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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tbc1d2 (spascer ID:381605)

Gene summary for Tbc1d2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tbc1d2
	Gene ID	381605
	Gene name	TBC1 domain family, member 2
	Synonyms	A630005A06Rik\|BC022630\|Gm1037\|PARIS-1\|PARIS1
	Cytomap	4\|4 B1
	Type of gene	protein-coding
	Description	TBC1 domain family member 2Alikely ortholog of H. sapiens TBC1 domain family, member 2 (TBC1D2)
	Modification date	20220424
	UniProtAcc	B1AVH7

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tbc1d2	GO:0005096	GTPase activator activity	21873635	Function
Tbc1d2	GO:0090630	activation of GTPase activity	21873635	Process

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Spatial pattern events for Tbc1d2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tbc1d2	Mouse	Kidney	CLP	34003797	2.19e-15
Tbc1d2	Mouse	Kidney	IRI	34003797	2.29e-15
Tbc1d2	Mouse	Kidney	Sham	34003797	3.07e-12
Tbc1d2	Mouse	Kidney	rep_5	34853151	1.73e-11
Tbc1d2	Mouse	Intestine	rep_1	35149721	3.66e-07
Tbc1d2	Mouse	Intestine	rep_3	35149721	5.21e-15
Tbc1d2	Mouse	Intestine	rep_4	35149721	3.90e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_5_H&E

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Spatial pattern pathway has Tbc1d2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tbc1d2	GOBP_Activation_Of_Gtpase_Activity	Mouse	Spinal cord	CN93_D2	2.8e-06
Tbc1d2	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Tbc1d2	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Tbc1d2	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Tbc1d2	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Tbc1d2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Spinal cord	L7CN45_C1	7.5e-06
Tbc1d2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	1.8e-08
Tbc1d2	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Tbc1d2	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_27	4.2e-05
Tbc1d2	GOBP_Activation_Of_Gtpase_Activity	Mouse	Brain	rep_1	4.7e-17
Tbc1d2	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Tbc1d2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	2.1e-36
Tbc1d2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_1	1.0e-11
Tbc1d2	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	5.6e-32
Tbc1d2	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Tbc1d2	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Tbc1d2	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Tbc1d2	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	1.4e-120
Tbc1d2	GOBP_Activation_Of_Gtpase_Activity	Mouse	Embryo	rep_14	1.4e-30
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	8.5e-07
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Tbc1d2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_1	1.6e-15
Tbc1d2	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Tbc1d2	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Tbc1d2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.4e-48
Tbc1d2	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.3e-36
Tbc1d2	GOBP_Activation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	2.2e-104
Tbc1d2	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Tbc1d2	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Tbc1d2	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Tbc1d2	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Tbc1d2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	2.1e-81
Tbc1d2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	3.6e-50
Tbc1d2	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Tbc1d2	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	1.2e-71
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	1.4e-60
Tbc1d2	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Liver	CN16-D2	1.9e-10
Tbc1d2	GOBP_Activation_Of_Gtpase_Activity	Mouse	Lymph	MS-1	1.2e-11
Tbc1d2	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Tbc1d2	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Tbc1d2	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Tbc1d2	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Tbc1d2	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	1.9e-08
Tbc1d2	GOBP_Activation_Of_Gtpase_Activity	Mouse	Brain	rep_4	5.3e-15
Tbc1d2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_4	7.8e-12
Tbc1d2	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Tbc1d2	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Tbc1d2	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Tbc1d2	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Tbc1d2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Tbc1d2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_ad_rep7	4.8e-07
Tbc1d2	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Tbc1d2	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_polb_rep9	4.2e-09
Tbc1d2	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	6.0e-09
Tbc1d2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_wt_rep2	2.1e-07

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Tbc1d2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tbc1d2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tbc1d2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tbc1d2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tbc1d2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Tbc1d2	C0033578	Prostatic Neoplasms	1	CTD_human
Tbc1d2	C0376358	Malignant neoplasm of prostate	1	CTD_human