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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Cers4 (spascer ID:67260)

Gene summary for Cers4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Cers4
	Gene ID	67260
	Gene name	ceramide synthase 4
	Synonyms	2900019C14Rik\|Lass4\|Trh1
	Cytomap	8\|8 A1.1
	Type of gene	protein-coding
	Description	ceramide synthase 4LAG1 homolog, ceramide synthase 4LAG1 longevity assurance homolog 4TRAM homolog 1longevity assurance homolog 4sphingosine N-acyltransferase CERS4translocating chain-associating membrane protein homolog 1
	Modification date	20220424
	UniProtAcc	Q9D6J1

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Cers4	GO:0005783	endoplasmic reticulum	21873635	Component
Cers4	GO:0016410	N-acyltransferase activity	21873635	Function
Cers4	GO:0046513	ceramide biosynthetic process	21873635	Process
Cers4	GO:0050291	sphingosine N-acyltransferase activity	21873635	Function

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Spatial pattern events for Cers4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Cers4	Mouse	Brain	S1	34413515	5.44e-07
Cers4	Mouse	Brain	S4	34413515	4.65e-15
Cers4	Mouse	Brain	S6	34413515	5.45e-13
Cers4	Mouse	Brain	S7	34413515	2.83e-11
Cers4	Mouse	Brain	rep_1	35141374	2.02e-15
Cers4	Mouse	Brain	rep_2	35141374	2.99e-10
Cers4	Mouse	Brain	rep_3	35141374	3.00e-15
Cers4	Mouse	Brain	rep_4	35141374	1.57e-15
Cers4	Mouse	Brain	rep_5	35141374	1.47e-15
Cers4	Mouse	Embryo	rep_1	34489600	3.74e-16
Cers4	Mouse	Embryo	rep_2	34489600	4.14e-16
Cers4	Mouse	Embryo	rep_3	34489600	4.04e-16
Cers4	Mouse	Embryo	rep_4	34489600	3.67e-16
Cers4	Mouse	Embryo	rep_5	34489600	4.08e-16
Cers4	Mouse	Embryo	rep_6	34489600	3.64e-16
Cers4	Mouse	Kidney	CLP	34003797	2.19e-15
Cers4	Mouse	Kidney	IRI	34003797	3.92e-15
Cers4	Mouse	Kidney	Sham	34003797	2.58e-15
Cers4	Mouse	Kidney	rep_1	34853151	4.33e-07
Cers4	Mouse	Kidney	rep_4	34853151	4.07e-15
Cers4	Mouse	Brain	rep_1	35027729	3.01e-09
Cers4	Mouse	Brain	rep_2	35027729	3.21e-07
Cers4	Mouse	Brain	rep_3	35027729	1.32e-15
Cers4	Mouse	Brain	rep_5	35027729	9.64e-08
Cers4	Mouse	Intestine	rep_2	35149721	3.44e-15
Cers4	Mouse	Intestine	rep_3	35149721	1.90e-09
Cers4	Mouse	Intestine	rep_4	35149721	4.29e-08
Cers4	Mouse	Testicle	rep_6	34731600	2.64e-06
Cers4	Mouse	Lung	rep_1	35290801	6.56e-15
Cers4	Mouse	Lung	rep_2	35290801	9.51e-14
Cers4	Mouse	Lung	rep_3	35290801	1.00e-10
Cers4	Mouse	Lung	rep_4	35290801	3.04e-15
Cers4	Mouse	Brain	rep_1	35210624	1.74e-15
Cers4	Mouse	Brain	rep_2	35210624	1.74e-15
Cers4	Mouse	Brain	rep_3	35210624	1.82e-15
Cers4	Mouse	Brain	rep_4	35210624	2.07e-09
Cers4	Mouse	Brain	rep_5	35210624	4.32e-10
Cers4	Mouse	Brain	rep_6	35210624	2.05e-15
Cers4	Mouse	Brain	rep_7	35210624	1.33e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_4_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_5_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Cers4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Cers4	GOBP_Membrane_Lipid_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.4e-06
Cers4	GOBP_Sphingolipid_Metabolic_Process	Mouse	Spinal cord	CN94_E1	2.7e-06
Cers4	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	3.7e-06
Cers4	GOBP_Ceramide_Biosynthetic_Process	Mouse	Spinal cord	L7bCN02_E1	5.7e-06
Cers4	GOBP_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	8.9e-07
Cers4	GOBP_Amide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Cers4	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Cers4	GOBP_Ceramide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.7e-09
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Cers4	GOBP_Membrane_Lipid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.5e-06
Cers4	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Cers4	GOBP_Ceramide_Biosynthetic_Process	Mouse	Brain	rep_71	1.8e-05
Cers4	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	rep_3	2.5e-86
Cers4	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Cers4	GOBP_Ceramide_Biosynthetic_Process	Mouse	Brain	rep_3	2.2e-75
Cers4	GOBP_Ceramide_Metabolic_Process	Mouse	Brain	rep_3	1.6e-72
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Brain	rep_3	4.4e-66
Cers4	GOBP_Membrane_Lipid_Biosynthetic_Process	Mouse	Brain	rep_3	5.7e-180
Cers4	GOBP_Membrane_Lipid_Metabolic_Process	Mouse	Brain	rep_3	2.1e-71
Cers4	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Cers4	GOBP_Sphingolipid_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-115
Cers4	GOBP_Sphingolipid_Metabolic_Process	Mouse	Brain	rep_3	4.7e-60
Cers4	GOBP_Amide_Biosynthetic_Process	Mouse	Embryo	rep_14	3.7e-18
Cers4	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Cers4	GOBP_Ceramide_Biosynthetic_Process	Mouse	Embryo	rep_14	2.2e-14
Cers4	GOBP_Ceramide_Metabolic_Process	Mouse	Embryo	rep_14	8.4e-25
Cers4	GOBP_Membrane_Lipid_Biosynthetic_Process	Mouse	Embryo	rep_14	1.8e-16
Cers4	GOBP_Membrane_Lipid_Metabolic_Process	Mouse	Embryo	rep_14	1.6e-15
Cers4	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Cers4	GOBP_Sphingolipid_Biosynthetic_Process	Mouse	Embryo	rep_14	1.2e-21
Cers4	GOBP_Sphingolipid_Metabolic_Process	Mouse	Embryo	rep_14	1.3e-29
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Embryo	rep_1	1.0e-146
Cers4	GOBP_Lipid_Metabolic_Process	Mouse	Embryo	rep_1	2.1e-39
Cers4	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Cers4	GOBP_Amide_Biosynthetic_Process	Mouse	Kidney	rep_2	1.9e-84
Cers4	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Cers4	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	7.4e-43
Cers4	GOBP_Ceramide_Biosynthetic_Process	Mouse	Kidney	rep_2	7.5e-14
Cers4	GOBP_Ceramide_Metabolic_Process	Mouse	Kidney	rep_2	9.5e-32
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Kidney	rep_2	3.0e-52
Cers4	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-78
Cers4	GOBP_Membrane_Lipid_Biosynthetic_Process	Mouse	Kidney	rep_2	1.3e-70
Cers4	GOBP_Membrane_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	6.0e-68
Cers4	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Cers4	GOBP_Sphingolipid_Biosynthetic_Process	Mouse	Kidney	rep_2	3.0e-40
Cers4	GOBP_Sphingolipid_Metabolic_Process	Mouse	Kidney	rep_2	2.2e-69
Cers4	GOBP_Membrane_Lipid_Biosynthetic_Process	Mouse	Liver	CN16-E1	5.1e-09
Cers4	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Liver	CN73-C1	9.9e-09
Cers4	GOBP_Ceramide_Metabolic_Process	Mouse	Liver	CN73-C1	1.0e-07
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Liver	CN73-C1	1.6e-12
Cers4	GOBP_Amide_Biosynthetic_Process	Mouse	Lymph	MS-1	1.3e-09
Cers4	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Cers4	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	1.1e-14
Cers4	GOBP_Ceramide_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-11
Cers4	GOBP_Ceramide_Metabolic_Process	Mouse	Lymph	MS-1	2.4e-18
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Lymph	MS-1	2.0e-17
Cers4	GOBP_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	9.7e-11
Cers4	GOBP_Membrane_Lipid_Biosynthetic_Process	Mouse	Lymph	MS-1	1.1e-07
Cers4	GOBP_Membrane_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	1.6e-07
Cers4	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Cers4	GOBP_Sphingolipid_Biosynthetic_Process	Mouse	Lymph	MS-1	2.4e-12
Cers4	GOBP_Sphingolipid_Metabolic_Process	Mouse	Lymph	MS-1	9.3e-07
Cers4	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	8.0e-10
Cers4	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Cers4	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Cers4	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.9e-07
Cers4	GOBP_Lipid_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	1.2e-14
Cers4	GOBP_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-11
Cers4	GOBP_Membrane_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.0e-08
Cers4	GOBP_Sphingolipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.5e-08

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Cers4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Cers4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Cers4 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
CERS4	Skin	tumor	Tumor_KC_Diff	PPARG,REEP6,HMGCS1, etc.	0.316
CERS4	Skin	tumor	Keratinocyte	PPARG,REEP6,HMGCS1, etc.	0.349

Motif information.

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Related Drugs for Cers4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Cers4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source