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Spatial pattern gene: Pon2 (spascer ID:330260) |
Gene summary for Pon2 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Pon2 | Gene ID | 330260 |
| Gene name | paraoxonase 2 |
| Synonyms | 6330405I24Rik|AI481612 |
| Cytomap | 6 A1|6 1.99 cM |
| Type of gene | protein-coding |
| Description | serum paraoxonase/arylesterase 2A-esterase 2aromatic esterase 2serum aryldialkylphosphatase 2 |
| Modification date | 20220424 |
| UniProtAcc | Q62086 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Pon2 | GO:0004064 | arylesterase activity | 21873635 | Function |
| Pon2 | GO:0009636 | response to toxic substance | 21873635 | Process |
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Spatial pattern events for Pon2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Pon2 | Mouse | Brain | S1 | 34413515 | 3.73e-15 |
| Pon2 | Mouse | Brain | S2 | 34413515 | 1.56e-15 |
| Pon2 | Mouse | Brain | S3 | 34413515 | 1.64e-15 |
| Pon2 | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Pon2 | Mouse | Brain | S6 | 34413515 | 1.46e-15 |
| Pon2 | Mouse | Brain | S7 | 34413515 | 2.85e-15 |
| Pon2 | Mouse | Brain | rep_1 | 35141374 | 1.12e-10 |
| Pon2 | Mouse | Brain | rep_2 | 35141374 | 3.05e-15 |
| Pon2 | Mouse | Brain | rep_4 | 35141374 | 5.42e-15 |
| Pon2 | Mouse | Brain | rep_5 | 35141374 | 7.13e-10 |
| Pon2 | Mouse | Embryo | rep_4 | 33188776 | 3.93e-10 |
| Pon2 | Mouse | Kidney | CLP | 34003797 | 6.92e-15 |
| Pon2 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Pon2 | Mouse | Brain | rep_1 | 35027729 | 1.24e-11 |
| Pon2 | Mouse | Brain | rep_2 | 35027729 | 1.57e-15 |
| Pon2 | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Pon2 | Mouse | Brain | rep_4 | 35027729 | 2.19e-13 |
| Pon2 | Mouse | Brain | rep_5 | 35027729 | 2.62e-15 |
| Pon2 | Mouse | Intestine | rep_1 | 35149721 | 6.08e-15 |
| Pon2 | Mouse | Intestine | rep_2 | 35149721 | 3.44e-15 |
| Pon2 | Mouse | Intestine | rep_3 | 35149721 | 3.25e-15 |
| Pon2 | Mouse | Intestine | rep_4 | 35149721 | 2.30e-15 |
| Pon2 | Mouse | Lymph | A1 | 0 | 3.29e-15 |
| Pon2 | Mouse | Lymph | B1 | 0 | 2.07e-13 |
| Pon2 | Mouse | Brain | rep_1 | 35210624 | 1.74e-15 |
| Pon2 | Mouse | Brain | rep_2 | 35210624 | 7.72e-08 |
| Pon2 | Mouse | Brain | rep_3 | 35210624 | 5.48e-14 |
| Pon2 | Mouse | Brain | rep_5 | 35210624 | 7.81e-09 |
| Pon2 | Mouse | Brain | rep_7 | 35210624 | 9.74e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Kidney_CLP_H&E  |  |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
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Spatial pattern pathway has Pon2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Pon2 | GOBP_Cellular_Lipid_Metabolic_Process | Mouse | Spinal cord | L7bCN02_E1 | 3.7e-06 |
| Pon2 | GOBP_Lipid_Metabolic_Process | Mouse | Spinal cord | L7bCN02_E1 | 8.9e-07 |
| Pon2 | GOBP_Organic_Acid_Metabolic_Process | Mouse | Spinal cord | L7bCN02_E1 | 7.1e-06 |
| Pon2 | GOBP_Fatty_Acid_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 6.6e-10 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 7.8e-08 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 6.2e-09 |
| Pon2 | GOBP_Response_To_Toxic_Substance | Mouse | Spinal cord | L7CN45_C1 | 2.1e-08 |
| Pon2 | GOBP_Small_Molecule_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 1.7e-07 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Spinal cord | L7CN97_E2 | 1.9e-06 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Brain | rep_71 | 8.1e-05 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Brain | rep_1 | 2.0e-09 |
| Pon2 | GOBP_Fatty_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 1.5e-41 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Brain | rep_3 | 6.5e-27 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 3.2e-119 |
| Pon2 | GOBP_Organic_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 1.5e-154 |
| Pon2 | GOBP_Small_Molecule_Metabolic_Process | Mouse | Brain | rep_3 | 2.7e-19 |
| Pon2 | GOBP_Response_To_Toxic_Substance | Mouse | Embryo | rep_6 | 8.4e-07 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Embryo | rep_14 | 3.7e-32 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Embryo | rep_14 | 3.7e-43 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Embryo | rep_14 | 7.3e-13 |
| Pon2 | GOBP_Lipid_Metabolic_Process | Mouse | Embryo | rep_1 | 2.1e-39 |
| Pon2 | GOBP_Small_Molecule_Metabolic_Process | Mouse | Embryo | rep_1 | 1.4e-55 |
| Pon2 | GOBP_Fatty_Acid_Metabolic_Process | Mouse | Embryo | rep_3 | 1.7e-52 |
| Pon2 | GOBP_Organic_Acid_Metabolic_Process | Mouse | Embryo | rep_3 | 1.4e-07 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Embryo | rep_4 | 0.0e+00 |
| Pon2 | GOBP_Lipid_Metabolic_Process | Mouse | Kidney | Nep | 4.2e-26 |
| Pon2 | GOBP_Cellular_Lipid_Metabolic_Process | Mouse | Kidney | rep_2 | 7.4e-43 |
| Pon2 | GOBP_Fatty_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 2.1e-55 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Kidney | rep_2 | 8.7e-25 |
| Pon2 | GOBP_Lipid_Metabolic_Process | Mouse | Kidney | rep_2 | 1.4e-78 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Kidney | rep_2 | 1.1e-141 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 4.4e-73 |
| Pon2 | GOBP_Organic_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 3.8e-62 |
| Pon2 | GOBP_Response_To_Toxic_Substance | Mouse | Kidney | rep_2 | 1.3e-34 |
| Pon2 | GOBP_Small_Molecule_Metabolic_Process | Mouse | Kidney | rep_2 | 1.8e-43 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Liver | CN16-D1 | 4.3e-14 |
| Pon2 | GOBP_Cellular_Lipid_Metabolic_Process | Mouse | Liver | CN73-C1 | 9.9e-09 |
| Pon2 | GOBP_Fatty_Acid_Metabolic_Process | Mouse | Intestine | rep_2 | 3.9e-25 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Intestine | rep_2 | 4.6e-106 |
| Pon2 | GOBP_Cellular_Lipid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.1e-14 |
| Pon2 | GOBP_Fatty_Acid_Metabolic_Process | Mouse | Lymph | MS-1 | 8.4e-16 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.3e-21 |
| Pon2 | GOBP_Lipid_Metabolic_Process | Mouse | Lymph | MS-1 | 9.7e-11 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Lymph | MS-1 | 7.8e-13 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.3e-15 |
| Pon2 | GOBP_Organic_Acid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.3e-15 |
| Pon2 | GOBP_Small_Molecule_Metabolic_Process | Mouse | Lymph | MS-1 | 2.6e-11 |
| Pon2 | GOBP_Response_To_Toxic_Substance | Mouse | Lung | rep_1 | 3.0e-08 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Brain | rep_4 | 4.1e-41 |
| Pon2 | GOBP_Organic_Acid_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 4.1e-08 |
| Pon2 | GOBP_Icosanoid_Metabolic_Process | Mouse | Brain | HP_ad_rep8 | 2.5e-07 |
| Pon2 | GOBP_Lipoxygenase_Pathway | Mouse | Brain | HP_ad_rep8 | 8.5e-09 |
| Pon2 | GOBP_Cellular_Lipid_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 2.9e-07 |
| Pon2 | GOBP_Lipid_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 9.9e-11 |
| Pon2 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 1.7e-11 |
| Pon2 | GOBP_Small_Molecule_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 2.0e-09 |
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Pon2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Pon2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication | ||
| Pon2 | Htr2a | Pon2_Htr2a | Brain | rep_1 |
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Transcription factor for Pon2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Pon2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Pon2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Pon2 | C0002736 | Amyotrophic Lateral Sclerosis | 2 | ORPHANET |
| Pon2 | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Pon2 | C0020445 | Hypercholesterolemia, Familial | 1 | CTD_human |
| Pon2 | C0745103 | Hyperlipoproteinemia Type IIa | 1 | CTD_human |
| Pon2 | C1704417 | Hyperlipoproteinemia Type IIb | 1 | CTD_human |
