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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Itga8 (spascer ID:241226)

Gene summary for Itga8

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Itga8

Gene ID

241226

Gene nameintegrin alpha 8
SynonymsAI447669
Cytomap2 A1|2 9.12 cM
Type of geneprotein-coding
Descriptionintegrin alpha-8
Modification date20220424
UniProtAcc

A2ARA8


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Itga8

GO:0005178

integrin binding

21873635

Function
Itga8

GO:0007160

cell-matrix adhesion

21873635

Process
Itga8

GO:0007229

integrin-mediated signaling pathway

21873635

Process
Itga8

GO:0008305

integrin complex

21873635

Component
Itga8

GO:0009897

external side of plasma membrane

21873635

Component
Itga8

GO:0033627

cell adhesion mediated by integrin

21873635

Process
Itga8

GO:0098609

cell-cell adhesion

21873635

Process

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Spatial pattern events for Itga8

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Itga8MouseBrainS2 344135151.56e-15
Itga8MouseEmbryo4E 342108878.13e-11
Itga8MouseEmbryorep_3 331887762.04e-07
Itga8MouseEmbryorep_4 331887768.29e-15
Itga8MouseKidneyCLP 340037975.03e-10
Itga8MouseLiverrep_20 350210639.91e-15
Itga8MouseLiverrep_21 350210638.03e-15
Itga8MouseLungrep_1 352908014.52e-15
Itga8MouseLungrep_2 352908017.23e-15
Itga8MouseLungrep_3 352908018.40e-15
Itga8MouseLungrep_4 352908013.04e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Kidney_CLP_H&E
boxplot
boxplot
Liver_rep_20_H&E
boxplot
Liver_rep_21_H&E
boxplot
Lung_rep_1_H&E
boxplot
boxplot
Lung_rep_2_H&E
boxplot
boxplot
Lung_rep_3_H&E
boxplot
boxplot
Lung_rep_4_H&E
boxplot
boxplot


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Spatial pattern pathway has Itga8 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseSpinal cordCN94_E1 1.2e-06
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseSpinal cordCN94_E1 3.6e-06
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseSpinal cordCN94_E1 3.0e-06
Itga8GOBP_Mesoderm_DevelopmentMouseSpinal cordCN94_E1 5.8e-06
Itga8GOBP_Mesoderm_MorphogenesisMouseSpinal cordCN94_E1 1.8e-06
Itga8GOBP_Urogenital_System_DevelopmentMouseSpinal cordCN94_E1 2.7e-06
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseSpinal cordL7CN45_C1 5.6e-06
Itga8GOBP_Biological_AdhesionMouseSpinal cordL7CN45_C1 2.4e-08
Itga8GOBP_Cell_Cell_AdhesionMouseSpinal cordL7CN45_C1 6.8e-10
Itga8GOBP_Cell_MorphogenesisMouseSpinal cordL7CN45_C1 8.5e-07
Itga8GOBP_Cell_Morphogenesis_Involved_In_DifferentiationMouseSpinal cordL7CN45_C1 2.8e-06
Itga8GOBP_Central_Nervous_System_DevelopmentMouseSpinal cordL7CN45_C1 5.5e-10
Itga8GOBP_Embryo_DevelopmentMouseSpinal cordL7CN45_C1 3.4e-09
Itga8GOBP_Embryonic_MorphogenesisMouseSpinal cordL7CN45_C1 3.4e-09
Itga8GOBP_GastrulationMouseSpinal cordL7CN45_C1 3.2e-07
Itga8GOBP_Head_DevelopmentMouseSpinal cordL7CN45_C1 3.4e-09
Itga8GOBP_Tissue_MorphogenesisMouseSpinal cordL7CN45_C1 8.3e-08
Itga8GOBP_Cell_Substrate_AdhesionMouseSpinal cordL7CN97_E2 2.2e-06
Itga8GOBP_Urogenital_System_DevelopmentMouseBrainrep_27 1.1e-05
Itga8GOBP_Cell_MorphogenesisMouseBrainrep_1 7.6e-08
Itga8GOBP_Cell_Morphogenesis_Involved_In_DifferentiationMouseBrainrep_1 5.7e-33
Itga8GOBP_Central_Nervous_System_DevelopmentMouseBrainrep_1 8.6e-30
Itga8GOBP_Head_DevelopmentMouseBrainrep_1 3.9e-29
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseBrainrep_1 3.5e-10
Itga8GOBP_Substrate_Adhesion_Dependent_Cell_SpreadingMouseBrainrep_1 4.3e-11
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseBrainrep_3 5.3e-58
Itga8GOBP_Biological_AdhesionMouseBrainrep_34.3e-106
Itga8GOBP_Cell_Cell_AdhesionMouseBrainrep_35.2e-118
Itga8GOBP_Cell_Substrate_AdhesionMouseBrainrep_3 1.8e-27
Itga8GOBP_Embryo_DevelopmentMouseBrainrep_31.3e-126
Itga8GOBP_Embryonic_MorphogenesisMouseBrainrep_35.0e-165
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseBrainrep_38.9e-180
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseBrainrep_31.6e-137
Itga8GOBP_GastrulationMouseBrainrep_3 2.3e-75
Itga8GOBP_Mesoderm_DevelopmentMouseBrainrep_33.3e-168
Itga8GOBP_Mesoderm_MorphogenesisMouseBrainrep_34.5e-163
Itga8GOBP_Mesodermal_Cell_DifferentiationMouseBrainrep_3 1.4e-94
Itga8GOBP_Tissue_MorphogenesisMouseBrainrep_34.8e-136
Itga8GOBP_Urogenital_System_DevelopmentMouseBrainrep_32.4e-187
Itga8GOBP_GastrulationMouseEmbryorep_6 5.8e-07
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseEmbryorep_6 4.9e-29
Itga8GOBP_Mesoderm_MorphogenesisMouseEmbryorep_6 1.9e-10
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseEmbryorep_14 1.1e-10
Itga8GOBP_Mesoderm_DevelopmentMouseEmbryorep_14 5.8e-16
Itga8GOBP_Mesodermal_Cell_DifferentiationMouseEmbryorep_14 1.2e-55
Itga8GOBP_Biological_AdhesionMouseEmbryorep_1 2.2e-19
Itga8GOBP_Cell_Matrix_AdhesionMouseEmbryorep_1 1.6e-47
Itga8GOBP_Cell_Substrate_AdhesionMouseEmbryorep_1 2.0e-34
Itga8GOBP_Central_Nervous_System_DevelopmentMouseEmbryorep_13.0e-261
Itga8GOBP_Head_DevelopmentMouseEmbryorep_1 1.8e-91
Itga8GOBP_Mesodermal_Cell_DifferentiationMouseEmbryorep_1 1.3e-29
Itga8GOBP_Urogenital_System_DevelopmentMouseEmbryorep_1 1.8e-45
Itga8GOBP_Substrate_Adhesion_Dependent_Cell_SpreadingMouseEmbryorep_2 9.1e-35
Itga8GOBP_Cell_Morphogenesis_Involved_In_DifferentiationMouseEmbryorep_3 1.7e-20
Itga8GOBP_Embryo_DevelopmentMouseEmbryorep_31.2e-173
Itga8GOBP_Cell_MorphogenesisMouseEmbryorep_5 2.2e-13
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseEmbryorep_6 3.8e-28
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseEmbryorep_6 1.1e-18
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseKidneyNep 5.6e-37
Itga8GOBP_Cell_MorphogenesisMouseKidneyNep 1.1e-16
Itga8GOBP_Central_Nervous_System_DevelopmentMouseKidneyNep 4.2e-26
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseKidneyrep_25.6e-148
Itga8GOBP_Biological_AdhesionMouseKidneyrep_2 1.3e-48
Itga8GOBP_Cell_Cell_AdhesionMouseKidneyrep_2 1.1e-24
Itga8GOBP_Cell_Matrix_AdhesionMouseKidneyrep_2 2.0e-31
Itga8GOBP_Cell_MorphogenesisMouseKidneyrep_2 1.7e-84
Itga8GOBP_Cell_Morphogenesis_Involved_In_DifferentiationMouseKidneyrep_2 7.8e-42
Itga8GOBP_Cell_Substrate_AdhesionMouseKidneyrep_2 4.0e-46
Itga8GOBP_Central_Nervous_System_DevelopmentMouseKidneyrep_2 1.3e-23
Itga8GOBP_Embryo_DevelopmentMouseKidneyrep_2 7.4e-46
Itga8GOBP_Embryonic_MorphogenesisMouseKidneyrep_2 7.3e-66
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseKidneyrep_2 5.6e-85
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseKidneyrep_2 2.0e-41
Itga8GOBP_GastrulationMouseKidneyrep_2 2.6e-89
Itga8GOBP_Head_DevelopmentMouseKidneyrep_2 1.9e-29
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseKidneyrep_2 6.2e-70
Itga8GOBP_Mesoderm_DevelopmentMouseKidneyrep_2 2.4e-61
Itga8GOBP_Mesoderm_MorphogenesisMouseKidneyrep_2 3.1e-33
Itga8GOBP_Substrate_Adhesion_Dependent_Cell_SpreadingMouseKidneyrep_2 7.7e-70
Itga8GOBP_Tissue_MorphogenesisMouseKidneyrep_2 2.3e-21
Itga8GOBP_Urogenital_System_DevelopmentMouseKidneyrep_2 2.5e-57
Itga8GOBP_Substrate_Adhesion_Dependent_Cell_SpreadingMouseLiverCN16-D1 1.7e-08
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseLiverCN16-E1 2.0e-07
Itga8GOBP_Mesoderm_MorphogenesisMouseLiverCN16-E1 1.8e-09
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseLiverCN73-C1 1.4e-08
Itga8GOBP_Mesodermal_Cell_DifferentiationMouseLiverrep_15 1.3e-14
Itga8GOBP_Biological_AdhesionMouseLiverrep_16 2.1e-07
Itga8GOBP_Cell_Cell_AdhesionMouseLiverrep_16 1.4e-11
Itga8GOBP_Cell_Matrix_AdhesionMouseLiverrep_16 2.7e-08
Itga8GOBP_Central_Nervous_System_DevelopmentMouseLiverrep_16 8.2e-15
Itga8GOBP_Head_DevelopmentMouseLiverrep_16 4.3e-18
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseLymphMS-1 6.4e-13
Itga8GOBP_Biological_AdhesionMouseLymphMS-1 8.0e-14
Itga8GOBP_Cell_Cell_AdhesionMouseLymphMS-1 1.9e-13
Itga8GOBP_Cell_Matrix_AdhesionMouseLymphMS-1 3.5e-08
Itga8GOBP_Cell_MorphogenesisMouseLymphMS-1 3.9e-13
Itga8GOBP_Cell_Morphogenesis_Involved_In_DifferentiationMouseLymphMS-1 2.1e-10
Itga8GOBP_Central_Nervous_System_DevelopmentMouseLymphMS-1 3.8e-07
Itga8GOBP_Embryo_DevelopmentMouseLymphMS-1 2.5e-08
Itga8GOBP_Embryonic_MorphogenesisMouseLymphMS-1 5.6e-07
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseLymphMS-1 6.5e-12
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseLymphMS-1 1.3e-08
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseLymphMS-1 1.5e-10
Itga8GOBP_Mesoderm_DevelopmentMouseLymphMS-1 5.8e-10
Itga8GOBP_Mesoderm_MorphogenesisMouseLymphMS-1 6.5e-08
Itga8GOBP_Substrate_Adhesion_Dependent_Cell_SpreadingMouseLymphMS-1 1.9e-09
Itga8GOBP_Tissue_MorphogenesisMouseLymphMS-1 1.4e-12
Itga8GOBP_Urogenital_System_DevelopmentMouseLymphMS-1 5.4e-09
Itga8GOBP_GastrulationMouseLymphMS-2 2.0e-07
Itga8GOBP_Biological_AdhesionMouseLungrep_1 3.0e-22
Itga8GOBP_Cell_Cell_AdhesionMouseLungrep_1 2.9e-07
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseLungrep_1 1.3e-11
Itga8GOBP_Cell_Matrix_AdhesionMouseBrainrep_4 7.1e-07
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseBrainrep_4 3.1e-21
Itga8GOBP_Mesoderm_MorphogenesisMouseBrainrep_4 6.7e-13
Itga8GOBP_Urogenital_System_DevelopmentMouseBrainrep_7 8.1e-17
Itga8GOBP_Mesodermal_Cell_DifferentiationMouseBrainHP_ad_rep3 1.9e-07
Itga8GOBP_Cell_Matrix_AdhesionMouseBrainHP_ad_rep7 5.6e-10
Itga8GOBP_Cell_MorphogenesisMouseBrainHP_ad_rep7 8.4e-10
Itga8GOBP_Cell_Morphogenesis_Involved_In_DifferentiationMouseBrainHP_ad_rep7 8.1e-09
Itga8GOBP_Central_Nervous_System_DevelopmentMouseBrainHP_ad_rep7 2.3e-07
Itga8GOBP_External_Encapsulating_Structure_OrganizationMouseBrainHP_ad_rep7 1.9e-11
Itga8GOBP_Head_DevelopmentMouseBrainHP_ad_rep7 3.0e-07
Itga8GOBP_Integrin_Mediated_Signaling_PathwayMouseBrainHP_ad_rep7 9.5e-09
Itga8GOBP_Mesoderm_DevelopmentMouseBrainHP_ad_rep7 1.9e-08
Itga8GOBP_Substrate_Adhesion_Dependent_Cell_SpreadingMouseBrainHP_ad_rep7 1.3e-09
Itga8GOBP_Urogenital_System_DevelopmentMouseBrainHP_ad_rep7 3.6e-14
Itga8GOBP_Formation_Of_Primary_Germ_LayerMouseBrainHP_adpolb_rep1 1.4e-09
Itga8GOBP_Mesoderm_MorphogenesisMouseBrainHP_adpolb_rep5 7.9e-07
Itga8GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseBrainHP_polb_rep9 6.3e-08
Itga8GOBP_Biological_AdhesionMouseBrainHP_polb_rep9 1.5e-07
Itga8GOBP_Cell_Cell_AdhesionMouseBrainHP_polb_rep9 3.6e-11
Itga8GOBP_Cell_Substrate_AdhesionMouseBrainHP_polb_rep9 3.3e-07
Itga8GOBP_Embryo_DevelopmentMouseBrainHP_polb_rep9 1.5e-10
Itga8GOBP_Embryonic_MorphogenesisMouseBrainHP_polb_rep9 3.7e-09
Itga8GOBP_Tissue_MorphogenesisMouseBrainHP_polb_rep9 1.2e-10

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Itga8 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Itga8 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication
VtnItga8Vtn_Itga8Brainrep_5
Spp1Itga8Spp1_Itga8BrainHPO_polb_rep1
NpntItga8Npnt_Itga8Brain12A
VtnItga8Vtn_Itga8Liverrep_21
Spp1Itga8Spp1_Itga8Liverrep_21
NpntItga8Npnt_Itga8Liverrep_21
TncItga8Tnc_Itga8Liverrep_21

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Transcription factor for Itga8 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Itga8

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Itga8

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Itga8C0024623Malignant neoplasm of stomach1CTD_human
Itga8C0036341Schizophrenia1PSYGENET
Itga8C0038356Stomach Neoplasms1CTD_human
Itga8C0919267ovarian neoplasm1CTD_human
Itga8C1140680Malignant neoplasm of ovary1CTD_human
Itga8C1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET
Itga8C1619700RENAL ADYSPLASIA1GENOMICS_ENGLAND;UNIPROT
Itga8C1708349Hereditary Diffuse Gastric Cancer1CTD_human