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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Rgs6 (spascer ID:50779)

Gene summary for Rgs6

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Rgs6
	Gene ID	50779
	Gene name	regulator of G-protein signaling 6
	Synonyms	-
	Cytomap	12 D1\|12 38.14 cM
	Type of gene	protein-coding
	Description	regulator of G-protein signaling 6
	Modification date	20220515
	UniProtAcc	Q9Z2H2

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for Rgs6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Rgs6	Mouse	Brain	S1	34413515	2.07e-15
Rgs6	Mouse	Brain	S2	34413515	1.56e-15
Rgs6	Mouse	Brain	S3	34413515	1.64e-15
Rgs6	Mouse	Brain	S4	34413515	1.37e-15
Rgs6	Mouse	Brain	S6	34413515	1.46e-15
Rgs6	Mouse	Brain	S7	34413515	1.55e-15
Rgs6	Mouse	Brain	08A	32637622	6.35e-12
Rgs6	Mouse	Brain	12B	32637622	8.61e-09
Rgs6	Mouse	Brain	13A	32637622	4.71e-06
Rgs6	Mouse	Brain	25A	32637622	3.51e-07
Rgs6	Mouse	Brain	26A	32637622	3.84e-06
Rgs6	Mouse	Brain	27A	32637622	3.25e-12
Rgs6	Mouse	Brain	27B	32637622	5.12e-13
Rgs6	Mouse	Brain	28A	32637622	1.86e-14
Rgs6	Mouse	Brain	30A	32637622	1.29e-10
Rgs6	Mouse	Brain	31A	32637622	5.51e-07
Rgs6	Mouse	Brain	rep_1	35141374	2.02e-15
Rgs6	Mouse	Brain	rep_2	35141374	1.69e-15
Rgs6	Mouse	Brain	rep_3	35141374	1.64e-15
Rgs6	Mouse	Brain	rep_4	35141374	1.57e-15
Rgs6	Mouse	Brain	rep_5	35141374	1.47e-15
Rgs6	Mouse	Brain	rep_6	35141374	1.73e-15
Rgs6	Mouse	Embryo	4E	34210887	7.01e-07
Rgs6	Mouse	Kidney	Sham	34003797	4.30e-15
Rgs6	Mouse	Brain	rep_1	33469025	1.30e-15
Rgs6	Mouse	Brain	rep_1	35027729	1.66e-15
Rgs6	Mouse	Brain	rep_2	35027729	1.57e-15
Rgs6	Mouse	Brain	rep_3	35027729	1.32e-15
Rgs6	Mouse	Brain	rep_4	35027729	1.76e-15
Rgs6	Mouse	Brain	rep_5	35027729	1.46e-15
Rgs6	Mouse	Brain	B07_C2	32702314	1.94e-09
Rgs6	Mouse	Brain	N03_C2	32702314	9.23e-06
Rgs6	Mouse	Brain	N04_D1	32702314	3.70e-07
Rgs6	Mouse	Brain	rep_1	35210624	1.74e-15
Rgs6	Mouse	Brain	rep_2	35210624	1.74e-15
Rgs6	Mouse	Brain	rep_3	35210624	1.82e-15
Rgs6	Mouse	Brain	rep_5	35210624	2.07e-15
Rgs6	Mouse	Brain	rep_6	35210624	2.05e-15
Rgs6	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_Sham_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B07_C2_H&E
Brain_N03_C2_H&E
Brain_N04_D1_H&E

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Spatial pattern pathway has Rgs6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	2.5e-06
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.8e-08
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Rgs6	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Spinal cord	L7CN45_C1	7.5e-06
Rgs6	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	1.8e-08
Rgs6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Rgs6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Spinal cord	L8CN17_E1	8.3e-06
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_27	8.0e-06
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_27	4.5e-08
Rgs6	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_27	4.2e-05
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	4.5e-16
Rgs6	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	2.1e-36
Rgs6	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_1	1.0e-11
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	2.4e-43
Rgs6	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	5.6e-32
Rgs6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Rgs6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	rep_3	7.8e-106
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Rgs6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	1.4e-120
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	8.5e-07
Rgs6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Rgs6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Embryo	rep_1	5.6e-10
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Rgs6	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_1	1.6e-15
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Embryo	rep_3	0.0e+00
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Embryo	rep_3	4.4e-96
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	Nep	4.2e-26
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Rgs6	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.4e-48
Rgs6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	Nep	4.2e-26
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.3e-36
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	3.0e-37
Rgs6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Rgs6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Kidney	rep_2	4.0e-40
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Rgs6	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	2.1e-81
Rgs6	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	3.6e-50
Rgs6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	3.4e-47
Rgs6	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	1.2e-71
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	1.4e-60
Rgs6	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Liver	CN16-D2	1.9e-10
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Liver	rep_16	7.2e-08
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	1.8e-08
Rgs6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Rgs6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Lymph	MS-1	1.0e-14
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Rgs6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	1.9e-08
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	1.7e-17
Rgs6	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_4	7.8e-12
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	3.8e-61
Rgs6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Rgs6	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_ad_rep7	4.8e-07
Rgs6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Rgs6	GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	2.3e-11
Rgs6	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	6.4e-16
Rgs6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Rgs6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.4e-11
Rgs6	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_polb_rep9	4.2e-09
Rgs6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	6.0e-09
Rgs6	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_wt_rep2	2.1e-07

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Rgs6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Rgs6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Rgs6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Rgs6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Rgs6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Rgs6	C0525045	Mood Disorders	1	PSYGENET