SPASCER Logo

Home

Download & Upload

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Fbxo6 (spascer ID:50762)

Gene summary for Fbxo6

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Fbxo6

Gene ID

50762

Gene nameF-box protein 6
SynonymsAA408845|FBG2|Fbs2|Fbx6b|Fbxo6b
Cytomap4 E2|4 78.67 cM
Type of geneprotein-coding
DescriptionF-box only protein 6F-box only protein 6bF-box protein that recognizes sugar chains 2F-box/G-domain protein 2
Modification date20220424
UniProtAcc

Q9QZN4


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Fbxo6

GO:0005737

cytoplasm

21873635

Component
Fbxo6

GO:0006516

glycoprotein catabolic process

21873635

Process
Fbxo6

GO:0019005

SCF ubiquitin ligase complex

21873635

Component
Fbxo6

GO:0030433

ubiquitin-dependent ERAD pathway

21873635

Process
Fbxo6

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

21873635

Process
Fbxo6

GO:0044322

endoplasmic reticulum quality control compartment

21873635

Component
Fbxo6

GO:0061630

ubiquitin protein ligase activity

21873635

Function

Top

Spatial pattern events for Fbxo6

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Fbxo6MouseKidneyIRI 340037977.37e-15
Fbxo6MouseKidneySham 340037972.42e-13
Fbxo6MouseKidneyrep_1 348531512.42e-15
Fbxo6MouseBrainrep_1 334690258.88e-06
Fbxo6MouseIntestinerep_4 351497215.15e-11

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Kidney_IRI_H&E
boxplot
boxplot
Kidney_Sham_H&E
boxplot
boxplot
Kidney_rep_1_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot


Top

Spatial pattern pathway has Fbxo6 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Fbxo6GOBP_Cell_CycleMouseSpinal cordCN94_E1 1.1e-06
Fbxo6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseSpinal cordCN94_E1 8.0e-06
Fbxo6GOBP_Dna_Metabolic_ProcessMouseSpinal cordCN94_E1 2.7e-06
Fbxo6GOBP_Glycoprotein_Metabolic_ProcessMouseSpinal cordCN94_E1 3.5e-06
Fbxo6GOBP_Negative_Regulation_Of_Cell_CycleMouseSpinal cordCN94_E1 3.2e-06
Fbxo6GOBP_Response_To_Nitrogen_CompoundMouseSpinal cordCN94_E1 5.6e-06
Fbxo6GOBP_Protein_PolyubiquitinationMouseSpinal cordL7bCN02_E1 2.8e-06
Fbxo6GOBP_Carbohydrate_Derivative_Catabolic_ProcessMouseSpinal cordL7CN45_C1 2.7e-07
Fbxo6GOBP_Carbohydrate_Derivative_Metabolic_ProcessMouseSpinal cordL7CN45_C1 1.8e-07
Fbxo6GOBP_Dna_RepairMouseSpinal cordL7CN45_C1 9.4e-06
Fbxo6GOBP_Erad_PathwayMouseSpinal cordL7CN45_C1 1.3e-06
Fbxo6GOBP_Glycoprotein_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.0e-06
Fbxo6GOBP_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 7.5e-06
Fbxo6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 2.7e-07
Fbxo6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.1e-08
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseSpinal cordL7CN45_C1 5.2e-06
Fbxo6GOBP_Protein_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.6e-06
Fbxo6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseSpinal cordL7CN45_C1 2.2e-07
Fbxo6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseSpinal cordL7CN45_C1 1.4e-06
Fbxo6GOBP_ProteolysisMouseSpinal cordL7CN45_C1 1.1e-06
Fbxo6GOBP_Regulation_Of_Cell_CycleMouseSpinal cordL7CN45_C1 3.0e-07
Fbxo6GOBP_Response_To_Endoplasmic_Reticulum_StressMouseSpinal cordL7CN45_C1 2.7e-07
Fbxo6GOBP_Response_To_Topologically_Incorrect_ProteinMouseSpinal cordL7CN45_C1 5.1e-07
Fbxo6GOBP_Ubiquitin_Dependent_Erad_PathwayMouseSpinal cordL7CN45_C1 1.3e-06
Fbxo6GOBP_Cell_CycleMouseBrainrep_27 8.4e-07
Fbxo6GOBP_Negative_Regulation_Of_Cell_CycleMouseBrainrep_27 1.7e-08
Fbxo6GOBP_Cell_CycleMouseBrainrep_1 7.0e-10
Fbxo6GOBP_Dna_Metabolic_ProcessMouseBrainrep_1 1.1e-07
Fbxo6GOBP_Protein_PolyubiquitinationMouseBrainrep_1 2.1e-07
Fbxo6GOBP_Regulation_Of_Cell_CycleMouseBrainrep_1 3.9e-14
Fbxo6GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseBrainrep_1 2.9e-36
Fbxo6GOBP_Carbohydrate_Derivative_Catabolic_ProcessMouseBrainrep_33.4e-221
Fbxo6GOBP_Carbohydrate_Derivative_Metabolic_ProcessMouseBrainrep_3 4.5e-61
Fbxo6GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainrep_32.9e-162
Fbxo6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainrep_35.0e-192
Fbxo6GOBP_Dna_RepairMouseBrainrep_34.0e-216
Fbxo6GOBP_Erad_PathwayMouseBrainrep_38.8e-162
Fbxo6GOBP_Glycoprotein_Catabolic_ProcessMouseBrainrep_33.2e-102
Fbxo6GOBP_Glycoprotein_Metabolic_ProcessMouseBrainrep_31.9e-173
Fbxo6GOBP_Macromolecule_Catabolic_ProcessMouseBrainrep_31.7e-159
Fbxo6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainrep_38.7e-167
Fbxo6GOBP_Negative_Regulation_Of_Cell_CycleMouseBrainrep_31.9e-186
Fbxo6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainrep_37.1e-166
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseBrainrep_36.2e-128
Fbxo6GOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainrep_32.9e-169
Fbxo6GOBP_Protein_Catabolic_ProcessMouseBrainrep_33.0e-174
Fbxo6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainrep_31.4e-184
Fbxo6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainrep_36.3e-190
Fbxo6GOBP_ProteolysisMouseBrainrep_31.8e-168
Fbxo6GOBP_Response_To_Endoplasmic_Reticulum_StressMouseBrainrep_36.3e-133
Fbxo6GOBP_Response_To_Nitrogen_CompoundMouseBrainrep_3 2.5e-82
Fbxo6GOBP_Response_To_Topologically_Incorrect_ProteinMouseBrainrep_38.7e-153
Fbxo6GOBP_Ubiquitin_Dependent_Erad_PathwayMouseBrainrep_31.5e-163
Fbxo6GOBP_Carbohydrate_Derivative_Catabolic_ProcessMouseEmbryorep_14 1.7e-43
Fbxo6GOBP_Erad_PathwayMouseEmbryorep_14 1.8e-28
Fbxo6GOBP_Glycoprotein_Catabolic_ProcessMouseEmbryorep_14 3.3e-25
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseEmbryorep_14 1.7e-45
Fbxo6GOBP_Response_To_Topologically_Incorrect_ProteinMouseEmbryorep_14 7.2e-14
Fbxo6GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseEmbryorep_14 6.9e-43
Fbxo6GOBP_Ubiquitin_Dependent_Erad_PathwayMouseEmbryorep_14 6.4e-17
Fbxo6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseEmbryorep_1 7.5e-10
Fbxo6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseEmbryorep_1 5.7e-21
Fbxo6GOBP_Protein_Catabolic_ProcessMouseEmbryorep_1 4.1e-19
Fbxo6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseEmbryorep_1 4.4e-16
Fbxo6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseEmbryorep_2 1.4e-08
Fbxo6GOBP_Dna_Metabolic_ProcessMouseEmbryorep_27.2e-216
Fbxo6GOBP_Dna_RepairMouseEmbryorep_21.6e-282
Fbxo6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseEmbryorep_3 4.2e-21
Fbxo6GOBP_Response_To_Endoplasmic_Reticulum_StressMouseEmbryorep_3 1.8e-13
Fbxo6GOBP_Response_To_Nitrogen_CompoundMouseEmbryorep_3 0.0e+00
Fbxo6GOBP_Response_To_Topologically_Incorrect_ProteinMouseEmbryorep_32.3e-263
Fbxo6GOBP_Protein_PolyubiquitinationMouseEmbryorep_6 1.0e-23
Fbxo6GOBP_ProteolysisMouseKidneyNep 6.8e-23
Fbxo6GOBP_Carbohydrate_Derivative_Catabolic_ProcessMouseKidneyrep_2 5.9e-48
Fbxo6GOBP_Carbohydrate_Derivative_Metabolic_ProcessMouseKidneyrep_2 2.5e-42
Fbxo6GOBP_Cell_CycleMouseKidneyrep_2 1.0e-24
Fbxo6GOBP_Cellular_Protein_Catabolic_ProcessMouseKidneyrep_2 3.2e-21
Fbxo6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseKidneyrep_25.5e-146
Fbxo6GOBP_Dna_Metabolic_ProcessMouseKidneyrep_2 1.4e-12
Fbxo6GOBP_Dna_RepairMouseKidneyrep_2 5.5e-70
Fbxo6GOBP_Erad_PathwayMouseKidneyrep_2 2.9e-66
Fbxo6GOBP_Glycoprotein_Catabolic_ProcessMouseKidneyrep_2 1.9e-89
Fbxo6GOBP_Glycoprotein_Metabolic_ProcessMouseKidneyrep_21.1e-102
Fbxo6GOBP_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 7.0e-40
Fbxo6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 1.0e-26
Fbxo6GOBP_Negative_Regulation_Of_Cell_CycleMouseKidneyrep_2 2.8e-71
Fbxo6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseKidneyrep_2 1.2e-14
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseKidneyrep_2 7.2e-84
Fbxo6GOBP_Proteasomal_Protein_Catabolic_ProcessMouseKidneyrep_2 5.3e-33
Fbxo6GOBP_Protein_Catabolic_ProcessMouseKidneyrep_2 7.3e-30
Fbxo6GOBP_Protein_PolyubiquitinationMouseKidneyrep_2 4.9e-79
Fbxo6GOBP_ProteolysisMouseKidneyrep_26.0e-106
Fbxo6GOBP_Response_To_Endoplasmic_Reticulum_StressMouseKidneyrep_2 1.2e-89
Fbxo6GOBP_Response_To_Nitrogen_CompoundMouseKidneyrep_2 1.0e-56
Fbxo6GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseKidneyrep_2 1.0e-11
Fbxo6GOBP_Ubiquitin_Dependent_Erad_PathwayMouseKidneyrep_2 7.8e-51
Fbxo6GOBP_Dna_Metabolic_ProcessMouseLiverCN16-D2 2.6e-07
Fbxo6GOBP_Carbohydrate_Derivative_Metabolic_ProcessMouseLiverCN73-C1 5.1e-08
Fbxo6GOBP_Glycoprotein_Metabolic_ProcessMouseLiverCN73-C1 1.4e-07
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseLiverCN73-C1 9.0e-07
Fbxo6GOBP_Glycoprotein_Catabolic_ProcessMouseLiverrep_16 5.0e-12
Fbxo6GOBP_Carbohydrate_Derivative_Catabolic_ProcessMouseLymphMS-1 6.0e-17
Fbxo6GOBP_Carbohydrate_Derivative_Metabolic_ProcessMouseLymphMS-1 2.8e-10
Fbxo6GOBP_Cell_CycleMouseLymphMS-1 1.3e-07
Fbxo6GOBP_Cellular_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxo6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseLymphMS-1 8.5e-13
Fbxo6GOBP_Dna_Metabolic_ProcessMouseLymphMS-1 6.8e-10
Fbxo6GOBP_Erad_PathwayMouseLymphMS-1 8.7e-14
Fbxo6GOBP_Glycoprotein_Metabolic_ProcessMouseLymphMS-1 1.1e-07
Fbxo6GOBP_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Fbxo6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxo6GOBP_Negative_Regulation_Of_Cell_CycleMouseLymphMS-1 9.2e-07
Fbxo6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Fbxo6GOBP_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxo6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseLymphMS-1 1.4e-09
Fbxo6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseLymphMS-1 1.4e-09
Fbxo6GOBP_Protein_PolyubiquitinationMouseLymphMS-1 3.6e-11
Fbxo6GOBP_ProteolysisMouseLymphMS-1 2.8e-10
Fbxo6GOBP_Regulation_Of_Cell_CycleMouseLymphMS-1 6.4e-09
Fbxo6GOBP_Response_To_Endoplasmic_Reticulum_StressMouseLymphMS-1 1.7e-11
Fbxo6GOBP_Response_To_Nitrogen_CompoundMouseLymphMS-1 1.8e-09
Fbxo6GOBP_Response_To_Topologically_Incorrect_ProteinMouseLymphMS-1 2.8e-07
Fbxo6GOBP_Ubiquitin_Dependent_Erad_PathwayMouseLymphMS-1 1.1e-11
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseLymphPBS 6.0e-07
Fbxo6GOBP_Macromolecule_Catabolic_ProcessMouseLungrep_1 2.0e-21
Fbxo6GOBP_Protein_PolyubiquitinationMouseBrainrep_4 1.0e-15
Fbxo6GOBP_Cell_CycleMouseBrainHP_ad_rep7 6.6e-08
Fbxo6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainHP_ad_rep7 6.8e-10
Fbxo6GOBP_Dna_Metabolic_ProcessMouseBrainHP_ad_rep7 3.1e-11
Fbxo6GOBP_Dna_RepairMouseBrainHP_ad_rep7 2.4e-12
Fbxo6GOBP_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-09
Fbxo6GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-08
Fbxo6GOBP_Negative_Regulation_Of_Cell_CycleMouseBrainHP_ad_rep7 9.2e-08
Fbxo6GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Fbxo6GOBP_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Fbxo6GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainHP_ad_rep7 1.7e-09
Fbxo6GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainHP_ad_rep7 6.9e-09
Fbxo6GOBP_Protein_PolyubiquitinationMouseBrainHP_ad_rep7 1.4e-10
Fbxo6GOBP_ProteolysisMouseBrainHP_ad_rep7 3.3e-07
Fbxo6GOBP_Regulation_Of_Cell_CycleMouseBrainHP_ad_rep7 1.6e-08
Fbxo6GOBP_Response_To_Nitrogen_CompoundMouseBrainHP_ad_rep7 3.5e-10
Fbxo6GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 9.8e-10
Fbxo6GOBP_Erad_PathwayMouseBrainHP_ad_rep8 5.7e-07
Fbxo6GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 7.2e-07
Fbxo6GOBP_Glycoprotein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 6.3e-08
Fbxo6GOBP_Glycoprotein_Metabolic_ProcessMouseBrainHP_adpolb_rep1 2.0e-07
Fbxo6GOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 1.1e-07
Fbxo6GOBP_Ubiquitin_Dependent_Erad_PathwayMouseBrainHP_adpolb_rep1 1.8e-08
Fbxo6GOBP_Carbohydrate_Derivative_Catabolic_ProcessMouseBrainHP_polb_rep9 4.0e-16
Fbxo6GOBP_Carbohydrate_Derivative_Metabolic_ProcessMouseBrainHP_polb_rep9 5.2e-12
Fbxo6GOBP_Post_Translational_Protein_ModificationMouseBrainHP_polb_rep9 5.1e-14
Fbxo6GOBP_Response_To_Endoplasmic_Reticulum_StressMouseBrainHP_polb_rep9 3.5e-12
Fbxo6GOBP_Response_To_Topologically_Incorrect_ProteinMouseBrainHP_polb_rep9 5.0e-08

Top

Fbxo6 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

Top

Fbxo6 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

Top

Transcription factor for Fbxo6 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

Top

Related Drugs for Fbxo6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for Fbxo6

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Fbxo6C0014518Toxic Epidermal Necrolysis1CTD_human
Fbxo6C0038325Stevens-Johnson Syndrome1CTD_human
Fbxo6C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
Fbxo6C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
Fbxo6C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human