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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Nampt (spascer ID:59027)

Gene summary for Nampt

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Nampt

Gene ID

59027

Gene namenicotinamide phosphoribosyltransferase
Synonyms1110035O14Rik|AI314458|AI480535|NAmPRTase|Pbef|Pbef1|Visfatin
Cytomap12|12 A3
Type of geneprotein-coding
Descriptionnicotinamide phosphoribosyltransferasepre-B-cell colony-enhancing factor 1 homolog
Modification date20220515
UniProtAcc

Q99KQ4


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Nampt

GO:0009435

NAD biosynthetic process

21873635

Process
Nampt

GO:0047280

nicotinamide phosphoribosyltransferase activity

21873635

Function

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Spatial pattern events for Nampt

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
NamptMouseBrainS3 344135152.96e-15
NamptMouseBrainS7 344135159.01e-06
NamptMouseBrainrep_4 351413741.89e-07
NamptMouseKidneyCLP 340037971.13e-13
NamptMouseKidneyIRI 340037972.29e-15
NamptMouseKidneySham 340037972.58e-15
NamptMouseKidneyrep_1 348531516.64e-12
NamptMouseKidneyrep_3 348531517.67e-08
NamptMouseKidneyrep_4 348531514.07e-15
NamptMouseKidneyrep_5 348531514.02e-14
NamptMouseBrainrep_1 334690252.91e-08
NamptMouseLiverrep_21 350210639.22e-09
NamptMouseLymphMS-2 06.63e-11
NamptMouseLymphPBS 05.99e-11
NamptMouseLymphA1 08.69e-08
NamptMouseLymphB1 07.58e-10
NamptMouseLungrep_1 352908012.20e-12
NamptMouseLungrep_2 352908013.53e-06
NamptMouseLungrep_3 352908011.68e-09
NamptMouseLungrep_4 352908011.45e-10

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_4_H&E
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Kidney_CLP_H&E
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Kidney_IRI_H&E
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Kidney_Sham_H&E
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Kidney_rep_1_H&E
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Kidney_rep_3_H&E
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Kidney_rep_4_H&E
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Kidney_rep_5_H&E
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Brain_rep_1_H&E
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Liver_rep_21_H&E
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Lung_rep_1_H&E
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Lung_rep_2_H&E
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Lung_rep_3_H&E
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Lung_rep_4_H&E
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Spatial pattern pathway has Nampt envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
NamptGOBP_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseSpinal cordCN78_C1 4.8e-06
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseSpinal cordCN93_D2 4.3e-06
NamptGOBP_Circadian_Regulation_Of_Gene_ExpressionMouseSpinal cordCN94_E1 4.9e-06
NamptGOBP_Circadian_RhythmMouseSpinal cordL7bCN02_E1 4.0e-06
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseSpinal cordL7bCN02_E1 8.8e-07
NamptGOBP_Positive_Regulation_Of_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseSpinal cordL7CN44_D1 6.8e-08
NamptGOBP_Cell_Cell_SignalingMouseSpinal cordL7CN45_C1 3.5e-08
NamptGOBP_Nucleobase_Containing_Small_Molecule_Metabolic_ProcessMouseSpinal cordL7CN45_C1 1.1e-07
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseSpinal cordL7CN45_C1 1.4e-07
NamptGOBP_Organonitrogen_Compound_Biosynthetic_ProcessMouseSpinal cordL7CN45_C1 5.6e-08
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseSpinal cordL7CN45_C1 1.7e-07
NamptGOBP_Organophosphate_Metabolic_ProcessMouseSpinal cordL7CN45_C1 2.0e-07
NamptGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseSpinal cordL7CN45_C1 1.4e-06
NamptGOBP_Rhythmic_ProcessMouseSpinal cordL7CN45_C1 1.9e-06
NamptGOBP_Small_Molecule_Metabolic_ProcessMouseSpinal cordL7CN45_C1 1.7e-07
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseSpinal cordL7CN85_E1 4.1e-08
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseSpinal cordL8CN14_E2 8.1e-17
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseBrainrep_11 2.9e-05
NamptGOBP_Circadian_Regulation_Of_Gene_ExpressionMouseBrainrep_72 3.3e-05
NamptGOBP_Cell_Cell_SignalingMouseBrainrep_1 5.1e-48
NamptGOBP_Circadian_Regulation_Of_Gene_ExpressionMouseBrainrep_1 3.1e-14
NamptGOBP_Circadian_RhythmMouseBrainrep_1 2.6e-25
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseBrainrep_1 3.5e-11
NamptGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseBrainrep_1 2.5e-12
NamptGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseBrainrep_1 1.6e-17
NamptGOBP_Rhythmic_ProcessMouseBrainrep_1 4.6e-47
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseBrainrep_3 1.0e-66
NamptGOBP_Organonitrogen_Compound_Biosynthetic_ProcessMouseBrainrep_32.9e-144
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseBrainrep_3 2.9e-25
NamptGOBP_Organophosphate_Metabolic_ProcessMouseBrainrep_3 8.1e-43
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseBrainrep_38.8e-172
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseBrainrep_3 9.3e-98
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseBrainrep_31.8e-150
NamptGOBP_Small_Molecule_Metabolic_ProcessMouseBrainrep_3 2.7e-19
NamptGOBP_Positive_Regulation_Of_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseEmbryorep_6 1.2e-09
NamptGOBP_Circadian_RhythmMouseEmbryorep_14 5.3e-08
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseEmbryorep_14 5.1e-14
NamptGOBP_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseEmbryorep_14 2.1e-41
NamptGOBP_Nucleobase_Containing_Small_Molecule_Metabolic_ProcessMouseEmbryorep_14 1.8e-12
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseEmbryorep_14 4.8e-21
NamptGOBP_Organonitrogen_Compound_Biosynthetic_ProcessMouseEmbryorep_14 2.4e-12
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseEmbryorep_14 1.8e-11
NamptGOBP_Organophosphate_Metabolic_ProcessMouseEmbryorep_14 2.0e-09
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseEmbryorep_14 3.6e-92
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseEmbryorep_14 7.5e-67
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseEmbryorep_1 7.1e-65
NamptGOBP_Small_Molecule_Metabolic_ProcessMouseEmbryorep_1 1.4e-55
NamptGOBP_Circadian_RhythmMouseEmbryorep_2 5.3e-10
NamptGOBP_Rhythmic_ProcessMouseEmbryorep_27.6e-139
NamptGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseEmbryorep_3 0.0e+00
NamptGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseEmbryorep_3 0.0e+00
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseKidneyNep 2.0e-14
NamptGOBP_Cell_Cell_SignalingMouseKidneyrep_2 6.2e-72
NamptGOBP_Circadian_Regulation_Of_Gene_ExpressionMouseKidneyrep_2 6.4e-21
NamptGOBP_Circadian_RhythmMouseKidneyrep_2 1.8e-75
NamptGOBP_Nucleobase_Containing_Small_Molecule_Metabolic_ProcessMouseKidneyrep_2 2.4e-27
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseKidneyrep_2 4.6e-07
NamptGOBP_Organonitrogen_Compound_Biosynthetic_ProcessMouseKidneyrep_2 8.9e-78
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseKidneyrep_2 1.2e-09
NamptGOBP_Organophosphate_Metabolic_ProcessMouseKidneyrep_2 1.7e-41
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseKidneyrep_2 3.8e-57
NamptGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseKidneyrep_2 4.5e-10
NamptGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseKidneyrep_2 8.3e-40
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseKidneyrep_2 1.2e-41
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseKidneyrep_2 1.6e-68
NamptGOBP_Rhythmic_ProcessMouseKidneyrep_2 4.7e-69
NamptGOBP_Small_Molecule_Metabolic_ProcessMouseKidneyrep_2 1.8e-43
NamptGOBP_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseLiverCN16-D2 3.4e-07
NamptGOBP_Positive_Regulation_Of_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseLiverCN16-E1 2.2e-07
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseLiverCN16-E1 3.4e-08
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseLiverCN16-E1 1.7e-10
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseLiverCN73-C1 2.5e-07
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseLiverCN73-C1 3.0e-11
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseLiverrep_15 3.6e-11
NamptGOBP_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseLiverrep_15 1.4e-13
NamptGOBP_Positive_Regulation_Of_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseLiverrep_15 1.2e-22
NamptGOBP_Circadian_Regulation_Of_Gene_ExpressionMouseLiverrep_16 7.9e-10
NamptGOBP_Circadian_RhythmMouseLiverrep_16 4.6e-09
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseLiverrep_16 1.6e-18
NamptGOBP_Cell_Cell_SignalingMouseLymphMS-1 9.7e-11
NamptGOBP_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseLymphMS-1 1.5e-14
NamptGOBP_Nucleobase_Containing_Small_Molecule_Metabolic_ProcessMouseLymphMS-1 2.7e-09
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseLymphMS-1 3.6e-07
NamptGOBP_Organonitrogen_Compound_Biosynthetic_ProcessMouseLymphMS-1 1.4e-09
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseLymphMS-1 6.7e-07
NamptGOBP_Organophosphate_Metabolic_ProcessMouseLymphMS-1 7.3e-07
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseLymphMS-1 2.3e-12
NamptGOBP_Positive_Regulation_Of_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseLymphMS-1 1.9e-11
NamptGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseLymphMS-1 4.4e-12
NamptGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseLymphMS-1 1.7e-12
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseLymphMS-1 7.2e-12
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseLymphMS-1 4.4e-12
NamptGOBP_Small_Molecule_Metabolic_ProcessMouseLymphMS-1 2.6e-11
NamptGOBP_Circadian_RhythmMouseBrainrep_4 2.1e-77
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseBrainrep_4 1.6e-09
NamptGOBP_Rhythmic_ProcessMouseBrainrep_4 3.3e-35
NamptGOBP_Positive_Regulation_Of_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseBrainHP_ad_rep3 3.7e-08
NamptGOBP_Cell_Cell_SignalingMouseBrainHP_ad_rep7 1.6e-08
NamptGOBP_Circadian_Regulation_Of_Gene_ExpressionMouseBrainHP_ad_rep7 1.2e-07
NamptGOBP_Circadian_RhythmMouseBrainHP_ad_rep7 4.9e-12
NamptGOBP_Nad_Biosynthesis_Via_Nicotinamide_Riboside_Salvage_PathwayMouseBrainHP_ad_rep7 2.1e-08
NamptGOBP_Nucleoside_Phosphate_Biosynthetic_ProcessMouseBrainHP_ad_rep7 2.4e-07
NamptGOBP_Organonitrogen_Compound_Biosynthetic_ProcessMouseBrainHP_ad_rep7 2.8e-08
NamptGOBP_Organophosphate_Biosynthetic_ProcessMouseBrainHP_ad_rep7 3.2e-11
NamptGOBP_Positive_Regulation_Of_Cell_Population_ProliferationMouseBrainHP_ad_rep7 1.9e-10
NamptGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseBrainHP_ad_rep7 2.8e-11
NamptGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseBrainHP_ad_rep7 7.3e-11
NamptGOBP_Rhythmic_ProcessMouseBrainHP_ad_rep7 4.3e-13
NamptGOBP_Nitric_Oxide_Synthase_Biosynthetic_ProcessMouseBrainHP_adpolb_rep1 1.7e-08
NamptGOBP_Pyridine_Containing_Compound_Biosynthetic_ProcessMouseBrainHP_adpolb_rep1 1.8e-07
NamptGOBP_Pyridine_Containing_Compound_Metabolic_ProcessMouseBrainHP_adpolb_rep1 1.9e-07
NamptGOBP_Nucleobase_Containing_Small_Molecule_Metabolic_ProcessMouseBrainHP_polb_rep9 6.9e-09
NamptGOBP_Organophosphate_Metabolic_ProcessMouseBrainHP_polb_rep9 7.1e-09
NamptGOBP_Small_Molecule_Metabolic_ProcessMouseBrainHP_polb_rep9 2.0e-09

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Nampt function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Nampt function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Nampt envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Nampt

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Nampt

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
NamptC0009319Colitis1CTD_human
NamptC0009402Colorectal Carcinoma1CTD_human;UNIPROT
NamptC0009404Colorectal Neoplasms1CTD_human
NamptC0026640Mouth Neoplasms1CTD_human
NamptC0028754Obesity1CTD_human
NamptC0153381Malignant neoplasm of mouth1CTD_human
NamptC0162820Dermatitis, Allergic Contact1CTD_human
NamptC1168401Squamous cell carcinoma of the head and neck1CTD_human