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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tpm3 (spascer ID:59069)

Gene summary for Tpm3

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tpm3
	Gene ID	59069
	Gene name	tropomyosin 3, gamma
	Synonyms	TM30nm\|TMnm\|Tm5NM\|Tpm-5\|Tpm5\|Trop-5\|gamma-TM\|hTM30nm\|hTMnm
	Cytomap	3\|3 F1
	Type of gene	protein-coding
	Description	tropomyosin alpha-3 chaingamma-tropomyosinskalphaTM.2tropomyosin 5tropomyosin-3
	Modification date	20220424
	UniProtAcc	P21107

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tpm3	GO:0005884	actin filament	21873635	Component
Tpm3	GO:0006936	muscle contraction	21873635	Process
Tpm3	GO:0007015	actin filament organization	21873635	Process
Tpm3	GO:0051015	actin filament binding	21873635	Function

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Spatial pattern events for Tpm3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tpm3	Mouse	Brain	S1	34413515	2.07e-15
Tpm3	Mouse	Brain	S2	34413515	1.56e-15
Tpm3	Mouse	Brain	S3	34413515	1.64e-15
Tpm3	Mouse	Brain	S4	34413515	1.37e-15
Tpm3	Mouse	Brain	S6	34413515	1.46e-15
Tpm3	Mouse	Brain	S7	34413515	1.55e-15
Tpm3	Mouse	Brain	21A	32637622	6.56e-07
Tpm3	Mouse	Brain	22B	32637622	2.55e-07
Tpm3	Mouse	Brain	23B	32637622	2.84e-06
Tpm3	Mouse	Brain	30A	32637622	4.32e-07
Tpm3	Mouse	Brain	rep_1	35141374	2.22e-11
Tpm3	Mouse	Brain	rep_2	35141374	1.69e-15
Tpm3	Mouse	Brain	rep_3	35141374	6.14e-09
Tpm3	Mouse	Brain	rep_4	35141374	2.84e-15
Tpm3	Mouse	Brain	rep_5	35141374	5.13e-15
Tpm3	Mouse	Brain	rep_6	35141374	3.21e-06
Tpm3	Mouse	Embryo	rep_4	33188776	9.41e-07
Tpm3	Mouse	Embryo	rep_13	33188776	2.05e-06
Tpm3	Mouse	Kidney	CLP	34003797	5.23e-07
Tpm3	Mouse	Kidney	IRI	34003797	2.29e-15
Tpm3	Mouse	Kidney	rep_1	34853151	2.42e-15
Tpm3	Mouse	Kidney	rep_2	34853151	3.38e-15
Tpm3	Mouse	Kidney	rep_3	34853151	2.29e-10
Tpm3	Mouse	Kidney	rep_4	34853151	4.07e-15
Tpm3	Mouse	Kidney	rep_5	34853151	3.18e-15
Tpm3	Mouse	Brain	rep_1	33469025	1.30e-15
Tpm3	Mouse	Brain	rep_1	35027729	1.66e-15
Tpm3	Mouse	Brain	rep_2	35027729	1.57e-15
Tpm3	Mouse	Brain	rep_3	35027729	1.32e-15
Tpm3	Mouse	Brain	rep_4	35027729	1.76e-15
Tpm3	Mouse	Brain	rep_5	35027729	1.46e-15
Tpm3	Mouse	Intestine	rep_1	35149721	1.03e-14
Tpm3	Mouse	Intestine	rep_2	35149721	3.44e-15
Tpm3	Mouse	Intestine	rep_3	35149721	5.21e-15
Tpm3	Mouse	Intestine	rep_4	35149721	2.30e-15
Tpm3	Mouse	Brain	B02_E1	32702314	3.53e-07
Tpm3	Mouse	Brain	N03_D2	32702314	1.65e-13
Tpm3	Mouse	Lymph	A1	0	3.29e-15
Tpm3	Mouse	Lymph	B1	0	3.66e-15
Tpm3	Mouse	Lung	rep_1	35290801	3.66e-13
Tpm3	Mouse	Lung	rep_2	35290801	8.75e-15
Tpm3	Mouse	Lung	rep_3	35290801	5.26e-15
Tpm3	Mouse	Lung	rep_4	35290801	1.04e-08
Tpm3	Mouse	Brain	rep_1	35210624	1.74e-15
Tpm3	Mouse	Brain	rep_2	35210624	1.74e-15
Tpm3	Mouse	Brain	rep_3	35210624	1.82e-15
Tpm3	Mouse	Brain	rep_5	35210624	7.46e-12
Tpm3	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B02_E1_H&E
Brain_N03_D2_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Tpm3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tpm3	GOBP_Cytoskeleton_Organization	Mouse	Spinal cord	L7bCN02_E1	8.3e-06
Tpm3	GOBP_Actin_Mediated_Cell_Contraction	Mouse	Spinal cord	L7CN45_C1	9.3e-06
Tpm3	GOBP_Actin_Filament_Based_Process	Mouse	Spinal cord	L7CN47_C1	3.4e-06
Tpm3	GOBP_Actin_Filament_Based_Movement	Mouse	Spinal cord	L7CN47_D1	1.0e-05
Tpm3	GOBP_Actin_Filament_Organization	Mouse	Spinal cord	L8CN17_E1	2.1e-07
Tpm3	GOBP_Actin_Filament_Based_Movement	Mouse	Brain	rep_1	7.9e-40
Tpm3	GOBP_Actin_Filament_Based_Process	Mouse	Brain	rep_1	2.1e-24
Tpm3	GOBP_Actin_Filament_Organization	Mouse	Brain	rep_1	4.6e-31
Tpm3	GOBP_Actin_Mediated_Cell_Contraction	Mouse	Brain	rep_1	8.8e-38
Tpm3	GOBP_Cytoskeleton_Organization	Mouse	Brain	rep_1	1.1e-11
Tpm3	GOBP_Muscle_Contraction	Mouse	Brain	rep_1	6.0e-18
Tpm3	GOBP_Muscle_System_Process	Mouse	Brain	rep_1	8.3e-21
Tpm3	GOBP_Supramolecular_Fiber_Organization	Mouse	Brain	rep_3	6.7e-78
Tpm3	GOBP_Actin_Mediated_Cell_Contraction	Mouse	Embryo	rep_14	5.2e-15
Tpm3	GOBP_Muscle_Contraction	Mouse	Embryo	rep_14	1.7e-07
Tpm3	GOBP_Supramolecular_Fiber_Organization	Mouse	Embryo	rep_3	0.0e+00
Tpm3	GOBP_Actin_Filament_Based_Movement	Mouse	Kidney	rep_2	8.1e-151
Tpm3	GOBP_Actin_Filament_Based_Process	Mouse	Kidney	rep_2	2.6e-107
Tpm3	GOBP_Actin_Filament_Organization	Mouse	Kidney	rep_2	4.0e-81
Tpm3	GOBP_Actin_Mediated_Cell_Contraction	Mouse	Kidney	rep_2	4.2e-158
Tpm3	GOBP_Cytoskeleton_Organization	Mouse	Kidney	rep_2	1.5e-44
Tpm3	GOBP_Muscle_Contraction	Mouse	Kidney	rep_2	1.1e-89
Tpm3	GOBP_Muscle_System_Process	Mouse	Kidney	rep_2	1.2e-86
Tpm3	GOBP_Supramolecular_Fiber_Organization	Mouse	Kidney	rep_2	9.5e-65
Tpm3	GOBP_Muscle_System_Process	Mouse	Liver	rep_15	9.3e-22
Tpm3	GOBP_Actin_Filament_Based_Movement	Mouse	Liver	rep_16	2.3e-08
Tpm3	GOBP_Actin_Filament_Based_Movement	Mouse	Lymph	MS-1	1.2e-21
Tpm3	GOBP_Actin_Filament_Based_Process	Mouse	Lymph	MS-1	1.4e-10
Tpm3	GOBP_Actin_Filament_Organization	Mouse	Lymph	MS-1	4.2e-11
Tpm3	GOBP_Actin_Mediated_Cell_Contraction	Mouse	Lymph	MS-1	2.5e-14
Tpm3	GOBP_Cytoskeleton_Organization	Mouse	Lymph	MS-1	1.8e-13
Tpm3	GOBP_Muscle_Contraction	Mouse	Lymph	MS-1	3.4e-09
Tpm3	GOBP_Muscle_System_Process	Mouse	Lymph	MS-1	1.6e-08
Tpm3	GOBP_Supramolecular_Fiber_Organization	Mouse	Lymph	MS-1	1.5e-12
Tpm3	GOBP_Actin_Filament_Based_Movement	Mouse	Brain	HP_ad_rep7	2.8e-08
Tpm3	GOBP_Actin_Mediated_Cell_Contraction	Mouse	Brain	HP_ad_rep7	2.8e-07
Tpm3	GOBP_Cytoskeleton_Organization	Mouse	Brain	HP_ad_rep7	5.3e-08
Tpm3	GOBP_Supramolecular_Fiber_Organization	Mouse	Brain	HP_ad_rep7	5.2e-07
Tpm3	GOBP_Actin_Filament_Based_Process	Mouse	Brain	HP_polb_rep9	3.0e-07
Tpm3	GOBP_Muscle_Contraction	Mouse	Brain	HP_polb_rep9	8.1e-07

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Tpm3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tpm3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tpm3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tpm3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tpm3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Tpm3	C1836448	Nemaline myopathy 1	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tpm3	C0546264	Congenital Fiber Type Disproportion	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tpm3	C0007097	Carcinoma	2	CTD_human
Tpm3	C0024667	Animal Mammary Neoplasms	2	CTD_human
Tpm3	C0024668	Mammary Neoplasms, Experimental	2	CTD_human
Tpm3	C0205696	Anaplastic carcinoma	2	CTD_human
Tpm3	C0205697	Carcinoma, Spindle-Cell	2	CTD_human
Tpm3	C0205698	Undifferentiated carcinoma	2	CTD_human
Tpm3	C0205699	Carcinomatosis	2	CTD_human
Tpm3	C0206157	Myopathies, Nemaline	2	GENOMICS_ENGLAND
Tpm3	C1257925	Mammary Carcinoma, Animal	2	CTD_human
Tpm3	C0001418	Adenocarcinoma	1	CTD_human
Tpm3	C0007102	Malignant tumor of colon	1	CTD_human
Tpm3	C0009375	Colonic Neoplasms	1	CTD_human
Tpm3	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tpm3	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tpm3	C0038356	Stomach Neoplasms	1	CTD_human
Tpm3	C0040136	Thyroid Neoplasm	1	CTD_human
Tpm3	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Tpm3	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tpm3	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tpm3	C0205643	Carcinoma, Cribriform	1	CTD_human
Tpm3	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tpm3	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tpm3	C0270960	Congenital myopathy (disorder)	1	GENOMICS_ENGLAND
Tpm3	C0334121	Inflammatory Myofibroblastic Tumor	1	ORPHANET
Tpm3	C0546125	Nemaline Myopathy, Childhood Onset	1	ORPHANET
Tpm3	C0549473	Thyroid carcinoma	1	CTD_human
Tpm3	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tpm3	C3710589	Cap Myopathy	1	ORPHANET