppa2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	rep_3	1.3e-86
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Brain	rep_3	2.4e-199
Ppa2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Ppa2	GOBP_Trna_Metabolic_Process	Mouse	Brain	rep_3	2.5e-229
Ppa2	GOBP_Amide_Biosynthetic_Process	Mouse	Embryo	rep_14	3.7e-18
Ppa2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Ppa2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Ppa2	GOBP_Peptide_Biosynthetic_Process	Mouse	Embryo	rep_14	2.8e-15
Ppa2	GOBP_Peptide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Embryo	rep_14	6.8e-40
Ppa2	GOBP_Protein_Dephosphorylation	Mouse	Embryo	rep_1	1.2e-29
Ppa2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Embryo	rep_3	9.9e-51
Ppa2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Embryo	rep_3	1.0e-33
Ppa2	GOBP_Amide_Biosynthetic_Process	Mouse	Kidney	rep_2	1.9e-84
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Kidney	rep_2	4.4e-95
Ppa2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-34
Ppa2	GOBP_Dephosphorylation	Mouse	Kidney	rep_2	1.4e-90
Ppa2	GOBP_Ncrna_Metabolic_Process	Mouse	Kidney	rep_2	6.2e-81
Ppa2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Ppa2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Ppa2	GOBP_Peptide_Biosynthetic_Process	Mouse	Kidney	rep_2	2.9e-85
Ppa2	GOBP_Peptide_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-80
Ppa2	GOBP_Protein_Dephosphorylation	Mouse	Kidney	rep_2	2.0e-69
Ppa2	GOBP_Regulation_Of_Membrane_Potential	Mouse	Kidney	rep_2	1.8e-73
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Kidney	rep_2	1.5e-07
Ppa2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Ppa2	GOBP_Trna_Metabolic_Process	Mouse	Kidney	rep_2	1.9e-92
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Liver	CN65-C1	4.2e-10
Ppa2	GOBP_Ncrna_Metabolic_Process	Mouse	Liver	CN73-C1	1.4e-08
Ppa2	GOBP_Amide_Biosynthetic_Process	Mouse	Lymph	MS-1	1.3e-09
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Lymph	MS-1	1.4e-08
Ppa2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-13
Ppa2	GOBP_Dephosphorylation	Mouse	Lymph	MS-1	3.6e-12
Ppa2	GOBP_Ncrna_Metabolic_Process	Mouse	Lymph	MS-1	1.4e-09
Ppa2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Ppa2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Ppa2	GOBP_Peptide_Biosynthetic_Process	Mouse	Lymph	MS-1	7.1e-07
Ppa2	GOBP_Peptide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Ppa2	GOBP_Protein_Dephosphorylation	Mouse	Lymph	MS-1	2.7e-12
Ppa2	GOBP_Regulation_Of_Membrane_Potential	Mouse	Lymph	MS-1	6.3e-10
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Lymph	MS-1	1.5e-09
Ppa2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Ppa2	GOBP_Trna_Metabolic_Process	Mouse	Lymph	MS-1	1.0e-08
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Brain	rep_4	9.9e-142
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_4	1.9e-21
Ppa2	GOBP_Trna_Metabolic_Process	Mouse	Brain	rep_4	2.6e-107
Ppa2	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	8.0e-10
Ppa2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Ppa2	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.0e-14
Ppa2	GOBP_Dephosphorylation	Mouse	Brain	HP_ad_rep7	3.9e-08
Ppa2	GOBP_Ncrna_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-10
Ppa2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Ppa2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Ppa2	GOBP_Peptide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	4.4e-10
Ppa2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Ppa2	GOBP_Regulation_Of_Membrane_Potential	Mouse	Brain	HP_ad_rep7	1.9e-07
Ppa2	GOBP_Regulation_Of_Mitochondrial_Membrane_Potential	Mouse	Brain	HP_adpolb_rep1	7.1e-07
Ppa2	GOBP_Trna_Metabolic_Process	Mouse	Brain	HP_adpolb_rep5	9.9e-10
Ppa2	GOBP_Amino_Acid_Activation	Mouse	Brain	HP_polb_rep9	9.7e-14
Ppa2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09

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Ppa2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Ppa2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Ppa2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Ppa2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Ppa2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Ppa2	C4310663	SUDDEN CARDIAC FAILURE, ALCOHOL-INDUCED	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Ppa2	C4310664	SUDDEN CARDIAC FAILURE, INFANTILE	2	CTD_human;GENOMICS_ENGLAND;UNIPROT