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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Lsr (spascer ID:54135)

Gene summary for Lsr

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Lsr
	Gene ID	54135
	Gene name	lipolysis stimulated lipoprotein receptor
	Synonyms	ILDR3\|Lisch7
	Cytomap	7\|7 B1
	Type of gene	protein-coding
	Description	lipolysis-stimulated lipoprotein receptorangulin-3lipolysis stimulated receptorliver-specific bHLH-Zip transcription factorliver-specific gene on mouse chromosome 7 protein
	Modification date	20220424
	UniProtAcc	Q99KG5

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Lsr	GO:0005886	plasma membrane	21873635	Component
Lsr	GO:0016020	membrane	21873635	Component
Lsr	GO:0060856	establishment of blood-brain barrier	21873635	Process
Lsr	GO:0061689	tricellular tight junction	21873635	Component
Lsr	GO:1904274	tricellular tight junction assembly	21873635	Process

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Spatial pattern events for Lsr

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Lsr	Mouse	Brain	S4	34413515	6.81e-07
Lsr	Mouse	Brain	S6	34413515	2.48e-06
Lsr	Mouse	Kidney	CLP	34003797	7.45e-09
Lsr	Mouse	Kidney	IRI	34003797	2.29e-15
Lsr	Mouse	Kidney	rep_1	34853151	1.56e-14
Lsr	Mouse	Kidney	rep_5	34853151	4.55e-11
Lsr	Mouse	Liver	rep_20	35021063	9.91e-15
Lsr	Mouse	Liver	rep_21	35021063	8.03e-15
Lsr	Mouse	Liver	rep_22	35021063	1.07e-14
Lsr	Mouse	Intestine	rep_1	35149721	6.08e-15
Lsr	Mouse	Intestine	rep_2	35149721	3.44e-15
Lsr	Mouse	Intestine	rep_3	35149721	3.25e-15
Lsr	Mouse	Intestine	rep_4	35149721	2.30e-15
Lsr	Mouse	Lung	rep_1	35290801	4.52e-15
Lsr	Mouse	Lung	rep_2	35290801	1.42e-14
Lsr	Mouse	Lung	rep_3	35290801	5.26e-15
Lsr	Mouse	Lung	rep_4	35290801	3.04e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_rep_1_H&E
Kidney_rep_5_H&E
Liver_rep_20_H&E
Liver_rep_21_H&E
Liver_rep_22_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Lsr envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Lsr	GOBP_Anatomical_Structure_Homeostasis	Mouse	Spinal cord	CN94_E1	6.4e-06
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Spinal cord	CN94_E1	9.1e-06
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Spinal cord	CN94_E1	6.4e-06
Lsr	GOBP_Skin_Development	Mouse	Spinal cord	CN94_E1	1.6e-06
Lsr	GOBP_Cell_Junction_Organization	Mouse	Spinal cord	L7bCN02_E1	4.0e-06
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Spinal cord	L7bCN02_E1	2.9e-06
Lsr	GOBP_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	8.9e-07
Lsr	GOBP_Cell_Cell_Junction_Assembly	Mouse	Spinal cord	L7CN45_C1	3.2e-06
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Spinal cord	L7CN45_C1	5.5e-10
Lsr	GOBP_Chemical_Homeostasis	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Lsr	GOBP_Establishment_Of_Blood_Brain_Barrier	Mouse	Spinal cord	L7CN45_C1	7.7e-06
Lsr	GOBP_Homeostatic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Lsr	GOBP_Maintenance_Of_Blood_Brain_Barrier	Mouse	Spinal cord	L7CN45_C1	4.4e-07
Lsr	GOBP_Protein_Localization_To_Cell_Cell_Junction	Mouse	Spinal cord	L7CN45_C1	3.5e-06
Lsr	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Spinal cord	L7CN45_C1	9.1e-06
Lsr	GOBP_Regulation_Of_Water_Loss_Via_Skin	Mouse	Spinal cord	L7CN45_C1	7.2e-07
Lsr	GOBP_Protein_Localization_To_Cell_Junction	Mouse	Spinal cord	L7CN47_C1	1.1e-06
Lsr	GOBP_Cell_Cell_Junction_Organization	Mouse	Spinal cord	L7CN47_D1	8.4e-06
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Spinal cord	L8CN11_D2	2.5e-11
Lsr	GOBP_Cell_Junction_Organization	Mouse	Brain	rep_27	5.8e-05
Lsr	GOBP_Establishment_Of_Blood_Brain_Barrier	Mouse	Brain	rep_30	6.6e-08
Lsr	GOBP_Regulation_Of_Water_Loss_Via_Skin	Mouse	Brain	rep_37	1.3e-08
Lsr	GOBP_Water_Homeostasis	Mouse	Brain	rep_41	5.2e-11
Lsr	GOBP_Chemical_Homeostasis	Mouse	Brain	rep_71	8.4e-05
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Brain	rep_1	1.2e-14
Lsr	GOBP_Cell_Junction_Organization	Mouse	Brain	rep_1	1.5e-30
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Brain	rep_1	8.6e-30
Lsr	GOBP_Gland_Development	Mouse	Brain	rep_1	4.1e-23
Lsr	GOBP_Protein_Localization_To_Cell_Junction	Mouse	Brain	rep_1	5.6e-48
Lsr	GOBP_Regulation_Of_Water_Loss_Via_Skin	Mouse	Brain	rep_1	8.4e-16
Lsr	GOBP_Anatomical_Structure_Homeostasis	Mouse	Brain	rep_3	1.8e-76
Lsr	GOBP_Cell_Cell_Junction_Assembly	Mouse	Brain	rep_3	9.8e-91
Lsr	GOBP_Cell_Cell_Junction_Organization	Mouse	Brain	rep_3	8.4e-79
Lsr	GOBP_Establishment_Of_Blood_Brain_Barrier	Mouse	Brain	rep_3	6.1e-59
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Brain	rep_3	4.1e-188
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Brain	rep_3	6.7e-70
Lsr	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Brain	rep_3	1.1e-62
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Brain	rep_3	2.9e-55
Lsr	GOBP_Skin_Development	Mouse	Brain	rep_3	5.0e-187
Lsr	GOBP_Maintenance_Of_Blood_Brain_Barrier	Mouse	Brain	rep_4	2.8e-25
Lsr	GOBP_Protein_Localization_To_Cell_Cell_Junction	Mouse	Brain	rep_4	6.8e-13
Lsr	GOBP_Water_Homeostasis	Mouse	Brain	rep_5	2.1e-82
Lsr	GOBP_Homeostatic_Process	Mouse	Brain	rep_7	2.5e-13
Lsr	GOBP_Establishment_Of_Blood_Brain_Barrier	Mouse	Embryo	rep_6	3.2e-28
Lsr	GOBP_Cell_Cell_Junction_Assembly	Mouse	Embryo	rep_14	2.0e-07
Lsr	GOBP_Cell_Cell_Junction_Organization	Mouse	Embryo	rep_14	5.8e-15
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Embryo	rep_14	7.2e-30
Lsr	GOBP_Maintenance_Of_Blood_Brain_Barrier	Mouse	Embryo	rep_14	7.8e-37
Lsr	GOBP_Protein_Localization_To_Cell_Cell_Junction	Mouse	Embryo	rep_14	1.7e-40
Lsr	GOBP_Protein_Localization_To_Cell_Junction	Mouse	Embryo	rep_14	1.7e-07
Lsr	GOBP_Regulation_Of_Water_Loss_Via_Skin	Mouse	Embryo	rep_14	3.3e-61
Lsr	GOBP_Water_Homeostasis	Mouse	Embryo	rep_14	2.3e-61
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Embryo	rep_1	3.0e-261
Lsr	GOBP_Homeostatic_Process	Mouse	Embryo	rep_1	2.0e-30
Lsr	GOBP_Lipid_Metabolic_Process	Mouse	Embryo	rep_1	2.1e-39
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Embryo	rep_1	7.9e-50
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Embryo	rep_2	0.0e+00
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Embryo	rep_3	4.6e-28
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Embryo	rep_3	5.4e-203
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Kidney	Nep	4.2e-26
Lsr	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Lsr	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Kidney	Nep	1.6e-16
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Lsr	GOBP_Anatomical_Structure_Homeostasis	Mouse	Kidney	rep_2	8.4e-22
Lsr	GOBP_Cell_Cell_Junction_Assembly	Mouse	Kidney	rep_2	9.3e-26
Lsr	GOBP_Cell_Cell_Junction_Organization	Mouse	Kidney	rep_2	9.3e-36
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Kidney	rep_2	5.4e-41
Lsr	GOBP_Cell_Junction_Organization	Mouse	Kidney	rep_2	6.2e-52
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Kidney	rep_2	1.3e-23
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Kidney	rep_2	1.3e-24
Lsr	GOBP_Homeostatic_Process	Mouse	Kidney	rep_2	2.2e-10
Lsr	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-78
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Kidney	rep_2	1.3e-51
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	3.6e-73
Lsr	GOBP_Regulation_Of_Water_Loss_Via_Skin	Mouse	Kidney	rep_2	3.6e-17
Lsr	GOBP_Skin_Development	Mouse	Kidney	rep_2	3.4e-46
Lsr	GOBP_Water_Homeostasis	Mouse	Kidney	rep_2	2.4e-36
Lsr	GOBP_Skin_Development	Mouse	Liver	CN16-D2	5.4e-07
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Liver	CN73-C1	5.5e-08
Lsr	GOBP_Water_Homeostasis	Mouse	Liver	CN73-C1	2.4e-09
Lsr	GOBP_Maintenance_Of_Blood_Brain_Barrier	Mouse	Liver	rep_15	7.9e-18
Lsr	GOBP_Protein_Localization_To_Cell_Cell_Junction	Mouse	Liver	rep_15	4.5e-21
Lsr	GOBP_Protein_Localization_To_Cell_Junction	Mouse	Liver	rep_15	1.7e-13
Lsr	GOBP_Anatomical_Structure_Homeostasis	Mouse	Liver	rep_16	8.1e-23
Lsr	GOBP_Cell_Cell_Junction_Assembly	Mouse	Liver	rep_16	5.6e-18
Lsr	GOBP_Cell_Cell_Junction_Organization	Mouse	Liver	rep_16	2.9e-08
Lsr	GOBP_Cell_Junction_Organization	Mouse	Liver	rep_16	1.6e-07
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Liver	rep_16	8.2e-15
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Liver	rep_16	7.0e-09
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Liver	rep_16	4.4e-20
Lsr	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Liver	rep_16	6.1e-20
Lsr	GOBP_Skin_Development	Mouse	Liver	rep_16	1.5e-13
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Intestine	rep_2	1.2e-12
Lsr	GOBP_Anatomical_Structure_Homeostasis	Mouse	Lymph	MS-1	1.1e-14
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Lymph	MS-1	7.9e-08
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Lymph	MS-1	3.8e-07
Lsr	GOBP_Chemical_Homeostasis	Mouse	Lymph	MS-1	8.2e-11
Lsr	GOBP_Gland_Development	Mouse	Lymph	MS-1	1.7e-10
Lsr	GOBP_Homeostatic_Process	Mouse	Lymph	MS-1	2.3e-12
Lsr	GOBP_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	9.7e-11
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Lymph	MS-1	1.1e-12
Lsr	GOBP_Protein_Localization_To_Cell_Junction	Mouse	Lymph	MS-1	2.2e-08
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	4.6e-15
Lsr	GOBP_Skin_Development	Mouse	Lymph	MS-1	8.0e-14
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Brain	rep_4	6.5e-07
Lsr	GOBP_Cell_Junction_Organization	Mouse	Brain	rep_4	3.7e-07
Lsr	GOBP_Water_Homeostasis	Mouse	Brain	rep_7	2.4e-12
Lsr	GOBP_Establishment_Of_Blood_Brain_Barrier	Mouse	Brain	HP_ad_rep3	7.1e-18
Lsr	GOBP_Cell_Junction_Assembly	Mouse	Brain	HP_ad_rep7	1.3e-11
Lsr	GOBP_Cell_Junction_Organization	Mouse	Brain	HP_ad_rep7	2.9e-10
Lsr	GOBP_Central_Nervous_System_Development	Mouse	Brain	HP_ad_rep7	2.3e-07
Lsr	GOBP_Gland_Development	Mouse	Brain	HP_ad_rep7	3.2e-13
Lsr	GOBP_Hepaticobiliary_System_Development	Mouse	Brain	HP_ad_rep7	4.6e-18
Lsr	GOBP_Protein_Localization_To_Cell_Junction	Mouse	Brain	HP_ad_rep7	2.0e-08
Lsr	GOBP_Regulation_Of_Water_Loss_Via_Skin	Mouse	Brain	HP_ad_rep7	1.5e-08
Lsr	GOBP_Skin_Development	Mouse	Brain	HP_ad_rep7	5.7e-08
Lsr	GOBP_Water_Homeostasis	Mouse	Brain	HP_adpolb_rep1	3.9e-10
Lsr	GOBP_Chemical_Homeostasis	Mouse	Brain	HP_polb_rep9	9.6e-10
Lsr	GOBP_Homeostatic_Process	Mouse	Brain	HP_polb_rep9	6.4e-11
Lsr	GOBP_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-11
Lsr	GOBP_Multicellular_Organismal_Homeostasis	Mouse	Brain	HP_polb_rep9	3.2e-07
Lsr	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Brain	HP_polb_rep9	2.9e-10
Lsr	GOBP_Regulation_Of_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.8e-10
Lsr	GOBP_Protein_Localization_To_Cell_Cell_Junction	Mouse	Brain	HP_wt_rep2	5.4e-07

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Lsr function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Lsr function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand	Receptor	LR pair	Tissue	Replication
Apob	Lsr	Apob_Lsr	Lung	rep_3

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Transcription factor for Lsr envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Lsr

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Lsr

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Lsr	C0007097	Carcinoma	2	CTD_human
Lsr	C0024667	Animal Mammary Neoplasms	2	CTD_human
Lsr	C0024668	Mammary Neoplasms, Experimental	2	CTD_human
Lsr	C0205696	Anaplastic carcinoma	2	CTD_human
Lsr	C0205697	Carcinoma, Spindle-Cell	2	CTD_human
Lsr	C0205698	Undifferentiated carcinoma	2	CTD_human
Lsr	C0205699	Carcinomatosis	2	CTD_human
Lsr	C1257925	Mammary Carcinoma, Animal	2	CTD_human