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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tmem109 (spascer ID:68539)

Gene summary for Tmem109

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tmem109
	Gene ID	68539
	Gene name	transmembrane protein 109
	Synonyms	1110006I15Rik\|AA958958\|C77652
	Cytomap	19\|19 A
	Type of gene	protein-coding
	Description	transmembrane protein 109mg23mitsugumin-23mitsugumin23
	Modification date	20220424
	UniProtAcc	Q3UBX0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tmem109	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	21873635	Process
Tmem109	GO:0060548	negative regulation of cell death	21873635	Process
Tmem109	GO:0071480	cellular response to gamma radiation	21873635	Process

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Spatial pattern events for Tmem109

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tmem109	Mouse	Brain	S2	34413515	1.56e-15
Tmem109	Mouse	Brain	S4	34413515	4.65e-15
Tmem109	Mouse	Brain	S6	34413515	5.07e-15
Tmem109	Mouse	Brain	S7	34413515	5.30e-14
Tmem109	Mouse	Kidney	IRI	34003797	7.69e-13
Tmem109	Mouse	Kidney	rep_3	34853151	2.27e-14
Tmem109	Mouse	Brain	rep_1	33469025	1.30e-15
Tmem109	Mouse	Brain	rep_3	35027729	1.89e-08
Tmem109	Mouse	Intestine	rep_2	35149721	8.27e-08
Tmem109	Mouse	Intestine	rep_3	35149721	2.49e-07
Tmem109	Mouse	Intestine	rep_4	35149721	2.30e-15
Tmem109	Mouse	Lung	rep_1	35290801	4.52e-15
Tmem109	Mouse	Lung	rep_2	35290801	2.35e-10
Tmem109	Mouse	Lung	rep_4	35290801	4.47e-08
Tmem109	Mouse	Brain	rep_1	35210624	2.25e-07
Tmem109	Mouse	Brain	rep_3	35210624	2.94e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_IRI_H&E
Kidney_rep_3_H&E
Brain_rep_1_H&E
Brain_rep_3_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Tmem109 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tmem109	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Spinal cord	CN94_E1	8.0e-06
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Spinal cord	CN94_E1	5.3e-07
Tmem109	GOBP_Apoptotic_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Spinal cord	L7CN45_C1	5.3e-08
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Spinal cord	L7CN45_C1	3.1e-08
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Tmem109	GOBP_Regulation_Of_Ion_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Tmem109	GOBP_Regulation_Of_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	8.8e-08
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Spinal cord	L7CN45_C1	1.3e-07
Tmem109	GOBP_Response_To_Ionizing_Radiation	Mouse	Spinal cord	L7CN45_C1	6.9e-07
Tmem109	GOBP_Response_To_Radiation	Mouse	Spinal cord	L7CN45_C1	4.5e-07
Tmem109	GOBP_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Spinal cord	L7CN47_D1	2.5e-06
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Spinal cord	L7CN60_D1	8.9e-07
Tmem109	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_27	6.3e-05
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Brain	rep_75	4.3e-06
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Brain	rep_75	3.1e-05
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Brain	rep_75	4.2e-05
Tmem109	GOBP_Regulation_Of_Ion_Transport	Mouse	Brain	rep_1	8.9e-34
Tmem109	GOBP_Regulation_Of_Transmembrane_Transport	Mouse	Brain	rep_1	1.4e-17
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Brain	rep_1	3.9e-15
Tmem109	GOBP_Response_To_Abiotic_Stimulus	Mouse	Brain	rep_1	6.0e-28
Tmem109	GOBP_Transmembrane_Transport	Mouse	Brain	rep_1	3.1e-23
Tmem109	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	3.7e-187
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Brain	rep_3	5.3e-101
Tmem109	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	rep_3	5.0e-192
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Brain	rep_3	7.4e-142
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Brain	rep_3	4.9e-158
Tmem109	GOBP_Cellular_Response_To_Radiation	Mouse	Brain	rep_3	9.7e-149
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	1.4e-174
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Brain	rep_3	1.6e-154
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Brain	rep_3	1.0e-166
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Brain	rep_3	8.4e-161
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	2.5e-150
Tmem109	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	7.6e-107
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Brain	rep_3	9.8e-143
Tmem109	GOBP_Response_To_Ionizing_Radiation	Mouse	Brain	rep_3	7.3e-150
Tmem109	GOBP_Response_To_Radiation	Mouse	Brain	rep_3	4.6e-08
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Brain	rep_3	6.9e-120
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Embryo	rep_14	1.6e-15
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Embryo	rep_14	7.5e-38
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Embryo	rep_14	1.9e-22
Tmem109	GOBP_Cellular_Response_To_Radiation	Mouse	Embryo	rep_14	2.0e-21
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_14	6.3e-15
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Embryo	rep_14	6.0e-09
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Embryo	rep_14	1.5e-19
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Embryo	rep_14	1.2e-31
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Embryo	rep_14	7.8e-29
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Embryo	rep_14	6.6e-44
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Embryo	rep_1	1.5e-32
Tmem109	GOBP_Cellular_Response_To_Radiation	Mouse	Embryo	rep_1	2.5e-07
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Embryo	rep_1	0.0e+00
Tmem109	GOBP_Regulation_Of_Cell_Death	Mouse	Embryo	rep_1	8.4e-30
Tmem109	GOBP_Response_To_Ionizing_Radiation	Mouse	Embryo	rep_1	8.2e-74
Tmem109	GOBP_Response_To_Radiation	Mouse	Embryo	rep_1	0.0e+00
Tmem109	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Embryo	rep_2	1.4e-08
Tmem109	GOBP_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	2.2e-45
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	0.0e+00
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Embryo	rep_3	1.9e-126
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Embryo	rep_3	2.6e-234
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Embryo	rep_3	2.8e-65
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Embryo	rep_4	3.5e-48
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Embryo	rep_5	7.7e-33
Tmem109	GOBP_Regulation_Of_Transmembrane_Transport	Mouse	Kidney	Nep	4.2e-26
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Kidney	Nep	2.6e-47
Tmem109	GOBP_Transmembrane_Transport	Mouse	Kidney	Nep	4.2e-26
Tmem109	GOBP_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	1.1e-44
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Kidney	rep_2	3.2e-12
Tmem109	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Kidney	rep_2	5.5e-146
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	3.8e-88
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Kidney	rep_2	2.9e-73
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Kidney	rep_2	3.1e-133
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Kidney	rep_2	1.1e-41
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Kidney	rep_2	4.6e-36
Tmem109	GOBP_Regulation_Of_Ion_Transport	Mouse	Kidney	rep_2	5.5e-106
Tmem109	GOBP_Regulation_Of_Transmembrane_Transport	Mouse	Kidney	rep_2	2.0e-115
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Kidney	rep_2	2.4e-58
Tmem109	GOBP_Response_To_Ionizing_Radiation	Mouse	Kidney	rep_2	6.8e-10
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Kidney	rep_2	1.0e-97
Tmem109	GOBP_Transmembrane_Transport	Mouse	Kidney	rep_2	2.7e-23
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Liver	CN16-D2	2.8e-09
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Liver	CN16-D2	1.7e-07
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Liver	CN16-D2	9.3e-07
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Liver	CN73-C1	9.3e-08
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Liver	CN73-C1	1.8e-07
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Liver	rep_15	1.9e-17
Tmem109	GOBP_Cellular_Response_To_Radiation	Mouse	Liver	rep_15	3.9e-14
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Liver	rep_16	7.4e-28
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Liver	rep_16	2.1e-07
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Liver	rep_16	1.5e-11
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.7e-09
Tmem109	GOBP_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.0e-13
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Liver	rep_16	2.8e-11
Tmem109	GOBP_Transmembrane_Transport	Mouse	Liver	rep_16	1.4e-13
Tmem109	GOBP_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	1.2e-12
Tmem109	GOBP_Cellular_Response_To_Abiotic_Stimulus	Mouse	Lymph	MS-1	3.8e-08
Tmem109	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Lymph	MS-1	8.5e-13
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Lymph	MS-1	3.9e-07
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Lymph	MS-1	1.1e-07
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	2.5e-14
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Lymph	MS-1	4.9e-14
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Lymph	MS-1	1.1e-13
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Lymph	MS-1	1.5e-13
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	3.9e-13
Tmem109	GOBP_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	1.9e-12
Tmem109	GOBP_Regulation_Of_Ion_Transport	Mouse	Lymph	MS-1	1.5e-09
Tmem109	GOBP_Regulation_Of_Transmembrane_Transport	Mouse	Lymph	MS-1	3.3e-13
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Lymph	MS-1	1.4e-12
Tmem109	GOBP_Response_To_Abiotic_Stimulus	Mouse	Lymph	MS-1	1.5e-07
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Lymph	MS-1	3.4e-18
Tmem109	GOBP_Response_To_Ionizing_Radiation	Mouse	Lymph	MS-1	2.5e-12
Tmem109	GOBP_Response_To_Radiation	Mouse	Lymph	MS-1	9.1e-12
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Lymph	MS-1	3.2e-10
Tmem109	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	HP_ad_rep7	6.8e-10
Tmem109	GOBP_Cellular_Response_To_Gamma_Radiation	Mouse	Brain	HP_ad_rep7	4.6e-10
Tmem109	GOBP_Cellular_Response_To_Ionizing_Radiation	Mouse	Brain	HP_ad_rep7	4.2e-08
Tmem109	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	HP_ad_rep7	1.6e-07
Tmem109	GOBP_Regulation_Of_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	1.5e-07
Tmem109	GOBP_Regulation_Of_Transport	Mouse	Brain	HP_ad_rep7	9.2e-09
Tmem109	GOBP_Response_To_Abiotic_Stimulus	Mouse	Brain	HP_ad_rep7	4.3e-08
Tmem109	GOBP_Response_To_Gamma_Radiation	Mouse	Brain	HP_ad_rep7	1.1e-07
Tmem109	GOBP_Response_To_Ionizing_Radiation	Mouse	Brain	HP_ad_rep7	2.5e-09
Tmem109	GOBP_Response_To_Radiation	Mouse	Brain	HP_ad_rep7	9.1e-09
Tmem109	GOBP_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	3.4e-07
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_Mediator	Mouse	Brain	HP_adpolb_rep1	3.0e-10
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage	Mouse	Brain	HP_adpolb_rep1	3.4e-11
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_Damage_By_P53_Class_Mediator	Mouse	Brain	HP_adpolb_rep1	6.6e-07
Tmem109	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Brain	HP_adpolb_rep1	5.9e-12
Tmem109	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	3.2e-07
Tmem109	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	2.7e-09
Tmem109	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Brain	HP_polb_rep9	9.2e-10

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Tmem109 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tmem109 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tmem109 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tmem109

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tmem109

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source