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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Map1lc3b (spascer ID:67443)

Gene summary for Map1lc3b

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Map1lc3b

Gene ID

67443

Gene namemicrotubule-associated protein 1 light chain 3 beta
Synonyms1010001C15Rik|Atg8|LC3b|MAP1A/MAP1B|Map1lc3
Cytomap8|8 E1
Type of geneprotein-coding
Descriptionmicrotubule-associated proteins 1A/1B light chain 3BMAP1 light chain 3-like protein 2MAP1A/MAP1B light chain 3 Bautophagy-related protein LC3 Bautophagy-related ubiquitin-like modifier LC3 B
Modification date20220424
UniProtAcc

Q9CQV6


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Map1lc3b

GO:0000045

autophagosome assembly

21873635

Process
Map1lc3b

GO:0000421

autophagosome membrane

21873635

Component
Map1lc3b

GO:0000422

autophagy of mitochondrion

21873635

Process
Map1lc3b

GO:0005776

autophagosome

21873635

Component
Map1lc3b

GO:0005829

cytosol

21873635

Component
Map1lc3b

GO:0006995

cellular response to nitrogen starvation

21873635

Process
Map1lc3b

GO:0008017

microtubule binding

21873635

Function
Map1lc3b

GO:0016236

macroautophagy

21873635

Process
Map1lc3b

GO:0031625

ubiquitin protein ligase binding

21873635

Function
Map1lc3b

GO:0097352

autophagosome maturation

21873635

Process

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Spatial pattern events for Map1lc3b

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Map1lc3bMouseBrainS1 344135152.07e-15
Map1lc3bMouseBrainS2 344135151.56e-15
Map1lc3bMouseBrainS3 344135151.64e-15
Map1lc3bMouseBrainS4 344135151.37e-15
Map1lc3bMouseBrainS6 344135151.46e-15
Map1lc3bMouseBrainS7 344135151.55e-15
Map1lc3bMouseBrain24B 326376221.65e-08
Map1lc3bMouseBrain27B 326376227.64e-09
Map1lc3bMouseBrain28A 326376223.15e-11
Map1lc3bMouseBrain28B 326376229.82e-09
Map1lc3bMouseBrain29A 326376221.82e-14
Map1lc3bMouseBrain29B 326376225.26e-07
Map1lc3bMouseBrain31A 326376221.12e-09
Map1lc3bMouseBrain34A 326376229.00e-06
Map1lc3bMouseBrainrep_1 351413742.02e-15
Map1lc3bMouseBrainrep_2 351413741.69e-15
Map1lc3bMouseBrainrep_3 351413741.64e-15
Map1lc3bMouseBrainrep_4 351413741.57e-15
Map1lc3bMouseBrainrep_5 351413741.47e-15
Map1lc3bMouseBrainrep_6 351413741.73e-15
Map1lc3bMouseEmbryorep_12 331887763.05e-08
Map1lc3bMouseKidneyCLP 340037972.19e-15
Map1lc3bMouseKidneySham 340037974.30e-15
Map1lc3bMouseKidneyrep_1 348531512.42e-15
Map1lc3bMouseKidneyrep_4 348531511.95e-06
Map1lc3bMouseBrainrep_1 334690251.30e-15
Map1lc3bMouseIntestinerep_2 351497213.44e-15
Map1lc3bMouseIntestinerep_3 351497218.72e-06
Map1lc3bMouseBrainB04_E1 327023142.20e-06
Map1lc3bMouseBrainB05_D2 327023149.29e-10
Map1lc3bMouseBrainB05_E2 327023145.86e-06
Map1lc3bMouseBrainB07_C2 327023141.28e-06
Map1lc3bMouseBrainN07_C1 327023146.10e-07
Map1lc3bMouseTesticlerep_6 347316001.63e-15
Map1lc3bMouseLymphA1 03.29e-15
Map1lc3bMouseLymphB1 03.66e-15
Map1lc3bMouseLungrep_4 352908013.95e-08
Map1lc3bMouseBrainrep_1 352106242.60e-12
Map1lc3bMouseBrainrep_2 352106241.74e-15
Map1lc3bMouseBrainrep_3 352106246.25e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_rep_6_H&E
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Kidney_CLP_H&E
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Kidney_Sham_H&E
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Kidney_rep_1_H&E
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Kidney_rep_4_H&E
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Brain_rep_1_H&E
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Brain_B04_E1_H&E
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Brain_B05_D2_H&E
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Brain_B05_E2_H&E
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Brain_B07_C2_H&E
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Brain_N07_C1_H&E
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Lung_rep_4_H&E
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Spatial pattern pathway has Map1lc3b envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Map1lc3bGOBP_Autophagosome_MaturationMouseSpinal cordCN94_E1 4.8e-07
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseSpinal cordCN94_E1 9.3e-06
Map1lc3bGOBP_Cellular_Response_To_Nitrogen_StarvationMouseSpinal cordCN94_E1 4.9e-09
Map1lc3bGOBP_Organelle_AssemblyMouseSpinal cordCN94_E1 9.5e-06
Map1lc3bGOBP_Protein_Containing_Complex_DisassemblyMouseSpinal cordCN94_E1 5.8e-06
Map1lc3bGOBP_Selective_AutophagyMouseSpinal cordCN94_E1 2.4e-06
Map1lc3bGOBP_Autophagosome_OrganizationMouseSpinal cordL7bCN02_E1 5.0e-06
Map1lc3bGOBP_Autophagy_Of_MitochondrionMouseSpinal cordL7CN45_C1 1.2e-07
Map1lc3bGOBP_Cellular_Component_DisassemblyMouseSpinal cordL7CN45_C1 1.0e-06
Map1lc3bGOBP_Cellular_Response_To_External_StimulusMouseSpinal cordL7CN45_C1 2.4e-08
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseSpinal cordL7CN45_C1 2.3e-07
Map1lc3bGOBP_MacroautophagyMouseSpinal cordL7CN45_C1 1.0e-06
Map1lc3bGOBP_Mitochondrion_OrganizationMouseSpinal cordL7CN45_C1 3.6e-07
Map1lc3bGOBP_MitophagyMouseSpinal cordL7CN45_C1 5.8e-08
Map1lc3bGOBP_Organelle_DisassemblyMouseSpinal cordL7CN45_C1 5.6e-07
Map1lc3bGOBP_Process_Utilizing_Autophagic_MechanismMouseSpinal cordL7CN45_C1 3.6e-07
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseSpinal cordL7CN45_C1 1.7e-07
Map1lc3bGOBP_Response_To_StarvationMouseSpinal cordL7CN45_C1 4.3e-07
Map1lc3bGOBP_Autophagosome_OrganizationMouseBrainrep_27 9.0e-05
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseBrainrep_27 1.3e-05
Map1lc3bGOBP_Response_To_StarvationMouseBrainrep_27 7.4e-08
Map1lc3bGOBP_Autophagosome_MaturationMouseBrainrep_1 1.3e-21
Map1lc3bGOBP_Cellular_Component_DisassemblyMouseBrainrep_1 1.5e-15
Map1lc3bGOBP_MacroautophagyMouseBrainrep_1 6.7e-14
Map1lc3bGOBP_Protein_Containing_Complex_DisassemblyMouseBrainrep_1 4.1e-29
Map1lc3bGOBP_Autophagosome_OrganizationMouseBrainrep_35.9e-105
Map1lc3bGOBP_Autophagy_Of_MitochondrionMouseBrainrep_32.1e-106
Map1lc3bGOBP_Cellular_Response_To_External_StimulusMouseBrainrep_3 1.9e-53
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseBrainrep_3 5.2e-44
Map1lc3bGOBP_Cellular_Response_To_Nitrogen_StarvationMouseBrainrep_31.4e-103
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseBrainrep_31.1e-148
Map1lc3bGOBP_Mitochondrion_OrganizationMouseBrainrep_3 1.3e-89
Map1lc3bGOBP_MitophagyMouseBrainrep_3 5.1e-90
Map1lc3bGOBP_Organelle_AssemblyMouseBrainrep_32.0e-160
Map1lc3bGOBP_Organelle_DisassemblyMouseBrainrep_3 2.0e-93
Map1lc3bGOBP_Process_Utilizing_Autophagic_MechanismMouseBrainrep_31.0e-145
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseBrainrep_32.2e-117
Map1lc3bGOBP_Response_To_StarvationMouseBrainrep_35.8e-139
Map1lc3bGOBP_Selective_AutophagyMouseBrainrep_3 6.0e-85
Map1lc3bGOBP_Vacuole_OrganizationMouseBrainrep_39.7e-150
Map1lc3bGOBP_Autophagosome_MaturationMouseEmbryorep_14 2.1e-12
Map1lc3bGOBP_Autophagy_Of_MitochondrionMouseEmbryorep_14 2.1e-07
Map1lc3bGOBP_Cellular_Response_To_Nitrogen_StarvationMouseEmbryorep_14 3.6e-23
Map1lc3bGOBP_Mitochondrion_OrganizationMouseEmbryorep_14 1.8e-11
Map1lc3bGOBP_MitophagyMouseEmbryorep_14 2.0e-13
Map1lc3bGOBP_Organelle_DisassemblyMouseEmbryorep_14 2.6e-21
Map1lc3bGOBP_Selective_AutophagyMouseEmbryorep_14 1.9e-17
Map1lc3bGOBP_Cellular_Response_To_External_StimulusMouseEmbryorep_1 2.1e-63
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseEmbryorep_1 1.7e-07
Map1lc3bGOBP_Mitochondrion_OrganizationMouseEmbryorep_3 4.0e-48
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseEmbryorep_4 1.2e-08
Map1lc3bGOBP_Organelle_AssemblyMouseEmbryorep_6 4.1e-70
Map1lc3bGOBP_Autophagosome_MaturationMouseKidneyrep_2 1.4e-65
Map1lc3bGOBP_Autophagosome_OrganizationMouseKidneyrep_2 5.0e-88
Map1lc3bGOBP_Autophagy_Of_MitochondrionMouseKidneyrep_2 1.9e-41
Map1lc3bGOBP_Cellular_Component_DisassemblyMouseKidneyrep_2 4.2e-70
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseKidneyrep_2 1.6e-13
Map1lc3bGOBP_Cellular_Response_To_Nitrogen_StarvationMouseKidneyrep_2 1.2e-44
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseKidneyrep_2 4.8e-18
Map1lc3bGOBP_MacroautophagyMouseKidneyrep_2 1.3e-64
Map1lc3bGOBP_Mitochondrion_OrganizationMouseKidneyrep_2 1.7e-21
Map1lc3bGOBP_MitophagyMouseKidneyrep_2 1.9e-44
Map1lc3bGOBP_Organelle_AssemblyMouseKidneyrep_2 2.8e-62
Map1lc3bGOBP_Organelle_DisassemblyMouseKidneyrep_2 1.2e-56
Map1lc3bGOBP_Process_Utilizing_Autophagic_MechanismMouseKidneyrep_2 1.8e-66
Map1lc3bGOBP_Protein_Containing_Complex_DisassemblyMouseKidneyrep_2 1.4e-54
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseKidneyrep_2 3.8e-52
Map1lc3bGOBP_Response_To_StarvationMouseKidneyrep_2 1.3e-11
Map1lc3bGOBP_Selective_AutophagyMouseKidneyrep_2 1.9e-18
Map1lc3bGOBP_Vacuole_OrganizationMouseKidneyrep_2 2.6e-92
Map1lc3bGOBP_Cellular_Response_To_Nitrogen_StarvationMouseLiverCN16-D1 3.2e-09
Map1lc3bGOBP_Cellular_Response_To_External_StimulusMouseLiverrep_16 6.3e-14
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseLiverrep_16 4.1e-17
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseLiverrep_16 1.1e-15
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseLiverrep_16 8.0e-26
Map1lc3bGOBP_Response_To_StarvationMouseLiverrep_16 9.4e-25
Map1lc3bGOBP_Autophagosome_MaturationMouseLymphMS-1 1.6e-08
Map1lc3bGOBP_Autophagosome_OrganizationMouseLymphMS-1 3.1e-11
Map1lc3bGOBP_Autophagy_Of_MitochondrionMouseLymphMS-1 4.2e-14
Map1lc3bGOBP_Cellular_Component_DisassemblyMouseLymphMS-1 2.4e-16
Map1lc3bGOBP_Cellular_Response_To_External_StimulusMouseLymphMS-1 4.4e-13
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseLymphMS-1 1.6e-14
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseLymphMS-1 7.4e-11
Map1lc3bGOBP_MacroautophagyMouseLymphMS-1 3.3e-11
Map1lc3bGOBP_Mitochondrion_OrganizationMouseLymphMS-1 4.2e-09
Map1lc3bGOBP_Organelle_AssemblyMouseLymphMS-1 5.5e-08
Map1lc3bGOBP_Organelle_DisassemblyMouseLymphMS-1 5.9e-12
Map1lc3bGOBP_Process_Utilizing_Autophagic_MechanismMouseLymphMS-1 3.9e-13
Map1lc3bGOBP_Protein_Containing_Complex_DisassemblyMouseLymphMS-1 5.5e-11
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseLymphMS-1 1.1e-12
Map1lc3bGOBP_Response_To_StarvationMouseLymphMS-1 1.7e-10
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseBrainrep_7 1.9e-09
Map1lc3bGOBP_Organelle_DisassemblyMouseBrainrep_7 4.5e-11
Map1lc3bGOBP_Response_To_StarvationMouseBrainrep_7 5.6e-09
Map1lc3bGOBP_Cellular_Response_To_StarvationMouseBrainHP_ad_rep7 3.0e-14
Map1lc3bGOBP_MacroautophagyMouseBrainHP_ad_rep7 1.6e-07
Map1lc3bGOBP_Process_Utilizing_Autophagic_MechanismMouseBrainHP_ad_rep7 3.5e-08
Map1lc3bGOBP_Response_To_Extracellular_StimulusMouseBrainHP_ad_rep7 1.4e-09
Map1lc3bGOBP_Response_To_StarvationMouseBrainHP_ad_rep7 4.4e-12
Map1lc3bGOBP_Organelle_AssemblyMouseBrainHP_adpolb_rep1 1.8e-07
Map1lc3bGOBP_Autophagosome_OrganizationMouseBrainHP_polb_rep9 4.0e-09
Map1lc3bGOBP_Autophagy_Of_MitochondrionMouseBrainHP_polb_rep9 3.2e-12
Map1lc3bGOBP_Cellular_Component_DisassemblyMouseBrainHP_polb_rep9 3.4e-08
Map1lc3bGOBP_Cellular_Response_To_External_StimulusMouseBrainHP_polb_rep9 4.1e-14
Map1lc3bGOBP_Cellular_Response_To_Extracellular_StimulusMouseBrainHP_polb_rep9 1.7e-11
Map1lc3bGOBP_Cellular_Response_To_Nitrogen_StarvationMouseBrainHP_polb_rep9 2.2e-12
Map1lc3bGOBP_Mitochondrion_OrganizationMouseBrainHP_polb_rep9 1.2e-11
Map1lc3bGOBP_MitophagyMouseBrainHP_polb_rep9 3.2e-13
Map1lc3bGOBP_Organelle_DisassemblyMouseBrainHP_polb_rep9 4.4e-13
Map1lc3bGOBP_Protein_Containing_Complex_DisassemblyMouseBrainHP_polb_rep9 1.8e-08
Map1lc3bGOBP_Selective_AutophagyMouseBrainHP_polb_rep9 7.9e-08
Map1lc3bGOBP_Vacuole_OrganizationMouseBrainHP_polb_rep9 9.0e-08

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Map1lc3b function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Map1lc3b function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Map1lc3b envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Map1lc3b

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Map1lc3b

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Map1lc3bC0019193Hepatitis, Toxic1CTD_human
Map1lc3bC0860207Drug-Induced Liver Disease1CTD_human
Map1lc3bC1262760Hepatitis, Drug-Induced1CTD_human
Map1lc3bC3658290Drug-Induced Acute Liver Injury1CTD_human
Map1lc3bC4277682Chemical and Drug Induced Liver Injury1CTD_human
Map1lc3bC4279912Chemically-Induced Liver Toxicity1CTD_human