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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Eps8l1 (spascer ID:67425)

Gene summary for Eps8l1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Eps8l1
	Gene ID	67425
	Gene name	EPS8-like 1
	Synonyms	2310051G19Rik\|4632407K17Rik\|AW060268\|DRC3\|EPS8R1
	Cytomap	7\|7 A1
	Type of gene	protein-coding
	Description	epidermal growth factor receptor kinase substrate 8-like protein 1EPS8-like protein 1EPS8-related protein 1epidermal growth factor receptor pathway substrate 8-related protein 1
	Modification date	20220424
	UniProtAcc	Q8R5F8

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Eps8l1	GO:0003779	actin binding	21873635	Function
Eps8l1	GO:0005886	plasma membrane	21873635	Component
Eps8l1	GO:0007266	Rho protein signal transduction	21873635	Process
Eps8l1	GO:0032587	ruffle membrane	21873635	Component
Eps8l1	GO:0035023	regulation of Rho protein signal transduction	21873635	Process
Eps8l1	GO:1900029	positive regulation of ruffle assembly	21873635	Process

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Spatial pattern events for Eps8l1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Eps8l1	Mouse	Kidney	IRI	34003797	2.29e-15
Eps8l1	Mouse	Kidney	rep_1	34853151	2.42e-15
Eps8l1	Mouse	Kidney	rep_5	34853151	1.02e-10
Eps8l1	Mouse	Brain	rep_1	33469025	2.87e-11
Eps8l1	Mouse	Testicle	rep_5	34731600	2.64e-07
Eps8l1	Mouse	Brain	OFB_adpolb_rep1	33083725	1.14e-02

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_IRI_H&E
Kidney_rep_1_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_OFB_adpolb_rep1_H&E

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Spatial pattern pathway has Eps8l1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Eps8l1	GOBP_Cell_Projection_Assembly	Mouse	Spinal cord	CN94_E1	3.2e-06
Eps8l1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Spinal cord	CN94_E1	4.2e-06
Eps8l1	GOBP_Ruffle_Organization	Mouse	Spinal cord	CN94_E1	8.3e-07
Eps8l1	GOBP_Regulation_Of_Rho_Protein_Signal_Transduction	Mouse	Spinal cord	L7bCN01_D2	5.1e-06
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Spinal cord	L7CN45_C1	1.2e-07
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Spinal cord	L7CN45_C1	4.1e-06
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Mouse	Spinal cord	L7CN45_C1	3.0e-06
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Assembly	Mouse	Spinal cord	L7CN45_C1	1.6e-06
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Spinal cord	L7CN45_C1	7.5e-08
Eps8l1	GOBP_Regulation_Of_Ruffle_Assembly	Mouse	Spinal cord	L7CN45_C1	5.2e-06
Eps8l1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Eps8l1	GOBP_Rho_Protein_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Eps8l1	GOBP_Ruffle_Assembly	Mouse	Spinal cord	L7CN45_C1	4.8e-08
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Spinal cord	L7CN47_C1	7.7e-06
Eps8l1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Spinal cord	L8CN17_E1	6.9e-06
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	rep_27	1.1e-05
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Brain	rep_27	1.6e-05
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Brain	rep_27	3.9e-05
Eps8l1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_27	6.4e-05
Eps8l1	GOBP_Cell_Projection_Assembly	Mouse	Brain	rep_1	8.3e-09
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Brain	rep_1	2.6e-08
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	rep_1	3.6e-13
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Brain	rep_1	2.1e-32
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Brain	rep_1	5.2e-09
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Brain	rep_1	1.1e-11
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Assembly	Mouse	Brain	rep_1	3.2e-33
Eps8l1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	rep_1	1.3e-27
Eps8l1	GOBP_Regulation_Of_Ruffle_Assembly	Mouse	Brain	rep_1	4.9e-20
Eps8l1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_1	5.2e-13
Eps8l1	GOBP_Ruffle_Assembly	Mouse	Brain	rep_1	1.1e-21
Eps8l1	GOBP_Ruffle_Organization	Mouse	Brain	rep_1	4.5e-22
Eps8l1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_1	5.1e-22
Eps8l1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Mouse	Brain	rep_3	8.7e-26
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Mouse	Brain	rep_3	7.0e-65
Eps8l1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Eps8l1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Mouse	Brain	rep_3	8.3e-130
Eps8l1	GOBP_Regulation_Of_Rho_Protein_Signal_Transduction	Mouse	Brain	rep_3	3.4e-138
Eps8l1	GOBP_Rho_Protein_Signal_Transduction	Mouse	Brain	rep_3	2.0e-147
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Brain	rep_5	1.6e-42
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Embryo	rep_14	3.0e-35
Eps8l1	GOBP_Regulation_Of_Ruffle_Assembly	Mouse	Embryo	rep_14	6.3e-43
Eps8l1	GOBP_Ruffle_Assembly	Mouse	Embryo	rep_14	8.1e-39
Eps8l1	GOBP_Ruffle_Organization	Mouse	Embryo	rep_14	3.1e-21
Eps8l1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Mouse	Embryo	rep_2	1.1e-173
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Mouse	Embryo	rep_2	2.3e-14
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Embryo	rep_3	1.7e-72
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Embryo	rep_3	5.2e-68
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Embryo	rep_3	0.0e+00
Eps8l1	GOBP_Rho_Protein_Signal_Transduction	Mouse	Embryo	rep_3	2.7e-14
Eps8l1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Embryo	rep_3	5.2e-68
Eps8l1	GOBP_Cell_Projection_Assembly	Mouse	Kidney	rep_2	3.6e-69
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Kidney	rep_2	4.1e-48
Eps8l1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Mouse	Kidney	rep_2	4.4e-77
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Kidney	rep_2	2.9e-38
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Mouse	Kidney	rep_2	2.4e-38
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Kidney	rep_2	2.1e-43
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Kidney	rep_2	1.4e-17
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Kidney	rep_2	3.5e-92
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Assembly	Mouse	Kidney	rep_2	3.0e-76
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Kidney	rep_2	7.7e-90
Eps8l1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Kidney	rep_2	8.3e-40
Eps8l1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Eps8l1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Mouse	Kidney	rep_2	4.4e-65
Eps8l1	GOBP_Regulation_Of_Rho_Protein_Signal_Transduction	Mouse	Kidney	rep_2	1.3e-93
Eps8l1	GOBP_Regulation_Of_Ruffle_Assembly	Mouse	Kidney	rep_2	1.0e-84
Eps8l1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Kidney	rep_2	1.0e-93
Eps8l1	GOBP_Rho_Protein_Signal_Transduction	Mouse	Kidney	rep_2	2.4e-81
Eps8l1	GOBP_Ruffle_Assembly	Mouse	Kidney	rep_2	3.6e-103
Eps8l1	GOBP_Ruffle_Organization	Mouse	Kidney	rep_2	1.9e-88
Eps8l1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Kidney	rep_2	1.2e-75
Eps8l1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Liver	CN16-D2	1.3e-07
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Liver	rep_16	3.4e-07
Eps8l1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Mouse	Liver	rep_16	3.4e-08
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Liver	rep_16	9.3e-08
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Liver	rep_16	2.3e-08
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Liver	rep_16	2.6e-08
Eps8l1	GOBP_Cell_Projection_Assembly	Mouse	Lymph	MS-1	1.4e-09
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Lymph	MS-1	1.5e-09
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Lymph	MS-1	3.6e-08
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Mouse	Lymph	MS-1	1.8e-09
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Lymph	MS-1	2.1e-08
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Lymph	MS-1	7.8e-07
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Lymph	MS-1	1.1e-08
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Lymph	MS-1	1.3e-07
Eps8l1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Lymph	MS-1	2.2e-09
Eps8l1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Eps8l1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Mouse	Lymph	MS-1	3.8e-08
Eps8l1	GOBP_Regulation_Of_Rho_Protein_Signal_Transduction	Mouse	Lymph	MS-1	8.3e-07
Eps8l1	GOBP_Regulation_Of_Ruffle_Assembly	Mouse	Lymph	MS-1	6.5e-10
Eps8l1	GOBP_Rho_Protein_Signal_Transduction	Mouse	Lymph	MS-1	8.4e-07
Eps8l1	GOBP_Ruffle_Assembly	Mouse	Lymph	MS-1	2.4e-10
Eps8l1	GOBP_Ruffle_Organization	Mouse	Lymph	MS-1	1.6e-11
Eps8l1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Lymph	MS-1	3.5e-10
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	rep_4	1.5e-12
Eps8l1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Mouse	Brain	rep_4	1.0e-16
Eps8l1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_4	6.8e-16
Eps8l1	GOBP_Cell_Projection_Assembly	Mouse	Brain	HP_ad_rep7	1.0e-07
Eps8l1	GOBP_Cell_Projection_Organization	Mouse	Brain	HP_ad_rep7	8.1e-09
Eps8l1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Mouse	Brain	HP_ad_rep7	4.4e-10
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	HP_ad_rep7	1.7e-11
Eps8l1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Mouse	Brain	HP_ad_rep7	2.0e-07
Eps8l1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Mouse	Brain	HP_ad_rep7	4.6e-11
Eps8l1	GOBP_Positive_Regulation_Of_Ruffle_Assembly	Mouse	Brain	HP_ad_rep7	1.0e-13
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Assembly	Mouse	Brain	HP_ad_rep7	8.5e-09
Eps8l1	GOBP_Regulation_Of_Cell_Projection_Organization	Mouse	Brain	HP_ad_rep7	1.1e-07
Eps8l1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	HP_ad_rep7	6.5e-10
Eps8l1	GOBP_Rho_Protein_Signal_Transduction	Mouse	Brain	HP_ad_rep7	1.7e-07
Eps8l1	GOBP_Ruffle_Assembly	Mouse	Brain	HP_ad_rep7	3.5e-10
Eps8l1	GOBP_Ruffle_Organization	Mouse	Brain	HP_ad_rep7	5.7e-07
Eps8l1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	HP_ad_rep7	4.6e-08
Eps8l1	GOBP_Regulation_Of_Rho_Protein_Signal_Transduction	Mouse	Brain	HP_adpolb_rep1	2.5e-12
Eps8l1	GOBP_Regulation_Of_Ruffle_Assembly	Mouse	Brain	HP_adpolb_rep1	2.6e-12
Eps8l1	GOBP_Ras_Protein_Signal_Transduction	Mouse	Brain	HP_polb_rep9	7.2e-09
Eps8l1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11
Eps8l1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Mouse	Brain	HP_polb_rep9	4.3e-10
Eps8l1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	HP_polb_rep9	5.2e-07

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Eps8l1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Eps8l1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Eps8l1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Eps8l1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Eps8l1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source