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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Papss2 (spascer ID:23972)

Gene summary for Papss2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Papss2
	Gene ID	23972
	Gene name	3'-phosphoadenosine 5'-phosphosulfate synthase 2
	Synonyms	1810018P12Rik\|AI159688\|AtpsU2\|Atpsk2\|Sk2\|bm
	Cytomap	19 C1\|19 27.46 cM
	Type of gene	protein-coding
	Description	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2PAPS synthase 2brachymorphicsulfurylase kinase 2
	Modification date	20220424
	UniProtAcc	O88428

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Papss2	GO:0000103	sulfate assimilation	21873635	Process
Papss2	GO:0004020	adenylylsulfate kinase activity	21873635	Function
Papss2	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	21873635	Process

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Spatial pattern events for Papss2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Papss2	Mouse	Brain	S1	34413515	1.76e-10
Papss2	Mouse	Brain	S2	34413515	1.13e-08
Papss2	Mouse	Brain	S3	34413515	3.90e-14
Papss2	Mouse	Brain	S6	34413515	1.15e-12
Papss2	Mouse	Brain	S7	34413515	6.79e-08
Papss2	Mouse	Embryo	rep_4	33188776	5.08e-15
Papss2	Mouse	Kidney	CLP	34003797	2.19e-15
Papss2	Mouse	Kidney	IRI	34003797	2.29e-15
Papss2	Mouse	Kidney	Sham	34003797	2.58e-15
Papss2	Mouse	Kidney	rep_1	34853151	2.42e-15
Papss2	Mouse	Kidney	rep_2	34853151	3.38e-15
Papss2	Mouse	Kidney	rep_3	34853151	2.94e-15
Papss2	Mouse	Kidney	rep_4	34853151	3.63e-06
Papss2	Mouse	Kidney	rep_5	34853151	3.18e-15
Papss2	Mouse	Brain	rep_1	35027729	8.16e-09
Papss2	Mouse	Brain	rep_3	35027729	1.97e-06
Papss2	Mouse	Brain	rep_4	35027729	4.14e-13
Papss2	Mouse	Brain	rep_5	35027729	7.68e-13
Papss2	Mouse	Intestine	rep_1	35149721	6.08e-15
Papss2	Mouse	Intestine	rep_2	35149721	3.44e-15
Papss2	Mouse	Intestine	rep_3	35149721	3.25e-15
Papss2	Mouse	Intestine	rep_4	35149721	3.03e-09
Papss2	Mouse	Lung	rep_3	35290801	8.36e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_3_H&E

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Spatial pattern pathway has Papss2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Biosynthetic_Process	Mouse	Spinal cord	CN90_C1	2.8e-06
Papss2	GOBP_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	5.6e-06
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	5.6e-06
Papss2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Papss2	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7bCN02_E1	1.8e-07
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Spinal cord	L7CN44_C1	6.0e-06
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Papss2	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.8e-07
Papss2	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Papss2	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-08
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.4e-07
Papss2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Papss2	GOBP_Organophosphate_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.0e-07
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Papss2	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.7e-07
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Papss2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.4e-07
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_71	5.1e-05
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Brain	rep_72	8.3e-05
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_1	3.5e-11
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Brain	rep_1	3.6e-14
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_1	1.2e-16
Papss2	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Brain	rep_1	8.2e-08
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Biosynthetic_Process	Mouse	Brain	rep_3	2.1e-50
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Brain	rep_3	7.2e-67
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Brain	rep_3	2.7e-27
Papss2	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	rep_3	4.5e-61
Papss2	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Brain	rep_3	2.2e-156
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Brain	rep_3	6.5e-148
Papss2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Papss2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-25
Papss2	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	rep_3	8.1e-43
Papss2	GOBP_Skeletal_System_Development	Mouse	Brain	rep_3	3.3e-190
Papss2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	rep_3	1.4e-160
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Biosynthetic_Process	Mouse	Embryo	rep_6	2.1e-13
Papss2	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Embryo	rep_6	4.3e-08
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Embryo	rep_14	3.0e-14
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Embryo	rep_14	4.5e-09
Papss2	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_14	1.8e-12
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Embryo	rep_14	9.1e-21
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	4.8e-21
Papss2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	1.8e-11
Papss2	GOBP_Organophosphate_Metabolic_Process	Mouse	Embryo	rep_14	2.0e-09
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	4.8e-28
Papss2	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_14	6.5e-20
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	9.6e-35
Papss2	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	3.3e-48
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Embryo	rep_14	5.8e-13
Papss2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Papss2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Papss2	GOBP_Skeletal_System_Development	Mouse	Embryo	rep_6	3.1e-59
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Biosynthetic_Process	Mouse	Kidney	rep_2	1.1e-37
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Kidney	rep_2	1.1e-15
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Kidney	rep_2	1.3e-08
Papss2	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-42
Papss2	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	2.4e-27
Papss2	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	2.1e-62
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Kidney	rep_2	1.5e-39
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	4.6e-07
Papss2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Papss2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	1.2e-09
Papss2	GOBP_Organophosphate_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-41
Papss2	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-17
Papss2	GOBP_Skeletal_System_Development	Mouse	Kidney	rep_2	7.5e-46
Papss2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Kidney	rep_2	8.6e-17
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Biosynthetic_Process	Mouse	Liver	CN16-D1	1.3e-07
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Liver	CN16-D1	3.4e-08
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Liver	CN16-D1	9.2e-10
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.2e-07
Papss2	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Liver	CN73-C1	5.1e-08
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Liver	CN73-C1	2.1e-08
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Liver	CN73-C1	2.5e-07
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.0e-11
Papss2	GOBP_Skeletal_System_Development	Mouse	Liver	CN73-C1	9.4e-07
Papss2	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.0e-08
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Liver	rep_16	3.1e-14
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Liver	rep_16	2.6e-08
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Liver	rep_16	1.6e-18
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Liver	rep_16	7.0e-15
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Liver	rep_16	4.5e-22
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Intestine	rep_2	6.0e-29
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Intestine	rep_2	7.1e-07
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-07
Papss2	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Lymph	MS-1	2.8e-10
Papss2	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.7e-09
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Papss2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Papss2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	6.7e-07
Papss2	GOBP_Organophosphate_Metabolic_Process	Mouse	Lymph	MS-1	7.3e-07
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Papss2	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	8.0e-08
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Papss2	GOBP_Skeletal_System_Development	Mouse	Lymph	MS-1	2.6e-12
Papss2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Papss2	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	4.5e-10
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Lymph	MS-1	7.8e-10
Papss2	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	9.8e-07
Papss2	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Papss2	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.8e-08
Papss2	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.4e-07
Papss2	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Papss2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Papss2	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.2e-11
Papss2	GOBP_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	3.7e-09
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Biosynthetic_Process	Mouse	Brain	HP_adpolb_rep1	1.8e-08
Papss2	GOBP_3_Phosphoadenosine_5_Phosphosulfate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.9e-12
Papss2	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	HP_polb_rep9	5.2e-12
Papss2	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.9e-09
Papss2	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	7.1e-09
Papss2	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	6.8e-08
Papss2	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.4e-07
Papss2	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	1.4e-08
Papss2	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Papss2	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	2.2e-10
Papss2	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-08

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Papss2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Papss2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Papss2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Papss2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Papss2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Papss2	C2748515	Spondyloepimetaphyseal Dysplasia, Pakistani Type	6	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT