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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Ppp2r5c (spascer ID:26931)

Gene summary for Ppp2r5c

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Ppp2r5c

Gene ID

26931

Gene nameprotein phosphatase 2, regulatory subunit B', gamma
Synonyms2610043M05Rik|2700063L20Rik|AI060890|AW545884|C85228|D12Bwg0916e
Cytomap12 F1|12 60.56 cM
Type of geneprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB56/PP2A gammaBand 8A
Modification date20220424
UniProtAcc

Q60996


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Ppp2r5c

GO:0000159

protein phosphatase type 2A complex

21873635

Component
Ppp2r5c

GO:0005634

nucleus

21873635

Component
Ppp2r5c

GO:0005829

cytosol

21873635

Component
Ppp2r5c

GO:0006470

protein dephosphorylation

21873635

Process
Ppp2r5c

GO:0072542

protein phosphatase activator activity

21873635

Function

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Spatial pattern events for Ppp2r5c

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Ppp2r5cMouseBrainS2 344135155.44e-15
Ppp2r5cMouseBrainS3 344135151.98e-06
Ppp2r5cMouseBrainS4 344135151.37e-15
Ppp2r5cMouseBrainS6 344135151.46e-15
Ppp2r5cMouseBrainS7 344135153.22e-14
Ppp2r5cMouseBrainrep_1 351413746.80e-15
Ppp2r5cMouseBrainrep_2 351413741.69e-15
Ppp2r5cMouseBrainrep_3 351413741.64e-15
Ppp2r5cMouseBrainrep_4 351413741.57e-15
Ppp2r5cMouseBrainrep_5 351413741.47e-15
Ppp2r5cMouseBrainrep_6 351413745.96e-15
Ppp2r5cMouseKidneyIRI 340037971.79e-08
Ppp2r5cMouseKidneyrep_3 348531515.30e-06
Ppp2r5cMouseBrainrep_1 334690253.84e-07
Ppp2r5cMouseBrainrep_1 350277295.64e-15
Ppp2r5cMouseBrainrep_2 350277291.57e-15
Ppp2r5cMouseBrainrep_3 350277291.32e-15
Ppp2r5cMouseBrainrep_4 350277294.01e-14
Ppp2r5cMouseBrainrep_5 350277291.46e-15
Ppp2r5cMouseLymphA1 09.68e-09
Ppp2r5cMouseLungrep_3 352908012.37e-06

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_rep_6_H&E
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Kidney_IRI_H&E
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Kidney_rep_3_H&E
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Brain_rep_1_H&E
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Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Lung_rep_3_H&E
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Spatial pattern pathway has Ppp2r5c envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Ppp2r5cGOBP_Regulation_Of_Protein_DephosphorylationMouseSpinal cordCN93_D2 6.8e-06
Ppp2r5cGOBP_Protein_DephosphorylationMouseSpinal cordCN94_E1 5.2e-07
Ppp2r5cGOBP_Regulation_Of_Phosphatase_ActivityMouseSpinal cordCN94_E1 1.6e-06
Ppp2r5cGOBP_Regulation_Of_Phosphoprotein_Phosphatase_ActivityMouseSpinal cordCN94_E1 5.2e-08
Ppp2r5cGOBP_Regulation_Of_Protein_AutophosphorylationMouseSpinal cordCN94_E1 9.1e-08
Ppp2r5cGOBP_DephosphorylationMouseSpinal cordL7CN45_C1 3.3e-07
Ppp2r5cGOBP_Inositol_Lipid_Mediated_SignalingMouseSpinal cordL7CN45_C1 8.8e-10
Ppp2r5cGOBP_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 7.5e-06
Ppp2r5cGOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseSpinal cordL7CN45_C1 2.7e-07
Ppp2r5cGOBP_Negative_Regulation_Of_Cell_Population_ProliferationMouseSpinal cordL7CN45_C1 1.3e-08
Ppp2r5cGOBP_Organonitrogen_Compound_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.1e-08
Ppp2r5cGOBP_Phosphatidylinositol_3_Kinase_SignalingMouseSpinal cordL7CN45_C1 2.0e-07
Ppp2r5cGOBP_Protein_AutophosphorylationMouseSpinal cordL7CN45_C1 3.8e-08
Ppp2r5cGOBP_Protein_Catabolic_ProcessMouseSpinal cordL7CN45_C1 5.6e-06
Ppp2r5cGOBP_Protein_Kinase_B_SignalingMouseSpinal cordL7CN45_C1 4.2e-06
Ppp2r5cGOBP_ProteolysisMouseSpinal cordL7CN45_C1 1.1e-06
Ppp2r5cGOBP_Regulation_Of_DephosphorylationMouseSpinal cordL7CN45_C1 1.4e-06
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseSpinal cordL7CN45_C1 2.3e-07
Ppp2r5cGOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_SignalingMouseSpinal cordL7CN45_C1 1.7e-07
Ppp2r5cGOBP_Regulation_Of_Protein_Modification_ProcessMouseSpinal cordL7CN45_C1 4.2e-07
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseSpinal cordL7CN45_C1 5.6e-06
Ppp2r5cGOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseSpinal cordL8CN11_C1 3.6e-13
Ppp2r5cGOBP_Regulation_Of_Intracellular_Signal_TransductionMouseSpinal cordL8CN11_D1 5.6e-09
Ppp2r5cGOBP_Negative_Regulation_Of_SignalingMouseSpinal cordL8CN17_E1 8.3e-06
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseBrainrep_27 5.2e-05
Ppp2r5cGOBP_DephosphorylationMouseBrainrep_1 1.5e-40
Ppp2r5cGOBP_Protein_AutophosphorylationMouseBrainrep_1 1.5e-46
Ppp2r5cGOBP_Protein_DephosphorylationMouseBrainrep_1 1.0e-26
Ppp2r5cGOBP_Regulation_Of_DephosphorylationMouseBrainrep_1 1.4e-28
Ppp2r5cGOBP_Regulation_Of_Phosphatase_ActivityMouseBrainrep_1 2.0e-14
Ppp2r5cGOBP_Regulation_Of_Phosphoprotein_Phosphatase_ActivityMouseBrainrep_1 2.0e-07
Ppp2r5cGOBP_Regulation_Of_Protein_AutophosphorylationMouseBrainrep_1 8.5e-65
Ppp2r5cGOBP_Regulation_Of_Protein_DephosphorylationMouseBrainrep_1 8.8e-22
Ppp2r5cGOBP_Cellular_Protein_Catabolic_ProcessMouseBrainrep_32.9e-162
Ppp2r5cGOBP_Inositol_Lipid_Mediated_SignalingMouseBrainrep_3 6.4e-57
Ppp2r5cGOBP_Macromolecule_Catabolic_ProcessMouseBrainrep_31.7e-159
Ppp2r5cGOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainrep_38.7e-167
Ppp2r5cGOBP_Negative_Regulation_Of_Cell_Population_ProliferationMouseBrainrep_31.6e-104
Ppp2r5cGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseBrainrep_39.2e-120
Ppp2r5cGOBP_Negative_Regulation_Of_Protein_Kinase_B_SignalingMouseBrainrep_36.0e-108
Ppp2r5cGOBP_Negative_Regulation_Of_Response_To_StimulusMouseBrainrep_31.3e-138
Ppp2r5cGOBP_Negative_Regulation_Of_SignalingMouseBrainrep_37.8e-106
Ppp2r5cGOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainrep_37.1e-166
Ppp2r5cGOBP_Phosphatidylinositol_3_Kinase_SignalingMouseBrainrep_3 2.0e-77
Ppp2r5cGOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainrep_32.9e-169
Ppp2r5cGOBP_Protein_Catabolic_ProcessMouseBrainrep_33.0e-174
Ppp2r5cGOBP_Protein_Kinase_B_SignalingMouseBrainrep_32.0e-104
Ppp2r5cGOBP_ProteolysisMouseBrainrep_31.8e-168
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseBrainrep_31.4e-120
Ppp2r5cGOBP_Regulation_Of_Intracellular_Signal_TransductionMouseBrainrep_31.3e-132
Ppp2r5cGOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_SignalingMouseBrainrep_3 4.9e-99
Ppp2r5cGOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainrep_3 3.0e-62
Ppp2r5cGOBP_Regulation_Of_Protein_Modification_ProcessMouseBrainrep_32.2e-188
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseBrainrep_3 8.6e-94
Ppp2r5cGOBP_Negative_Regulation_Of_Protein_Kinase_B_SignalingMouseEmbryorep_14 2.2e-46
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseEmbryorep_14 8.5e-07
Ppp2r5cGOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_SignalingMouseEmbryorep_14 2.2e-08
Ppp2r5cGOBP_Regulation_Of_Phosphoprotein_Phosphatase_ActivityMouseEmbryorep_14 6.3e-12
Ppp2r5cGOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseEmbryorep_1 7.5e-10
Ppp2r5cGOBP_Negative_Regulation_Of_Cell_Population_ProliferationMouseEmbryorep_13.5e-170
Ppp2r5cGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseEmbryorep_1 1.0e-64
Ppp2r5cGOBP_Negative_Regulation_Of_Response_To_StimulusMouseEmbryorep_1 1.1e-25
Ppp2r5cGOBP_Negative_Regulation_Of_SignalingMouseEmbryorep_1 5.6e-10
Ppp2r5cGOBP_Organonitrogen_Compound_Catabolic_ProcessMouseEmbryorep_1 5.7e-21
Ppp2r5cGOBP_Protein_Catabolic_ProcessMouseEmbryorep_1 4.1e-19
Ppp2r5cGOBP_Protein_DephosphorylationMouseEmbryorep_1 1.2e-29
Ppp2r5cGOBP_Inositol_Lipid_Mediated_SignalingMouseEmbryorep_3 6.5e-43
Ppp2r5cGOBP_Phosphatidylinositol_3_Kinase_SignalingMouseEmbryorep_3 6.5e-43
Ppp2r5cGOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_SignalingMouseEmbryorep_3 4.8e-34
Ppp2r5cGOBP_Protein_AutophosphorylationMouseEmbryorep_6 9.9e-40
Ppp2r5cGOBP_Protein_Kinase_B_SignalingMouseKidneyNep 5.3e-07
Ppp2r5cGOBP_ProteolysisMouseKidneyNep 6.8e-23
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseKidneyNep 1.3e-36
Ppp2r5cGOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseKidneyNep 4.6e-22
Ppp2r5cGOBP_Regulation_Of_Protein_Modification_ProcessMouseKidneyNep 4.6e-22
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseKidneyNep 4.6e-22
Ppp2r5cGOBP_Cellular_Protein_Catabolic_ProcessMouseKidneyrep_2 3.2e-21
Ppp2r5cGOBP_DephosphorylationMouseKidneyrep_2 1.4e-90
Ppp2r5cGOBP_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 7.0e-40
Ppp2r5cGOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseKidneyrep_2 1.0e-26
Ppp2r5cGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseKidneyrep_2 9.1e-83
Ppp2r5cGOBP_Negative_Regulation_Of_Protein_Kinase_B_SignalingMouseKidneyrep_2 2.4e-42
Ppp2r5cGOBP_Negative_Regulation_Of_Response_To_StimulusMouseKidneyrep_2 1.7e-39
Ppp2r5cGOBP_Negative_Regulation_Of_SignalingMouseKidneyrep_2 4.0e-40
Ppp2r5cGOBP_Organonitrogen_Compound_Catabolic_ProcessMouseKidneyrep_2 1.2e-14
Ppp2r5cGOBP_Proteasomal_Protein_Catabolic_ProcessMouseKidneyrep_2 5.3e-33
Ppp2r5cGOBP_Protein_AutophosphorylationMouseKidneyrep_2 7.6e-46
Ppp2r5cGOBP_Protein_Catabolic_ProcessMouseKidneyrep_2 7.3e-30
Ppp2r5cGOBP_Protein_DephosphorylationMouseKidneyrep_2 2.0e-69
Ppp2r5cGOBP_ProteolysisMouseKidneyrep_26.0e-106
Ppp2r5cGOBP_Regulation_Of_DephosphorylationMouseKidneyrep_2 1.8e-67
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseKidneyrep_2 1.4e-60
Ppp2r5cGOBP_Regulation_Of_Intracellular_Signal_TransductionMouseKidneyrep_2 1.4e-17
Ppp2r5cGOBP_Regulation_Of_Phosphatase_ActivityMouseKidneyrep_2 2.5e-75
Ppp2r5cGOBP_Regulation_Of_Phosphoprotein_Phosphatase_ActivityMouseKidneyrep_2 8.2e-73
Ppp2r5cGOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseKidneyrep_2 1.3e-41
Ppp2r5cGOBP_Regulation_Of_Protein_DephosphorylationMouseKidneyrep_2 1.4e-61
Ppp2r5cGOBP_Regulation_Of_Protein_Modification_ProcessMouseKidneyrep_2 2.2e-44
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseKidneyrep_2 1.8e-44
Ppp2r5cGOBP_Regulation_Of_DephosphorylationMouseLiverCN16-E1 1.3e-11
Ppp2r5cGOBP_Regulation_Of_Protein_DephosphorylationMouseLiverCN16-E1 9.7e-13
Ppp2r5cGOBP_Protein_Kinase_B_SignalingMouseLiverrep_26 1.6e-10
Ppp2r5cGOBP_Cellular_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Ppp2r5cGOBP_DephosphorylationMouseLymphMS-1 3.6e-12
Ppp2r5cGOBP_Inositol_Lipid_Mediated_SignalingMouseLymphMS-1 5.3e-12
Ppp2r5cGOBP_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Ppp2r5cGOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Ppp2r5cGOBP_Negative_Regulation_Of_Cell_Population_ProliferationMouseLymphMS-1 5.6e-14
Ppp2r5cGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseLymphMS-1 1.5e-16
Ppp2r5cGOBP_Negative_Regulation_Of_Protein_Kinase_B_SignalingMouseLymphMS-1 3.7e-07
Ppp2r5cGOBP_Negative_Regulation_Of_Response_To_StimulusMouseLymphMS-1 1.5e-11
Ppp2r5cGOBP_Negative_Regulation_Of_SignalingMouseLymphMS-1 1.0e-14
Ppp2r5cGOBP_Organonitrogen_Compound_Catabolic_ProcessMouseLymphMS-1 1.2e-13
Ppp2r5cGOBP_Phosphatidylinositol_3_Kinase_SignalingMouseLymphMS-1 5.9e-11
Ppp2r5cGOBP_Protein_AutophosphorylationMouseLymphMS-1 3.0e-10
Ppp2r5cGOBP_Protein_Catabolic_ProcessMouseLymphMS-1 1.1e-11
Ppp2r5cGOBP_Protein_DephosphorylationMouseLymphMS-1 2.7e-12
Ppp2r5cGOBP_ProteolysisMouseLymphMS-1 2.8e-10
Ppp2r5cGOBP_Regulation_Of_DephosphorylationMouseLymphMS-1 3.0e-12
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseLymphMS-1 1.9e-08
Ppp2r5cGOBP_Regulation_Of_Intracellular_Signal_TransductionMouseLymphMS-1 1.0e-14
Ppp2r5cGOBP_Regulation_Of_Phosphatase_ActivityMouseLymphMS-1 6.8e-12
Ppp2r5cGOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_SignalingMouseLymphMS-1 1.5e-10
Ppp2r5cGOBP_Regulation_Of_Phosphoprotein_Phosphatase_ActivityMouseLymphMS-1 4.9e-09
Ppp2r5cGOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseLymphMS-1 5.6e-12
Ppp2r5cGOBP_Regulation_Of_Protein_DephosphorylationMouseLymphMS-1 1.1e-09
Ppp2r5cGOBP_Regulation_Of_Protein_Modification_ProcessMouseLymphMS-1 1.9e-12
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseLymphMS-1 1.4e-12
Ppp2r5cGOBP_Macromolecule_Catabolic_ProcessMouseLungrep_1 2.0e-21
Ppp2r5cGOBP_DephosphorylationMouseBrainHP_ad_rep7 3.9e-08
Ppp2r5cGOBP_Inositol_Lipid_Mediated_SignalingMouseBrainHP_ad_rep7 4.4e-12
Ppp2r5cGOBP_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-09
Ppp2r5cGOBP_Modification_Dependent_Macromolecule_Catabolic_ProcessMouseBrainHP_ad_rep7 1.3e-08
Ppp2r5cGOBP_Negative_Regulation_Of_Protein_Kinase_B_SignalingMouseBrainHP_ad_rep7 3.7e-14
Ppp2r5cGOBP_Organonitrogen_Compound_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Ppp2r5cGOBP_Phosphatidylinositol_3_Kinase_SignalingMouseBrainHP_ad_rep7 6.8e-07
Ppp2r5cGOBP_Protein_AutophosphorylationMouseBrainHP_ad_rep7 5.6e-08
Ppp2r5cGOBP_Protein_Catabolic_ProcessMouseBrainHP_ad_rep7 3.3e-07
Ppp2r5cGOBP_ProteolysisMouseBrainHP_ad_rep7 3.3e-07
Ppp2r5cGOBP_Regulation_Of_Phosphatase_ActivityMouseBrainHP_ad_rep7 4.1e-07
Ppp2r5cGOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_SignalingMouseBrainHP_ad_rep7 2.4e-07
Ppp2r5cGOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainHP_ad_rep7 1.7e-08
Ppp2r5cGOBP_Regulation_Of_Protein_Modification_ProcessMouseBrainHP_ad_rep7 1.1e-07
Ppp2r5cGOBP_Regulation_Of_Protein_PhosphorylationMouseBrainHP_ad_rep7 4.0e-09
Ppp2r5cGOBP_Cellular_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 7.2e-07
Ppp2r5cGOBP_Proteasomal_Protein_Catabolic_ProcessMouseBrainHP_adpolb_rep1 1.1e-07
Ppp2r5cGOBP_Negative_Regulation_Of_Cell_Population_ProliferationMouseBrainHP_polb_rep9 2.8e-10
Ppp2r5cGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseBrainHP_polb_rep9 9.4e-11
Ppp2r5cGOBP_Negative_Regulation_Of_Response_To_StimulusMouseBrainHP_polb_rep9 3.1e-09
Ppp2r5cGOBP_Negative_Regulation_Of_SignalingMouseBrainHP_polb_rep9 1.4e-11
Ppp2r5cGOBP_Protein_Kinase_B_SignalingMouseBrainHP_polb_rep9 1.2e-10
Ppp2r5cGOBP_Regulation_Of_Hydrolase_ActivityMouseBrainHP_polb_rep9 6.0e-09
Ppp2r5cGOBP_Regulation_Of_Intracellular_Signal_TransductionMouseBrainHP_polb_rep9 3.9e-11
Ppp2r5cGOBP_Regulation_Of_Phosphoprotein_Phosphatase_ActivityMouseBrainHP_polb_rep9 9.3e-07
Ppp2r5cGOBP_Regulation_Of_Protein_AutophosphorylationMouseBrainHP_polb_rep9 5.2e-07

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Ppp2r5c function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Ppp2r5c function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Ppp2r5c envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Ppp2r5c

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Ppp2r5c

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Ppp2r5cC0023434Chronic Lymphocytic Leukemia1CTD_human
Ppp2r5cC0238463Papillary thyroid carcinoma1CTD_human
Ppp2r5cC1257806Chromosomal Instability1CTD_human
Ppp2r5cC1449861Micronuclei, Chromosome-Defective1CTD_human
Ppp2r5cC1449862Micronuclei, Genotoxicant-Induced1CTD_human
Ppp2r5cC3501843Nonmedullary Thyroid Carcinoma1CTD_human
Ppp2r5cC3501844Familial Nonmedullary Thyroid Cancer1CTD_human