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Spatial pattern gene: Ndufb8 (spascer ID:67264) |
Gene summary for Ndufb8 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Ndufb8 | Gene ID | 67264 |
| Gene name | NADH:ubiquinone oxidoreductase subunit B8 |
| Synonyms | 2900010I05Rik|AI987932|CI-ASHI |
| Cytomap | 19|19 C3 |
| Type of gene | protein-coding |
| Description | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialNADH dehydrogenase (ubiquinone) 1 beta subcomplex 8NADH-ubiquinone oxidoreductase ASHI subunitcomplex I-ASHI |
| Modification date | 20220426 |
| UniProtAcc | Q9D6J5 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Ndufb8 | GO:0005747 | mitochondrial respiratory chain complex I | 21873635 | Component |
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Spatial pattern events for Ndufb8 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Ndufb8 | Mouse | Brain | S1 | 34413515 | 3.73e-15 |
| Ndufb8 | Mouse | Brain | S2 | 34413515 | 1.56e-15 |
| Ndufb8 | Mouse | Brain | S3 | 34413515 | 1.64e-15 |
| Ndufb8 | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Ndufb8 | Mouse | Brain | S6 | 34413515 | 1.46e-15 |
| Ndufb8 | Mouse | Brain | S7 | 34413515 | 1.55e-15 |
| Ndufb8 | Mouse | Brain | 22A | 32637622 | 3.26e-06 |
| Ndufb8 | Mouse | Brain | 22B | 32637622 | 5.59e-14 |
| Ndufb8 | Mouse | Brain | 24B | 32637622 | 2.84e-06 |
| Ndufb8 | Mouse | Brain | 27A | 32637622 | 4.70e-11 |
| Ndufb8 | Mouse | Brain | 27B | 32637622 | 2.30e-07 |
| Ndufb8 | Mouse | Brain | 28A | 32637622 | 4.09e-06 |
| Ndufb8 | Mouse | Brain | 29A | 32637622 | 1.82e-14 |
| Ndufb8 | Mouse | Brain | 29B | 32637622 | 5.84e-09 |
| Ndufb8 | Mouse | Brain | 30A | 32637622 | 1.48e-14 |
| Ndufb8 | Mouse | Brain | 31A | 32637622 | 1.85e-13 |
| Ndufb8 | Mouse | Brain | 32A | 32637622 | 1.67e-12 |
| Ndufb8 | Mouse | Brain | 33A | 32637622 | 2.59e-14 |
| Ndufb8 | Mouse | Brain | 33B | 32637622 | 3.05e-06 |
| Ndufb8 | Mouse | Brain | 34A | 32637622 | 1.42e-14 |
| Ndufb8 | Mouse | Brain | 34B | 32637622 | 1.77e-08 |
| Ndufb8 | Mouse | Brain | 35A | 32637622 | 3.56e-06 |
| Ndufb8 | Mouse | Brain | 35B | 32637622 | 1.05e-12 |
| Ndufb8 | Mouse | Brain | 36B | 32637622 | 4.83e-14 |
| Ndufb8 | Mouse | Brain | 38B | 32637622 | 2.76e-08 |
| Ndufb8 | Mouse | Brain | rep_1 | 35141374 | 2.02e-15 |
| Ndufb8 | Mouse | Brain | rep_2 | 35141374 | 1.69e-15 |
| Ndufb8 | Mouse | Brain | rep_3 | 35141374 | 1.64e-15 |
| Ndufb8 | Mouse | Brain | rep_4 | 35141374 | 1.57e-15 |
| Ndufb8 | Mouse | Brain | rep_5 | 35141374 | 1.47e-15 |
| Ndufb8 | Mouse | Brain | rep_6 | 35141374 | 1.73e-15 |
| Ndufb8 | Mouse | Embryo | rep_5 | 33188776 | 4.43e-07 |
| Ndufb8 | Mouse | Embryo | rep_13 | 33188776 | 9.57e-06 |
| Ndufb8 | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| Ndufb8 | Mouse | Kidney | IRI | 34003797 | 2.29e-15 |
| Ndufb8 | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| Ndufb8 | Mouse | Kidney | rep_1 | 34853151 | 2.42e-15 |
| Ndufb8 | Mouse | Kidney | rep_2 | 34853151 | 5.42e-15 |
| Ndufb8 | Mouse | Kidney | rep_3 | 34853151 | 2.94e-15 |
| Ndufb8 | Mouse | Kidney | rep_4 | 34853151 | 1.12e-09 |
| Ndufb8 | Mouse | Kidney | rep_5 | 34853151 | 3.18e-15 |
| Ndufb8 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Ndufb8 | Mouse | Brain | rep_1 | 35027729 | 1.66e-15 |
| Ndufb8 | Mouse | Brain | rep_2 | 35027729 | 1.57e-15 |
| Ndufb8 | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Ndufb8 | Mouse | Brain | rep_4 | 35027729 | 1.76e-15 |
| Ndufb8 | Mouse | Brain | rep_5 | 35027729 | 1.46e-15 |
| Ndufb8 | Mouse | Intestine | rep_2 | 35149721 | 1.22e-07 |
| Ndufb8 | Mouse | Intestine | rep_3 | 35149721 | 4.10e-07 |
| Ndufb8 | Mouse | Intestine | rep_4 | 35149721 | 2.30e-15 |
| Ndufb8 | Mouse | Brain | B04_E1 | 32702314 | 6.13e-09 |
| Ndufb8 | Mouse | Brain | B05_D2 | 32702314 | 3.99e-09 |
| Ndufb8 | Mouse | Brain | B06_E1 | 32702314 | 6.00e-07 |
| Ndufb8 | Mouse | Brain | N03_D2 | 32702314 | 1.94e-12 |
| Ndufb8 | Mouse | Brain | N07_C1 | 32702314 | 1.42e-08 |
| Ndufb8 | Mouse | Lymph | A1 | 0 | 1.89e-06 |
| Ndufb8 | Mouse | Lung | rep_1 | 35290801 | 8.15e-14 |
| Ndufb8 | Mouse | Lung | rep_2 | 35290801 | 7.40e-08 |
| Ndufb8 | Mouse | Brain | rep_1 | 35210624 | 1.74e-15 |
| Ndufb8 | Mouse | Brain | rep_2 | 35210624 | 1.74e-15 |
| Ndufb8 | Mouse | Brain | rep_3 | 35210624 | 1.82e-15 |
| Ndufb8 | Mouse | Brain | rep_5 | 35210624 | 6.82e-15 |
| Ndufb8 | Mouse | Brain | rep_6 | 35210624 | 2.05e-15 |
| Ndufb8 | Mouse | Brain | rep_7 | 35210624 | 1.87e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_6_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_2_H&E  |  |
Kidney_rep_3_H&E  |  |
Kidney_rep_4_H&E  |  |
Kidney_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_B04_E1_H&E  |  |
Brain_B05_D2_H&E  |  |
Brain_B06_E1_H&E  |  |
Brain_N03_D2_H&E  |  |
Brain_N07_C1_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
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Spatial pattern pathway has Ndufb8 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Ndufb8 | GOBP_Cellular_Respiration | Mouse | Spinal cord | L7CN45_C1 | 7.0e-07 |
| Ndufb8 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Mouse | Spinal cord | L7CN45_C1 | 6.8e-07 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Spinal cord | L7CN45_C1 | 2.2e-08 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Spinal cord | L7CN45_C1 | 3.6e-07 |
| Ndufb8 | GOBP_Oxidative_Phosphorylation | Mouse | Spinal cord | L7CN45_C1 | 5.1e-07 |
| Ndufb8 | GOBP_Atp_Metabolic_Process | Mouse | Spinal cord | L7CN47_D1 | 3.0e-06 |
| Ndufb8 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Mouse | Spinal cord | L7CN47_D1 | 3.7e-06 |
| Ndufb8 | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Mouse | Spinal cord | L7CN47_D1 | 2.6e-06 |
| Ndufb8 | GOBP_Atp_Metabolic_Process | Mouse | Brain | rep_71 | 2.7e-06 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Brain | rep_71 | 1.2e-05 |
| Ndufb8 | GOBP_Cellular_Respiration | Mouse | Brain | rep_71 | 1.7e-06 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Brain | rep_71 | 2.4e-06 |
| Ndufb8 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Mouse | Brain | rep_71 | 3.4e-07 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Brain | rep_71 | 2.1e-06 |
| Ndufb8 | GOBP_Mitochondrial_Electron_Transport_Nadh_To_Ubiquinone | Mouse | Brain | rep_71 | 2.1e-06 |
| Ndufb8 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Mouse | Brain | rep_71 | 2.8e-06 |
| Ndufb8 | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Mouse | Brain | rep_71 | 3.5e-06 |
| Ndufb8 | GOBP_Oxidative_Phosphorylation | Mouse | Brain | rep_71 | 5.5e-06 |
| Ndufb8 | GOBP_Respiratory_Electron_Transport_Chain | Mouse | Brain | rep_71 | 1.2e-05 |
| Ndufb8 | GOBP_Atp_Metabolic_Process | Mouse | Brain | rep_1 | 2.0e-14 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Brain | rep_1 | 7.9e-39 |
| Ndufb8 | GOBP_Cellular_Respiration | Mouse | Brain | rep_1 | 9.5e-36 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Brain | rep_1 | 1.3e-47 |
| Ndufb8 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Mouse | Brain | rep_1 | 1.1e-29 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Brain | rep_1 | 5.4e-15 |
| Ndufb8 | GOBP_Mitochondrial_Electron_Transport_Nadh_To_Ubiquinone | Mouse | Brain | rep_1 | 1.2e-28 |
| Ndufb8 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Mouse | Brain | rep_1 | 5.0e-26 |
| Ndufb8 | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Mouse | Brain | rep_1 | 9.2e-45 |
| Ndufb8 | GOBP_Oxidative_Phosphorylation | Mouse | Brain | rep_1 | 7.5e-43 |
| Ndufb8 | GOBP_Respiratory_Electron_Transport_Chain | Mouse | Brain | rep_1 | 4.5e-44 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Brain | rep_3 | 1.3e-89 |
| Ndufb8 | GOBP_Cellular_Respiration | Mouse | Embryo | rep_6 | 3.9e-08 |
| Ndufb8 | GOBP_Atp_Metabolic_Process | Mouse | Embryo | rep_14 | 3.7e-37 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Embryo | rep_14 | 3.4e-58 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Embryo | rep_14 | 5.7e-46 |
| Ndufb8 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Mouse | Embryo | rep_14 | 2.3e-31 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Embryo | rep_14 | 2.9e-37 |
| Ndufb8 | GOBP_Mitochondrial_Electron_Transport_Nadh_To_Ubiquinone | Mouse | Embryo | rep_14 | 2.4e-71 |
| Ndufb8 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Mouse | Embryo | rep_14 | 5.0e-27 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Embryo | rep_14 | 1.8e-11 |
| Ndufb8 | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Mouse | Embryo | rep_14 | 2.8e-58 |
| Ndufb8 | GOBP_Oxidative_Phosphorylation | Mouse | Embryo | rep_14 | 7.0e-41 |
| Ndufb8 | GOBP_Respiratory_Electron_Transport_Chain | Mouse | Embryo | rep_14 | 8.9e-41 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Embryo | rep_3 | 3.7e-124 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Embryo | rep_3 | 4.0e-48 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Kidney | rep_2 | 3.3e-14 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Kidney | rep_2 | 1.7e-21 |
| Ndufb8 | GOBP_Mitochondrial_Electron_Transport_Nadh_To_Ubiquinone | Mouse | Liver | CN16-D1 | 1.6e-07 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Liver | CN65-C1 | 1.6e-09 |
| Ndufb8 | GOBP_Atp_Metabolic_Process | Mouse | Liver | rep_16 | 1.2e-30 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Liver | rep_16 | 4.4e-24 |
| Ndufb8 | GOBP_Cellular_Respiration | Mouse | Liver | rep_16 | 8.0e-25 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Liver | rep_16 | 1.7e-16 |
| Ndufb8 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Mouse | Liver | rep_16 | 2.0e-28 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Liver | rep_16 | 7.4e-11 |
| Ndufb8 | GOBP_Mitochondrial_Electron_Transport_Nadh_To_Ubiquinone | Mouse | Liver | rep_16 | 1.4e-13 |
| Ndufb8 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Mouse | Liver | rep_16 | 4.3e-23 |
| Ndufb8 | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Mouse | Liver | rep_16 | 3.7e-23 |
| Ndufb8 | GOBP_Oxidative_Phosphorylation | Mouse | Liver | rep_16 | 1.4e-27 |
| Ndufb8 | GOBP_Respiratory_Electron_Transport_Chain | Mouse | Liver | rep_16 | 2.4e-29 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Intestine | rep_2 | 3.8e-16 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Intestine | rep_2 | 8.8e-09 |
| Ndufb8 | GOBP_Respiratory_Electron_Transport_Chain | Mouse | Intestine | rep_2 | 2.9e-16 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Lymph | MS-1 | 4.2e-09 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Lymph | MS-2 | 8.2e-07 |
| Ndufb8 | GOBP_Atp_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 1.0e-11 |
| Ndufb8 | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Mouse | Brain | HP_polb_rep9 | 4.5e-08 |
| Ndufb8 | GOBP_Cellular_Respiration | Mouse | Brain | HP_polb_rep9 | 2.1e-07 |
| Ndufb8 | GOBP_Electron_Transport_Chain | Mouse | Brain | HP_polb_rep9 | 5.9e-10 |
| Ndufb8 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Mouse | Brain | HP_polb_rep9 | 3.0e-10 |
| Ndufb8 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Mouse | Brain | HP_polb_rep9 | 5.4e-11 |
| Ndufb8 | GOBP_Mitochondrial_Electron_Transport_Nadh_To_Ubiquinone | Mouse | Brain | HP_polb_rep9 | 1.9e-08 |
| Ndufb8 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Mouse | Brain | HP_polb_rep9 | 7.2e-14 |
| Ndufb8 | GOBP_Mitochondrion_Organization | Mouse | Brain | HP_polb_rep9 | 1.2e-11 |
| Ndufb8 | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Mouse | Brain | HP_polb_rep9 | 1.3e-07 |
| Ndufb8 | GOBP_Oxidative_Phosphorylation | Mouse | Brain | HP_polb_rep9 | 9.8e-11 |
| Ndufb8 | GOBP_Respiratory_Electron_Transport_Chain | Mouse | Brain | HP_polb_rep9 | 1.8e-08 |
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Ndufb8 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Ndufb8 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Ndufb8 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Ndufb8 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Ndufb8 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Ndufb8 | C4748839 | MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 32 | 2 | GENOMICS_ENGLAND;UNIPROT |
| Ndufb8 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Ndufb8 | C0274861 | Arsenic Poisoning, Inorganic | 1 | CTD_human |
| Ndufb8 | C0274862 | Nervous System, Organic Arsenic Poisoning | 1 | CTD_human |
| Ndufb8 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
| Ndufb8 | C0751851 | Arsenic Encephalopathy | 1 | CTD_human |
| Ndufb8 | C0751852 | Arsenic Induced Polyneuropathy | 1 | CTD_human |
| Ndufb8 | C1838979 | MITOCHONDRIAL COMPLEX I DEFICIENCY | 1 | GENOMICS_ENGLAND |
