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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Prss22 (spascer ID:70835)

Gene summary for Prss22

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Prss22
	Gene ID	70835
	Gene name	protease, serine 22
	Synonyms	4733401N09Rik\|BSSP-4\|SP001LA
	Cytomap	17 A3.3\|17 12.18 cM
	Type of gene	protein-coding
	Description	brain-specific serine protease 4serine protease 22serine protease 26tryptase epsilon
	Modification date	20220424
	UniProtAcc	Q9ER10

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for Prss22

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Prss22	Mouse	Kidney	IRI	34003797	2.29e-15
Prss22	Mouse	Lung	rep_1	35290801	4.52e-15
Prss22	Mouse	Lung	rep_2	35290801	7.23e-15
Prss22	Mouse	Lung	rep_3	35290801	8.40e-15
Prss22	Mouse	Lung	rep_4	35290801	3.04e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_IRI_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Prss22 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Spinal cord	CN94_E1	2.4e-06
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Prss22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	1.8e-08
Prss22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Prss22	GOBP_Positive_Regulation_Of_Peptidase_Activity	Mouse	Spinal cord	L7CN45_C1	1.5e-07
Prss22	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Prss22	GOBP_Positive_Regulation_Of_Proteolysis	Mouse	Spinal cord	L7CN45_C1	4.7e-10
Prss22	GOBP_Proteolysis	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Brain	rep_61	2.0e-05
Prss22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_1	1.0e-11
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Prss22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Prss22	GOBP_Positive_Regulation_Of_Peptidase_Activity	Mouse	Brain	rep_3	6.0e-162
Prss22	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	rep_3	9.9e-174
Prss22	GOBP_Positive_Regulation_Of_Proteolysis	Mouse	Brain	rep_3	3.7e-138
Prss22	GOBP_Proteolysis	Mouse	Brain	rep_3	1.8e-168
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	1.4e-120
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Brain	rep_3	9.5e-157
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Brain	rep_3	6.6e-161
Prss22	GOBP_Positive_Regulation_Of_Peptidase_Activity	Mouse	Embryo	rep_14	7.0e-34
Prss22	GOBP_Positive_Regulation_Of_Proteolysis	Mouse	Embryo	rep_14	3.1e-16
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	8.5e-07
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Embryo	rep_14	6.4e-29
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Embryo	rep_14	3.6e-20
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Prss22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_1	1.6e-15
Prss22	GOBP_Positive_Regulation_Of_Peptidase_Activity	Mouse	Embryo	rep_1	5.0e-25
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Prss22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.4e-48
Prss22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Prss22	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	Nep	4.3e-38
Prss22	GOBP_Positive_Regulation_Of_Proteolysis	Mouse	Kidney	Nep	1.9e-36
Prss22	GOBP_Proteolysis	Mouse	Kidney	Nep	6.8e-23
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.3e-36
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Kidney	Nep	5.6e-37
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Kidney	Nep	4.3e-38
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Prss22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	3.6e-50
Prss22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Prss22	GOBP_Positive_Regulation_Of_Peptidase_Activity	Mouse	Kidney	rep_2	3.0e-111
Prss22	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-43
Prss22	GOBP_Positive_Regulation_Of_Proteolysis	Mouse	Kidney	rep_2	7.0e-61
Prss22	GOBP_Proteolysis	Mouse	Kidney	rep_2	6.0e-106
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	1.4e-60
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Kidney	rep_2	5.7e-75
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Kidney	rep_2	4.3e-62
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Prss22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Prss22	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Lymph	MS-1	1.9e-12
Prss22	GOBP_Proteolysis	Mouse	Lymph	MS-1	2.8e-10
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	1.9e-08
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Lymph	MS-1	4.0e-08
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Lymph	MS-1	7.3e-10
Prss22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Prss22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_ad_rep7	4.8e-07
Prss22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Prss22	GOBP_Proteolysis	Mouse	Brain	HP_ad_rep7	3.3e-07
Prss22	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.0e-11
Prss22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	6.0e-09
Prss22	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Brain	HP_polb_rep9	5.2e-09
Prss22	GOBP_Regulation_Of_Proteolysis	Mouse	Brain	HP_polb_rep9	1.5e-07

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Prss22 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Prss22 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Prss22 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Prss22

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Prss22

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source