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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tmem117 (spascer ID:320709)

Gene summary for Tmem117

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tmem117
	Gene ID	320709
	Gene name	transmembrane protein 117
	Synonyms	B930062P21Rik
	Cytomap	15\|15 E3
	Type of gene	protein-coding
	Description	transmembrane protein 117
	Modification date	20220424
	UniProtAcc	Q8BH18

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tmem117	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	21873635	Process

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Spatial pattern events for Tmem117

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tmem117	Mouse	Brain	S1	34413515	2.07e-15
Tmem117	Mouse	Brain	S2	34413515	1.56e-15
Tmem117	Mouse	Brain	S3	34413515	2.96e-15
Tmem117	Mouse	Brain	S4	34413515	1.37e-15
Tmem117	Mouse	Brain	S6	34413515	1.46e-15
Tmem117	Mouse	Brain	S7	34413515	1.55e-15
Tmem117	Mouse	Brain	22A	32637622	5.40e-06
Tmem117	Mouse	Brain	26A	32637622	3.87e-07
Tmem117	Mouse	Brain	27A	32637622	9.57e-07
Tmem117	Mouse	Brain	27B	32637622	1.05e-06
Tmem117	Mouse	Kidney	CLP	34003797	1.34e-07
Tmem117	Mouse	Brain	rep_1	33469025	1.30e-15
Tmem117	Mouse	Brain	rep_1	35027729	1.66e-15
Tmem117	Mouse	Brain	rep_3	35027729	2.38e-15
Tmem117	Mouse	Brain	rep_4	35027729	1.76e-15
Tmem117	Mouse	Brain	rep_5	35027729	1.46e-15
Tmem117	Mouse	Brain	rep_1	35210624	1.74e-15
Tmem117	Mouse	Brain	rep_2	35210624	1.74e-15
Tmem117	Mouse	Brain	rep_3	35210624	1.82e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Tmem117 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Spinal cord	CN94_E1	1.7e-06
Tmem117	GOBP_Apoptotic_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Tmem117	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Tmem117	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	3.7e-187
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	1.4e-174
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	rep_3	5.0e-93
Tmem117	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	rep_3	6.3e-133
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_14	6.3e-15
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Embryo	rep_14	1.2e-36
Tmem117	GOBP_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	2.2e-45
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	0.0e+00
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Embryo	rep_3	2.0e-11
Tmem117	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Embryo	rep_3	1.8e-13
Tmem117	GOBP_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	1.1e-44
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	3.8e-88
Tmem117	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Kidney	rep_2	1.2e-89
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Liver	CN16-D2	6.1e-08
Tmem117	GOBP_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	1.2e-12
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	2.5e-14
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Lymph	MS-1	1.4e-09
Tmem117	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Lymph	MS-1	1.7e-11
Tmem117	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	3.2e-07
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	2.7e-09
Tmem117	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	HP_polb_rep9	2.0e-19
Tmem117	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	HP_polb_rep9	3.5e-12

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Tmem117 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tmem117 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tmem117 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tmem117

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tmem117

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Tmem117	C0008370	Cholestasis	1	CTD_human
Tmem117	C0019193	Hepatitis, Toxic	1	CTD_human
Tmem117	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tmem117	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tmem117	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tmem117	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tmem117	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human