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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Hacl1 (spascer ID:56794)

Gene summary for Hacl1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Hacl1
	Gene ID	56794
	Gene name	2-hydroxyacyl-CoA lyase 1
	Synonyms	1600020H07Rik\|Hpcl\|Phyh2
	Cytomap	14\|14 B
	Type of gene	protein-coding
	Description	2-hydroxyacyl-CoA lyase 12-HPCL2-hydroxyphytanoyl-CoA lyasephytanoyl-CoA 2-hydroxylase 2
	Modification date	20220424
	UniProtAcc	Q9QXE0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Hacl1	GO:0001561	fatty acid alpha-oxidation	21873635	Process
Hacl1	GO:0005777	peroxisome	21873635	Component
Hacl1	GO:0030976	thiamine pyrophosphate binding	21873635	Function

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Spatial pattern events for Hacl1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Hacl1	Mouse	Brain	S4	34413515	1.37e-15
Hacl1	Mouse	Kidney	rep_1	34853151	2.42e-15
Hacl1	Mouse	Kidney	rep_2	34853151	1.12e-07
Hacl1	Mouse	Kidney	rep_3	34853151	2.94e-15
Hacl1	Mouse	Kidney	rep_4	34853151	8.15e-08
Hacl1	Mouse	Kidney	rep_5	34853151	3.18e-15
Hacl1	Mouse	Liver	rep_22	35021063	3.49e-08

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Liver_rep_22_H&E

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Spatial pattern pathway has Hacl1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Spinal cord	CN94_E1	6.5e-06
Hacl1	GOBP_Long_Chain_Fatty_Acid_Metabolic_Process	Mouse	Spinal cord	CN94_E1	3.4e-07
Hacl1	GOBP_Organic_Acid_Catabolic_Process	Mouse	Spinal cord	CN94_E1	3.5e-07
Hacl1	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	3.7e-06
Hacl1	GOBP_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	8.9e-07
Hacl1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Hacl1	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.0e-07
Hacl1	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Hacl1	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.4e-06
Hacl1	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.6e-10
Hacl1	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Hacl1	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Hacl1	GOBP_Lipid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Hacl1	GOBP_Lipid_Modification	Mouse	Spinal cord	L7CN45_C1	1.8e-06
Hacl1	GOBP_Lipid_Oxidation	Mouse	Spinal cord	L7CN45_C1	8.8e-07
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.2e-09
Hacl1	GOBP_Peroxisomal_Transport	Mouse	Spinal cord	L7CN45_C1	2.1e-10
Hacl1	GOBP_Protein_Localization_To_Organelle	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Hacl1	GOBP_Protein_Targeting	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.6e-07
Hacl1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Brain	rep_11	2.7e-06
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Brain	rep_17	2.8e-05
Hacl1	GOBP_Lipid_Modification	Mouse	Brain	rep_71	7.0e-06
Hacl1	GOBP_Lipid_Oxidation	Mouse	Brain	rep_71	3.6e-06
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_71	8.1e-05
Hacl1	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Hacl1	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Brain	rep_3	3.5e-106
Hacl1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Hacl1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	1.2e-180
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Brain	rep_3	1.2e-193
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Brain	rep_3	1.3e-180
Hacl1	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-41
Hacl1	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Hacl1	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Hacl1	GOBP_Lipid_Catabolic_Process	Mouse	Brain	rep_3	1.4e-121
Hacl1	GOBP_Lipid_Modification	Mouse	Brain	rep_3	4.5e-101
Hacl1	GOBP_Lipid_Oxidation	Mouse	Brain	rep_3	1.2e-128
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Brain	rep_3	2.0e-175
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_3	3.2e-119
Hacl1	GOBP_Organic_Acid_Catabolic_Process	Mouse	Brain	rep_3	9.6e-181
Hacl1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Hacl1	GOBP_Peroxisomal_Transport	Mouse	Brain	rep_3	8.3e-139
Hacl1	GOBP_Peroxisome_Organization	Mouse	Brain	rep_3	1.3e-123
Hacl1	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	6.3e-172
Hacl1	GOBP_Protein_Targeting	Mouse	Brain	rep_3	2.9e-187
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Brain	rep_3	9.8e-142
Hacl1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Hacl1	GOBP_Long_Chain_Fatty_Acid_Metabolic_Process	Mouse	Brain	rep_4	1.8e-33
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Embryo	rep_6	1.4e-07
Hacl1	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Embryo	rep_14	6.6e-12
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Embryo	rep_14	1.8e-09
Hacl1	GOBP_Lipid_Modification	Mouse	Embryo	rep_14	3.4e-09
Hacl1	GOBP_Lipid_Oxidation	Mouse	Embryo	rep_14	9.5e-24
Hacl1	GOBP_Long_Chain_Fatty_Acid_Metabolic_Process	Mouse	Embryo	rep_14	1.8e-16
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Embryo	rep_14	7.1e-14
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_14	7.3e-13
Hacl1	GOBP_Organic_Acid_Catabolic_Process	Mouse	Embryo	rep_14	2.3e-13
Hacl1	GOBP_Peroxisomal_Transport	Mouse	Embryo	rep_14	4.0e-31
Hacl1	GOBP_Peroxisome_Organization	Mouse	Embryo	rep_14	3.3e-21
Hacl1	GOBP_Protein_Targeting	Mouse	Embryo	rep_14	6.3e-09
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Embryo	rep_14	7.6e-14
Hacl1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Embryo	rep_1	8.6e-17
Hacl1	GOBP_Lipid_Metabolic_Process	Mouse	Embryo	rep_1	2.1e-39
Hacl1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Hacl1	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Hacl1	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Embryo	rep_3	2.1e-07
Hacl1	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.7e-52
Hacl1	GOBP_Lipid_Catabolic_Process	Mouse	Embryo	rep_3	2.1e-07
Hacl1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Embryo	rep_3	2.9e-170
Hacl1	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_4	0.0e+00
Hacl1	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Hacl1	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Kidney	rep_2	2.5e-44
Hacl1	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	7.4e-43
Hacl1	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Hacl1	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Hacl1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.3e-19
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Kidney	rep_2	2.4e-19
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Kidney	rep_2	7.7e-56
Hacl1	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Kidney	rep_2	2.1e-55
Hacl1	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Hacl1	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Hacl1	GOBP_Lipid_Catabolic_Process	Mouse	Kidney	rep_2	1.4e-56
Hacl1	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-78
Hacl1	GOBP_Lipid_Modification	Mouse	Kidney	rep_2	1.7e-37
Hacl1	GOBP_Lipid_Oxidation	Mouse	Kidney	rep_2	2.1e-13
Hacl1	GOBP_Long_Chain_Fatty_Acid_Metabolic_Process	Mouse	Kidney	rep_2	1.3e-40
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Kidney	rep_2	2.6e-58
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	4.4e-73
Hacl1	GOBP_Organic_Acid_Catabolic_Process	Mouse	Kidney	rep_2	1.3e-83
Hacl1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Hacl1	GOBP_Peroxisomal_Transport	Mouse	Kidney	rep_2	9.4e-74
Hacl1	GOBP_Peroxisome_Organization	Mouse	Kidney	rep_2	1.7e-39
Hacl1	GOBP_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.4e-44
Hacl1	GOBP_Protein_Targeting	Mouse	Kidney	rep_2	1.7e-40
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Kidney	rep_2	4.4e-89
Hacl1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Liver	CN16-D2	1.0e-07
Hacl1	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Liver	CN73-C1	9.9e-09
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Intestine	rep_2	8.9e-20
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Intestine	rep_2	3.7e-18
Hacl1	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Intestine	rep_2	3.9e-25
Hacl1	GOBP_Long_Chain_Fatty_Acid_Metabolic_Process	Mouse	Intestine	rep_2	9.9e-71
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Intestine	rep_2	1.5e-14
Hacl1	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Lymph	MS-1	3.4e-07
Hacl1	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	1.1e-14
Hacl1	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Hacl1	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Hacl1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	3.3e-11
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Lymph	MS-1	6.3e-09
Hacl1	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Lymph	MS-1	8.4e-16
Hacl1	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Hacl1	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Hacl1	GOBP_Lipid_Catabolic_Process	Mouse	Lymph	MS-1	2.6e-07
Hacl1	GOBP_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	9.7e-11
Hacl1	GOBP_Lipid_Modification	Mouse	Lymph	MS-1	6.5e-09
Hacl1	GOBP_Lipid_Oxidation	Mouse	Lymph	MS-1	3.2e-11
Hacl1	GOBP_Long_Chain_Fatty_Acid_Metabolic_Process	Mouse	Lymph	MS-1	2.1e-10
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Lymph	MS-1	4.8e-07
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Hacl1	GOBP_Organic_Acid_Catabolic_Process	Mouse	Lymph	MS-1	4.1e-10
Hacl1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Hacl1	GOBP_Peroxisomal_Transport	Mouse	Lymph	MS-1	3.4e-10
Hacl1	GOBP_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	1.4e-09
Hacl1	GOBP_Protein_Targeting	Mouse	Lymph	MS-1	2.1e-09
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Lymph	MS-1	5.1e-07
Hacl1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Hacl1	GOBP_Fatty_Acid_Alpha_Oxidation	Mouse	Brain	HP_ad_rep3	3.6e-10
Hacl1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Hacl1	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Hacl1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	6.1e-09
Hacl1	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep7	4.7e-07
Hacl1	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Hacl1	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Hacl1	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.1e-10
Hacl1	GOBP_Organic_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep7	2.2e-13
Hacl1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Hacl1	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	4.8e-12
Hacl1	GOBP_Small_Molecule_Catabolic_Process	Mouse	Brain	HP_ad_rep7	2.3e-11
Hacl1	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.9e-07
Hacl1	GOBP_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-11
Hacl1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-11
Hacl1	GOBP_Peroxisomal_Transport	Mouse	Brain	HP_polb_rep9	6.5e-20
Hacl1	GOBP_Peroxisome_Organization	Mouse	Brain	HP_polb_rep9	8.3e-16
Hacl1	GOBP_Protein_Targeting	Mouse	Brain	HP_polb_rep9	1.8e-11
Hacl1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09

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Hacl1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Hacl1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Hacl1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Hacl1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Hacl1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Hacl1	C0008370	Cholestasis	1	CTD_human
Hacl1	C0019193	Hepatitis, Toxic	1	CTD_human
Hacl1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hacl1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hacl1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hacl1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hacl1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human