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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Chchd4 (spascer ID:72170)

Gene summary for Chchd4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Chchd4
	Gene ID	72170
	Gene name	coiled-coil-helix-coiled-coil-helix domain containing 4
	Synonyms	2410012P20Rik\|2810014D17Rik\|AI838740
	Cytomap	6\|6 D1
	Type of gene	protein-coding
	Description	mitochondrial intermembrane space import and assembly protein 40coiled-coil-helix-coiled-coil-helix domain-containing protein 4
	Modification date	20220424
	UniProtAcc	Q8VEA4

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Chchd4	GO:0005758	mitochondrial intermembrane space	21873635	Component
Chchd4	GO:0015035	protein-disulfide reductase activity	21873635	Function
Chchd4	GO:0022417	protein maturation by protein folding	21873635	Process
Chchd4	GO:0045041	protein import into mitochondrial intermembrane space	21873635	Process

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Spatial pattern events for Chchd4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Chchd4	Mouse	Brain	S1	34413515	5.18e-07
Chchd4	Mouse	Brain	S2	34413515	1.56e-15
Chchd4	Mouse	Brain	S3	34413515	2.96e-15
Chchd4	Mouse	Brain	S4	34413515	1.37e-15
Chchd4	Mouse	Brain	S6	34413515	1.46e-15
Chchd4	Mouse	Brain	S7	34413515	1.05e-13
Chchd4	Mouse	Brain	rep_2	35141374	1.83e-12
Chchd4	Mouse	Brain	rep_3	35141374	1.64e-15
Chchd4	Mouse	Brain	rep_4	35141374	1.66e-06
Chchd4	Mouse	Brain	rep_5	35141374	1.47e-15
Chchd4	Mouse	Brain	rep_6	35141374	1.16e-07
Chchd4	Mouse	Kidney	rep_4	34853151	1.04e-07
Chchd4	Mouse	Kidney	rep_5	34853151	5.23e-10
Chchd4	Mouse	Brain	rep_1	33469025	9.22e-10
Chchd4	Mouse	Brain	rep_1	35027729	1.66e-15
Chchd4	Mouse	Brain	rep_2	35027729	1.57e-15
Chchd4	Mouse	Brain	rep_3	35027729	2.38e-15
Chchd4	Mouse	Brain	rep_5	35027729	1.46e-15
Chchd4	Mouse	Intestine	rep_4	35149721	5.19e-08
Chchd4	Mouse	Brain	rep_1	35210624	7.74e-07
Chchd4	Mouse	Brain	rep_3	35210624	4.46e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Chchd4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Chchd4	GOBP_Protein_Import	Mouse	Spinal cord	CN94_E1	5.1e-06
Chchd4	GOBP_Protein_Maturation	Mouse	Spinal cord	CN94_E1	2.2e-06
Chchd4	GOBP_Mitochondrial_Transmembrane_Transport	Mouse	Spinal cord	L7bCN02_E1	9.2e-06
Chchd4	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Chchd4	GOBP_De_Novo_Protein_Folding	Mouse	Spinal cord	L7CN45_C1	8.9e-07
Chchd4	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Chchd4	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Chchd4	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Chchd4	GOBP_Mitochondrial_Transport	Mouse	Spinal cord	L7CN45_C1	6.6e-09
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Chchd4	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Chchd4	GOBP_Protein_Localization_To_Mitochondrion	Mouse	Spinal cord	L7CN45_C1	7.3e-07
Chchd4	GOBP_Protein_Localization_To_Organelle	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Chchd4	GOBP_Protein_Oxidation	Mouse	Spinal cord	L7CN45_C1	6.7e-09
Chchd4	GOBP_Protein_Targeting	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Chchd4	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Spinal cord	L7CN45_C1	1.5e-07
Chchd4	GOBP_Protein_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	3.8e-08
Chchd4	GOBP_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Chchd4	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Spinal cord	L7CN47_D1	3.7e-06
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Spinal cord	L7CN60_D1	7.1e-08
Chchd4	GOBP_Anion_Transmembrane_Transport	Mouse	Spinal cord	L7CN97_E2	6.0e-06
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Brain	rep_7	5.1e-07
Chchd4	GOBP_De_Novo_Protein_Folding	Mouse	Brain	rep_41	2.4e-06
Chchd4	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Brain	rep_71	2.8e-06
Chchd4	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Chchd4	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Brain	rep_1	5.0e-26
Chchd4	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	rep_1	9.0e-07
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Brain	rep_1	5.0e-18
Chchd4	GOBP_Transmembrane_Transport	Mouse	Brain	rep_1	3.1e-23
Chchd4	GOBP_Anion_Transmembrane_Transport	Mouse	Brain	rep_3	3.0e-77
Chchd4	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Chchd4	GOBP_De_Novo_Protein_Folding	Mouse	Brain	rep_3	1.7e-158
Chchd4	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	1.2e-180
Chchd4	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Chchd4	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Chchd4	GOBP_Mitochondrial_Transmembrane_Transport	Mouse	Brain	rep_3	1.8e-18
Chchd4	GOBP_Mitochondrial_Transport	Mouse	Brain	rep_3	5.2e-27
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Brain	rep_3	1.3e-89
Chchd4	GOBP_Peptidyl_Cysteine_Modification	Mouse	Brain	rep_3	7.9e-67
Chchd4	GOBP_Protein_Folding	Mouse	Brain	rep_3	5.7e-177
Chchd4	GOBP_Protein_Import	Mouse	Brain	rep_3	4.9e-170
Chchd4	GOBP_Protein_Localization_To_Mitochondrion	Mouse	Brain	rep_3	2.6e-172
Chchd4	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	6.3e-172
Chchd4	GOBP_Protein_Maturation	Mouse	Brain	rep_3	1.1e-160
Chchd4	GOBP_Protein_Oxidation	Mouse	Brain	rep_3	3.9e-31
Chchd4	GOBP_Protein_Targeting	Mouse	Brain	rep_3	2.9e-187
Chchd4	GOBP_Protein_Targeting_To_Mitochondrion	Mouse	Brain	rep_3	5.6e-190
Chchd4	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Brain	rep_3	1.1e-203
Chchd4	GOBP_Protein_Transmembrane_Transport	Mouse	Brain	rep_3	4.1e-194
Chchd4	GOBP_Anion_Transmembrane_Transport	Mouse	Embryo	rep_14	5.1e-40
Chchd4	GOBP_De_Novo_Protein_Folding	Mouse	Embryo	rep_14	7.6e-59
Chchd4	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Embryo	rep_14	5.0e-27
Chchd4	GOBP_Mitochondrial_Transmembrane_Transport	Mouse	Embryo	rep_14	2.8e-49
Chchd4	GOBP_Mitochondrial_Transport	Mouse	Embryo	rep_14	7.6e-20
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Embryo	rep_14	1.8e-11
Chchd4	GOBP_Peptidyl_Cysteine_Modification	Mouse	Embryo	rep_14	3.2e-53
Chchd4	GOBP_Protein_Folding	Mouse	Embryo	rep_14	3.2e-12
Chchd4	GOBP_Protein_Localization_To_Mitochondrion	Mouse	Embryo	rep_14	7.1e-11
Chchd4	GOBP_Protein_Maturation	Mouse	Embryo	rep_14	6.3e-10
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Embryo	rep_14	3.9e-30
Chchd4	GOBP_Protein_Oxidation	Mouse	Embryo	rep_14	6.3e-50
Chchd4	GOBP_Protein_Targeting	Mouse	Embryo	rep_14	6.3e-09
Chchd4	GOBP_Protein_Targeting_To_Mitochondrion	Mouse	Embryo	rep_14	5.3e-07
Chchd4	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Embryo	rep_14	8.4e-89
Chchd4	GOBP_Protein_Transmembrane_Transport	Mouse	Embryo	rep_14	1.3e-58
Chchd4	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Embryo	rep_1	8.6e-17
Chchd4	GOBP_Protein_Import	Mouse	Embryo	rep_1	1.6e-15
Chchd4	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Chchd4	GOBP_Mitochondrial_Transport	Mouse	Embryo	rep_3	1.5e-18
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Embryo	rep_3	4.0e-48
Chchd4	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Embryo	rep_3	0.0e+00
Chchd4	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Chchd4	GOBP_Protein_Maturation	Mouse	Kidney	IRI	2.5e-33
Chchd4	GOBP_Transmembrane_Transport	Mouse	Kidney	Nep	4.2e-26
Chchd4	GOBP_Anion_Transmembrane_Transport	Mouse	Kidney	rep_2	1.0e-56
Chchd4	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Chchd4	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Chchd4	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.3e-19
Chchd4	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Chchd4	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Chchd4	GOBP_Mitochondrial_Transmembrane_Transport	Mouse	Kidney	rep_2	1.8e-14
Chchd4	GOBP_Mitochondrial_Transport	Mouse	Kidney	rep_2	1.3e-10
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Kidney	rep_2	1.7e-21
Chchd4	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Kidney	rep_2	6.9e-23
Chchd4	GOBP_Peptidyl_Cysteine_Modification	Mouse	Kidney	rep_2	8.8e-94
Chchd4	GOBP_Protein_Import	Mouse	Kidney	rep_2	8.2e-25
Chchd4	GOBP_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.4e-44
Chchd4	GOBP_Protein_Maturation	Mouse	Kidney	rep_2	5.4e-103
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Kidney	rep_2	7.6e-67
Chchd4	GOBP_Protein_Oxidation	Mouse	Kidney	rep_2	1.0e-205
Chchd4	GOBP_Protein_Targeting	Mouse	Kidney	rep_2	1.7e-40
Chchd4	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Kidney	rep_2	3.6e-33
Chchd4	GOBP_Protein_Transmembrane_Transport	Mouse	Kidney	rep_2	4.9e-20
Chchd4	GOBP_Transmembrane_Transport	Mouse	Kidney	rep_2	2.7e-23
Chchd4	GOBP_Protein_Oxidation	Mouse	Liver	CN16-D1	1.6e-08
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Liver	CN16-E1	9.6e-09
Chchd4	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Liver	rep_16	4.3e-23
Chchd4	GOBP_Protein_Maturation	Mouse	Liver	rep_16	4.5e-09
Chchd4	GOBP_Transmembrane_Transport	Mouse	Liver	rep_16	1.4e-13
Chchd4	GOBP_Protein_Oxidation	Mouse	Liver	rep_23	9.2e-23
Chchd4	GOBP_Anion_Transmembrane_Transport	Mouse	Lymph	MS-1	7.5e-13
Chchd4	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Chchd4	GOBP_De_Novo_Protein_Folding	Mouse	Lymph	MS-1	2.6e-15
Chchd4	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Chchd4	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	3.3e-11
Chchd4	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Chchd4	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Lymph	MS-1	4.2e-09
Chchd4	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Lymph	MS-1	1.2e-13
Chchd4	GOBP_Peptidyl_Cysteine_Modification	Mouse	Lymph	MS-1	6.4e-08
Chchd4	GOBP_Protein_Folding	Mouse	Lymph	MS-1	1.6e-14
Chchd4	GOBP_Protein_Import	Mouse	Lymph	MS-1	8.2e-11
Chchd4	GOBP_Protein_Localization_To_Mitochondrion	Mouse	Lymph	MS-1	6.2e-09
Chchd4	GOBP_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	1.4e-09
Chchd4	GOBP_Protein_Maturation_By_Protein_Folding	Mouse	Lymph	MS-1	1.7e-11
Chchd4	GOBP_Protein_Oxidation	Mouse	Lymph	MS-1	4.8e-17
Chchd4	GOBP_Protein_Targeting	Mouse	Lymph	MS-1	2.1e-09
Chchd4	GOBP_Protein_Targeting_To_Mitochondrion	Mouse	Lymph	MS-1	2.3e-08
Chchd4	GOBP_Protein_Localization_To_Mitochondrion	Mouse	Brain	rep_7	5.0e-20
Chchd4	GOBP_Protein_Oxidation	Mouse	Brain	HP_ad_rep4	2.2e-08
Chchd4	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Chchd4	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Chchd4	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	6.1e-09
Chchd4	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Chchd4	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Chchd4	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	HP_ad_rep7	3.2e-08
Chchd4	GOBP_Peptidyl_Cysteine_Modification	Mouse	Brain	HP_ad_rep7	9.1e-16
Chchd4	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	4.8e-12
Chchd4	GOBP_Protein_Targeting_To_Mitochondrion	Mouse	Brain	HP_ad_rep7	1.0e-07
Chchd4	GOBP_Protein_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	2.7e-07
Chchd4	GOBP_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	3.4e-07
Chchd4	GOBP_Protein_Folding	Mouse	Brain	HP_adpolb_rep1	5.2e-07
Chchd4	GOBP_De_Novo_Protein_Folding	Mouse	Brain	HP_polb_rep2	8.2e-08
Chchd4	GOBP_Anion_Transmembrane_Transport	Mouse	Brain	HP_polb_rep9	6.5e-17
Chchd4	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Brain	HP_polb_rep9	7.2e-14
Chchd4	GOBP_Mitochondrial_Transmembrane_Transport	Mouse	Brain	HP_polb_rep9	4.7e-07
Chchd4	GOBP_Mitochondrial_Transport	Mouse	Brain	HP_polb_rep9	1.3e-11
Chchd4	GOBP_Mitochondrion_Organization	Mouse	Brain	HP_polb_rep9	1.2e-11
Chchd4	GOBP_Protein_Import	Mouse	Brain	HP_polb_rep9	1.1e-07
Chchd4	GOBP_Protein_Localization_To_Mitochondrion	Mouse	Brain	HP_polb_rep9	8.6e-11
Chchd4	GOBP_Protein_Maturation	Mouse	Brain	HP_polb_rep9	9.1e-14
Chchd4	GOBP_Protein_Targeting	Mouse	Brain	HP_polb_rep9	1.8e-11
Chchd4	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Brain	HP_polb_rep9	1.1e-17

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Chchd4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Chchd4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Chchd4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Chchd4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Chchd4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source