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Spatial pattern gene: Creg1 (spascer ID:433375) |
Gene summary for Creg1 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Creg1 | Gene ID | 433375 |
| Gene name | cellular repressor of E1A-stimulated genes 1 |
| Synonyms | AA755314|Creg |
| Cytomap | 1|1 H2.3 |
| Type of gene | protein-coding |
| Description | protein CREG1 |
| Modification date | 20220424 |
| UniProtAcc | O88668 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Creg1 | GO:0005615 | extracellular space | 21873635 | Component |
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Spatial pattern events for Creg1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Creg1 | Mouse | Brain | S1 | 34413515 | 2.07e-15 |
| Creg1 | Mouse | Brain | S2 | 34413515 | 1.56e-15 |
| Creg1 | Mouse | Brain | S3 | 34413515 | 1.64e-15 |
| Creg1 | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Creg1 | Mouse | Brain | S6 | 34413515 | 1.46e-15 |
| Creg1 | Mouse | Brain | S7 | 34413515 | 1.55e-15 |
| Creg1 | Mouse | Brain | 12A | 32637622 | 9.11e-06 |
| Creg1 | Mouse | Brain | 12B | 32637622 | 7.35e-08 |
| Creg1 | Mouse | Brain | 14A | 32637622 | 2.30e-14 |
| Creg1 | Mouse | Brain | 14B | 32637622 | 2.16e-14 |
| Creg1 | Mouse | Brain | 15A | 32637622 | 8.09e-07 |
| Creg1 | Mouse | Brain | 15B | 32637622 | 1.06e-09 |
| Creg1 | Mouse | Brain | 16A | 32637622 | 1.75e-14 |
| Creg1 | Mouse | Brain | 16B | 32637622 | 4.04e-08 |
| Creg1 | Mouse | Brain | 17A | 32637622 | 1.19e-14 |
| Creg1 | Mouse | Brain | 17B | 32637622 | 1.32e-14 |
| Creg1 | Mouse | Brain | 18A | 32637622 | 1.20e-14 |
| Creg1 | Mouse | Brain | 18B | 32637622 | 7.09e-08 |
| Creg1 | Mouse | Brain | 19A | 32637622 | 1.74e-09 |
| Creg1 | Mouse | Brain | 19B | 32637622 | 2.22e-14 |
| Creg1 | Mouse | Brain | 20A | 32637622 | 1.07e-12 |
| Creg1 | Mouse | Brain | 21A | 32637622 | 2.30e-14 |
| Creg1 | Mouse | Brain | 21B | 32637622 | 4.89e-09 |
| Creg1 | Mouse | Brain | 22A | 32637622 | 1.50e-14 |
| Creg1 | Mouse | Brain | 22B | 32637622 | 8.81e-15 |
| Creg1 | Mouse | Brain | 23B | 32637622 | 1.39e-06 |
| Creg1 | Mouse | Brain | 24A | 32637622 | 9.74e-06 |
| Creg1 | Mouse | Brain | 25A | 32637622 | 3.24e-08 |
| Creg1 | Mouse | Brain | 27B | 32637622 | 7.43e-10 |
| Creg1 | Mouse | Brain | 28A | 32637622 | 3.44e-14 |
| Creg1 | Mouse | Brain | rep_1 | 35141374 | 2.02e-15 |
| Creg1 | Mouse | Brain | rep_2 | 35141374 | 3.93e-14 |
| Creg1 | Mouse | Brain | rep_3 | 35141374 | 1.64e-15 |
| Creg1 | Mouse | Brain | rep_5 | 35141374 | 5.13e-15 |
| Creg1 | Mouse | Brain | rep_6 | 35141374 | 1.73e-15 |
| Creg1 | Mouse | Embryo | rep_1 | 33188776 | 9.22e-07 |
| Creg1 | Mouse | Embryo | rep_4 | 33188776 | 5.08e-15 |
| Creg1 | Mouse | Embryo | rep_13 | 33188776 | 4.49e-15 |
| Creg1 | Mouse | Kidney | CLP | 34003797 | 3.77e-15 |
| Creg1 | Mouse | Kidney | IRI | 34003797 | 2.29e-15 |
| Creg1 | Mouse | Kidney | Sham | 34003797 | 5.32e-14 |
| Creg1 | Mouse | Kidney | rep_1 | 34853151 | 5.85e-13 |
| Creg1 | Mouse | Kidney | rep_3 | 34853151 | 4.93e-15 |
| Creg1 | Mouse | Kidney | rep_4 | 34853151 | 4.07e-15 |
| Creg1 | Mouse | Kidney | rep_5 | 34853151 | 5.05e-09 |
| Creg1 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Creg1 | Mouse | Liver | rep_14 | 35021063 | 4.82e-14 |
| Creg1 | Mouse | Liver | rep_15 | 35021063 | 7.21e-14 |
| Creg1 | Mouse | Liver | rep_16 | 35021063 | 6.45e-14 |
| Creg1 | Mouse | Liver | rep_17 | 35021063 | 4.77e-14 |
| Creg1 | Mouse | Liver | rep_19 | 35021063 | 5.10e-14 |
| Creg1 | Mouse | Liver | rep_20 | 35021063 | 9.91e-15 |
| Creg1 | Mouse | Liver | rep_21 | 35021063 | 8.03e-15 |
| Creg1 | Mouse | Liver | rep_22 | 35021063 | 1.74e-14 |
| Creg1 | Mouse | Liver | rep_23 | 35021063 | 1.39e-14 |
| Creg1 | Mouse | Brain | rep_1 | 35027729 | 1.66e-15 |
| Creg1 | Mouse | Brain | rep_2 | 35027729 | 1.57e-15 |
| Creg1 | Mouse | Brain | rep_3 | 35027729 | 2.38e-15 |
| Creg1 | Mouse | Brain | rep_4 | 35027729 | 1.76e-15 |
| Creg1 | Mouse | Brain | rep_5 | 35027729 | 1.46e-15 |
| Creg1 | Mouse | Intestine | rep_1 | 35149721 | 2.40e-06 |
| Creg1 | Mouse | Intestine | rep_4 | 35149721 | 3.90e-15 |
| Creg1 | Mouse | Brain | B05_D2 | 32702314 | 5.47e-09 |
| Creg1 | Mouse | Brain | N05_C2 | 32702314 | 1.52e-07 |
| Creg1 | Mouse | Lung | rep_1 | 35290801 | 6.56e-15 |
| Creg1 | Mouse | Lung | rep_2 | 35290801 | 3.32e-11 |
| Creg1 | Mouse | Lung | rep_3 | 35290801 | 5.26e-15 |
| Creg1 | Mouse | Lung | rep_4 | 35290801 | 5.40e-15 |
| Creg1 | Mouse | Brain | rep_1 | 35210624 | 1.74e-15 |
| Creg1 | Mouse | Brain | rep_2 | 35210624 | 1.74e-15 |
| Creg1 | Mouse | Brain | rep_3 | 35210624 | 1.82e-15 |
| Creg1 | Mouse | Brain | rep_5 | 35210624 | 2.07e-15 |
| Creg1 | Mouse | Brain | rep_6 | 35210624 | 2.05e-15 |
| Creg1 | Mouse | Brain | rep_7 | 35210624 | 1.87e-15 |
| Creg1 | Mouse | Brain | OFB_wt_rep5 | 33083725 | 3.98e-03 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_6_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_3_H&E  |  |
Kidney_rep_4_H&E  |  |
Kidney_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Liver_rep_14_H&E  | |
Liver_rep_15_H&E  | |
Liver_rep_16_H&E  | |
Liver_rep_17_H&E  | |
Liver_rep_19_H&E  | |
Liver_rep_20_H&E  | |
Liver_rep_21_H&E  | |
Liver_rep_22_H&E  | |
Liver_rep_23_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_B05_D2_H&E  |  |
Brain_N05_C2_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
Lung_rep_3_H&E  |  |
Lung_rep_4_H&E  |  |
Brain_OFB_wt_rep5_H&E  |
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Spatial pattern pathway has Creg1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Creg1 | GOBP_Growth | Mouse | Spinal cord | CN94_E1 | 1.2e-06 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Spinal cord | CN94_E1 | 1.6e-06 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Spinal cord | CN94_E1 | 6.2e-07 |
| Creg1 | GOBP_Cell_Activation | Mouse | Spinal cord | L7CN45_C1 | 8.5e-07 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Spinal cord | L7CN45_C1 | 9.9e-07 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Spinal cord | L7CN45_C1 | 3.1e-07 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Spinal cord | L7CN45_C1 | 2.4e-06 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Spinal cord | L7CN45_C1 | 2.2e-07 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Spinal cord | L7CN45_C1 | 6.7e-06 |
| Creg1 | GOBP_Regulation_Of_Growth | Mouse | Spinal cord | L7CN45_C1 | 1.3e-06 |
| Creg1 | GOBP_Secretion | Mouse | Spinal cord | L7CN45_C1 | 8.1e-09 |
| Creg1 | GOBP_Exocytosis | Mouse | Spinal cord | L7CN47_C1 | 7.4e-07 |
| Creg1 | GOBP_Growth | Mouse | Brain | rep_27 | 5.5e-05 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Brain | rep_27 | 3.0e-05 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_27 | 7.2e-05 |
| Creg1 | GOBP_Secretion | Mouse | Brain | rep_27 | 8.9e-05 |
| Creg1 | GOBP_Cell_Activation | Mouse | Brain | rep_72 | 4.6e-06 |
| Creg1 | GOBP_Cell_Activation | Mouse | Brain | rep_1 | 1.8e-07 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Brain | rep_1 | 2.6e-13 |
| Creg1 | GOBP_Exocytosis | Mouse | Brain | rep_1 | 3.4e-73 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Brain | rep_1 | 1.5e-12 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Brain | rep_1 | 2.1e-07 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Brain | rep_1 | 1.3e-13 |
| Creg1 | GOBP_Secretion | Mouse | Brain | rep_1 | 4.1e-45 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_3 | 1.4e-196 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_3 | 9.4e-206 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Brain | rep_4 | 3.3e-32 |
| Creg1 | GOBP_Growth | Mouse | Brain | rep_7 | 5.0e-09 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Embryo | rep_6 | 1.4e-16 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Embryo | rep_14 | 3.3e-15 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Embryo | rep_14 | 3.8e-12 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Embryo | rep_14 | 2.9e-28 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Embryo | rep_14 | 1.7e-32 |
| Creg1 | GOBP_Growth | Mouse | Embryo | rep_1 | 5.0e-12 |
| Creg1 | GOBP_Regulation_Of_Growth | Mouse | Embryo | rep_1 | 7.1e-83 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Embryo | rep_2 | 3.4e-34 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Embryo | rep_2 | 1.7e-23 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Embryo | rep_2 | 8.0e-13 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 1.5e-267 |
| Creg1 | GOBP_Growth | Mouse | Kidney | Nep | 1.1e-16 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Kidney | Nep | 4.2e-26 |
| Creg1 | GOBP_Cell_Activation | Mouse | Kidney | rep_2 | 5.1e-83 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Kidney | rep_2 | 4.3e-101 |
| Creg1 | GOBP_Exocytosis | Mouse | Kidney | rep_2 | 3.2e-107 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Kidney | rep_2 | 3.4e-107 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Kidney | rep_2 | 2.7e-133 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Kidney | rep_2 | 2.2e-110 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Kidney | rep_2 | 6.6e-105 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Kidney | rep_2 | 7.3e-42 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 7.7e-30 |
| Creg1 | GOBP_Secretion | Mouse | Kidney | rep_2 | 1.6e-23 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Liver | rep_15 | 2.4e-09 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Liver | rep_16 | 1.6e-18 |
| Creg1 | GOBP_Exocytosis | Mouse | Liver | rep_16 | 8.5e-07 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Liver | rep_16 | 2.2e-20 |
| Creg1 | GOBP_Regulation_Of_Growth | Mouse | Liver | rep_16 | 1.5e-07 |
| Creg1 | GOBP_Cell_Activation | Mouse | Lymph | MS-1 | 1.6e-18 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Lymph | MS-1 | 9.7e-16 |
| Creg1 | GOBP_Exocytosis | Mouse | Lymph | MS-1 | 1.4e-14 |
| Creg1 | GOBP_Growth | Mouse | Lymph | MS-1 | 4.5e-14 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Lymph | MS-1 | 1.6e-18 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Lymph | MS-1 | 5.6e-21 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Lymph | MS-1 | 1.0e-18 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Lymph | MS-1 | 6.6e-07 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lymph | MS-1 | 6.1e-11 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 1.8e-10 |
| Creg1 | GOBP_Regulation_Of_Growth | Mouse | Lymph | MS-1 | 8.9e-15 |
| Creg1 | GOBP_Secretion | Mouse | Lymph | MS-1 | 2.3e-12 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lung | rep_1 | 7.5e-20 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lung | rep_1 | 5.8e-10 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Brain | rep_4 | 2.9e-33 |
| Creg1 | GOBP_Exocytosis | Mouse | Brain | rep_4 | 2.4e-43 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Brain | rep_4 | 7.2e-15 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Brain | rep_4 | 6.4e-19 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Brain | rep_4 | 3.5e-20 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Brain | rep_4 | 3.7e-62 |
| Creg1 | GOBP_Growth | Mouse | Brain | HP_ad_rep7 | 3.9e-09 |
| Creg1 | GOBP_Myeloid_Leukocyte_Mediated_Immunity | Mouse | Brain | HP_ad_rep7 | 4.4e-14 |
| Creg1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | HP_ad_rep7 | 3.3e-12 |
| Creg1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 5.9e-11 |
| Creg1 | GOBP_Regulation_Of_Growth | Mouse | Brain | HP_ad_rep7 | 5.8e-07 |
| Creg1 | GOBP_Secretion | Mouse | Brain | HP_ad_rep7 | 1.6e-08 |
| Creg1 | GOBP_Cell_Activation | Mouse | Brain | HP_polb_rep9 | 1.5e-08 |
| Creg1 | GOBP_Cell_Activation_Involved_In_Immune_Response | Mouse | Brain | HP_polb_rep9 | 8.8e-09 |
| Creg1 | GOBP_Exocytosis | Mouse | Brain | HP_polb_rep9 | 2.3e-13 |
| Creg1 | GOBP_Immune_Effector_Process | Mouse | Brain | HP_polb_rep9 | 1.0e-08 |
| Creg1 | GOBP_Leukocyte_Mediated_Immunity | Mouse | Brain | HP_polb_rep9 | 2.8e-07 |
| Creg1 | GOBP_Myeloid_Leukocyte_Activation | Mouse | Brain | HP_polb_rep9 | 2.6e-11 |
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Creg1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Creg1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Creg1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Creg1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Creg1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Creg1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Creg1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Creg1 | C1135196 | Heart Failure, Diastolic | 1 | CTD_human |
