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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tmed3 (spascer ID:66111)

Gene summary for Tmed3

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tmed3
	Gene ID	66111
	Gene name	transmembrane p24 trafficking protein 3
	Synonyms	1200002G13Rik\|AW546672\|P24b
	Cytomap	9\|9 E3.1
	Type of gene	protein-coding
	Description	transmembrane emp24 domain-containing protein 3integral type I proteinp24 family protein gamma-4p24gamma4transmembrane emp24 domain containing 3
	Modification date	20220424
	UniProtAcc	Q78IS1

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tmed3	GO:0005783	endoplasmic reticulum	21873635	Component
Tmed3	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	21873635	Component
Tmed3	GO:0005794	Golgi apparatus	21873635	Component
Tmed3	GO:0006886	intracellular protein transport	21873635	Process
Tmed3	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	21873635	Process
Tmed3	GO:0007030	Golgi organization	21873635	Process
Tmed3	GO:0030126	COPI vesicle coat	21873635	Component
Tmed3	GO:0030134	COPII-coated ER to Golgi transport vesicle	21873635	Component

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Spatial pattern events for Tmed3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tmed3	Mouse	Brain	S3	34413515	1.64e-15
Tmed3	Mouse	Brain	S4	34413515	1.37e-15
Tmed3	Mouse	Brain	S6	34413515	1.46e-15
Tmed3	Mouse	Brain	S7	34413515	1.55e-15
Tmed3	Mouse	Brain	rep_1	35141374	2.02e-15
Tmed3	Mouse	Brain	rep_2	35141374	1.69e-15
Tmed3	Mouse	Brain	rep_3	35141374	1.64e-15
Tmed3	Mouse	Brain	rep_4	35141374	1.57e-15
Tmed3	Mouse	Brain	rep_5	35141374	1.47e-15
Tmed3	Mouse	Brain	rep_6	35141374	1.73e-15
Tmed3	Mouse	Kidney	IRI	34003797	3.20e-09
Tmed3	Mouse	Kidney	rep_2	34853151	2.01e-09
Tmed3	Mouse	Brain	rep_1	33469025	1.30e-15
Tmed3	Mouse	Brain	rep_1	35027729	1.05e-08
Tmed3	Mouse	Brain	rep_2	35027729	4.90e-11
Tmed3	Mouse	Brain	rep_3	35027729	1.32e-15
Tmed3	Mouse	Brain	rep_4	35027729	1.21e-06
Tmed3	Mouse	Brain	rep_5	35027729	1.46e-15
Tmed3	Mouse	Intestine	rep_4	35149721	6.72e-06
Tmed3	Mouse	Lymph	A1	0	2.13e-06
Tmed3	Mouse	Lung	rep_3	35290801	3.72e-06
Tmed3	Mouse	Lung	rep_4	35290801	3.04e-15
Tmed3	Mouse	Brain	rep_1	35210624	3.60e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_IRI_H&E
Kidney_rep_2_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Tmed3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tmed3	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Tmed3	GOBP_Endomembrane_System_Organization	Mouse	Spinal cord	L7CN45_C1	1.0e-06
Tmed3	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Spinal cord	L7CN45_C1	7.4e-08
Tmed3	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Tmed3	GOBP_Golgi_Organization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Tmed3	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Tmed3	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Spinal cord	L7CN47_C1	5.1e-06
Tmed3	GOBP_Golgi_Organization	Mouse	Brain	rep_27	5.4e-06
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Brain	rep_27	5.1e-06
Tmed3	GOBP_Endomembrane_System_Organization	Mouse	Brain	rep_1	7.8e-10
Tmed3	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Tmed3	GOBP_Golgi_Organization	Mouse	Brain	rep_1	5.5e-18
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Brain	rep_1	1.2e-15
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Brain	rep_1	2.4e-31
Tmed3	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Tmed3	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Brain	rep_3	7.6e-183
Tmed3	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Tmed3	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Tmed3	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Embryo	rep_14	4.4e-33
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Embryo	rep_14	5.7e-09
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Embryo	rep_14	5.9e-39
Tmed3	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Tmed3	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Tmed3	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Tmed3	GOBP_Endomembrane_System_Organization	Mouse	Kidney	rep_2	1.0e-161
Tmed3	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Kidney	rep_2	1.8e-93
Tmed3	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Tmed3	GOBP_Golgi_Organization	Mouse	Kidney	rep_2	3.2e-78
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Kidney	rep_2	6.5e-131
Tmed3	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Tmed3	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Kidney	rep_2	3.5e-85
Tmed3	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Tmed3	GOBP_Endomembrane_System_Organization	Mouse	Lymph	MS-1	2.5e-09
Tmed3	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Lymph	MS-1	4.3e-11
Tmed3	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Tmed3	GOBP_Golgi_Organization	Mouse	Lymph	MS-1	9.6e-08
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Lymph	MS-1	5.2e-08
Tmed3	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Tmed3	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Lymph	MS-1	4.2e-07
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Brain	rep_4	1.1e-19
Tmed3	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Tmed3	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Brain	HP_ad_rep7	6.3e-08
Tmed3	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Tmed3	GOBP_Golgi_Organization	Mouse	Brain	HP_ad_rep7	2.6e-07
Tmed3	GOBP_Golgi_Vesicle_Transport	Mouse	Brain	HP_ad_rep7	1.1e-09
Tmed3	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Tmed3	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Tmed3	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Mouse	Brain	HP_ad_rep7	1.2e-09
Tmed3	GOBP_Endomembrane_System_Organization	Mouse	Brain	HP_polb_rep9	6.0e-11

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Tmed3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tmed3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tmed3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tmed3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tmed3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source