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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Wwc2 (spascer ID:52357)

Gene summary for Wwc2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Wwc2
	Gene ID	52357
	Gene name	WW, C2 and coiled-coil domain containing 2
	Synonyms	5330431C14Rik\|AU022508\|C85457\|D8Ertd594e
	Cytomap	8 B1.1\|8 26.91 cM
	Type of gene	protein-coding
	Description	protein WWC2WW domain-containing protein 2
	Modification date	20220424
	UniProtAcc	Q6NXJ0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Wwc2	GO:0005737	cytoplasm	21873635	Component
Wwc2	GO:0006355	regulation of transcription, DNA-templated	21873635	Process
Wwc2	GO:0016477	cell migration	21873635	Process
Wwc2	GO:0019900	kinase binding	21873635	Function
Wwc2	GO:0035330	regulation of hippo signaling	21873635	Process
Wwc2	GO:0046621	negative regulation of organ growth	21873635	Process
Wwc2	GO:0060090	molecular adaptor activity	21873635	Function

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Spatial pattern events for Wwc2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Wwc2	Mouse	Brain	S2	34413515	4.45e-10
Wwc2	Mouse	Embryo	rep_3	33188776	6.04e-07
Wwc2	Mouse	Embryo	rep_4	33188776	1.53e-14
Wwc2	Mouse	Embryo	rep_5	33188776	1.40e-14
Wwc2	Mouse	Embryo	rep_12	33188776	2.84e-08
Wwc2	Mouse	Embryo	rep_13	33188776	1.85e-06
Wwc2	Mouse	Kidney	CLP	34003797	2.19e-15
Wwc2	Mouse	Kidney	Sham	34003797	2.58e-15
Wwc2	Mouse	Kidney	rep_3	34853151	2.57e-10
Wwc2	Mouse	Brain	rep_1	33469025	4.30e-13
Wwc2	Mouse	Lung	rep_1	35290801	9.45e-08

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_Sham_H&E
Kidney_rep_3_H&E
Brain_rep_1_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has Wwc2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Spinal cord	CN93_D2	2.5e-06
Wwc2	GOBP_Developmental_Growth	Mouse	Spinal cord	CN94_E1	8.7e-06
Wwc2	GOBP_Growth	Mouse	Spinal cord	CN94_E1	1.2e-06
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Wwc2	GOBP_Negative_Regulation_Of_Growth	Mouse	Spinal cord	CN94_E1	4.1e-06
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	CN94_E1	2.2e-06
Wwc2	GOBP_Organ_Growth	Mouse	Spinal cord	CN94_E1	1.7e-06
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Spinal cord	L7CN44_C1	3.2e-08
Wwc2	GOBP_Hippo_Signaling	Mouse	Spinal cord	L7CN45_C1	6.6e-08
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Growth	Mouse	Spinal cord	L7CN45_C1	5.3e-07
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Process	Mouse	Spinal cord	L7CN45_C1	1.9e-10
Wwc2	GOBP_Negative_Regulation_Of_Organ_Growth	Mouse	Spinal cord	L7CN45_C1	6.2e-08
Wwc2	GOBP_Regulation_Of_Growth	Mouse	Spinal cord	L7CN45_C1	1.3e-06
Wwc2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Spinal cord	L8CN17_E1	2.6e-06
Wwc2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Spinal cord	L8CN17_E1	8.3e-06
Wwc2	GOBP_Developmental_Growth	Mouse	Brain	rep_27	4.1e-06
Wwc2	GOBP_Growth	Mouse	Brain	rep_27	5.5e-05
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_27	2.8e-05
Wwc2	GOBP_Regulation_Of_Developmental_Growth	Mouse	Brain	rep_27	4.5e-06
Wwc2	GOBP_Negative_Regulation_Of_Organ_Growth	Mouse	Brain	rep_41	4.2e-05
Wwc2	GOBP_Negative_Regulation_Of_Growth	Mouse	Brain	rep_71	9.4e-05
Wwc2	GOBP_Hippo_Signaling	Mouse	Brain	rep_75	5.3e-05
Wwc2	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_75	5.0e-05
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Growth	Mouse	Brain	rep_1	2.2e-15
Wwc2	GOBP_Organ_Growth	Mouse	Brain	rep_1	9.3e-07
Wwc2	GOBP_Regulation_Of_Developmental_Growth	Mouse	Brain	rep_1	4.9e-14
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Brain	rep_1	3.0e-66
Wwc2	GOBP_Developmental_Growth	Mouse	Brain	rep_3	4.3e-49
Wwc2	GOBP_Hippo_Signaling	Mouse	Brain	rep_3	7.8e-89
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Process	Mouse	Brain	rep_3	3.9e-71
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_3	5.2e-78
Wwc2	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	9.2e-120
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Brain	rep_3	2.0e-111
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Wwc2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Wwc2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	rep_3	7.8e-106
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_3	7.5e-168
Wwc2	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_3	3.4e-114
Wwc2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Wwc2	GOBP_Growth	Mouse	Brain	rep_7	5.0e-09
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Embryo	rep_6	1.6e-08
Wwc2	GOBP_Negative_Regulation_Of_Growth	Mouse	Embryo	rep_14	6.2e-17
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Embryo	rep_14	1.3e-30
Wwc2	GOBP_Negative_Regulation_Of_Organ_Growth	Mouse	Embryo	rep_14	2.9e-43
Wwc2	GOBP_Developmental_Growth	Mouse	Embryo	rep_1	9.7e-37
Wwc2	GOBP_Growth	Mouse	Embryo	rep_1	5.0e-12
Wwc2	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Embryo	rep_1	1.0e-64
Wwc2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Wwc2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Embryo	rep_1	5.6e-10
Wwc2	GOBP_Regulation_Of_Growth	Mouse	Embryo	rep_1	7.1e-83
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Wwc2	GOBP_Regulation_Of_Developmental_Growth	Mouse	Embryo	rep_3	0.0e+00
Wwc2	GOBP_Organ_Growth	Mouse	Embryo	rep_4	1.9e-27
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Embryo	rep_5	1.8e-10
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Embryo	rep_6	4.9e-12
Wwc2	GOBP_Growth	Mouse	Kidney	Nep	1.1e-16
Wwc2	GOBP_Developmental_Growth	Mouse	Kidney	rep_2	2.7e-30
Wwc2	GOBP_Hippo_Signaling	Mouse	Kidney	rep_2	8.2e-18
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Growth	Mouse	Kidney	rep_2	3.0e-60
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Process	Mouse	Kidney	rep_2	4.6e-113
Wwc2	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	9.1e-83
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Kidney	rep_2	2.6e-120
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Wwc2	GOBP_Negative_Regulation_Of_Organ_Growth	Mouse	Kidney	rep_2	3.0e-07
Wwc2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Wwc2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Kidney	rep_2	4.0e-40
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	2.2e-14
Wwc2	GOBP_Organ_Growth	Mouse	Kidney	rep_2	2.6e-39
Wwc2	GOBP_Regulation_Of_Developmental_Growth	Mouse	Kidney	rep_2	1.9e-62
Wwc2	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Kidney	rep_2	2.7e-16
Wwc2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Kidney	rep_2	1.5e-44
Wwc2	GOBP_Developmental_Growth	Mouse	Liver	CN16-D2	2.3e-10
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Growth	Mouse	Liver	CN16-D2	7.7e-11
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Liver	CN16-E1	3.0e-07
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Liver	rep_15	2.5e-12
Wwc2	GOBP_Hippo_Signaling	Mouse	Liver	rep_16	4.9e-07
Wwc2	GOBP_Negative_Regulation_Of_Growth	Mouse	Liver	rep_16	8.7e-10
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Liver	rep_16	1.3e-08
Wwc2	GOBP_Regulation_Of_Growth	Mouse	Liver	rep_16	1.5e-07
Wwc2	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Liver	rep_16	8.0e-12
Wwc2	GOBP_Developmental_Growth	Mouse	Lymph	MS-1	2.5e-13
Wwc2	GOBP_Growth	Mouse	Lymph	MS-1	4.5e-14
Wwc2	GOBP_Hippo_Signaling	Mouse	Lymph	MS-1	3.0e-09
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Growth	Mouse	Lymph	MS-1	1.3e-09
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Process	Mouse	Lymph	MS-1	4.0e-14
Wwc2	GOBP_Negative_Regulation_Of_Growth	Mouse	Lymph	MS-1	5.1e-08
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Lymph	MS-1	1.8e-10
Wwc2	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.5e-16
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Lymph	MS-1	6.6e-16
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Wwc2	GOBP_Negative_Regulation_Of_Organ_Growth	Mouse	Lymph	MS-1	8.9e-08
Wwc2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Wwc2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Lymph	MS-1	1.0e-14
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	2.2e-09
Wwc2	GOBP_Organ_Growth	Mouse	Lymph	MS-1	2.8e-10
Wwc2	GOBP_Regulation_Of_Developmental_Growth	Mouse	Lymph	MS-1	8.0e-12
Wwc2	GOBP_Regulation_Of_Growth	Mouse	Lymph	MS-1	8.9e-15
Wwc2	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Lymph	MS-1	3.9e-11
Wwc2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Lymph	MS-1	7.5e-08
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Lung	rep_1	1.3e-17
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_7	1.1e-10
Wwc2	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Brain	HP_ad_rep2	8.0e-08
Wwc2	GOBP_Developmental_Growth	Mouse	Brain	HP_ad_rep7	4.9e-10
Wwc2	GOBP_Growth	Mouse	Brain	HP_ad_rep7	3.9e-09
Wwc2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Process	Mouse	Brain	HP_ad_rep7	1.7e-11
Wwc2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Wwc2	GOBP_Negative_Regulation_Of_Organ_Growth	Mouse	Brain	HP_ad_rep7	2.1e-08
Wwc2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.1e-13
Wwc2	GOBP_Organ_Growth	Mouse	Brain	HP_ad_rep7	8.7e-09
Wwc2	GOBP_Regulation_Of_Developmental_Growth	Mouse	Brain	HP_ad_rep7	2.2e-07
Wwc2	GOBP_Regulation_Of_Growth	Mouse	Brain	HP_ad_rep7	5.8e-07
Wwc2	GOBP_Regulation_Of_Organ_Growth	Mouse	Brain	HP_ad_rep7	9.5e-14
Wwc2	GOBP_Hippo_Signaling	Mouse	Brain	HP_adpolb_rep1	6.7e-07
Wwc2	GOBP_Negative_Regulation_Of_Developmental_Growth	Mouse	Brain	HP_polb_rep9	2.5e-11
Wwc2	GOBP_Negative_Regulation_Of_Growth	Mouse	Brain	HP_polb_rep9	2.8e-08
Wwc2	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	9.4e-11
Wwc2	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Mouse	Brain	HP_polb_rep9	1.8e-08
Wwc2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Wwc2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.4e-11
Wwc2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11

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Wwc2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Wwc2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Wwc2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Wwc2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Wwc2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source