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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Arhgap22 (spascer ID:239027)

Gene summary for Arhgap22

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Arhgap22
	Gene ID	239027
	Gene name	Rho GTPase activating protein 22
	Synonyms	B230341L19Rik\|RHOGAP2\|p68RacGAP
	Cytomap	14\|14 B
	Type of gene	protein-coding
	Description	rho GTPase-activating protein 22rho-type GTPase-activating protein 22
	Modification date	20220424
	UniProtAcc	Q8BL80

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Arhgap22	GO:0005096	GTPase activator activity	21873635	Function
Arhgap22	GO:0090630	activation of GTPase activity	21873635	Process

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Spatial pattern events for Arhgap22

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Arhgap22	Mouse	Brain	S1	34413515	1.18e-07
Arhgap22	Mouse	Brain	S2	34413515	2.14e-14
Arhgap22	Mouse	Brain	S4	34413515	3.81e-12
Arhgap22	Mouse	Brain	S6	34413515	1.57e-10
Arhgap22	Mouse	Brain	S7	34413515	3.85e-09
Arhgap22	Mouse	Kidney	CLP	34003797	1.68e-09
Arhgap22	Mouse	Kidney	rep_5	34853151	1.14e-11
Arhgap22	Mouse	Testicle	rep_4	34731600	1.63e-15
Arhgap22	Mouse	Lymph	MS-1	0	1.91e-06
Arhgap22	Mouse	Lymph	MS-2	0	3.71e-11
Arhgap22	Mouse	Lymph	PBS	0	2.82e-13
Arhgap22	Mouse	Lymph	A1	0	3.29e-15
Arhgap22	Mouse	Lymph	B1	0	3.66e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_rep_5_H&E

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Spatial pattern pathway has Arhgap22 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Arhgap22	GOBP_Activation_Of_Gtpase_Activity	Mouse	Spinal cord	CN93_D2	2.8e-06
Arhgap22	GOBP_Regulation_Of_Postsynapse_Organization	Mouse	Spinal cord	L7bCN01_D2	2.2e-07
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Spinal cord	L7bCN02_E1	4.0e-06
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	1.0e-07
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Spinal cord	L7CN45_C1	5.7e-08
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Arhgap22	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Spinal cord	L7CN45_C1	7.5e-06
Arhgap22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	1.8e-08
Arhgap22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Arhgap22	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Arhgap22	GOBP_Synapse_Organization	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Arhgap22	GOBP_Tube_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Arhgap22	GOBP_Tube_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Arhgap22	GOBP_Vasculature_Development	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Arhgap22	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Spinal cord	L8CN17_E1	8.7e-07
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Brain	rep_27	5.8e-05
Arhgap22	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_27	4.2e-05
Arhgap22	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_27	6.4e-05
Arhgap22	GOBP_Synapse_Organization	Mouse	Brain	rep_27	6.2e-06
Arhgap22	GOBP_Activation_Of_Gtpase_Activity	Mouse	Brain	rep_1	4.7e-17
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Brain	rep_1	1.5e-30
Arhgap22	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	2.1e-36
Arhgap22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_1	1.0e-11
Arhgap22	GOBP_Postsynapse_Organization	Mouse	Brain	rep_1	7.8e-17
Arhgap22	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	5.6e-32
Arhgap22	GOBP_Regulation_Of_Postsynapse_Organization	Mouse	Brain	rep_1	3.6e-14
Arhgap22	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_1	5.2e-13
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Brain	rep_1	7.3e-19
Arhgap22	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_1	5.1e-22
Arhgap22	GOBP_Synapse_Organization	Mouse	Brain	rep_1	3.8e-27
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	rep_3	5.3e-58
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Brain	rep_3	7.4e-87
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Brain	rep_3	1.3e-81
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Arhgap22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	1.4e-120
Arhgap22	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Arhgap22	GOBP_Tube_Development	Mouse	Brain	rep_3	9.0e-136
Arhgap22	GOBP_Tube_Morphogenesis	Mouse	Brain	rep_3	4.7e-120
Arhgap22	GOBP_Vasculature_Development	Mouse	Brain	rep_3	2.6e-82
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Embryo	rep_6	1.6e-12
Arhgap22	GOBP_Activation_Of_Gtpase_Activity	Mouse	Embryo	rep_14	1.4e-30
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	8.5e-07
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Arhgap22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_1	1.6e-15
Arhgap22	GOBP_Postsynapse_Organization	Mouse	Embryo	rep_3	1.1e-51
Arhgap22	GOBP_Regulation_Of_Postsynapse_Organization	Mouse	Embryo	rep_3	0.0e+00
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Embryo	rep_3	0.0e+00
Arhgap22	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Embryo	rep_3	5.2e-68
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Embryo	rep_6	3.8e-28
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Embryo	rep_6	1.6e-86
Arhgap22	GOBP_Vasculature_Development	Mouse	Embryo	rep_6	1.9e-41
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Kidney	Nep	5.6e-37
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Arhgap22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.4e-48
Arhgap22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.3e-36
Arhgap22	GOBP_Tube_Development	Mouse	Kidney	Nep	5.6e-37
Arhgap22	GOBP_Tube_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Arhgap22	GOBP_Vasculature_Development	Mouse	Kidney	Nep	5.6e-37
Arhgap22	GOBP_Activation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	2.2e-104
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	rep_2	5.6e-148
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Kidney	rep_2	3.2e-114
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Kidney	rep_2	6.2e-52
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Kidney	rep_2	6.7e-139
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Arhgap22	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	2.1e-81
Arhgap22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	3.6e-50
Arhgap22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Arhgap22	GOBP_Postsynapse_Organization	Mouse	Kidney	rep_2	3.7e-17
Arhgap22	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	1.2e-71
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	1.4e-60
Arhgap22	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Arhgap22	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Kidney	rep_2	1.0e-93
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Kidney	rep_2	1.9e-31
Arhgap22	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Kidney	rep_2	1.2e-75
Arhgap22	GOBP_Synapse_Organization	Mouse	Kidney	rep_2	3.0e-45
Arhgap22	GOBP_Tube_Development	Mouse	Kidney	rep_2	1.2e-129
Arhgap22	GOBP_Tube_Morphogenesis	Mouse	Kidney	rep_2	2.1e-134
Arhgap22	GOBP_Vasculature_Development	Mouse	Kidney	rep_2	2.3e-129
Arhgap22	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Liver	CN16-D2	1.9e-10
Arhgap22	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Liver	CN16-D2	1.3e-07
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Liver	rep_16	1.6e-07
Arhgap22	GOBP_Postsynapse_Organization	Mouse	Liver	rep_16	3.7e-10
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Liver	rep_16	2.4e-08
Arhgap22	GOBP_Activation_Of_Gtpase_Activity	Mouse	Lymph	MS-1	1.2e-11
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Lymph	MS-1	6.4e-13
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Lymph	MS-1	3.6e-10
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Lymph	MS-1	1.6e-11
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Arhgap22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	1.9e-08
Arhgap22	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Arhgap22	GOBP_Regulation_Of_Postsynapse_Organization	Mouse	Lymph	MS-1	3.5e-09
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Lymph	MS-1	8.5e-09
Arhgap22	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Lymph	MS-1	3.5e-10
Arhgap22	GOBP_Tube_Development	Mouse	Lymph	MS-1	4.6e-09
Arhgap22	GOBP_Tube_Morphogenesis	Mouse	Lymph	MS-1	9.1e-10
Arhgap22	GOBP_Vasculature_Development	Mouse	Lymph	MS-1	3.0e-12
Arhgap22	GOBP_Activation_Of_Gtpase_Activity	Mouse	Brain	rep_4	5.3e-15
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Brain	rep_4	3.7e-07
Arhgap22	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_4	7.8e-12
Arhgap22	GOBP_Postsynapse_Organization	Mouse	Brain	rep_4	1.2e-12
Arhgap22	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_4	6.8e-16
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Brain	rep_4	6.1e-16
Arhgap22	GOBP_Synapse_Organization	Mouse	Brain	rep_4	3.8e-17
Arhgap22	GOBP_Cell_Junction_Organization	Mouse	Brain	HP_ad_rep7	2.9e-10
Arhgap22	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Arhgap22	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_ad_rep7	4.8e-07
Arhgap22	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Arhgap22	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	HP_ad_rep7	4.6e-08
Arhgap22	GOBP_Synapse_Organization	Mouse	Brain	HP_ad_rep7	7.3e-08
Arhgap22	GOBP_Tube_Development	Mouse	Brain	HP_ad_rep7	2.0e-08
Arhgap22	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	HP_polb_rep9	6.3e-08
Arhgap22	GOBP_Blood_Vessel_Morphogenesis	Mouse	Brain	HP_polb_rep9	1.0e-11
Arhgap22	GOBP_Circulatory_System_Development	Mouse	Brain	HP_polb_rep9	3.1e-09
Arhgap22	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_polb_rep9	4.2e-09
Arhgap22	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	6.0e-09
Arhgap22	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11
Arhgap22	GOBP_Regulation_Of_Postsynapse_Organization	Mouse	Brain	HP_polb_rep9	4.9e-07
Arhgap22	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	HP_polb_rep9	5.2e-07
Arhgap22	GOBP_Regulation_Of_Synapse_Structure_Or_Activity	Mouse	Brain	HP_polb_rep9	5.0e-10
Arhgap22	GOBP_Tube_Morphogenesis	Mouse	Brain	HP_polb_rep9	4.0e-10
Arhgap22	GOBP_Vasculature_Development	Mouse	Brain	HP_polb_rep9	3.4e-10
Arhgap22	GOBP_Positive_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_wt_rep2	2.1e-07

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Arhgap22 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Arhgap22 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Arhgap22 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Arhgap22

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Arhgap22

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source