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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

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Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Fbxl3 (spascer ID:50789)

Gene summary for Fbxl3

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Fbxl3

Gene ID

50789

Gene nameF-box and leucine-rich repeat protein 3
SynonymsAU041772|AW212966|FBK|Fbl3a|Fbxl3a|Ovtm|Play68
Cytomap14|14 E2.3
Type of geneprotein-coding
DescriptionF-box/LRR-repeat protein 3F-box and leucine-rich repeat protein 3aF-box/LRR-repeat protein 3Aprotein after-hoursprotein overtime
Modification date20220424
UniProtAcc

Q8C4V4


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Fbxl3

GO:0000086

G2/M transition of mitotic cell cycle

21873635

Process
Fbxl3

GO:0005634

nucleus

21873635

Component
Fbxl3

GO:0005829

cytosol

21873635

Component
Fbxl3

GO:0019005

SCF ubiquitin ligase complex

21873635

Component
Fbxl3

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

21873635

Process
Fbxl3

GO:0043153

entrainment of circadian clock by photoperiod

21873635

Process
Fbxl3

GO:0051726

regulation of cell cycle

21873635

Process

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Spatial pattern events for Fbxl3

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Fbxl3MouseBrainS2 344135152.44e-09
Fbxl3MouseBrainS4 344135154.65e-15
Fbxl3MouseBrainS6 344135155.07e-15
Fbxl3MouseBrainS7 344135152.85e-15
Fbxl3MouseBrain36B 326376222.14e-07
Fbxl3MouseBrainrep_4 351413741.57e-15
Fbxl3MouseBrainrep_5 351413744.41e-12
Fbxl3MouseBrainrep_6 351413745.77e-11
Fbxl3MouseKidneyIRI 340037976.34e-10
Fbxl3MouseBrainrep_1 334690251.39e-13
Fbxl3MouseBrainrep_4 350277292.58e-07
Fbxl3MouseIntestinerep_1 351497211.81e-14
Fbxl3MouseIntestinerep_2 351497213.44e-15
Fbxl3MouseIntestinerep_4 351497218.58e-10
Fbxl3MouseLymphB1 08.96e-09
Fbxl3MouseLungrep_1 352908013.30e-06

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_4_H&E
boxplot
boxplot
Brain_rep_5_H&E
boxplot
boxplot
Brain_rep_6_H&E
boxplot
boxplot
Kidney_IRI_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot
Brain_rep_4_H&E
boxplot
boxplot
Lung_rep_1_H&E
boxplot
boxplot


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Spatial pattern pathway has Fbxl3 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Fbxl3GOBP_Cell_CycleMouseSpinal cordCN94_E1 1.1e-06
Fbxl3GOBP_Cell_Cycle_ProcessMouseSpinal cordCN94_E1 3.8e-06
Fbxl3GOBP_Regulation_Of_Protein_StabilityMouseSpinal cordCN94_E1 9.3e-07
Fbxl3GOBP_Cell_Cycle_Phase_TransitionMouseSpinal cordL7bCN02_E1 1.5e-06
Fbxl3GOBP_Circadian_RhythmMouseSpinal cordL7bCN02_E1 4.0e-06
Fbxl3GOBP_Protein_PolyubiquitinationMouseSpinal cordL7bCN02_E1 2.8e-06
Fbxl3GOBP_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 7.5e-06
Fbxl3GOBP_Mitotic_Cell_CycleMouseSpinal cordL7CN45_C1 2.4e-08
Fbxl3GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 2.7e-07
Fbxl3GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.1e-08
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseSpinal cordL7CN45_C1 5.2e-06
Fbxl3GOBP_Protein_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.6e-06
Fbxl3GOBP_Protein_DestabilizationMouseSpinal cordL7CN45_C1 4.1e-06
Fbxl3GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseSpinal cordL7CN45_C1 2.2e-07
Fbxl3GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseSpinal cordL7CN45_C1 1.4e-06
Fbxl3GOBP_ProteolysisMouseSpinal cordL7CN45_C1 1.1e-06
Fbxl3GOBP_Regulation_Of_Cell_CycleMouseSpinal cordL7CN45_C1 3.0e-07
Fbxl3GOBP_Response_To_RadiationMouseSpinal cordL7CN45_C1 4.5e-07
Fbxl3GOBP_Rhythmic_ProcessMouseSpinal cordL7CN45_C1 1.9e-06
Fbxl3GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseSpinal cordL7CN47_C1 3.3e-07
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseSpinal cordL7CN47_C1 1.2e-07
Fbxl3GOBP_Response_To_Light_StimulusMouseSpinal cordL7CN47_C1 3.8e-06
Fbxl3GOBP_PhotoperiodismMouseSpinal cordL7CN85_E2 2.2e-06
Fbxl3GOBP_Cell_CycleMouseBrainrep_27 8.4e-07
Fbxl3GOBP_Mitotic_Cell_CycleMouseBrainrep_27 1.1e-05
Fbxl3GOBP_Protein_DestabilizationMouseBrainrep_27 7.9e-05
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseBrainrep_27 5.5e-05
Fbxl3GOBP_Cell_CycleMouseBrainrep_1 7.0e-10
Fbxl3GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseBrainrep_1 8.5e-51
Fbxl3GOBP_Cell_Cycle_Phase_TransitionMouseBrainrep_1 1.6e-31
Fbxl3GOBP_Cell_Cycle_ProcessMouseBrainrep_1 6.7e-14
Fbxl3GOBP_Circadian_RhythmMouseBrainrep_1 2.6e-25
Fbxl3GOBP_Entrainment_Of_Circadian_ClockMouseBrainrep_1 6.5e-19
Fbxl3GOBP_Mitotic_Cell_CycleMouseBrainrep_1 1.5e-25
Fbxl3GOBP_PhotoperiodismMouseBrainrep_1 3.4e-12
Fbxl3GOBP_Protein_DestabilizationMouseBrainrep_1 6.3e-23
Fbxl3GOBP_Protein_PolyubiquitinationMouseBrainrep_1 2.1e-07
Fbxl3GOBP_Regulation_Of_Cell_CycleMouseBrainrep_1 3.9e-14
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseBrainrep_1 1.6e-27
Fbxl3GOBP_Response_To_Abiotic_StimulusMouseBrainrep_1 6.0e-28
Fbxl3GOBP_Rhythmic_ProcessMouseBrainrep_1 4.6e-47
Fbxl3GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseBrainrep_1 2.9e-36
Fbxl3GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainrep_32.9e-162
Fbxl3GOBP_Macromolecule_Catabolic_ProcessMouseBrainrep_31.7e-159
Fbxl3GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainrep_38.7e-167
Fbxl3GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainrep_37.1e-166
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseBrainrep_36.2e-128
Fbxl3GOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainrep_32.9e-169
Fbxl3GOBP_Protein_Catabolic_ProcessMouseBrainrep_33.0e-174
Fbxl3GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainrep_31.4e-184
Fbxl3GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainrep_36.3e-190
Fbxl3GOBP_ProteolysisMouseBrainrep_31.8e-168
Fbxl3GOBP_Regulation_Of_Protein_StabilityMouseBrainrep_33.1e-136
Fbxl3GOBP_Response_To_Light_StimulusMouseBrainrep_3 3.8e-27
Fbxl3GOBP_Response_To_RadiationMouseBrainrep_3 4.6e-08
Fbxl3GOBP_Circadian_RhythmMouseEmbryorep_14 5.3e-08
Fbxl3GOBP_Entrainment_Of_Circadian_ClockMouseEmbryorep_14 6.4e-41
Fbxl3GOBP_PhotoperiodismMouseEmbryorep_14 6.4e-64
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseEmbryorep_14 1.7e-45
Fbxl3GOBP_Protein_DestabilizationMouseEmbryorep_14 6.1e-09
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseEmbryorep_14 4.4e-17
Fbxl3GOBP_Regulation_Of_Protein_StabilityMouseEmbryorep_14 4.3e-14
Fbxl3GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseEmbryorep_14 6.9e-43
Fbxl3GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseEmbryorep_1 7.5e-10
Fbxl3GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseEmbryorep_1 5.7e-21
Fbxl3GOBP_Protein_Catabolic_ProcessMouseEmbryorep_1 4.1e-19
Fbxl3GOBP_Protein_DestabilizationMouseEmbryorep_1 3.7e-16
Fbxl3GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseEmbryorep_1 4.4e-16
Fbxl3GOBP_Response_To_Light_StimulusMouseEmbryorep_11.5e-185
Fbxl3GOBP_Response_To_RadiationMouseEmbryorep_1 0.0e+00
Fbxl3GOBP_Circadian_RhythmMouseEmbryorep_2 5.3e-10
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseEmbryorep_21.1e-224
Fbxl3GOBP_Rhythmic_ProcessMouseEmbryorep_27.6e-139
Fbxl3GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseEmbryorep_3 4.2e-21
Fbxl3GOBP_Regulation_Of_Protein_StabilityMouseEmbryorep_5 6.2e-09
Fbxl3GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseEmbryorep_61.2e-274
Fbxl3GOBP_Protein_PolyubiquitinationMouseEmbryorep_6 1.0e-23
Fbxl3GOBP_ProteolysisMouseKidneyNep 6.8e-23
Fbxl3GOBP_Cell_CycleMouseKidneyrep_2 1.0e-24
Fbxl3GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseKidneyrep_2 8.2e-89
Fbxl3GOBP_Cell_Cycle_Phase_TransitionMouseKidneyrep_2 6.8e-67
Fbxl3GOBP_Cell_Cycle_ProcessMouseKidneyrep_2 3.0e-21
Fbxl3GOBP_Cellular_Protein_Catabolic_ProcessMouseKidneyrep_2 3.2e-21
Fbxl3GOBP_Circadian_RhythmMouseKidneyrep_2 1.8e-75
Fbxl3GOBP_Entrainment_Of_Circadian_ClockMouseKidneyrep_2 2.4e-86
Fbxl3GOBP_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 7.0e-40
Fbxl3GOBP_Mitotic_Cell_CycleMouseKidneyrep_2 1.1e-15
Fbxl3GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 1.0e-26
Fbxl3GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseKidneyrep_2 1.2e-14
Fbxl3GOBP_PhotoperiodismMouseKidneyrep_2 1.3e-53
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseKidneyrep_2 7.2e-84
Fbxl3GOBP_Proteasomal_Protein_Catabolic_ProcessMouseKidneyrep_2 5.3e-33
Fbxl3GOBP_Protein_Catabolic_ProcessMouseKidneyrep_2 7.3e-30
Fbxl3GOBP_Protein_DestabilizationMouseKidneyrep_2 4.8e-93
Fbxl3GOBP_Protein_PolyubiquitinationMouseKidneyrep_2 4.9e-79
Fbxl3GOBP_ProteolysisMouseKidneyrep_26.0e-106
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseKidneyrep_2 2.9e-35
Fbxl3GOBP_Response_To_Light_StimulusMouseKidneyrep_2 4.7e-16
Fbxl3GOBP_Rhythmic_ProcessMouseKidneyrep_2 4.7e-69
Fbxl3GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseKidneyrep_2 1.0e-11
Fbxl3GOBP_Protein_DestabilizationMouseLiverCN16-D2 6.8e-09
Fbxl3GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseLiverCN16-E1 4.3e-09
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseLiverCN73-C1 9.0e-07
Fbxl3GOBP_Entrainment_Of_Circadian_ClockMouseLiverrep_15 6.6e-15
Fbxl3GOBP_PhotoperiodismMouseLiverrep_15 5.7e-18
Fbxl3GOBP_Circadian_RhythmMouseLiverrep_16 4.6e-09
Fbxl3GOBP_Protein_DestabilizationMouseLiverrep_16 4.6e-11
Fbxl3GOBP_Cell_CycleMouseLymphMS-1 1.3e-07
Fbxl3GOBP_Cellular_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxl3GOBP_Entrainment_Of_Circadian_ClockMouseLymphMS-1 9.9e-08
Fbxl3GOBP_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Fbxl3GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxl3GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Fbxl3GOBP_PhotoperiodismMouseLymphMS-1 1.0e-09
Fbxl3GOBP_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxl3GOBP_Protein_DestabilizationMouseLymphMS-1 2.2e-15
Fbxl3GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseLymphMS-1 1.4e-09
Fbxl3GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseLymphMS-1 1.4e-09
Fbxl3GOBP_Protein_PolyubiquitinationMouseLymphMS-1 3.6e-11
Fbxl3GOBP_ProteolysisMouseLymphMS-1 2.8e-10
Fbxl3GOBP_Regulation_Of_Cell_CycleMouseLymphMS-1 6.4e-09
Fbxl3GOBP_Regulation_Of_Protein_StabilityMouseLymphMS-1 1.0e-14
Fbxl3GOBP_Response_To_Abiotic_StimulusMouseLymphMS-1 1.5e-07
Fbxl3GOBP_Response_To_Light_StimulusMouseLymphMS-1 3.8e-09
Fbxl3GOBP_Response_To_RadiationMouseLymphMS-1 9.1e-12
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseLymphPBS 6.0e-07
Fbxl3GOBP_Macromolecule_Catabolic_ProcessMouseLungrep_1 2.0e-21
Fbxl3GOBP_Circadian_RhythmMouseBrainrep_4 2.1e-77
Fbxl3GOBP_Protein_PolyubiquitinationMouseBrainrep_4 1.0e-15
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseBrainrep_4 6.3e-75
Fbxl3GOBP_Rhythmic_ProcessMouseBrainrep_4 3.3e-35
Fbxl3GOBP_Cell_CycleMouseBrainHP_ad_rep7 6.6e-08
Fbxl3GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseBrainHP_ad_rep7 3.1e-07
Fbxl3GOBP_Cell_Cycle_Phase_TransitionMouseBrainHP_ad_rep7 4.9e-09
Fbxl3GOBP_Cell_Cycle_ProcessMouseBrainHP_ad_rep7 1.7e-09
Fbxl3GOBP_Circadian_RhythmMouseBrainHP_ad_rep7 4.9e-12
Fbxl3GOBP_Entrainment_Of_Circadian_ClockMouseBrainHP_ad_rep7 4.4e-07
Fbxl3GOBP_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-09
Fbxl3GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-08
Fbxl3GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Fbxl3GOBP_PhotoperiodismMouseBrainHP_ad_rep7 4.1e-08
Fbxl3GOBP_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Fbxl3GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainHP_ad_rep7 1.7e-09
Fbxl3GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainHP_ad_rep7 6.9e-09
Fbxl3GOBP_Protein_PolyubiquitinationMouseBrainHP_ad_rep7 1.4e-10
Fbxl3GOBP_ProteolysisMouseBrainHP_ad_rep7 3.3e-07
Fbxl3GOBP_Regulation_Of_Cell_CycleMouseBrainHP_ad_rep7 1.6e-08
Fbxl3GOBP_Response_To_Abiotic_StimulusMouseBrainHP_ad_rep7 4.3e-08
Fbxl3GOBP_Response_To_Light_StimulusMouseBrainHP_ad_rep7 1.6e-09
Fbxl3GOBP_Response_To_RadiationMouseBrainHP_ad_rep7 9.1e-09
Fbxl3GOBP_Rhythmic_ProcessMouseBrainHP_ad_rep7 4.3e-13
Fbxl3GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 9.8e-10
Fbxl3GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 7.2e-07
Fbxl3GOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 1.1e-07
Fbxl3GOBP_Mitotic_Cell_CycleMouseBrainHP_polb_rep9 1.6e-10
Fbxl3GOBP_Post_Translational_Protein_ModificationMouseBrainHP_polb_rep9 5.1e-14
Fbxl3GOBP_Regulation_Of_Circadian_RhythmMouseBrainHP_polb_rep9 1.8e-10
Fbxl3GOBP_Regulation_Of_Protein_StabilityMouseBrainHP_polb_rep9 8.6e-09

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Fbxl3 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Fbxl3 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Fbxl3 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Fbxl3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Fbxl3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Fbxl3C0005586Bipolar Disorder1PSYGENET
Fbxl3C0013336Dwarfism1GENOMICS_ENGLAND
Fbxl3C0349588Short stature1GENOMICS_ENGLAND
Fbxl3C1853507Mental Retardation, Short Stature, Facial Anomalies, and Joint Dislocations1GENOMICS_ENGLAND;UNIPROT
Fbxl3C2919142Short Stature, CTCAE1GENOMICS_ENGLAND
Fbxl3C3714756Intellectual Disability1GENOMICS_ENGLAND