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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Dysf (spascer ID:26903)

Gene summary for Dysf

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Dysf

Gene ID

26903

Gene namedysferlin
Synonyms2310004N10Rik|AI604795|D6Pas3
Cytomap6 C3|6 36.14 cM
Type of geneprotein-coding
Descriptiondysferlindysferlin_adystrophy-associated fer-1-like proteinfer-1-like protein 1
Modification date20220428
UniProtAcc

Q9ESD7


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Dysf

GO:0001778

plasma membrane repair

21873635

Process
Dysf

GO:0002280

monocyte activation involved in immune response

21873635

Process
Dysf

GO:0002281

macrophage activation involved in immune response

21873635

Process
Dysf

GO:0005509

calcium ion binding

21873635

Function
Dysf

GO:0005544

calcium-dependent phospholipid binding

21873635

Function
Dysf

GO:0006906

vesicle fusion

21873635

Process
Dysf

GO:0007009

plasma membrane organization

21873635

Process
Dysf

GO:0030315

T-tubule

21873635

Component
Dysf

GO:0031410

cytoplasmic vesicle

21873635

Component
Dysf

GO:0033292

T-tubule organization

21873635

Process
Dysf

GO:0050765

negative regulation of phagocytosis

21873635

Process
Dysf

GO:0061025

membrane fusion

21873635

Process

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Spatial pattern events for Dysf

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
DysfMouseBrainS2 344135151.23e-06
DysfMouseBrainS6 344135153.51e-13
DysfMouseKidneyCLP 340037973.77e-15
DysfMouseKidneyIRI 340037972.29e-15
DysfMouseKidneySham 340037974.30e-15
DysfMouseBrainrep_1 334690252.37e-15
DysfMouseTesticlerep_2 347316003.10e-15
DysfMouseTesticlerep_3 347316002.29e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Kidney_CLP_H&E
boxplot
boxplot
Kidney_IRI_H&E
boxplot
boxplot
Kidney_Sham_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot


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Spatial pattern pathway has Dysf envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
DysfGOBP_Regulation_Of_PhagocytosisMouseSpinal cordCN93_D2 3.7e-06
DysfGOBP_Monocyte_ActivationMouseSpinal cordCN94_E1 2.2e-08
DysfGOBP_Muscle_Structure_DevelopmentMouseSpinal cordCN94_E1 7.5e-07
DysfGOBP_Plasma_Membrane_OrganizationMouseSpinal cordCN94_E1 3.1e-06
DysfGOBP_Regulation_Of_TransportMouseSpinal cordCN94_E1 5.3e-07
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseSpinal cordCN94_E1 5.3e-06
DysfGOBP_Response_To_WoundingMouseSpinal cordCN94_E1 4.7e-06
DysfGOBP_T_Tubule_OrganizationMouseSpinal cordL7bCN02_E1 3.1e-07
DysfGOBP_Cell_ActivationMouseSpinal cordL7CN45_C1 8.5e-07
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseSpinal cordL7CN45_C1 9.9e-07
DysfGOBP_Endomembrane_System_OrganizationMouseSpinal cordL7CN45_C1 1.0e-06
DysfGOBP_Immune_Effector_ProcessMouseSpinal cordL7CN45_C1 3.1e-07
DysfGOBP_Macrophage_ActivationMouseSpinal cordL7CN45_C1 6.2e-07
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseSpinal cordL7CN45_C1 9.6e-08
DysfGOBP_Membrane_OrganizationMouseSpinal cordL7CN45_C1 2.7e-07
DysfGOBP_Muscle_Cell_DifferentiationMouseSpinal cordL7CN45_C1 5.6e-06
DysfGOBP_Myeloid_Leukocyte_ActivationMouseSpinal cordL7CN45_C1 2.2e-07
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseSpinal cordL7CN45_C1 3.5e-07
DysfGOBP_PhagocytosisMouseSpinal cordL7CN45_C1 8.6e-06
DysfGOBP_Plasma_Membrane_RepairMouseSpinal cordL7CN45_C1 8.6e-09
DysfGOBP_Vesicle_OrganizationMouseSpinal cordL7CN45_C1 7.6e-07
DysfGOBP_Membrane_FusionMouseSpinal cordL7CN47_C1 4.7e-06
DysfGOBP_Muscle_Cell_DevelopmentMouseSpinal cordL7CN47_C1 5.4e-06
DysfGOBP_Organelle_FusionMouseSpinal cordL7CN47_C1 2.3e-06
DysfGOBP_Organelle_Membrane_FusionMouseSpinal cordL7CN47_C1 4.4e-06
DysfGOBP_Wound_HealingMouseSpinal cordL7CN47_C1 8.4e-07
DysfGOBP_Macrophage_ActivationMouseBrainrep_27 4.5e-05
DysfGOBP_Monocyte_ActivationMouseBrainrep_41 3.4e-07
DysfGOBP_Plasma_Membrane_RepairMouseBrainrep_71 2.8e-05
DysfGOBP_Cell_ActivationMouseBrainrep_72 4.6e-06
DysfGOBP_Cell_ActivationMouseBrainrep_1 1.8e-07
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseBrainrep_1 2.6e-13
DysfGOBP_Endomembrane_System_OrganizationMouseBrainrep_1 7.8e-10
DysfGOBP_Immune_Effector_ProcessMouseBrainrep_1 1.5e-12
DysfGOBP_Membrane_FusionMouseBrainrep_1 3.8e-47
DysfGOBP_Muscle_Cell_DevelopmentMouseBrainrep_1 4.8e-19
DysfGOBP_Muscle_Cell_DifferentiationMouseBrainrep_1 2.6e-13
DysfGOBP_Muscle_ContractionMouseBrainrep_1 6.0e-18
DysfGOBP_Muscle_System_ProcessMouseBrainrep_1 8.3e-21
DysfGOBP_Myeloid_Leukocyte_ActivationMouseBrainrep_1 2.1e-07
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseBrainrep_1 3.2e-13
DysfGOBP_Negative_Regulation_Of_TransportMouseBrainrep_1 1.2e-09
DysfGOBP_Organelle_FusionMouseBrainrep_1 1.0e-55
DysfGOBP_Organelle_Membrane_FusionMouseBrainrep_1 1.3e-56
DysfGOBP_PhagocytosisMouseBrainrep_1 1.8e-16
DysfGOBP_Plasma_Membrane_RepairMouseBrainrep_1 8.1e-26
DysfGOBP_Regulation_Of_TransportMouseBrainrep_1 3.9e-15
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseBrainrep_1 5.0e-23
DysfGOBP_T_Tubule_OrganizationMouseBrainrep_1 2.0e-44
DysfGOBP_Vesicle_OrganizationMouseBrainrep_1 7.9e-37
DysfGOBP_Macrophage_ActivationMouseBrainrep_3 1.5e-39
DysfGOBP_Membrane_OrganizationMouseBrainrep_3 1.9e-41
DysfGOBP_Muscle_Structure_DevelopmentMouseBrainrep_3 3.3e-77
DysfGOBP_Plasma_Membrane_OrganizationMouseBrainrep_3 2.3e-56
DysfGOBP_Regulation_Of_PhagocytosisMouseBrainrep_3 1.0e-52
DysfGOBP_Response_To_WoundingMouseBrainrep_36.2e-112
DysfGOBP_Wound_HealingMouseBrainrep_36.2e-109
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseEmbryorep_6 1.4e-16
DysfGOBP_Muscle_Cell_DifferentiationMouseEmbryorep_6 1.6e-07
DysfGOBP_Immune_Effector_ProcessMouseEmbryorep_14 3.3e-15
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseEmbryorep_14 9.3e-26
DysfGOBP_Monocyte_ActivationMouseEmbryorep_14 1.3e-29
DysfGOBP_Muscle_Cell_DevelopmentMouseEmbryorep_14 9.1e-11
DysfGOBP_Muscle_ContractionMouseEmbryorep_14 1.7e-07
DysfGOBP_Myeloid_Leukocyte_ActivationMouseEmbryorep_14 2.9e-28
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseEmbryorep_14 1.6e-39
DysfGOBP_Organelle_Membrane_FusionMouseEmbryorep_14 4.9e-07
DysfGOBP_Regulation_Of_PhagocytosisMouseEmbryorep_14 2.0e-31
DysfGOBP_T_Tubule_OrganizationMouseEmbryorep_14 5.7e-18
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseEmbryorep_1 3.8e-34
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseEmbryorep_2 3.4e-34
DysfGOBP_Immune_Effector_ProcessMouseEmbryorep_2 1.7e-23
DysfGOBP_Organelle_FusionMouseEmbryorep_31.8e-198
DysfGOBP_Negative_Regulation_Of_TransportMouseEmbryorep_4 7.5e-23
DysfGOBP_Regulation_Of_PhagocytosisMouseEmbryorep_4 4.8e-83
DysfGOBP_Membrane_FusionMouseEmbryorep_5 2.5e-16
DysfGOBP_PhagocytosisMouseKidneyNep 2.7e-48
DysfGOBP_Regulation_Of_PhagocytosisMouseKidneyNep 2.7e-48
DysfGOBP_Regulation_Of_TransportMouseKidneyNep 2.6e-47
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseKidneyNep 2.7e-48
DysfGOBP_Response_To_WoundingMouseKidneyNep 1.6e-16
DysfGOBP_Wound_HealingMouseKidneyNep 1.6e-16
DysfGOBP_Cell_ActivationMouseKidneyrep_2 5.1e-83
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseKidneyrep_24.3e-101
DysfGOBP_Endomembrane_System_OrganizationMouseKidneyrep_21.0e-161
DysfGOBP_Immune_Effector_ProcessMouseKidneyrep_23.4e-107
DysfGOBP_Macrophage_ActivationMouseKidneyrep_29.1e-118
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseKidneyrep_2 4.6e-46
DysfGOBP_Membrane_FusionMouseKidneyrep_23.4e-106
DysfGOBP_Membrane_OrganizationMouseKidneyrep_2 8.5e-74
DysfGOBP_Muscle_Cell_DevelopmentMouseKidneyrep_2 1.8e-96
DysfGOBP_Muscle_Cell_DifferentiationMouseKidneyrep_2 4.1e-93
DysfGOBP_Muscle_ContractionMouseKidneyrep_2 1.1e-89
DysfGOBP_Muscle_Structure_DevelopmentMouseKidneyrep_2 2.7e-36
DysfGOBP_Muscle_System_ProcessMouseKidneyrep_2 1.2e-86
DysfGOBP_Myeloid_Leukocyte_ActivationMouseKidneyrep_22.2e-110
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseKidneyrep_2 7.8e-52
DysfGOBP_Negative_Regulation_Of_TransportMouseKidneyrep_2 4.0e-19
DysfGOBP_Organelle_FusionMouseKidneyrep_2 1.4e-95
DysfGOBP_Organelle_Membrane_FusionMouseKidneyrep_2 5.0e-66
DysfGOBP_PhagocytosisMouseKidneyrep_23.4e-104
DysfGOBP_Plasma_Membrane_OrganizationMouseKidneyrep_22.5e-150
DysfGOBP_Plasma_Membrane_RepairMouseKidneyrep_2 1.2e-54
DysfGOBP_Regulation_Of_PhagocytosisMouseKidneyrep_2 3.5e-65
DysfGOBP_Regulation_Of_TransportMouseKidneyrep_2 2.4e-58
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseKidneyrep_28.7e-134
DysfGOBP_Response_To_WoundingMouseKidneyrep_2 2.1e-60
DysfGOBP_T_Tubule_OrganizationMouseKidneyrep_2 1.3e-26
DysfGOBP_Vesicle_OrganizationMouseKidneyrep_2 6.0e-62
DysfGOBP_Wound_HealingMouseKidneyrep_2 6.5e-45
DysfGOBP_Regulation_Of_PhagocytosisMouseLiverCN73-C1 9.5e-07
DysfGOBP_Regulation_Of_TransportMouseLiverCN73-C1 1.8e-07
DysfGOBP_Response_To_WoundingMouseLiverCN73-C1 1.1e-07
DysfGOBP_Wound_HealingMouseLiverCN73-C1 1.1e-08
DysfGOBP_Macrophage_ActivationMouseLiverrep_15 3.6e-42
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseLiverrep_15 1.9e-10
DysfGOBP_Muscle_System_ProcessMouseLiverrep_15 9.3e-22
DysfGOBP_Myeloid_Leukocyte_ActivationMouseLiverrep_15 2.4e-09
DysfGOBP_Organelle_Membrane_FusionMouseLiverrep_15 4.3e-11
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseLiverrep_16 1.6e-18
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseLiverrep_16 4.4e-13
DysfGOBP_Plasma_Membrane_RepairMouseLiverrep_16 1.1e-07
DysfGOBP_Response_To_WoundingMouseLiverrep_16 1.3e-13
DysfGOBP_T_Tubule_OrganizationMouseLiverrep_16 3.8e-07
DysfGOBP_Wound_HealingMouseLiverrep_16 3.5e-11
DysfGOBP_Cell_ActivationMouseLymphMS-1 1.6e-18
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseLymphMS-1 9.7e-16
DysfGOBP_Endomembrane_System_OrganizationMouseLymphMS-1 2.5e-09
DysfGOBP_Immune_Effector_ProcessMouseLymphMS-1 1.6e-18
DysfGOBP_Macrophage_ActivationMouseLymphMS-1 4.5e-17
DysfGOBP_Membrane_OrganizationMouseLymphMS-1 5.8e-20
DysfGOBP_Monocyte_ActivationMouseLymphMS-1 1.0e-10
DysfGOBP_Muscle_Cell_DevelopmentMouseLymphMS-1 6.4e-10
DysfGOBP_Muscle_Cell_DifferentiationMouseLymphMS-1 1.8e-07
DysfGOBP_Muscle_ContractionMouseLymphMS-1 3.4e-09
DysfGOBP_Muscle_Structure_DevelopmentMouseLymphMS-1 3.8e-09
DysfGOBP_Muscle_System_ProcessMouseLymphMS-1 1.6e-08
DysfGOBP_Myeloid_Leukocyte_ActivationMouseLymphMS-1 1.0e-18
DysfGOBP_Negative_Regulation_Of_TransportMouseLymphMS-1 1.0e-17
DysfGOBP_PhagocytosisMouseLymphMS-1 9.1e-20
DysfGOBP_Plasma_Membrane_OrganizationMouseLymphMS-1 2.6e-09
DysfGOBP_Plasma_Membrane_RepairMouseLymphMS-1 4.6e-13
DysfGOBP_Regulation_Of_PhagocytosisMouseLymphMS-1 4.1e-13
DysfGOBP_Regulation_Of_TransportMouseLymphMS-1 1.4e-12
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseLymphMS-1 1.8e-09
DysfGOBP_Vesicle_OrganizationMouseLymphMS-1 1.9e-12
DysfGOBP_T_Tubule_OrganizationMouseLymphMS-2 1.5e-09
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseLymphPBS 3.7e-08
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseLymphPBS 3.8e-08
DysfGOBP_T_Tubule_OrganizationMouseLungrep_1 2.0e-10
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseBrainrep_4 2.9e-33
DysfGOBP_Immune_Effector_ProcessMouseBrainrep_4 7.2e-15
DysfGOBP_Macrophage_ActivationMouseBrainrep_4 1.7e-13
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseBrainrep_4 2.8e-08
DysfGOBP_Myeloid_Leukocyte_ActivationMouseBrainrep_4 3.5e-20
DysfGOBP_Organelle_FusionMouseBrainrep_4 8.5e-11
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseBrainrep_4 5.3e-09
DysfGOBP_T_Tubule_OrganizationMouseBrainrep_4 1.4e-20
DysfGOBP_Vesicle_OrganizationMouseBrainrep_4 7.9e-08
DysfGOBP_Macrophage_ActivationMouseBrainHP_ad_rep7 2.4e-08
DysfGOBP_Muscle_Cell_DifferentiationMouseBrainHP_ad_rep7 5.5e-07
DysfGOBP_Negative_Regulation_Of_PhagocytosisMouseBrainHP_ad_rep7 4.5e-07
DysfGOBP_Negative_Regulation_Of_TransportMouseBrainHP_ad_rep7 1.7e-07
DysfGOBP_Plasma_Membrane_RepairMouseBrainHP_ad_rep7 1.9e-07
DysfGOBP_Regulation_Of_TransportMouseBrainHP_ad_rep7 9.2e-09
DysfGOBP_Response_To_WoundingMouseBrainHP_ad_rep7 4.3e-07
DysfGOBP_Cell_ActivationMouseBrainHP_polb_rep9 1.5e-08
DysfGOBP_Cell_Activation_Involved_In_Immune_ResponseMouseBrainHP_polb_rep9 8.8e-09
DysfGOBP_Endomembrane_System_OrganizationMouseBrainHP_polb_rep9 6.0e-11
DysfGOBP_Immune_Effector_ProcessMouseBrainHP_polb_rep9 1.0e-08
DysfGOBP_Macrophage_Activation_Involved_In_Immune_ResponseMouseBrainHP_polb_rep9 4.7e-10
DysfGOBP_Membrane_FusionMouseBrainHP_polb_rep9 6.9e-14
DysfGOBP_Membrane_OrganizationMouseBrainHP_polb_rep9 1.4e-13
DysfGOBP_Monocyte_ActivationMouseBrainHP_polb_rep9 4.9e-12
DysfGOBP_Muscle_ContractionMouseBrainHP_polb_rep9 8.1e-07
DysfGOBP_Myeloid_Leukocyte_ActivationMouseBrainHP_polb_rep9 2.6e-11
DysfGOBP_Organelle_FusionMouseBrainHP_polb_rep9 1.4e-10
DysfGOBP_Organelle_Membrane_FusionMouseBrainHP_polb_rep9 1.5e-11
DysfGOBP_PhagocytosisMouseBrainHP_polb_rep9 2.5e-08
DysfGOBP_Regulation_Of_PhagocytosisMouseBrainHP_polb_rep9 2.0e-08
DysfGOBP_Regulation_Of_Vesicle_Mediated_TransportMouseBrainHP_polb_rep9 9.9e-09
DysfGOBP_Vesicle_OrganizationMouseBrainHP_polb_rep9 4.1e-14

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Dysf function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Dysf function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Dysf envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Dysf

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Dysf

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
DysfC4551973Miyoshi Muscular Dystrophy 119CTD_human;GENOMICS_ENGLAND;UNIPROT
DysfC1850889MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B17CTD_human;GENOMICS_ENGLAND;UNIPROT
DysfC1847532MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET3CTD_human;GENOMICS_ENGLAND;ORPHANET
DysfC0023893Liver Cirrhosis, Experimental1CTD_human
DysfC0087031Juvenile-Onset Still Disease1CTD_human
DysfC1850808Miyoshi myopathy1ORPHANET
DysfC3495559Juvenile arthritis1CTD_human
DysfC3714758Juvenile psoriatic arthritis1CTD_human
DysfC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
DysfC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human