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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Irf6 (spascer ID:54139)

Gene summary for Irf6

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Irf6
	Gene ID	54139
	Gene name	interferon regulatory factor 6
	Synonyms	AI876454\|E230028I05Rik\|mirf6
	Cytomap	1 H6\|1 97.6 cM
	Type of gene	protein-coding
	Description	interferon regulatory factor 6IRF-6
	Modification date	20220424
	UniProtAcc	P97431

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Irf6	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	21873635	Function
Irf6	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Irf6	GO:0002376	immune system process	21873635	Process
Irf6	GO:0005634	nucleus	21873635	Component
Irf6	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process

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Spatial pattern events for Irf6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Irf6	Mouse	Kidney	Sham	34003797	4.98e-09
Irf6	Mouse	Intestine	rep_2	35149721	3.44e-15
Irf6	Mouse	Testicle	rep_5	34731600	1.63e-15
Irf6	Mouse	Lung	rep_1	35290801	4.13e-12
Irf6	Mouse	Lung	rep_4	35290801	2.37e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_Sham_H&E
Lung_rep_1_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Irf6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Irf6	GOBP_Cell_Cycle	Mouse	Spinal cord	CN94_E1	1.1e-06
Irf6	GOBP_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	3.8e-06
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	2.5e-06
Irf6	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	3.0e-06
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.9e-07
Irf6	GOBP_Epidermis_Development	Mouse	Spinal cord	CN94_E1	8.2e-07
Irf6	GOBP_Epithelial_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.3e-07
Irf6	GOBP_Mammary_Gland_Development	Mouse	Spinal cord	CN94_E1	6.6e-06
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	1.4e-06
Irf6	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	CN94_E1	3.2e-06
Irf6	GOBP_Skin_Development	Mouse	Spinal cord	CN94_E1	1.6e-06
Irf6	GOBP_Mammary_Gland_Epithelium_Development	Mouse	Spinal cord	L7bCN01_D2	4.0e-06
Irf6	GOBP_Response_To_Type_I_Interferon	Mouse	Spinal cord	L7CN44_C1	6.9e-06
Irf6	GOBP_Appendage_Development	Mouse	Spinal cord	L7CN45_C1	2.2e-06
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Irf6	GOBP_Epithelium_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Spinal cord	L7CN45_C1	1.5e-06
Irf6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Spinal cord	L7CN45_C1	1.3e-08
Irf6	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Irf6	GOBP_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	3.0e-07
Irf6	GOBP_Response_To_Cytokine	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Spinal cord	L7CN45_C1	5.4e-06
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Spinal cord	L7CN97_E2	7.9e-07
Irf6	GOBP_Innate_Immune_Response	Mouse	Spinal cord	L7CN97_E2	2.7e-06
Irf6	GOBP_Defense_Response	Mouse	Spinal cord	L8CN11_C1	3.3e-17
Irf6	GOBP_Cell_Cycle	Mouse	Brain	rep_27	8.4e-07
Irf6	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_27	1.7e-08
Irf6	GOBP_Mammary_Gland_Development	Mouse	Brain	rep_41	1.2e-08
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Brain	rep_41	6.5e-05
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Brain	rep_72	3.4e-06
Irf6	GOBP_Cell_Cycle	Mouse	Brain	rep_1	7.0e-10
Irf6	GOBP_Cell_Cycle_Process	Mouse	Brain	rep_1	6.7e-14
Irf6	GOBP_Gland_Development	Mouse	Brain	rep_1	4.1e-23
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Brain	rep_1	7.8e-11
Irf6	GOBP_Mammary_Gland_Development	Mouse	Brain	rep_1	1.1e-43
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Brain	rep_1	7.2e-11
Irf6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Irf6	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
Irf6	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_1	3.9e-14
Irf6	GOBP_Response_To_Interferon_Gamma	Mouse	Brain	rep_1	1.9e-14
Irf6	GOBP_Appendage_Development	Mouse	Brain	rep_3	9.3e-152
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Brain	rep_3	7.3e-113
Irf6	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Brain	rep_3	4.9e-10
Irf6	GOBP_Defense_Response	Mouse	Brain	rep_3	8.7e-77
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	rep_3	6.0e-105
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Brain	rep_3	9.0e-134
Irf6	GOBP_Epidermis_Development	Mouse	Brain	rep_3	3.2e-173
Irf6	GOBP_Epithelial_Cell_Differentiation	Mouse	Brain	rep_3	4.7e-108
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Brain	rep_3	1.4e-179
Irf6	GOBP_Epithelium_Development	Mouse	Brain	rep_3	8.3e-102
Irf6	GOBP_Innate_Immune_Response	Mouse	Brain	rep_3	7.5e-97
Irf6	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Brain	rep_3	1.7e-145
Irf6	GOBP_Keratinocyte_Proliferation	Mouse	Brain	rep_3	1.1e-33
Irf6	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_3	1.9e-186
Irf6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Brain	rep_3	1.6e-104
Irf6	GOBP_Response_To_Cytokine	Mouse	Brain	rep_3	1.2e-08
Irf6	GOBP_Response_To_Type_I_Interferon	Mouse	Brain	rep_3	3.1e-105
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Brain	rep_3	1.3e-148
Irf6	GOBP_Skin_Development	Mouse	Brain	rep_3	5.0e-187
Irf6	GOBP_Appendage_Development	Mouse	Embryo	rep_4	2.9e-07
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Embryo	rep_4	2.7e-14
Irf6	GOBP_Keratinocyte_Proliferation	Mouse	Embryo	rep_13	3.8e-08
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Embryo	rep_14	5.2e-63
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Embryo	rep_14	2.9e-08
Irf6	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Embryo	rep_14	2.5e-13
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Embryo	rep_14	1.4e-08
Irf6	GOBP_Mammary_Gland_Development	Mouse	Embryo	rep_14	1.4e-14
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Embryo	rep_14	3.5e-37
Irf6	GOBP_Mammary_Gland_Epithelium_Development	Mouse	Embryo	rep_14	2.4e-21
Irf6	GOBP_Response_To_Type_I_Interferon	Mouse	Embryo	rep_14	6.7e-26
Irf6	GOBP_Defense_Response	Mouse	Embryo	rep_1	5.2e-63
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Embryo	rep_1	0.0e+00
Irf6	GOBP_Epithelium_Development	Mouse	Embryo	rep_1	1.7e-09
Irf6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Embryo	rep_1	3.5e-170
Irf6	GOBP_Response_To_Cytokine	Mouse	Embryo	rep_1	8.2e-211
Irf6	GOBP_Appendage_Development	Mouse	Embryo	rep_2	7.3e-30
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Embryo	rep_2	3.6e-126
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Embryo	rep_2	3.7e-74
Irf6	GOBP_Response_To_Type_I_Interferon	Mouse	Embryo	rep_2	1.3e-21
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Embryo	rep_3	0.0e+00
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Embryo	rep_3	2.6e-164
Irf6	GOBP_Innate_Immune_Response	Mouse	Embryo	rep_3	2.0e-259
Irf6	GOBP_Keratinocyte_Proliferation	Mouse	Embryo	rep_3	0.0e+00
Irf6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Irf6	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Irf6	GOBP_Response_To_Interferon_Gamma	Mouse	Embryo	rep_3	2.5e-25
Irf6	GOBP_Appendage_Development	Mouse	Kidney	rep_2	7.9e-84
Irf6	GOBP_Cell_Cycle	Mouse	Kidney	rep_2	1.0e-24
Irf6	GOBP_Cell_Cycle_Process	Mouse	Kidney	rep_2	3.0e-21
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Kidney	rep_2	2.5e-28
Irf6	GOBP_Defense_Response	Mouse	Kidney	rep_2	6.8e-127
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Kidney	rep_2	2.3e-129
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Kidney	rep_2	8.0e-54
Irf6	GOBP_Epidermis_Development	Mouse	Kidney	rep_2	3.0e-27
Irf6	GOBP_Epithelial_Cell_Differentiation	Mouse	Kidney	rep_2	4.2e-114
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Kidney	rep_2	1.8e-43
Irf6	GOBP_Epithelium_Development	Mouse	Kidney	rep_2	3.5e-92
Irf6	GOBP_Innate_Immune_Response	Mouse	Kidney	rep_2	3.1e-117
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Kidney	rep_2	1.4e-48
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Kidney	rep_2	1.4e-33
Irf6	GOBP_Mammary_Gland_Epithelium_Development	Mouse	Kidney	rep_2	1.6e-94
Irf6	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Kidney	rep_2	2.8e-71
Irf6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Irf6	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
Irf6	GOBP_Response_To_Cytokine	Mouse	Kidney	rep_2	3.1e-14
Irf6	GOBP_Response_To_Interferon_Gamma	Mouse	Kidney	rep_2	1.3e-61
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Kidney	rep_2	5.0e-42
Irf6	GOBP_Skin_Development	Mouse	Kidney	rep_2	3.4e-46
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Liver	CN16-D2	1.9e-08
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Liver	CN16-D2	7.3e-10
Irf6	GOBP_Epidermis_Development	Mouse	Liver	CN16-D2	1.2e-09
Irf6	GOBP_Skin_Development	Mouse	Liver	CN16-D2	5.4e-07
Irf6	GOBP_Appendage_Development	Mouse	Liver	CN16-E1	2.0e-11
Irf6	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Liver	CN16-E1	7.3e-11
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Liver	CN73-C1	1.7e-07
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Liver	CN73-C1	2.4e-07
Irf6	GOBP_Appendage_Development	Mouse	Liver	rep_15	1.7e-18
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Liver	rep_15	1.4e-09
Irf6	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Liver	rep_15	3.7e-07
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Liver	rep_15	1.1e-15
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Liver	rep_15	1.0e-26
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Liver	rep_15	1.1e-07
Irf6	GOBP_Defense_Response	Mouse	Liver	rep_16	8.0e-16
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Liver	rep_16	1.8e-13
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Liver	rep_16	4.2e-10
Irf6	GOBP_Innate_Immune_Response	Mouse	Liver	rep_16	5.5e-09
Irf6	GOBP_Mammary_Gland_Development	Mouse	Liver	rep_16	1.2e-12
Irf6	GOBP_Response_To_Cytokine	Mouse	Liver	rep_16	1.4e-13
Irf6	GOBP_Response_To_Interferon_Gamma	Mouse	Liver	rep_16	3.2e-16
Irf6	GOBP_Skin_Development	Mouse	Liver	rep_16	1.5e-13
Irf6	GOBP_Appendage_Development	Mouse	Lymph	MS-1	2.7e-13
Irf6	GOBP_Cell_Cycle	Mouse	Lymph	MS-1	1.3e-07
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Lymph	MS-1	2.4e-13
Irf6	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Lymph	MS-1	6.7e-17
Irf6	GOBP_Defense_Response	Mouse	Lymph	MS-1	8.6e-18
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Lymph	MS-1	6.7e-20
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Lymph	MS-1	3.3e-13
Irf6	GOBP_Epidermis_Development	Mouse	Lymph	MS-1	4.0e-14
Irf6	GOBP_Epithelial_Cell_Differentiation	Mouse	Lymph	MS-1	1.2e-07
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Lymph	MS-1	1.0e-07
Irf6	GOBP_Epithelium_Development	Mouse	Lymph	MS-1	8.5e-09
Irf6	GOBP_Gland_Development	Mouse	Lymph	MS-1	1.7e-10
Irf6	GOBP_Innate_Immune_Response	Mouse	Lymph	MS-1	6.7e-20
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Lymph	MS-1	9.7e-12
Irf6	GOBP_Keratinocyte_Proliferation	Mouse	Lymph	MS-1	1.1e-08
Irf6	GOBP_Mammary_Gland_Development	Mouse	Lymph	MS-1	1.3e-12
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Lymph	MS-1	4.5e-07
Irf6	GOBP_Mammary_Gland_Epithelium_Development	Mouse	Lymph	MS-1	9.8e-14
Irf6	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	9.2e-07
Irf6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Lymph	MS-1	5.6e-14
Irf6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Irf6	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
Irf6	GOBP_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	6.4e-09
Irf6	GOBP_Response_To_Cytokine	Mouse	Lymph	MS-1	5.7e-15
Irf6	GOBP_Response_To_Interferon_Gamma	Mouse	Lymph	MS-1	1.3e-12
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Lymph	MS-1	6.4e-09
Irf6	GOBP_Skin_Development	Mouse	Lymph	MS-1	8.0e-14
Irf6	GOBP_Response_To_Cytokine	Mouse	Lung	rep_1	1.2e-17
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Lung	rep_1	2.2e-11
Irf6	GOBP_Mammary_Gland_Epithelial_Cell_Differentiation	Mouse	Brain	HP_ad_rep2	5.1e-08
Irf6	GOBP_Appendage_Development	Mouse	Brain	HP_ad_rep7	5.7e-10
Irf6	GOBP_Cell_Cycle	Mouse	Brain	HP_ad_rep7	6.6e-08
Irf6	GOBP_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Irf6	GOBP_Cranial_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	4.7e-11
Irf6	GOBP_Defense_Response	Mouse	Brain	HP_ad_rep7	5.6e-10
Irf6	GOBP_Epidermal_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	2.9e-12
Irf6	GOBP_Epithelial_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	1.7e-13
Irf6	GOBP_Epithelial_Cell_Proliferation	Mouse	Brain	HP_ad_rep7	8.1e-09
Irf6	GOBP_Epithelium_Development	Mouse	Brain	HP_ad_rep7	2.8e-08
Irf6	GOBP_Gland_Development	Mouse	Brain	HP_ad_rep7	3.2e-13
Irf6	GOBP_Keratinocyte_Differentiation	Mouse	Brain	HP_ad_rep7	2.3e-08
Irf6	GOBP_Mammary_Gland_Development	Mouse	Brain	HP_ad_rep7	7.5e-10
Irf6	GOBP_Mammary_Gland_Epithelium_Development	Mouse	Brain	HP_ad_rep7	1.7e-08
Irf6	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	9.2e-08
Irf6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Irf6	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
Irf6	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	1.6e-08
Irf6	GOBP_Response_To_Cytokine	Mouse	Brain	HP_ad_rep7	2.1e-08
Irf6	GOBP_Response_To_Interferon_Gamma	Mouse	Brain	HP_ad_rep7	2.2e-09
Irf6	GOBP_Roof_Of_Mouth_Development	Mouse	Brain	HP_ad_rep7	1.4e-08
Irf6	GOBP_Skin_Development	Mouse	Brain	HP_ad_rep7	5.7e-08
Irf6	GOBP_Keratinocyte_Proliferation	Mouse	Brain	HP_adpolb_rep1	4.1e-08
Irf6	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	5.5e-07
Irf6	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	HP_polb_rep9	2.1e-11
Irf6	GOBP_Epidermis_Development	Mouse	Brain	HP_polb_rep9	5.3e-12
Irf6	GOBP_Innate_Immune_Response	Mouse	Brain	HP_polb_rep9	3.9e-11
Irf6	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.9e-14
Irf6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Brain	HP_polb_rep9	2.8e-10
Irf6	GOBP_Response_To_Type_I_Interferon	Mouse	Brain	HP_polb_rep9	5.2e-13

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Irf6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Irf6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Irf6 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
IRF6	Uterus	early	Glandular	SLC12A7,KIAA1522,GLUD1, etc.	0.292
IRF6	Uterus	early	SOX9_LGR5	SLC12A7,KIAA1522,GLUD1, etc.	0.402
IRF6	Uterus	early	SOX9	SLC12A7,KIAA1522,GLUD1, etc.	0.353
IRF6	Uterus	early_mid	Glandular	FAT1,CCL2,FGGY, etc.	0.34
IRF6	Uterus	early_mid	Lumenal 1	FAT1,CCL2,FGGY, etc.	0.523
IRF6	Uterus	early_mid	Lumenal 2	FAT1,CCL2,FGGY, etc.	0.25
IRF6	Uterus	early_mid	Ciliated	FAT1,CCL2,FGGY, etc.	0.273
IRF6	Uterus	mid	Glandular_secretory	IL18,PLSCR1,DST, etc.	0.778
IRF6	Uterus	late	Glandular_secretory	VWA5A,ITM2C,ING2, etc.	0.67
IRF6	Uterus	late	Ciliated	VWA5A,ITM2C,ING2, etc.	0.345
IRF6	Intestine	development	Epithelium	PTHLH,RTP4,F2RL1, etc.	0.607
IRF6	Intestine	development	Fibroblasts	PTHLH,RTP4,F2RL1, etc.	0.305
IRF6	Uterus	proliferative	SOX9	EMP1,TACSTD2,ELK3, etc.	0.526
IRF6	Uterus	proliferative	SOX9_LGR5	EMP1,TACSTD2,ELK3, etc.	0.367
IRF6	Uterus	proliferative	SOX9_prolif	EMP1,TACSTD2,ELK3, etc.	0.315

Motif information.

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Related Drugs for Irf6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

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Related Diseases for Irf6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Irf6	C4551864	VAN DER WOUDE SYNDROME 1	9	GENOMICS_ENGLAND;UNIPROT
Irf6	C0008924	Cleft upper lip	4	CTD_human;ORPHANET
Irf6	C0265259	Popliteal pterygium syndrome	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Irf6	C0175697	Van der Woude syndrome	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Irf6	C1837213	OROFACIAL CLEFT 6, SUSCEPTIBILITY TO	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Irf6	C0008925	Cleft Palate	1	CTD_human;GENOMICS_ENGLAND
Irf6	C0037268	Skin Abnormalities	1	CTD_human
Irf6	C0158646	Cleft palate with cleft lip	1	ORPHANET
Irf6	C0206762	Limb Deformities, Congenital	1	CTD_human
Irf6	C0376634	Craniofacial Abnormalities	1	CTD_human
Irf6	C1298692	Cleft lip and alveolus	1	ORPHANET
Irf6	C1837218	Cleft palate, isolated	1	CTD_human