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Spatial pattern gene: Neurl1b (spascer ID:240055) |
Gene summary for Neurl1b |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Neurl1b | Gene ID | 240055 |
| Gene name | neuralized E3 ubiquitin protein ligase 1B |
| Synonyms | C230078M08Rik|EG240055 |
| Cytomap | 17 A3.3|17 |
| Type of gene | protein-coding |
| Description | E3 ubiquitin-protein ligase NEURL1BRING-type E3 ubiquitin transferase NEURL1Bneuralized homolog 1bneuralized-like protein 1B |
| Modification date | 20220424 |
| UniProtAcc | Q0MW30 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Neurl1b | GO:0005769 | early endosome | 21873635 | Component |
| Neurl1b | GO:0061630 | ubiquitin protein ligase activity | 21873635 | Function |
| Neurl1b | GO:0070086 | ubiquitin-dependent endocytosis | 21873635 | Process |
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Spatial pattern events for Neurl1b |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Neurl1b | Mouse | Brain | S1 | 34413515 | 7.10e-15 |
| Neurl1b | Mouse | Brain | S2 | 34413515 | 1.56e-15 |
| Neurl1b | Mouse | Brain | S3 | 34413515 | 1.64e-15 |
| Neurl1b | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Neurl1b | Mouse | Brain | S6 | 34413515 | 1.46e-15 |
| Neurl1b | Mouse | Brain | S7 | 34413515 | 1.55e-15 |
| Neurl1b | Mouse | Brain | 18A | 32637622 | 1.59e-07 |
| Neurl1b | Mouse | Brain | 26A | 32637622 | 5.92e-11 |
| Neurl1b | Mouse | Brain | 27A | 32637622 | 7.84e-13 |
| Neurl1b | Mouse | Brain | 27B | 32637622 | 1.51e-12 |
| Neurl1b | Mouse | Brain | 28A | 32637622 | 1.78e-11 |
| Neurl1b | Mouse | Brain | 28B | 32637622 | 2.29e-06 |
| Neurl1b | Mouse | Brain | 29A | 32637622 | 1.82e-14 |
| Neurl1b | Mouse | Brain | 29B | 32637622 | 4.81e-12 |
| Neurl1b | Mouse | Brain | 32A | 32637622 | 1.49e-07 |
| Neurl1b | Mouse | Brain | 33A | 32637622 | 8.78e-11 |
| Neurl1b | Mouse | Brain | 33B | 32637622 | 1.43e-11 |
| Neurl1b | Mouse | Brain | 34A | 32637622 | 6.29e-13 |
| Neurl1b | Mouse | Brain | 34B | 32637622 | 5.60e-10 |
| Neurl1b | Mouse | Brain | 35A | 32637622 | 2.70e-14 |
| Neurl1b | Mouse | Brain | 35B | 32637622 | 1.76e-09 |
| Neurl1b | Mouse | Brain | rep_1 | 35141374 | 2.02e-15 |
| Neurl1b | Mouse | Brain | rep_2 | 35141374 | 5.75e-15 |
| Neurl1b | Mouse | Brain | rep_3 | 35141374 | 1.64e-15 |
| Neurl1b | Mouse | Brain | rep_4 | 35141374 | 1.57e-15 |
| Neurl1b | Mouse | Brain | rep_5 | 35141374 | 5.13e-15 |
| Neurl1b | Mouse | Brain | rep_6 | 35141374 | 5.96e-15 |
| Neurl1b | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| Neurl1b | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| Neurl1b | Mouse | Kidney | rep_1 | 34853151 | 3.42e-11 |
| Neurl1b | Mouse | Kidney | rep_3 | 34853151 | 2.94e-15 |
| Neurl1b | Mouse | Kidney | rep_5 | 34853151 | 6.20e-10 |
| Neurl1b | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Neurl1b | Mouse | Brain | rep_1 | 35027729 | 3.79e-08 |
| Neurl1b | Mouse | Brain | rep_2 | 35027729 | 1.57e-15 |
| Neurl1b | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Neurl1b | Mouse | Brain | rep_4 | 35027729 | 2.32e-14 |
| Neurl1b | Mouse | Brain | rep_5 | 35027729 | 1.46e-15 |
| Neurl1b | Mouse | Intestine | rep_1 | 35149721 | 7.41e-11 |
| Neurl1b | Mouse | Intestine | rep_2 | 35149721 | 1.56e-08 |
| Neurl1b | Mouse | Testicle | rep_1 | 34731600 | 2.97e-14 |
| Neurl1b | Mouse | Lung | rep_4 | 35290801 | 6.01e-06 |
| Neurl1b | Mouse | Brain | rep_1 | 35210624 | 6.02e-15 |
| Neurl1b | Mouse | Brain | rep_2 | 35210624 | 1.74e-15 |
| Neurl1b | Mouse | Brain | rep_3 | 35210624 | 1.82e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_6_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_3_H&E  |  |
Kidney_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Lung_rep_4_H&E  |  |
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Spatial pattern pathway has Neurl1b envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Neurl1b | GOBP_Endocytosis | Mouse | Spinal cord | CN94_E1 | 8.2e-06 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Spinal cord | CN94_E1 | 1.5e-07 |
| Neurl1b | GOBP_Cellular_Macromolecule_Localization | Mouse | Spinal cord | L7CN45_C1 | 4.2e-07 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization | Mouse | Spinal cord | L7CN45_C1 | 4.4e-06 |
| Neurl1b | GOBP_Protein_Localization_To_Organelle | Mouse | Spinal cord | L7CN45_C1 | 3.6e-07 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Mouse | Spinal cord | L7CN45_C1 | 2.2e-07 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Mouse | Spinal cord | L7CN45_C1 | 1.4e-06 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Spinal cord | L7CN45_C1 | 2.3e-07 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Brain | rep_27 | 2.9e-06 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Brain | rep_30 | 1.4e-05 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization | Mouse | Brain | rep_1 | 6.6e-07 |
| Neurl1b | GOBP_Import_Into_Cell | Mouse | Brain | rep_1 | 3.8e-20 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Brain | rep_1 | 3.8e-12 |
| Neurl1b | GOBP_Cellular_Macromolecule_Localization | Mouse | Brain | rep_3 | 1.6e-125 |
| Neurl1b | GOBP_Endocytosis | Mouse | Brain | rep_3 | 2.6e-20 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Mouse | Brain | rep_3 | 1.2e-180 |
| Neurl1b | GOBP_Protein_Localization_To_Organelle | Mouse | Brain | rep_3 | 6.3e-172 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Mouse | Brain | rep_3 | 1.4e-184 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Mouse | Brain | rep_3 | 6.3e-190 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Brain | rep_3 | 2.5e-155 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Embryo | rep_6 | 4.5e-11 |
| Neurl1b | GOBP_Import_Into_Cell | Mouse | Embryo | rep_14 | 8.3e-23 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Mouse | Embryo | rep_1 | 8.6e-17 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Mouse | Embryo | rep_1 | 4.4e-16 |
| Neurl1b | GOBP_Cellular_Macromolecule_Localization | Mouse | Embryo | rep_2 | 5.5e-15 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Embryo | rep_3 | 6.4e-228 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Mouse | Embryo | rep_3 | 4.2e-21 |
| Neurl1b | GOBP_Endocytosis | Mouse | Kidney | Nep | 8.3e-23 |
| Neurl1b | GOBP_Cellular_Macromolecule_Localization | Mouse | Kidney | rep_2 | 3.5e-61 |
| Neurl1b | GOBP_Endocytosis | Mouse | Kidney | rep_2 | 1.4e-132 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization | Mouse | Kidney | rep_2 | 9.8e-86 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Mouse | Kidney | rep_2 | 3.3e-19 |
| Neurl1b | GOBP_Import_Into_Cell | Mouse | Kidney | rep_2 | 2.3e-111 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Kidney | rep_2 | 4.9e-143 |
| Neurl1b | GOBP_Protein_Localization_To_Organelle | Mouse | Kidney | rep_2 | 3.4e-44 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Kidney | rep_2 | 7.7e-63 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Liver | rep_15 | 3.4e-32 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Brain | rep_1 | 4.0e-22 |
| Neurl1b | GOBP_Cellular_Macromolecule_Localization | Mouse | Lymph | MS-1 | 1.1e-11 |
| Neurl1b | GOBP_Endocytosis | Mouse | Lymph | MS-1 | 1.8e-21 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization | Mouse | Lymph | MS-1 | 2.5e-11 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Mouse | Lymph | MS-1 | 3.3e-11 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Lymph | MS-1 | 3.0e-07 |
| Neurl1b | GOBP_Protein_Localization_To_Organelle | Mouse | Lymph | MS-1 | 1.4e-09 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Mouse | Lymph | MS-1 | 1.4e-09 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Mouse | Lymph | MS-1 | 1.4e-09 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Lymph | MS-1 | 3.1e-16 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Brain | rep_4 | 3.7e-18 |
| Neurl1b | GOBP_Ubiquitin_Dependent_Endocytosis | Mouse | Brain | HP_ad_rep3 | 1.2e-12 |
| Neurl1b | GOBP_Cellular_Macromolecule_Localization | Mouse | Brain | HP_ad_rep7 | 6.6e-10 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization | Mouse | Brain | HP_ad_rep7 | 8.7e-10 |
| Neurl1b | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Mouse | Brain | HP_ad_rep7 | 6.1e-09 |
| Neurl1b | GOBP_Import_Into_Cell | Mouse | Brain | HP_ad_rep7 | 7.5e-07 |
| Neurl1b | GOBP_Protein_Localization_To_Organelle | Mouse | Brain | HP_ad_rep7 | 4.8e-12 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Mouse | Brain | HP_ad_rep7 | 1.7e-09 |
| Neurl1b | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Mouse | Brain | HP_ad_rep7 | 6.9e-09 |
| Neurl1b | GOBP_Endocytosis | Mouse | Brain | HP_polb_rep9 | 3.2e-09 |
| Neurl1b | GOBP_Notch_Signaling_Pathway | Mouse | Brain | HP_polb_rep9 | 4.3e-09 |
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Neurl1b function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Neurl1b function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Neurl1b envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Neurl1b |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Neurl1b |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
