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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Nenf (spascer ID:66208)

Gene summary for Nenf

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Nenf
	Gene ID	66208
	Gene name	neuron derived neurotrophic factor
	Synonyms	1110060M21Rik\|SCIRP10\|Spuf
	Cytomap	1\|1 H6
	Type of gene	protein-coding
	Description	neudesinSCIRP10-related proteinSpinal cord injury related protein 10secreted protein of unknown function
	Modification date	20220424
	UniProtAcc	Q9CQ45

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Nenf	GO:0012505	endomembrane system	21873635	Component
Nenf	GO:0016020	membrane	21873635	Component

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Spatial pattern events for Nenf

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Nenf	Mouse	Brain	S1	34413515	2.07e-15
Nenf	Mouse	Brain	S2	34413515	1.56e-15
Nenf	Mouse	Brain	S3	34413515	1.64e-15
Nenf	Mouse	Brain	S4	34413515	1.37e-15
Nenf	Mouse	Brain	S6	34413515	1.46e-15
Nenf	Mouse	Brain	S7	34413515	1.55e-15
Nenf	Mouse	Brain	22A	32637622	2.43e-09
Nenf	Mouse	Brain	rep_1	35141374	2.02e-15
Nenf	Mouse	Brain	rep_2	35141374	1.69e-15
Nenf	Mouse	Brain	rep_3	35141374	1.64e-15
Nenf	Mouse	Brain	rep_4	35141374	1.57e-15
Nenf	Mouse	Brain	rep_5	35141374	1.47e-15
Nenf	Mouse	Brain	rep_6	35141374	1.73e-15
Nenf	Mouse	Embryo	rep_4	33188776	2.21e-07
Nenf	Mouse	Kidney	CLP	34003797	2.19e-15
Nenf	Mouse	Kidney	IRI	34003797	2.29e-15
Nenf	Mouse	Kidney	Sham	34003797	2.58e-15
Nenf	Mouse	Kidney	rep_1	34853151	2.42e-15
Nenf	Mouse	Kidney	rep_4	34853151	4.07e-15
Nenf	Mouse	Kidney	rep_5	34853151	5.45e-15
Nenf	Mouse	Brain	rep_1	33469025	1.30e-15
Nenf	Mouse	Liver	rep_20	35021063	2.02e-13
Nenf	Mouse	Liver	rep_21	35021063	8.03e-15
Nenf	Mouse	Liver	rep_22	35021063	3.12e-14
Nenf	Mouse	Brain	rep_1	35027729	1.66e-15
Nenf	Mouse	Brain	rep_2	35027729	1.57e-15
Nenf	Mouse	Brain	rep_3	35027729	1.32e-15
Nenf	Mouse	Brain	rep_4	35027729	1.76e-15
Nenf	Mouse	Brain	rep_5	35027729	1.46e-15
Nenf	Mouse	Intestine	rep_2	35149721	1.66e-06
Nenf	Mouse	Intestine	rep_4	35149721	2.30e-15
Nenf	Mouse	Testicle	rep_4	34731600	5.17e-10
Nenf	Mouse	Lymph	A1	0	3.29e-15
Nenf	Mouse	Lymph	B1	0	3.66e-15
Nenf	Mouse	Lung	rep_1	35290801	2.81e-08
Nenf	Mouse	Brain	rep_1	35210624	1.74e-15
Nenf	Mouse	Brain	rep_2	35210624	1.74e-15
Nenf	Mouse	Brain	rep_3	35210624	1.82e-15
Nenf	Mouse	Brain	rep_4	35210624	4.16e-15
Nenf	Mouse	Brain	rep_5	35210624	2.07e-15
Nenf	Mouse	Brain	rep_6	35210624	2.05e-15
Nenf	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Liver_rep_20_H&E
Liver_rep_21_H&E
Liver_rep_22_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has Nenf envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Spinal cord	L7bCN02_E1	2.3e-06
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Spinal cord	L7CN44_C1	8.8e-06
Nenf	GOBP_Mapk_Cascade	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Nenf	GOBP_Negative_Regulation_Of_Response_To_External_Stimulus	Mouse	Spinal cord	L7CN45_C1	2.5e-06
Nenf	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Nenf	GOBP_Response_To_Food	Mouse	Spinal cord	L7CN45_C1	1.1e-08
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Spinal cord	L7CN68_C2	7.5e-06
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Spinal cord	L7CN85_E1	3.8e-06
Nenf	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Spinal cord	L7CN97_E2	4.9e-06
Nenf	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Nenf	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_27	6.3e-05
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Brain	rep_27	6.7e-05
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Brain	rep_31	1.7e-05
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Brain	rep_33	5.1e-05
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Brain	rep_71	5.2e-06
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Brain	rep_71	2.9e-06
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	rep_1	3.1e-07
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Brain	rep_1	5.5e-39
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Brain	rep_1	7.9e-11
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Brain	rep_1	3.0e-11
Nenf	GOBP_Mapk_Cascade	Mouse	Brain	rep_3	4.8e-123
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	2.5e-150
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Brain	rep_3	4.0e-77
Nenf	GOBP_Negative_Regulation_Of_Response_To_External_Stimulus	Mouse	Brain	rep_3	2.0e-193
Nenf	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Nenf	GOBP_Neuron_Death	Mouse	Brain	rep_3	3.6e-120
Nenf	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	3.3e-214
Nenf	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	rep_3	4.0e-152
Nenf	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	7.6e-107
Nenf	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Brain	rep_3	1.2e-94
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Brain	rep_3	2.2e-117
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Brain	rep_6	3.0e-15
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Embryo	rep_14	3.8e-08
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Embryo	rep_14	5.8e-18
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Embryo	rep_14	6.9e-17
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Embryo	rep_14	9.4e-67
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Embryo	rep_14	5.2e-21
Nenf	GOBP_Response_To_Food	Mouse	Embryo	rep_14	6.8e-65
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Embryo	rep_1	3.6e-258
Nenf	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Nenf	GOBP_Neuron_Death	Mouse	Embryo	rep_1	0.0e+00
Nenf	GOBP_Regulation_Of_Cell_Death	Mouse	Embryo	rep_1	8.4e-30
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Embryo	rep_2	1.4e-07
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Embryo	rep_3	1.9e-126
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Embryo	rep_4	1.2e-08
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Embryo	rep_6	3.6e-24
Nenf	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	Nep	5.3e-07
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	Nep	1.1e-39
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Kidney	Nep	1.1e-60
Nenf	GOBP_Mapk_Cascade	Mouse	Kidney	rep_2	1.1e-19
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Kidney	rep_2	4.6e-36
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Kidney	rep_2	2.7e-17
Nenf	GOBP_Negative_Regulation_Of_Response_To_External_Stimulus	Mouse	Kidney	rep_2	9.9e-51
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Kidney	rep_2	3.9e-36
Nenf	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Nenf	GOBP_Neuron_Death	Mouse	Kidney	rep_2	3.1e-123
Nenf	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Kidney	rep_2	1.8e-39
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	rep_2	3.4e-17
Nenf	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Kidney	rep_2	1.3e-111
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Kidney	rep_2	1.8e-10
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Kidney	rep_2	3.8e-52
Nenf	GOBP_Response_To_Food	Mouse	Kidney	rep_2	1.3e-42
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Liver	CN16-D1	8.1e-14
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Liver	CN16-D1	8.1e-14
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Liver	CN16-D1	8.1e-14
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Liver	rep_15	1.8e-07
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Liver	rep_15	4.2e-07
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.7e-09
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Liver	rep_16	1.4e-15
Nenf	GOBP_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.0e-13
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Liver	rep_16	1.4e-07
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Liver	rep_16	8.0e-26
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Liver	rep_20	2.5e-28
Nenf	GOBP_Response_To_Food	Mouse	Liver	rep_20	1.3e-12
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Brain	rep_1	2.1e-05
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Intestine	rep_2	7.4e-10
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Intestine	rep_3	7.9e-30
Nenf	GOBP_Mapk_Cascade	Mouse	Lymph	MS-1	8.8e-20
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	3.9e-13
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Lymph	MS-1	1.5e-09
Nenf	GOBP_Negative_Regulation_Of_Response_To_External_Stimulus	Mouse	Lymph	MS-1	7.8e-13
Nenf	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Nenf	GOBP_Neuron_Death	Mouse	Lymph	MS-1	2.5e-07
Nenf	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	2.3e-12
Nenf	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Lymph	MS-1	2.7e-14
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Lymph	MS-1	2.3e-12
Nenf	GOBP_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	1.9e-12
Nenf	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Lymph	MS-1	3.8e-16
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Lymph	MS-1	6.9e-07
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Lymph	MS-1	1.1e-12
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Brain	rep_4	9.3e-16
Nenf	GOBP_Negative_Regulation_Of_Response_To_Food	Mouse	Brain	HP_ad_rep3	2.2e-09
Nenf	GOBP_Regulation_Of_Appetite	Mouse	Brain	HP_ad_rep3	7.3e-16
Nenf	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Brain	HP_ad_rep7	4.1e-12
Nenf	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	HP_ad_rep7	1.6e-07
Nenf	GOBP_Regulation_Of_Response_To_External_Stimulus	Mouse	Brain	HP_ad_rep7	1.3e-10
Nenf	GOBP_Response_To_Extracellular_Stimulus	Mouse	Brain	HP_ad_rep7	1.4e-09
Nenf	GOBP_Regulation_Of_Response_To_Extracellular_Stimulus	Mouse	Brain	HP_adpolb_rep6	4.2e-15
Nenf	GOBP_Regulation_Of_Response_To_Food	Mouse	Brain	HP_adpolb_rep6	1.2e-10
Nenf	GOBP_Response_To_Food	Mouse	Brain	HP_adpolb_rep6	1.0e-07
Nenf	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Brain	HP_polb_rep9	9.2e-10
Nenf	GOBP_Negative_Regulation_Of_Response_To_External_Stimulus	Mouse	Brain	HP_polb_rep9	8.9e-08
Nenf	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Nenf	GOBP_Neuron_Death	Mouse	Brain	HP_polb_rep9	8.3e-10
Nenf	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	1.7e-14
Nenf	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	HP_polb_rep9	6.9e-10
Nenf	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.3e-14
Nenf	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11

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Nenf function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Nenf function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Nenf envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Nenf

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Nenf

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source