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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Ecsit (spascer ID:26940)

Gene summary for Ecsit

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Ecsit
	Gene ID	26940
	Gene name	ECSIT signalling integrator
	Synonyms	Sitpec
	Cytomap	9\|9 A3
	Type of gene	protein-coding
	Description	evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT homologsignaling intermediate in Toll pathway-evolutionarily conserved
	Modification date	20220424
	UniProtAcc	Q9QZH6

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Ecsit	GO:0005739	mitochondrion	21873635	Component

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Spatial pattern events for Ecsit

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Ecsit	Mouse	Brain	rep_3	35141374	5.43e-09
Ecsit	Mouse	Kidney	IRI	34003797	1.04e-11
Ecsit	Mouse	Brain	rep_1	33469025	3.43e-11
Ecsit	Mouse	Brain	rep_2	35210624	3.78e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_3_H&E
Kidney_IRI_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Ecsit envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Ecsit	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Spinal cord	L7bCN01_D2	9.2e-06
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Ecsit	GOBP_Regulation_Of_Protein_Complex_Stability	Mouse	Spinal cord	L7CN45_C1	7.0e-08
Ecsit	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Spinal cord	L7CN47_D1	3.7e-06
Ecsit	GOBP_Nadh_Dehydrogenase_Complex_Assembly	Mouse	Spinal cord	L7CN47_D1	2.6e-06
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Spinal cord	L7CN97_E2	7.9e-07
Ecsit	GOBP_Innate_Immune_Response	Mouse	Spinal cord	L7CN97_E2	2.7e-06
Ecsit	GOBP_Defense_Response	Mouse	Spinal cord	L8CN11_C1	3.3e-17
Ecsit	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Brain	rep_71	2.8e-06
Ecsit	GOBP_Nadh_Dehydrogenase_Complex_Assembly	Mouse	Brain	rep_71	3.5e-06
Ecsit	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Brain	rep_1	5.0e-26
Ecsit	GOBP_Nadh_Dehydrogenase_Complex_Assembly	Mouse	Brain	rep_1	9.2e-45
Ecsit	GOBP_Defense_Response	Mouse	Brain	rep_3	8.7e-77
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	rep_3	6.0e-105
Ecsit	GOBP_Innate_Immune_Response	Mouse	Brain	rep_3	7.5e-97
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Brain	rep_3	1.3e-89
Ecsit	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Brain	rep_3	5.1e-114
Ecsit	GOBP_Regulation_Of_Protein_Complex_Stability	Mouse	Brain	rep_3	9.8e-168
Ecsit	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Embryo	rep_14	5.0e-27
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Embryo	rep_14	1.8e-11
Ecsit	GOBP_Nadh_Dehydrogenase_Complex_Assembly	Mouse	Embryo	rep_14	2.8e-58
Ecsit	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Embryo	rep_14	3.5e-10
Ecsit	GOBP_Regulation_Of_Protein_Complex_Stability	Mouse	Embryo	rep_14	1.4e-56
Ecsit	GOBP_Defense_Response	Mouse	Embryo	rep_1	5.2e-63
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Embryo	rep_3	2.6e-164
Ecsit	GOBP_Innate_Immune_Response	Mouse	Embryo	rep_3	2.0e-259
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Embryo	rep_3	4.0e-48
Ecsit	GOBP_Defense_Response	Mouse	Kidney	rep_2	6.8e-127
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Kidney	rep_2	2.3e-129
Ecsit	GOBP_Innate_Immune_Response	Mouse	Kidney	rep_2	3.1e-117
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Kidney	rep_2	1.7e-21
Ecsit	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Kidney	rep_2	1.9e-89
Ecsit	GOBP_Defense_Response	Mouse	Liver	rep_16	8.0e-16
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Liver	rep_16	1.8e-13
Ecsit	GOBP_Innate_Immune_Response	Mouse	Liver	rep_16	5.5e-09
Ecsit	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Liver	rep_16	4.3e-23
Ecsit	GOBP_Nadh_Dehydrogenase_Complex_Assembly	Mouse	Liver	rep_16	3.7e-23
Ecsit	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Liver	rep_16	6.1e-07
Ecsit	GOBP_Defense_Response	Mouse	Lymph	MS-1	8.6e-18
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Lymph	MS-1	6.7e-20
Ecsit	GOBP_Innate_Immune_Response	Mouse	Lymph	MS-1	6.7e-20
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Lymph	MS-1	4.2e-09
Ecsit	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Lymph	MS-1	2.3e-08
Ecsit	GOBP_Defense_Response	Mouse	Brain	HP_ad_rep7	5.6e-10
Ecsit	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	HP_polb_rep9	2.1e-11
Ecsit	GOBP_Innate_Immune_Response	Mouse	Brain	HP_polb_rep9	3.9e-11
Ecsit	GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly	Mouse	Brain	HP_polb_rep9	7.2e-14
Ecsit	GOBP_Mitochondrion_Organization	Mouse	Brain	HP_polb_rep9	1.2e-11
Ecsit	GOBP_Nadh_Dehydrogenase_Complex_Assembly	Mouse	Brain	HP_polb_rep9	1.3e-07
Ecsit	GOBP_Regulation_Of_Protein_Complex_Stability	Mouse	Brain	HP_polb_rep9	2.5e-11

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Ecsit function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Ecsit function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Ecsit envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Ecsit

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Ecsit

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Ecsit	C3495676	Anorectal Malformations	1	GENOMICS_ENGLAND