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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Spsb1 (spascer ID:74646)

Gene summary for Spsb1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Spsb1
	Gene ID	74646
	Gene name	splA/ryanodine receptor domain and SOCS box containing 1
	Synonyms	1110014L01Rik\|4930422J18Rik\|AI596360\|AI854583\|SSB-1\|SSB1
	Cytomap	4\|4 E2
	Type of gene	protein-coding
	Description	SPRY domain-containing SOCS box protein 1SPRY domain-containing SOCS box protein SSB-1
	Modification date	20220424
	UniProtAcc	Q9D5L7

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Spsb1	GO:0019005	SCF ubiquitin ligase complex	21873635	Component
Spsb1	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635	Process

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Spatial pattern events for Spsb1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Spsb1	Mouse	Brain	S1	34413515	3.73e-15
Spsb1	Mouse	Brain	S2	34413515	2.85e-15
Spsb1	Mouse	Brain	S3	34413515	8.21e-07
Spsb1	Mouse	Brain	S4	34413515	1.37e-15
Spsb1	Mouse	Brain	S6	34413515	1.46e-15
Spsb1	Mouse	Brain	S7	34413515	1.55e-15
Spsb1	Mouse	Brain	07B	32637622	4.89e-06
Spsb1	Mouse	Brain	rep_1	35141374	2.68e-14
Spsb1	Mouse	Brain	rep_2	35141374	3.05e-15
Spsb1	Mouse	Brain	rep_3	35141374	1.64e-15
Spsb1	Mouse	Brain	rep_4	35141374	1.14e-06
Spsb1	Mouse	Brain	rep_5	35141374	1.47e-15
Spsb1	Mouse	Brain	rep_6	35141374	4.67e-12
Spsb1	Mouse	Embryo	rep_3	33188776	2.33e-08
Spsb1	Mouse	Kidney	CLP	34003797	2.19e-15
Spsb1	Mouse	Kidney	IRI	34003797	2.29e-15
Spsb1	Mouse	Brain	rep_1	33469025	1.30e-15
Spsb1	Mouse	Brain	rep_1	35027729	1.66e-15
Spsb1	Mouse	Brain	rep_2	35027729	1.57e-15
Spsb1	Mouse	Brain	rep_3	35027729	1.32e-15
Spsb1	Mouse	Brain	rep_4	35027729	5.15e-13
Spsb1	Mouse	Brain	rep_5	35027729	1.46e-15
Spsb1	Mouse	Intestine	rep_2	35149721	1.23e-07
Spsb1	Mouse	Brain	B05_E2	32702314	1.34e-08
Spsb1	Mouse	Testicle	rep_1	34731600	1.11e-14
Spsb1	Mouse	Testicle	rep_4	34731600	8.48e-06
Spsb1	Mouse	Lymph	A1	0	3.29e-15
Spsb1	Mouse	Lymph	B1	0	6.08e-15
Spsb1	Mouse	Lung	rep_4	35290801	3.04e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B05_E2_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Spsb1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Spinal cord	L7bCN02_E1	2.8e-06
Spsb1	GOBP_Macromolecule_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	7.5e-06
Spsb1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Spsb1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.1e-08
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Spinal cord	L7CN45_C1	5.2e-06
Spsb1	GOBP_Protein_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Spsb1	GOBP_Proteolysis	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Brain	rep_1	2.1e-07
Spsb1	GOBP_Cellular_Protein_Catabolic_Process	Mouse	Brain	rep_3	2.9e-162
Spsb1	GOBP_Macromolecule_Catabolic_Process	Mouse	Brain	rep_3	1.7e-159
Spsb1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Mouse	Brain	rep_3	8.7e-167
Spsb1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	rep_3	7.1e-166
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Brain	rep_3	6.2e-128
Spsb1	GOBP_Proteasomal_Protein_Catabolic_Process	Mouse	Brain	rep_3	2.9e-169
Spsb1	GOBP_Protein_Catabolic_Process	Mouse	Brain	rep_3	3.0e-174
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Mouse	Brain	rep_3	1.4e-184
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Mouse	Brain	rep_3	6.3e-190
Spsb1	GOBP_Proteolysis	Mouse	Brain	rep_3	1.8e-168
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Embryo	rep_14	1.7e-45
Spsb1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Mouse	Embryo	rep_1	7.5e-10
Spsb1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Embryo	rep_1	5.7e-21
Spsb1	GOBP_Protein_Catabolic_Process	Mouse	Embryo	rep_1	4.1e-19
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Mouse	Embryo	rep_1	4.4e-16
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Mouse	Embryo	rep_3	4.2e-21
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Embryo	rep_6	1.0e-23
Spsb1	GOBP_Proteolysis	Mouse	Kidney	Nep	6.8e-23
Spsb1	GOBP_Cellular_Protein_Catabolic_Process	Mouse	Kidney	rep_2	3.2e-21
Spsb1	GOBP_Macromolecule_Catabolic_Process	Mouse	Kidney	rep_2	7.0e-40
Spsb1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Mouse	Kidney	rep_2	1.0e-26
Spsb1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Kidney	rep_2	1.2e-14
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Kidney	rep_2	7.2e-84
Spsb1	GOBP_Proteasomal_Protein_Catabolic_Process	Mouse	Kidney	rep_2	5.3e-33
Spsb1	GOBP_Protein_Catabolic_Process	Mouse	Kidney	rep_2	7.3e-30
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Kidney	rep_2	4.9e-79
Spsb1	GOBP_Proteolysis	Mouse	Kidney	rep_2	6.0e-106
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Liver	CN73-C1	9.0e-07
Spsb1	GOBP_Cellular_Protein_Catabolic_Process	Mouse	Lymph	MS-1	1.1e-11
Spsb1	GOBP_Macromolecule_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Spsb1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Mouse	Lymph	MS-1	1.1e-11
Spsb1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Spsb1	GOBP_Protein_Catabolic_Process	Mouse	Lymph	MS-1	1.1e-11
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Mouse	Lymph	MS-1	1.4e-09
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Mouse	Lymph	MS-1	1.4e-09
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Lymph	MS-1	3.6e-11
Spsb1	GOBP_Proteolysis	Mouse	Lymph	MS-1	2.8e-10
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Lymph	PBS	6.0e-07
Spsb1	GOBP_Macromolecule_Catabolic_Process	Mouse	Lung	rep_1	2.0e-21
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Brain	rep_4	1.0e-15
Spsb1	GOBP_Macromolecule_Catabolic_Process	Mouse	Brain	HP_ad_rep7	1.3e-09
Spsb1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Mouse	Brain	HP_ad_rep7	1.3e-08
Spsb1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.3e-07
Spsb1	GOBP_Protein_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.3e-07
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Mouse	Brain	HP_ad_rep7	1.7e-09
Spsb1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Mouse	Brain	HP_ad_rep7	6.9e-09
Spsb1	GOBP_Protein_Polyubiquitination	Mouse	Brain	HP_ad_rep7	1.4e-10
Spsb1	GOBP_Proteolysis	Mouse	Brain	HP_ad_rep7	3.3e-07
Spsb1	GOBP_Cellular_Protein_Catabolic_Process	Mouse	Brain	HP_adpolb_rep1	7.2e-07
Spsb1	GOBP_Proteasomal_Protein_Catabolic_Process	Mouse	Brain	HP_adpolb_rep1	1.1e-07
Spsb1	GOBP_Post_Translational_Protein_Modification	Mouse	Brain	HP_polb_rep9	5.1e-14

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Spsb1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Spsb1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Spsb1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Spsb1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Spsb1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source