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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Ube2l6 (spascer ID:56791)

Gene summary for Ube2l6

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Ube2l6

Gene ID

56791

Gene nameubiquitin-conjugating enzyme E2L 6
Synonyms2810489I21Rik|RIG-B|UBCH8|Ubce8|Ubcm8
Cytomap2|2 D
Type of geneprotein-coding
Descriptionubiquitin/ISG15-conjugating enzyme E2 L6E2 ubiquitin conjugating enzymeE2 ubiquitin-conjugating enzyme L6ubiquitin carrier protein L6ubiquitin-conjugating enzyme 8ubiquitin-protein ligase L6
Modification date20220424
UniProtAcc

Q9QZU9


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Ube2l6

GO:0000151

ubiquitin ligase complex

21873635

Component
Ube2l6

GO:0000209

protein polyubiquitination

21873635

Process
Ube2l6

GO:0005634

nucleus

21873635

Component
Ube2l6

GO:0006511

ubiquitin-dependent protein catabolic process

21873635

Process
Ube2l6

GO:0031625

ubiquitin protein ligase binding

21873635

Function
Ube2l6

GO:0032020

ISG15-protein conjugation

21873635

Process
Ube2l6

GO:0042296

ISG15 transferase activity

21873635

Function
Ube2l6

GO:0061631

ubiquitin conjugating enzyme activity

21873635

Function

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Spatial pattern events for Ube2l6

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Ube2l6MouseBrainS6 344135157.87e-11
Ube2l6MouseBrainrep_4 351413742.84e-15
Ube2l6MouseKidneyCLP 340037973.77e-15
Ube2l6MouseKidneyIRI 340037972.29e-15
Ube2l6MouseKidneySham 340037974.42e-07
Ube2l6MouseKidneyrep_1 348531517.83e-15
Ube2l6MouseBrainrep_1 334690258.69e-12
Ube2l6MouseBrainrep_1 350277291.91e-08
Ube2l6MouseLymphMS-2 04.06e-13
Ube2l6MouseLymphA1 03.29e-15
Ube2l6MouseLymphB1 03.66e-15
Ube2l6MouseLungrep_1 352908015.44e-12
Ube2l6MouseLungrep_2 352908011.42e-14
Ube2l6MouseLungrep_3 352908011.52e-14

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_4_H&E
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Kidney_CLP_H&E
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Kidney_IRI_H&E
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Kidney_Sham_H&E
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Kidney_rep_1_H&E
boxplot
boxplot
Brain_rep_1_H&E
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Brain_rep_1_H&E
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Lung_rep_1_H&E
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Lung_rep_2_H&E
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Lung_rep_3_H&E
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Spatial pattern pathway has Ube2l6 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Ube2l6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseSpinal cordCN94_E1 8.0e-06
Ube2l6GOBP_Dna_Metabolic_ProcessMouseSpinal cordCN94_E1 2.7e-06
Ube2l6GOBP_Protein_PolyubiquitinationMouseSpinal cordL7bCN02_E1 2.8e-06
Ube2l6GOBP_Dna_RepairMouseSpinal cordL7CN45_C1 9.4e-06
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseSpinal cordL7CN45_C1 1.3e-08
Ube2l6GOBP_Isg15_Protein_ConjugationMouseSpinal cordL7CN45_C1 6.0e-07
Ube2l6GOBP_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 7.5e-06
Ube2l6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 2.7e-07
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseSpinal cordL7CN45_C1 5.6e-06
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseSpinal cordL7CN45_C1 1.1e-06
Ube2l6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.1e-08
Ube2l6GOBP_Postreplication_RepairMouseSpinal cordL7CN45_C1 6.1e-08
Ube2l6GOBP_Protein_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.6e-06
Ube2l6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseSpinal cordL7CN45_C1 2.2e-07
Ube2l6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseSpinal cordL7CN45_C1 1.4e-06
Ube2l6GOBP_ProteolysisMouseSpinal cordL7CN45_C1 1.1e-06
Ube2l6GOBP_Translesion_SynthesisMouseSpinal cordL7CN45_C1 3.0e-07
Ube2l6GOBP_Cytokine_ProductionMouseSpinal cordL7CN80_D2 4.5e-06
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseSpinal cordL8CN17_E1 2.6e-06
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseBrainrep_27 4.7e-05
Ube2l6GOBP_Postreplication_RepairMouseBrainrep_41 2.1e-05
Ube2l6GOBP_Translesion_SynthesisMouseBrainrep_75 5.3e-06
Ube2l6GOBP_Dna_Metabolic_ProcessMouseBrainrep_1 1.1e-07
Ube2l6GOBP_Isg15_Protein_ConjugationMouseBrainrep_1 1.8e-90
Ube2l6GOBP_Negative_Regulation_Of_Cytokine_ProductionMouseBrainrep_1 1.0e-12
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseBrainrep_1 2.8e-46
Ube2l6GOBP_Postreplication_RepairMouseBrainrep_1 2.5e-11
Ube2l6GOBP_Protein_PolyubiquitinationMouseBrainrep_1 2.1e-07
Ube2l6GOBP_Translesion_SynthesisMouseBrainrep_1 4.4e-10
Ube2l6GOBP_Type_I_Interferon_ProductionMouseBrainrep_1 1.5e-07
Ube2l6GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainrep_32.9e-162
Ube2l6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainrep_35.0e-192
Ube2l6GOBP_Cytokine_ProductionMouseBrainrep_3 6.3e-65
Ube2l6GOBP_Dna_Biosynthetic_ProcessMouseBrainrep_31.9e-141
Ube2l6GOBP_Dna_RepairMouseBrainrep_34.0e-216
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseBrainrep_31.1e-210
Ube2l6GOBP_Macromolecule_Catabolic_ProcessMouseBrainrep_31.7e-159
Ube2l6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainrep_38.7e-167
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseBrainrep_31.1e-139
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseBrainrep_32.0e-111
Ube2l6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainrep_37.1e-166
Ube2l6GOBP_Protein_Catabolic_ProcessMouseBrainrep_33.0e-174
Ube2l6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainrep_31.4e-184
Ube2l6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainrep_36.3e-190
Ube2l6GOBP_ProteolysisMouseBrainrep_31.8e-168
Ube2l6GOBP_Isg15_Protein_ConjugationMouseEmbryorep_6 7.4e-08
Ube2l6GOBP_Cytokine_ProductionMouseEmbryorep_14 1.9e-09
Ube2l6GOBP_Dna_Biosynthetic_ProcessMouseEmbryorep_14 9.7e-10
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseEmbryorep_14 3.9e-52
Ube2l6GOBP_Negative_Regulation_Of_Cytokine_ProductionMouseEmbryorep_14 2.4e-09
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseEmbryorep_14 2.3e-34
Ube2l6GOBP_Postreplication_RepairMouseEmbryorep_14 1.6e-64
Ube2l6GOBP_Translesion_SynthesisMouseEmbryorep_14 4.8e-58
Ube2l6GOBP_Type_I_Interferon_ProductionMouseEmbryorep_14 3.8e-21
Ube2l6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseEmbryorep_1 7.5e-10
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseEmbryorep_1 9.4e-07
Ube2l6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseEmbryorep_1 5.7e-21
Ube2l6GOBP_Protein_Catabolic_ProcessMouseEmbryorep_1 4.1e-19
Ube2l6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseEmbryorep_1 4.4e-16
Ube2l6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseEmbryorep_2 1.4e-08
Ube2l6GOBP_Dna_Metabolic_ProcessMouseEmbryorep_27.2e-216
Ube2l6GOBP_Dna_RepairMouseEmbryorep_21.6e-282
Ube2l6GOBP_Negative_Regulation_Of_Cytokine_ProductionMouseEmbryorep_2 1.0e-20
Ube2l6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseEmbryorep_3 4.2e-21
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseEmbryorep_5 1.8e-10
Ube2l6GOBP_Protein_PolyubiquitinationMouseEmbryorep_6 1.0e-23
Ube2l6GOBP_Cytokine_ProductionMouseKidneyNep 1.3e-32
Ube2l6GOBP_ProteolysisMouseKidneyNep 6.8e-23
Ube2l6GOBP_Cellular_Protein_Catabolic_ProcessMouseKidneyrep_2 3.2e-21
Ube2l6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseKidneyrep_25.5e-146
Ube2l6GOBP_Dna_Metabolic_ProcessMouseKidneyrep_2 1.4e-12
Ube2l6GOBP_Dna_RepairMouseKidneyrep_2 5.5e-70
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseKidneyrep_2 1.7e-57
Ube2l6GOBP_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 7.0e-40
Ube2l6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 1.0e-26
Ube2l6GOBP_Negative_Regulation_Of_Cytokine_ProductionMouseKidneyrep_2 2.0e-18
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseKidneyrep_2 1.0e-19
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseKidneyrep_22.6e-120
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseKidneyrep_2 6.3e-42
Ube2l6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseKidneyrep_2 1.2e-14
Ube2l6GOBP_Postreplication_RepairMouseKidneyrep_2 5.7e-42
Ube2l6GOBP_Protein_Catabolic_ProcessMouseKidneyrep_2 7.3e-30
Ube2l6GOBP_Protein_PolyubiquitinationMouseKidneyrep_2 4.9e-79
Ube2l6GOBP_ProteolysisMouseKidneyrep_26.0e-106
Ube2l6GOBP_Translesion_SynthesisMouseKidneyrep_2 1.0e-86
Ube2l6GOBP_Isg15_Protein_ConjugationMouseKidneyrep_4 5.8e-04
Ube2l6GOBP_Dna_Metabolic_ProcessMouseLiverCN16-D2 2.6e-07
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseLiverCN16-D2 7.4e-07
Ube2l6GOBP_Postreplication_RepairMouseLiverCN16-D2 1.3e-08
Ube2l6GOBP_Translesion_SynthesisMouseLiverCN16-D2 3.9e-07
Ube2l6GOBP_Type_I_Interferon_ProductionMouseLiverCN65-C1 5.0e-08
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseLiverrep_16 2.3e-17
Ube2l6GOBP_Type_I_Interferon_ProductionMouseLiverrep_16 2.9e-18
Ube2l6GOBP_Cellular_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Ube2l6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseLymphMS-1 8.5e-13
Ube2l6GOBP_Cytokine_ProductionMouseLymphMS-1 1.1e-16
Ube2l6GOBP_Dna_Metabolic_ProcessMouseLymphMS-1 6.8e-10
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseLymphMS-1 3.0e-08
Ube2l6GOBP_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Ube2l6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Ube2l6GOBP_Negative_Regulation_Of_Cytokine_ProductionMouseLymphMS-1 3.2e-16
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseLymphMS-1 6.3e-11
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseLymphMS-1 6.6e-16
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseLymphMS-1 1.4e-13
Ube2l6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Ube2l6GOBP_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Ube2l6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseLymphMS-1 1.4e-09
Ube2l6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseLymphMS-1 1.4e-09
Ube2l6GOBP_Protein_PolyubiquitinationMouseLymphMS-1 3.6e-11
Ube2l6GOBP_ProteolysisMouseLymphMS-1 2.8e-10
Ube2l6GOBP_Type_I_Interferon_ProductionMouseLymphMS-1 2.0e-08
Ube2l6GOBP_Cytokine_ProductionMouseLungrep_1 1.7e-08
Ube2l6GOBP_Macromolecule_Catabolic_ProcessMouseLungrep_1 2.0e-21
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseLungrep_1 4.5e-23
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseLungrep_1 1.3e-17
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseBrainrep_4 9.8e-73
Ube2l6GOBP_Protein_PolyubiquitinationMouseBrainrep_4 1.0e-15
Ube2l6GOBP_Type_I_Interferon_ProductionMouseBrainrep_4 6.8e-13
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseBrainrep_7 6.2e-60
Ube2l6GOBP_Postreplication_RepairMouseBrainrep_7 9.9e-16
Ube2l6GOBP_Translesion_SynthesisMouseBrainrep_7 1.5e-13
Ube2l6GOBP_Isg15_Protein_ConjugationMouseBrainHP_ad_rep3 3.6e-23
Ube2l6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainHP_ad_rep7 6.8e-10
Ube2l6GOBP_Dna_Biosynthetic_ProcessMouseBrainHP_ad_rep7 1.2e-12
Ube2l6GOBP_Dna_Metabolic_ProcessMouseBrainHP_ad_rep7 3.1e-11
Ube2l6GOBP_Dna_RepairMouseBrainHP_ad_rep7 2.4e-12
Ube2l6GOBP_Dna_Synthesis_Involved_In_Dna_RepairMouseBrainHP_ad_rep7 3.2e-11
Ube2l6GOBP_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-09
Ube2l6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-08
Ube2l6GOBP_Negative_Regulation_Of_Gene_ExpressionMouseBrainHP_ad_rep7 2.1e-08
Ube2l6GOBP_Negative_Regulation_Of_Type_I_Interferon_ProductionMouseBrainHP_ad_rep7 2.2e-15
Ube2l6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Ube2l6GOBP_Postreplication_RepairMouseBrainHP_ad_rep7 1.1e-15
Ube2l6GOBP_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Ube2l6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainHP_ad_rep7 1.7e-09
Ube2l6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainHP_ad_rep7 6.9e-09
Ube2l6GOBP_Protein_PolyubiquitinationMouseBrainHP_ad_rep7 1.4e-10
Ube2l6GOBP_ProteolysisMouseBrainHP_ad_rep7 3.3e-07
Ube2l6GOBP_Translesion_SynthesisMouseBrainHP_ad_rep7 1.1e-10
Ube2l6GOBP_Type_I_Interferon_ProductionMouseBrainHP_ad_rep7 1.1e-07
Ube2l6GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 7.2e-07
Ube2l6GOBP_Cytokine_ProductionMouseBrainHP_polb_rep9 1.6e-09
Ube2l6GOBP_Negative_Regulation_Of_Multicellular_Organismal_ProcessMouseBrainHP_polb_rep9 1.8e-08

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Ube2l6 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Ube2l6 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Ube2l6 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Ube2l6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Ube2l6

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Ube2l6C0021400Influenza1CTD_human