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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

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Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Fbxl17 (spascer ID:50758)

Gene summary for Fbxl17

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Fbxl17

Gene ID

50758

Gene nameF-box and leucine-rich repeat protein 17
Synonyms6330576B01Rik|AI452053|BB073797|C130023C01Rik|Fbx13|Fbxo13
Cytomap17|17 E1.1
Type of geneprotein-coding
DescriptionF-box/LRR-repeat protein 17F-box only protein 13
Modification date20220424
UniProtAcc

Q9QZN1


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Fbxl17

GO:0000086

G2/M transition of mitotic cell cycle

21873635

Process
Fbxl17

GO:0005634

nucleus

21873635

Component
Fbxl17

GO:0005829

cytosol

21873635

Component
Fbxl17

GO:0019005

SCF ubiquitin ligase complex

21873635

Component
Fbxl17

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

21873635

Process
Fbxl17

GO:0043153

entrainment of circadian clock by photoperiod

21873635

Process
Fbxl17

GO:0051726

regulation of cell cycle

21873635

Process

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Spatial pattern events for Fbxl17

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Fbxl17MouseEmbryo4E 342108878.94e-06
Fbxl17MouseBrainrep_1 334690255.83e-09
Fbxl17MouseBrainrep_3 350277297.11e-14

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
boxplot
Brain_rep_3_H&E
boxplot
boxplot


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Spatial pattern pathway has Fbxl17 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Fbxl17GOBP_Cell_CycleMouseSpinal cordCN94_E1 1.1e-06
Fbxl17GOBP_Cell_Cycle_ProcessMouseSpinal cordCN94_E1 3.8e-06
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseSpinal cordCN94_E1 4.5e-07
Fbxl17GOBP_Cell_Cycle_Phase_TransitionMouseSpinal cordL7bCN02_E1 1.5e-06
Fbxl17GOBP_Circadian_RhythmMouseSpinal cordL7bCN02_E1 4.0e-06
Fbxl17GOBP_Protein_PolyubiquitinationMouseSpinal cordL7bCN02_E1 2.8e-06
Fbxl17GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseSpinal cordL7bCN02_E1 7.4e-06
Fbxl17GOBP_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 7.5e-06
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseSpinal cordL7CN45_C1 1.1e-06
Fbxl17GOBP_Mitotic_Cell_CycleMouseSpinal cordL7CN45_C1 2.4e-08
Fbxl17GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 2.7e-07
Fbxl17GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.1e-08
Fbxl17GOBP_Protein_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.6e-06
Fbxl17GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseSpinal cordL7CN45_C1 2.2e-07
Fbxl17GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseSpinal cordL7CN45_C1 1.4e-06
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseSpinal cordL7CN45_C1 4.9e-06
Fbxl17GOBP_ProteolysisMouseSpinal cordL7CN45_C1 1.1e-06
Fbxl17GOBP_Regulation_Of_Cell_CycleMouseSpinal cordL7CN45_C1 3.0e-07
Fbxl17GOBP_Response_To_RadiationMouseSpinal cordL7CN45_C1 4.5e-07
Fbxl17GOBP_Rhythmic_ProcessMouseSpinal cordL7CN45_C1 1.9e-06
Fbxl17GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseSpinal cordL7CN47_C1 3.3e-07
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseSpinal cordL7CN47_C1 1.2e-07
Fbxl17GOBP_Response_To_Light_StimulusMouseSpinal cordL7CN47_C1 3.8e-06
Fbxl17GOBP_PhotoperiodismMouseSpinal cordL7CN85_E2 2.2e-06
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseBrainrep_11 8.5e-05
Fbxl17GOBP_Cell_CycleMouseBrainrep_27 8.4e-07
Fbxl17GOBP_Mitotic_Cell_CycleMouseBrainrep_27 1.1e-05
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseBrainrep_27 5.5e-05
Fbxl17GOBP_Stem_Cell_DifferentiationMouseBrainrep_27 1.5e-05
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseBrainrep_37 2.6e-05
Fbxl17GOBP_Cell_CycleMouseBrainrep_1 7.0e-10
Fbxl17GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseBrainrep_1 8.5e-51
Fbxl17GOBP_Cell_Cycle_Phase_TransitionMouseBrainrep_1 1.6e-31
Fbxl17GOBP_Cell_Cycle_ProcessMouseBrainrep_1 6.7e-14
Fbxl17GOBP_Circadian_RhythmMouseBrainrep_1 2.6e-25
Fbxl17GOBP_Entrainment_Of_Circadian_ClockMouseBrainrep_1 6.5e-19
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseBrainrep_1 1.9e-31
Fbxl17GOBP_Mesenchyme_DevelopmentMouseBrainrep_1 2.9e-34
Fbxl17GOBP_Mitotic_Cell_CycleMouseBrainrep_1 1.5e-25
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseBrainrep_1 6.1e-20
Fbxl17GOBP_PhotoperiodismMouseBrainrep_1 3.4e-12
Fbxl17GOBP_Protein_PolyubiquitinationMouseBrainrep_1 2.1e-07
Fbxl17GOBP_Regulation_Of_Cell_CycleMouseBrainrep_1 3.9e-14
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseBrainrep_1 1.6e-27
Fbxl17GOBP_Response_To_Abiotic_StimulusMouseBrainrep_1 6.0e-28
Fbxl17GOBP_Rhythmic_ProcessMouseBrainrep_1 4.6e-47
Fbxl17GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseBrainrep_1 2.9e-36
Fbxl17GOBP_Stem_Cell_DifferentiationMouseBrainrep_1 6.0e-11
Fbxl17GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainrep_32.9e-162
Fbxl17GOBP_Macromolecule_Catabolic_ProcessMouseBrainrep_31.7e-159
Fbxl17GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainrep_38.7e-167
Fbxl17GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainrep_37.1e-166
Fbxl17GOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainrep_32.9e-169
Fbxl17GOBP_Protein_Catabolic_ProcessMouseBrainrep_33.0e-174
Fbxl17GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainrep_31.4e-184
Fbxl17GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainrep_36.3e-190
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseBrainrep_35.2e-184
Fbxl17GOBP_ProteolysisMouseBrainrep_31.8e-168
Fbxl17GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainrep_32.1e-100
Fbxl17GOBP_Response_To_Light_StimulusMouseBrainrep_3 3.8e-27
Fbxl17GOBP_Response_To_RadiationMouseBrainrep_3 4.6e-08
Fbxl17GOBP_Smoothened_Signaling_PathwayMouseBrainrep_38.0e-137
Fbxl17GOBP_Circadian_RhythmMouseEmbryorep_14 5.3e-08
Fbxl17GOBP_Entrainment_Of_Circadian_ClockMouseEmbryorep_14 6.4e-41
Fbxl17GOBP_PhotoperiodismMouseEmbryorep_14 6.4e-64
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseEmbryorep_14 1.6e-93
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseEmbryorep_14 4.4e-17
Fbxl17GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseEmbryorep_14 9.2e-37
Fbxl17GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseEmbryorep_14 6.9e-43
Fbxl17GOBP_Smoothened_Signaling_PathwayMouseEmbryorep_14 7.6e-35
Fbxl17GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseEmbryorep_1 7.5e-10
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseEmbryorep_1 6.7e-91
Fbxl17GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseEmbryorep_1 5.7e-21
Fbxl17GOBP_Protein_Catabolic_ProcessMouseEmbryorep_1 4.1e-19
Fbxl17GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseEmbryorep_1 4.4e-16
Fbxl17GOBP_Response_To_Light_StimulusMouseEmbryorep_11.5e-185
Fbxl17GOBP_Response_To_RadiationMouseEmbryorep_1 0.0e+00
Fbxl17GOBP_Circadian_RhythmMouseEmbryorep_2 5.3e-10
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseEmbryorep_21.1e-224
Fbxl17GOBP_Rhythmic_ProcessMouseEmbryorep_27.6e-139
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseEmbryorep_3 1.0e-07
Fbxl17GOBP_Mesenchyme_DevelopmentMouseEmbryorep_31.1e-182
Fbxl17GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseEmbryorep_3 4.2e-21
Fbxl17GOBP_Stem_Cell_DifferentiationMouseEmbryorep_37.7e-264
Fbxl17GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseEmbryorep_61.2e-274
Fbxl17GOBP_Protein_PolyubiquitinationMouseEmbryorep_6 1.0e-23
Fbxl17GOBP_ProteolysisMouseKidneyNep 6.8e-23
Fbxl17GOBP_Cell_CycleMouseKidneyrep_2 1.0e-24
Fbxl17GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseKidneyrep_2 8.2e-89
Fbxl17GOBP_Cell_Cycle_Phase_TransitionMouseKidneyrep_2 6.8e-67
Fbxl17GOBP_Cell_Cycle_ProcessMouseKidneyrep_2 3.0e-21
Fbxl17GOBP_Cellular_Protein_Catabolic_ProcessMouseKidneyrep_2 3.2e-21
Fbxl17GOBP_Circadian_RhythmMouseKidneyrep_2 1.8e-75
Fbxl17GOBP_Entrainment_Of_Circadian_ClockMouseKidneyrep_2 2.4e-86
Fbxl17GOBP_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 7.0e-40
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseKidneyrep_2 7.0e-70
Fbxl17GOBP_Mesenchyme_DevelopmentMouseKidneyrep_2 3.6e-61
Fbxl17GOBP_Mitotic_Cell_CycleMouseKidneyrep_2 1.1e-15
Fbxl17GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 1.0e-26
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseKidneyrep_2 1.7e-14
Fbxl17GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseKidneyrep_2 1.2e-14
Fbxl17GOBP_PhotoperiodismMouseKidneyrep_2 1.3e-53
Fbxl17GOBP_Proteasomal_Protein_Catabolic_ProcessMouseKidneyrep_2 5.3e-33
Fbxl17GOBP_Protein_Catabolic_ProcessMouseKidneyrep_2 7.3e-30
Fbxl17GOBP_Protein_PolyubiquitinationMouseKidneyrep_2 4.9e-79
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseKidneyrep_2 2.1e-68
Fbxl17GOBP_ProteolysisMouseKidneyrep_26.0e-106
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseKidneyrep_2 2.9e-35
Fbxl17GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseKidneyrep_2 2.9e-90
Fbxl17GOBP_Response_To_Light_StimulusMouseKidneyrep_2 4.7e-16
Fbxl17GOBP_Rhythmic_ProcessMouseKidneyrep_2 4.7e-69
Fbxl17GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseKidneyrep_2 1.0e-11
Fbxl17GOBP_Smoothened_Signaling_PathwayMouseKidneyrep_2 5.6e-72
Fbxl17GOBP_Stem_Cell_DifferentiationMouseKidneyrep_2 1.5e-50
Fbxl17GOBP_Stem_Cell_DifferentiationMouseLiverCN16-D2 4.9e-10
Fbxl17GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseLiverCN16-E1 4.3e-09
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseLiverCN16-E1 8.9e-15
Fbxl17GOBP_Entrainment_Of_Circadian_ClockMouseLiverrep_15 6.6e-15
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseLiverrep_15 1.5e-07
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseLiverrep_15 4.4e-13
Fbxl17GOBP_PhotoperiodismMouseLiverrep_15 5.7e-18
Fbxl17GOBP_Circadian_RhythmMouseLiverrep_16 4.6e-09
Fbxl17GOBP_Cell_CycleMouseLymphMS-1 1.3e-07
Fbxl17GOBP_Cellular_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxl17GOBP_Entrainment_Of_Circadian_ClockMouseLymphMS-1 9.9e-08
Fbxl17GOBP_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseLymphMS-1 3.1e-15
Fbxl17GOBP_Mesenchyme_DevelopmentMouseLymphMS-1 3.7e-14
Fbxl17GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseLymphMS-1 7.1e-13
Fbxl17GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Fbxl17GOBP_PhotoperiodismMouseLymphMS-1 1.0e-09
Fbxl17GOBP_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Fbxl17GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseLymphMS-1 1.4e-09
Fbxl17GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseLymphMS-1 1.4e-09
Fbxl17GOBP_Protein_PolyubiquitinationMouseLymphMS-1 3.6e-11
Fbxl17GOBP_ProteolysisMouseLymphMS-1 2.8e-10
Fbxl17GOBP_Regulation_Of_Cell_CycleMouseLymphMS-1 6.4e-09
Fbxl17GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseLymphMS-1 1.5e-07
Fbxl17GOBP_Response_To_Abiotic_StimulusMouseLymphMS-1 1.5e-07
Fbxl17GOBP_Response_To_Light_StimulusMouseLymphMS-1 3.8e-09
Fbxl17GOBP_Response_To_RadiationMouseLymphMS-1 9.1e-12
Fbxl17GOBP_Stem_Cell_DifferentiationMouseLymphMS-1 1.2e-10
Fbxl17GOBP_Macromolecule_Catabolic_ProcessMouseLungrep_1 2.0e-21
Fbxl17GOBP_Circadian_RhythmMouseBrainrep_4 2.1e-77
Fbxl17GOBP_Protein_PolyubiquitinationMouseBrainrep_4 1.0e-15
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseBrainrep_4 8.0e-16
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseBrainrep_4 6.3e-75
Fbxl17GOBP_Rhythmic_ProcessMouseBrainrep_4 3.3e-35
Fbxl17GOBP_Smoothened_Signaling_PathwayMouseBrainrep_7 3.2e-08
Fbxl17GOBP_Cell_CycleMouseBrainHP_ad_rep7 6.6e-08
Fbxl17GOBP_Cell_Cycle_G2_M_Phase_TransitionMouseBrainHP_ad_rep7 3.1e-07
Fbxl17GOBP_Cell_Cycle_Phase_TransitionMouseBrainHP_ad_rep7 4.9e-09
Fbxl17GOBP_Cell_Cycle_ProcessMouseBrainHP_ad_rep7 1.7e-09
Fbxl17GOBP_Circadian_RhythmMouseBrainHP_ad_rep7 4.9e-12
Fbxl17GOBP_Entrainment_Of_Circadian_ClockMouseBrainHP_ad_rep7 4.4e-07
Fbxl17GOBP_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-09
Fbxl17GOBP_Mesenchymal_Cell_DifferentiationMouseBrainHP_ad_rep7 8.5e-07
Fbxl17GOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-08
Fbxl17GOBP_Neural_Crest_Cell_DifferentiationMouseBrainHP_ad_rep7 7.7e-16
Fbxl17GOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Fbxl17GOBP_PhotoperiodismMouseBrainHP_ad_rep7 4.1e-08
Fbxl17GOBP_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Fbxl17GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainHP_ad_rep7 1.7e-09
Fbxl17GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainHP_ad_rep7 6.9e-09
Fbxl17GOBP_Protein_PolyubiquitinationMouseBrainHP_ad_rep7 1.4e-10
Fbxl17GOBP_ProteolysisMouseBrainHP_ad_rep7 3.3e-07
Fbxl17GOBP_Regulation_Of_Cell_CycleMouseBrainHP_ad_rep7 1.6e-08
Fbxl17GOBP_Response_To_Abiotic_StimulusMouseBrainHP_ad_rep7 4.3e-08
Fbxl17GOBP_Response_To_Light_StimulusMouseBrainHP_ad_rep7 1.6e-09
Fbxl17GOBP_Response_To_RadiationMouseBrainHP_ad_rep7 9.1e-09
Fbxl17GOBP_Rhythmic_ProcessMouseBrainHP_ad_rep7 4.3e-13
Fbxl17GOBP_Scf_Dependent_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 9.8e-10
Fbxl17GOBP_Stem_Cell_DifferentiationMouseBrainHP_ad_rep7 3.8e-12
Fbxl17GOBP_Cellular_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 7.2e-07
Fbxl17GOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 1.1e-07
Fbxl17GOBP_Mitotic_Cell_CycleMouseBrainHP_polb_rep9 1.6e-10
Fbxl17GOBP_Protein_Quality_Control_For_Misfolded_Or_Incompletely_Synthesized_ProteinsMouseBrainHP_polb_rep9 6.9e-13
Fbxl17GOBP_Regulation_Of_Circadian_RhythmMouseBrainHP_polb_rep9 1.8e-10
Fbxl17GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainHP_polb_rep9 6.8e-09
Fbxl17GOBP_Smoothened_Signaling_PathwayMouseBrainHP_polb_rep9 5.0e-12
Fbxl17GOBP_Mesenchyme_DevelopmentMouseBrainHP_wt_rep2 5.0e-08

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Fbxl17 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Fbxl17 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Fbxl17 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Fbxl17

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Fbxl17

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource