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Spatial pattern gene: Afap1 (spascer ID:70292) |
Gene summary for Afap1 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Afap1 | Gene ID | 70292 |
| Gene name | actin filament associated protein 1 |
| Synonyms | 2600003E23Rik|9630044L16Rik|AI848729|Afap|mKIAA3018 |
| Cytomap | 5|5 B3 |
| Type of gene | protein-coding |
| Description | actin filament-associated protein 1110 kDa actin filament-associated proteinAFAP-110 |
| Modification date | 20220428 |
| UniProtAcc | Q80YS6 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Afap1 | GO:0005829 | cytosol | 21873635 | Component |
| Afap1 | GO:0017124 | SH3 domain binding | 21873635 | Function |
| Afap1 | GO:0042169 | SH2 domain binding | 21873635 | Function |
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Spatial pattern events for Afap1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Afap1 | Mouse | Brain | S2 | 34413515 | 7.54e-07 |
| Afap1 | Mouse | Brain | S6 | 34413515 | 8.09e-11 |
| Afap1 | Mouse | Embryo | rep_1 | 33188776 | 9.94e-15 |
| Afap1 | Mouse | Embryo | rep_2 | 33188776 | 3.54e-10 |
| Afap1 | Mouse | Embryo | rep_3 | 33188776 | 1.95e-12 |
| Afap1 | Mouse | Embryo | rep_5 | 33188776 | 3.67e-08 |
| Afap1 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Afap1 | Mouse | Brain | rep_1 | 35027729 | 1.23e-06 |
| Afap1 | Mouse | Brain | rep_3 | 35027729 | 6.28e-13 |
| Afap1 | Mouse | Intestine | rep_3 | 35149721 | 5.86e-07 |
| Afap1 | Mouse | Intestine | rep_4 | 35149721 | 2.30e-15 |
| Afap1 | Mouse | Lymph | A1 | 0 | 6.07e-11 |
| Afap1 | Mouse | Lymph | B1 | 0 | 9.50e-10 |
| Afap1 | Mouse | Brain | rep_2 | 35210624 | 8.35e-07 |
| Afap1 | Mouse | Brain | rep_7 | 35210624 | 2.45e-14 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_3_H&E  |  |
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Spatial pattern pathway has Afap1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Afap1 | GOBP_Cytoskeleton_Organization | Mouse | Spinal cord | L7bCN02_E1 | 8.3e-06 |
| Afap1 | GOBP_Cytoskeleton_Organization | Mouse | Brain | rep_1 | 1.1e-11 |
| Afap1 | GOBP_Regulation_Of_Cytoskeleton_Organization | Mouse | Brain | rep_1 | 1.1e-40 |
| Afap1 | GOBP_Regulation_Of_Organelle_Organization | Mouse | Brain | rep_1 | 7.9e-20 |
| Afap1 | GOBP_Regulation_Of_Cytoskeleton_Organization | Mouse | Embryo | rep_1 | 2.6e-63 |
| Afap1 | GOBP_Regulation_Of_Organelle_Organization | Mouse | Embryo | rep_3 | 1.3e-27 |
| Afap1 | GOBP_Cytoskeleton_Organization | Mouse | Kidney | rep_2 | 1.5e-44 |
| Afap1 | GOBP_Regulation_Of_Cytoskeleton_Organization | Mouse | Kidney | rep_2 | 1.8e-22 |
| Afap1 | GOBP_Regulation_Of_Organelle_Organization | Mouse | Kidney | rep_2 | 6.7e-77 |
| Afap1 | GOBP_Cytoskeleton_Organization | Mouse | Lymph | MS-1 | 1.8e-13 |
| Afap1 | GOBP_Regulation_Of_Cytoskeleton_Organization | Mouse | Lymph | MS-1 | 8.4e-09 |
| Afap1 | GOBP_Regulation_Of_Organelle_Organization | Mouse | Lymph | MS-1 | 1.4e-10 |
| Afap1 | GOBP_Cytoskeleton_Organization | Mouse | Brain | HP_ad_rep7 | 5.3e-08 |
| Afap1 | GOBP_Regulation_Of_Organelle_Organization | Mouse | Brain | HP_ad_rep7 | 8.1e-07 |
| Afap1 | GOBP_Regulation_Of_Cytoskeleton_Organization | Mouse | Brain | HP_polb_rep9 | 1.1e-07 |
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Afap1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Afap1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Afap1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Afap1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Afap1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
