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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tipin (spascer ID:66131)

Gene summary for Tipin

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tipin
	Gene ID	66131
	Gene name	timeless interacting protein
	Synonyms	1110005A05Rik\|1110018P21Rik
	Cytomap	9 C\|9 34.6 cM
	Type of gene	protein-coding
	Description	TIMELESS-interacting protein
	Modification date	20220424
	UniProtAcc	Q91WA1

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tipin	GO:0000076	DNA replication checkpoint signaling	21873635	Process
Tipin	GO:0003677	DNA binding	21873635	Function
Tipin	GO:0031298	replication fork protection complex	21873635	Component
Tipin	GO:0043111	replication fork arrest	21873635	Process
Tipin	GO:0048478	replication fork protection	21873635	Process

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Spatial pattern events for Tipin

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tipin	Mouse	Brain	rep_3	35141374	6.99e-09
Tipin	Mouse	Kidney	CLP	34003797	3.77e-15
Tipin	Mouse	Kidney	Sham	34003797	8.96e-09
Tipin	Mouse	Brain	rep_1	33469025	1.30e-15
Tipin	Mouse	Lymph	A1	0	8.75e-13
Tipin	Mouse	Lymph	B1	0	3.66e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_3_H&E
Kidney_CLP_H&E
Kidney_Sham_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Tipin envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tipin	GOBP_Cell_Cycle	Mouse	Spinal cord	CN94_E1	1.1e-06
Tipin	GOBP_Cell_Cycle_Dna_Replication	Mouse	Spinal cord	CN94_E1	7.4e-07
Tipin	GOBP_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	3.8e-06
Tipin	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Spinal cord	CN94_E1	8.0e-06
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Spinal cord	CN94_E1	2.7e-06
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Tipin	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	CN94_E1	3.2e-06
Tipin	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Spinal cord	CN94_E1	4.0e-06
Tipin	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	7.5e-07
Tipin	GOBP_Regulation_Of_Dna_Replication	Mouse	Spinal cord	CN94_E1	5.2e-07
Tipin	GOBP_Cell_Cycle_Phase_Transition	Mouse	Spinal cord	L7bCN02_E1	1.5e-06
Tipin	GOBP_Cell_Division	Mouse	Spinal cord	L7CN45_C1	2.6e-06
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Spinal cord	L7CN45_C1	4.8e-07
Tipin	GOBP_Dna_Replication	Mouse	Spinal cord	L7CN45_C1	2.8e-07
Tipin	GOBP_Mitotic_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Tipin	GOBP_Negative_Regulation_Of_Dna_Replication	Mouse	Spinal cord	L7CN45_C1	9.0e-06
Tipin	GOBP_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	3.0e-07
Tipin	GOBP_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Spinal cord	L7CN45_C1	5.2e-08
Tipin	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	5.4e-08
Tipin	GOBP_Response_To_Radiation	Mouse	Spinal cord	L7CN45_C1	4.5e-07
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Spinal cord	L7CN45_E1	9.1e-06
Tipin	GOBP_Dna_Dependent_Dna_Replication	Mouse	Spinal cord	L7CN47_C1	6.6e-06
Tipin	GOBP_Response_To_Light_Stimulus	Mouse	Spinal cord	L7CN47_C1	3.8e-06
Tipin	GOBP_Response_To_Uv	Mouse	Spinal cord	L7CN47_C1	5.1e-06
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Spinal cord	L7CN75_C2	2.7e-08
Tipin	GOBP_Replication_Fork_Protection	Mouse	Spinal cord	L7CN85_E2	4.3e-06
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Spinal cord	L8CN14_E2	8.1e-17
Tipin	GOBP_Replication_Fork_Protection	Mouse	Brain	rep_17	3.4e-05
Tipin	GOBP_Cell_Cycle	Mouse	Brain	rep_27	8.4e-07
Tipin	GOBP_Cell_Division	Mouse	Brain	rep_27	3.6e-05
Tipin	GOBP_Dna_Replication	Mouse	Brain	rep_27	6.4e-06
Tipin	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	rep_27	1.1e-05
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Tipin	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_27	1.7e-08
Tipin	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_27	4.4e-08
Tipin	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	rep_27	7.4e-07
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Brain	rep_41	5.2e-08
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Brain	rep_42	1.5e-05
Tipin	GOBP_Cell_Cycle	Mouse	Brain	rep_1	7.0e-10
Tipin	GOBP_Cell_Cycle_Dna_Replication	Mouse	Brain	rep_1	3.4e-08
Tipin	GOBP_Cell_Cycle_Phase_Transition	Mouse	Brain	rep_1	1.6e-31
Tipin	GOBP_Cell_Cycle_Process	Mouse	Brain	rep_1	6.7e-14
Tipin	GOBP_Cell_Division	Mouse	Brain	rep_1	9.7e-23
Tipin	GOBP_Dna_Dependent_Dna_Replication	Mouse	Brain	rep_1	1.5e-17
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Brain	rep_1	3.7e-22
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Brain	rep_1	1.1e-07
Tipin	GOBP_Dna_Replication	Mouse	Brain	rep_1	4.3e-10
Tipin	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	rep_1	1.5e-25
Tipin	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_1	3.9e-14
Tipin	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_1	4.4e-18
Tipin	GOBP_Regulation_Of_Dna_Replication	Mouse	Brain	rep_1	2.4e-09
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Brain	rep_1	3.0e-40
Tipin	GOBP_Response_To_Abiotic_Stimulus	Mouse	Brain	rep_1	6.0e-28
Tipin	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	rep_3	5.0e-192
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Tipin	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_3	1.9e-186
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Brain	rep_3	4.6e-176
Tipin	GOBP_Negative_Regulation_Of_Dna_Replication	Mouse	Brain	rep_3	9.7e-81
Tipin	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	rep_3	3.7e-178
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Brain	rep_3	8.8e-172
Tipin	GOBP_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Brain	rep_3	6.7e-128
Tipin	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	rep_3	1.7e-200
Tipin	GOBP_Replication_Fork_Protection	Mouse	Brain	rep_3	2.9e-156
Tipin	GOBP_Response_To_Light_Stimulus	Mouse	Brain	rep_3	3.8e-27
Tipin	GOBP_Response_To_Radiation	Mouse	Brain	rep_3	4.6e-08
Tipin	GOBP_Response_To_Uv	Mouse	Brain	rep_3	7.7e-209
Tipin	GOBP_Negative_Regulation_Of_Dna_Replication	Mouse	Embryo	rep_6	2.0e-19
Tipin	GOBP_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Embryo	rep_6	2.5e-11
Tipin	GOBP_Replication_Fork_Protection	Mouse	Embryo	rep_6	4.2e-08
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Embryo	rep_14	7.3e-18
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Embryo	rep_14	3.3e-44
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Embryo	rep_14	7.2e-32
Tipin	GOBP_Response_To_Uv	Mouse	Embryo	rep_14	9.0e-16
Tipin	GOBP_Cell_Division	Mouse	Embryo	rep_1	0.0e+00
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Embryo	rep_1	7.1e-65
Tipin	GOBP_Response_To_Light_Stimulus	Mouse	Embryo	rep_1	1.5e-185
Tipin	GOBP_Response_To_Radiation	Mouse	Embryo	rep_1	0.0e+00
Tipin	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Embryo	rep_2	1.4e-08
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Embryo	rep_2	7.2e-216
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Tipin	GOBP_Response_To_Uv	Mouse	Embryo	rep_3	7.0e-131
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Kidney	Nep	2.0e-14
Tipin	GOBP_Cell_Cycle	Mouse	Kidney	rep_2	1.0e-24
Tipin	GOBP_Cell_Cycle_Dna_Replication	Mouse	Kidney	rep_2	3.6e-23
Tipin	GOBP_Cell_Cycle_Phase_Transition	Mouse	Kidney	rep_2	6.8e-67
Tipin	GOBP_Cell_Cycle_Process	Mouse	Kidney	rep_2	3.0e-21
Tipin	GOBP_Cell_Division	Mouse	Kidney	rep_2	5.3e-77
Tipin	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Kidney	rep_2	5.5e-146
Tipin	GOBP_Dna_Dependent_Dna_Replication	Mouse	Kidney	rep_2	1.1e-109
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Kidney	rep_2	1.5e-19
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-12
Tipin	GOBP_Dna_Replication	Mouse	Kidney	rep_2	5.9e-43
Tipin	GOBP_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	1.1e-15
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Tipin	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Kidney	rep_2	2.8e-71
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Kidney	rep_2	1.0e-15
Tipin	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	8.9e-62
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Kidney	rep_2	3.8e-57
Tipin	GOBP_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Kidney	rep_2	1.5e-51
Tipin	GOBP_Regulation_Of_Dna_Replication	Mouse	Kidney	rep_2	7.8e-10
Tipin	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	3.2e-49
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Kidney	rep_2	3.4e-14
Tipin	GOBP_Replication_Fork_Protection	Mouse	Kidney	rep_2	4.4e-26
Tipin	GOBP_Response_To_Light_Stimulus	Mouse	Kidney	rep_2	4.7e-16
Tipin	GOBP_Response_To_Uv	Mouse	Kidney	rep_2	1.0e-65
Tipin	GOBP_Dna_Dependent_Dna_Replication	Mouse	Liver	CN16-D2	3.1e-08
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Liver	CN16-D2	2.6e-07
Tipin	GOBP_Negative_Regulation_Of_Dna_Replication	Mouse	Liver	CN16-D2	2.6e-11
Tipin	GOBP_Response_To_Uv	Mouse	Liver	CN16-E1	1.9e-07
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Liver	rep_15	1.9e-10
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Liver	rep_15	4.9e-16
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Liver	rep_16	2.4e-08
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Brain	rep_1	1.2e-13
Tipin	GOBP_Replication_Fork_Protection	Mouse	Brain	rep_1	1.1e-05
Tipin	GOBP_Cell_Cycle	Mouse	Lymph	MS-1	1.3e-07
Tipin	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Lymph	MS-1	8.5e-13
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Lymph	MS-1	3.1e-11
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Lymph	MS-1	6.8e-10
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Tipin	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	9.2e-07
Tipin	GOBP_Negative_Regulation_Of_Dna_Replication	Mouse	Lymph	MS-1	5.2e-10
Tipin	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Lymph	MS-1	2.4e-09
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Lymph	MS-1	2.3e-12
Tipin	GOBP_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	6.4e-09
Tipin	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Lymph	MS-1	4.1e-08
Tipin	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Lymph	MS-1	6.9e-07
Tipin	GOBP_Response_To_Abiotic_Stimulus	Mouse	Lymph	MS-1	1.5e-07
Tipin	GOBP_Response_To_Light_Stimulus	Mouse	Lymph	MS-1	3.8e-09
Tipin	GOBP_Response_To_Radiation	Mouse	Lymph	MS-1	9.1e-12
Tipin	GOBP_Response_To_Uv	Mouse	Lymph	MS-1	2.7e-11
Tipin	GOBP_Cell_Cycle_Dna_Replication	Mouse	Lymph	MS-2	7.1e-08
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Lymph	MS-2	2.9e-08
Tipin	GOBP_Dna_Dependent_Dna_Replication	Mouse	Lymph	PBS	2.2e-07
Tipin	GOBP_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Lymph	PBS	3.8e-07
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Brain	rep_7	3.9e-16
Tipin	GOBP_Negative_Regulation_Of_Dna_Replication	Mouse	Brain	HP_ad_rep2	1.1e-07
Tipin	GOBP_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Brain	HP_ad_rep2	3.5e-07
Tipin	GOBP_Negative_Regulation_Of_Dna_Dependent_Dna_Replication	Mouse	Brain	HP_ad_rep3	1.6e-16
Tipin	GOBP_Replication_Fork_Protection	Mouse	Brain	HP_ad_rep3	2.6e-10
Tipin	GOBP_Cell_Cycle	Mouse	Brain	HP_ad_rep7	6.6e-08
Tipin	GOBP_Cell_Cycle_Dna_Replication	Mouse	Brain	HP_ad_rep7	2.9e-18
Tipin	GOBP_Cell_Cycle_Phase_Transition	Mouse	Brain	HP_ad_rep7	4.9e-09
Tipin	GOBP_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Tipin	GOBP_Cell_Division	Mouse	Brain	HP_ad_rep7	2.6e-09
Tipin	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	HP_ad_rep7	6.8e-10
Tipin	GOBP_Dna_Dependent_Dna_Replication	Mouse	Brain	HP_ad_rep7	1.6e-15
Tipin	GOBP_Dna_Metabolic_Process	Mouse	Brain	HP_ad_rep7	3.1e-11
Tipin	GOBP_Dna_Replication	Mouse	Brain	HP_ad_rep7	1.1e-10
Tipin	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Tipin	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	9.2e-08
Tipin	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	HP_ad_rep7	5.7e-10
Tipin	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Mouse	Brain	HP_ad_rep7	1.9e-10
Tipin	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	1.6e-08
Tipin	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	9.9e-08
Tipin	GOBP_Regulation_Of_Dna_Replication	Mouse	Brain	HP_ad_rep7	1.3e-09
Tipin	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	HP_ad_rep7	3.4e-10
Tipin	GOBP_Response_To_Abiotic_Stimulus	Mouse	Brain	HP_ad_rep7	4.3e-08
Tipin	GOBP_Response_To_Light_Stimulus	Mouse	Brain	HP_ad_rep7	1.6e-09
Tipin	GOBP_Response_To_Radiation	Mouse	Brain	HP_ad_rep7	9.1e-09
Tipin	GOBP_Regulation_Of_Nuclear_Cell_Cycle_Dna_Replication	Mouse	Brain	HP_ad_rep8	6.5e-08
Tipin	GOBP_Response_To_Uv	Mouse	Brain	HP_adpolb_rep1	4.1e-10
Tipin	GOBP_Dna_Dependent_Dna_Replication_Maintenance_Of_Fidelity	Mouse	Brain	HP_polb_rep1	5.3e-07
Tipin	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	HP_polb_rep9	1.6e-10

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Tipin function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tipin function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tipin envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tipin

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tipin

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source