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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Topbp1 (spascer ID:235559)

Gene summary for Topbp1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Topbp1
	Gene ID	235559
	Gene name	topoisomerase (DNA) II binding protein 1
	Synonyms	1110031N14Rik\|2810429C13Rik\|AI256758\|D430026L04Rik\|mKIAA0259
	Cytomap	9\|9 F1
	Type of gene	protein-coding
	Description	DNA topoisomerase 2-binding protein 1DNA topoisomerase II-beta-binding protein 1DNA topoisomerase II-binding protein 1topoisomerase (DNA) II beta binding protein
	Modification date	20220424
	UniProtAcc	Q6ZQF0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Topbp1	GO:0006270	DNA replication initiation	21873635	Process
Topbp1	GO:0007095	mitotic G2 DNA damage checkpoint signaling	21873635	Process
Topbp1	GO:0033314	mitotic DNA replication checkpoint signaling	21873635	Process

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Spatial pattern events for Topbp1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Topbp1	Mouse	Embryo	4E	34210887	1.42e-09
Topbp1	Mouse	Embryo	rep_3	33188776	5.29e-08
Topbp1	Mouse	Embryo	rep_13	33188776	1.08e-08
Topbp1	Mouse	Kidney	rep_5	34853151	2.71e-07
Topbp1	Mouse	Brain	rep_1	33469025	4.99e-12
Topbp1	Mouse	Testicle	rep_4	34731600	2.29e-15
Topbp1	Mouse	Lymph	A1	0	4.27e-14
Topbp1	Mouse	Lymph	B1	0	3.66e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_rep_5_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Topbp1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Topbp1	GOBP_Cell_Cycle	Mouse	Spinal cord	CN94_E1	1.1e-06
Topbp1	GOBP_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	3.8e-06
Topbp1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Spinal cord	CN94_E1	8.0e-06
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Spinal cord	CN94_E1	2.7e-06
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	CN94_E1	3.2e-06
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Spinal cord	CN94_E1	2.9e-07
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	5.0e-07
Topbp1	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Spinal cord	CN94_E1	4.0e-06
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Spinal cord	CN94_E1	3.3e-06
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	7.5e-07
Topbp1	GOBP_Cell_Cycle_Phase_Transition	Mouse	Spinal cord	L7bCN02_E1	1.5e-06
Topbp1	GOBP_Dna_Repair	Mouse	Spinal cord	L7CN45_C1	9.4e-06
Topbp1	GOBP_Dna_Replication	Mouse	Spinal cord	L7CN45_C1	2.8e-07
Topbp1	GOBP_Dna_Replication_Initiation	Mouse	Spinal cord	L7CN45_C1	6.9e-06
Topbp1	GOBP_Mitotic_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Topbp1	GOBP_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	3.0e-07
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Spinal cord	L7CN45_C1	5.9e-07
Topbp1	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	5.4e-08
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Topbp1	GOBP_Response_To_Ionizing_Radiation	Mouse	Spinal cord	L7CN45_C1	6.9e-07
Topbp1	GOBP_Response_To_Radiation	Mouse	Spinal cord	L7CN45_C1	4.5e-07
Topbp1	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Spinal cord	L7CN47_C1	3.3e-07
Topbp1	GOBP_Dna_Dependent_Dna_Replication	Mouse	Spinal cord	L7CN47_C1	6.6e-06
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Spinal cord	L7CN97_E2	3.6e-06
Topbp1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	rep_11	7.1e-05
Topbp1	GOBP_Cell_Cycle	Mouse	Brain	rep_27	8.4e-07
Topbp1	GOBP_Dna_Replication	Mouse	Brain	rep_27	6.4e-06
Topbp1	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	rep_27	1.1e-05
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_27	1.7e-08
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_27	4.4e-08
Topbp1	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	rep_27	7.4e-07
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	rep_37	6.9e-05
Topbp1	GOBP_Cell_Cycle	Mouse	Brain	rep_1	7.0e-10
Topbp1	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	rep_1	8.5e-51
Topbp1	GOBP_Cell_Cycle_Phase_Transition	Mouse	Brain	rep_1	1.6e-31
Topbp1	GOBP_Cell_Cycle_Process	Mouse	Brain	rep_1	6.7e-14
Topbp1	GOBP_Dna_Dependent_Dna_Replication	Mouse	Brain	rep_1	1.5e-17
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Brain	rep_1	1.1e-07
Topbp1	GOBP_Dna_Replication	Mouse	Brain	rep_1	4.3e-10
Topbp1	GOBP_Dna_Replication_Initiation	Mouse	Brain	rep_1	1.9e-10
Topbp1	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	rep_1	1.5e-25
Topbp1	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_1	3.9e-14
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	rep_1	4.2e-12
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_1	4.4e-18
Topbp1	GOBP_Response_To_Abiotic_Stimulus	Mouse	Brain	rep_1	6.0e-28
Topbp1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	rep_3	5.0e-192
Topbp1	GOBP_Dna_Repair	Mouse	Brain	rep_3	4.0e-216
Topbp1	GOBP_Mitotic_G2_M_Transition_Checkpoint	Mouse	Brain	rep_3	1.1e-182
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_3	1.9e-186
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	rep_3	9.7e-193
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Brain	rep_3	1.7e-195
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_3	4.5e-183
Topbp1	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	rep_3	3.7e-178
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Brain	rep_3	3.1e-201
Topbp1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Topbp1	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	rep_3	1.7e-200
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Brain	rep_3	1.2e-89
Topbp1	GOBP_Response_To_Ionizing_Radiation	Mouse	Brain	rep_3	7.3e-150
Topbp1	GOBP_Response_To_Radiation	Mouse	Brain	rep_3	4.6e-08
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Brain	rep_3	6.9e-120
Topbp1	GOBP_Dna_Replication_Initiation	Mouse	Embryo	rep_14	3.1e-28
Topbp1	GOBP_Mitotic_G2_M_Transition_Checkpoint	Mouse	Embryo	rep_14	1.0e-18
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Embryo	rep_14	2.6e-12
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Embryo	rep_14	1.3e-11
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Embryo	rep_14	3.3e-08
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Embryo	rep_14	9.5e-37
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Embryo	rep_14	6.6e-44
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Embryo	rep_1	6.7e-65
Topbp1	GOBP_Response_To_Ionizing_Radiation	Mouse	Embryo	rep_1	8.2e-74
Topbp1	GOBP_Response_To_Radiation	Mouse	Embryo	rep_1	0.0e+00
Topbp1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Embryo	rep_2	1.4e-08
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Embryo	rep_2	7.2e-216
Topbp1	GOBP_Dna_Repair	Mouse	Embryo	rep_2	1.6e-282
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Embryo	rep_3	4.8e-13
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Embryo	rep_3	2.8e-65
Topbp1	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Embryo	rep_6	1.2e-274
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Embryo	rep_6	1.2e-274
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Embryo	rep_6	1.2e-274
Topbp1	GOBP_Cell_Cycle	Mouse	Kidney	rep_2	1.0e-24
Topbp1	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Kidney	rep_2	8.2e-89
Topbp1	GOBP_Cell_Cycle_Phase_Transition	Mouse	Kidney	rep_2	6.8e-67
Topbp1	GOBP_Cell_Cycle_Process	Mouse	Kidney	rep_2	3.0e-21
Topbp1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Kidney	rep_2	5.5e-146
Topbp1	GOBP_Dna_Dependent_Dna_Replication	Mouse	Kidney	rep_2	1.1e-109
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-12
Topbp1	GOBP_Dna_Repair	Mouse	Kidney	rep_2	5.5e-70
Topbp1	GOBP_Dna_Replication	Mouse	Kidney	rep_2	5.9e-43
Topbp1	GOBP_Dna_Replication_Initiation	Mouse	Kidney	rep_2	3.5e-30
Topbp1	GOBP_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	1.1e-15
Topbp1	GOBP_Mitotic_G2_M_Transition_Checkpoint	Mouse	Kidney	rep_2	1.1e-79
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Kidney	rep_2	2.8e-71
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Kidney	rep_2	9.2e-94
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Kidney	rep_2	1.2e-75
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Kidney	rep_2	6.0e-76
Topbp1	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	8.9e-62
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Kidney	rep_2	6.1e-79
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Kidney	rep_2	4.2e-70
Topbp1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Topbp1	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	3.2e-49
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Kidney	rep_2	4.2e-64
Topbp1	GOBP_Response_To_Ionizing_Radiation	Mouse	Kidney	rep_2	6.8e-10
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Kidney	rep_2	1.0e-97
Topbp1	GOBP_Dna_Dependent_Dna_Replication	Mouse	Liver	CN16-D2	3.1e-08
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Liver	CN16-D2	2.6e-07
Topbp1	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Liver	CN16-E1	4.3e-09
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Liver	CN16-E1	3.4e-13
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Liver	CN16-E1	1.4e-11
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Liver	CN16-E1	1.6e-18
Topbp1	GOBP_Dna_Replication_Initiation	Mouse	Liver	rep_15	9.0e-18
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Liver	rep_16	1.2e-09
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Liver	rep_16	3.1e-15
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Liver	rep_16	9.0e-07
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Liver	rep_16	1.4e-13
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Liver	rep_16	2.8e-11
Topbp1	GOBP_Cell_Cycle	Mouse	Lymph	MS-1	1.3e-07
Topbp1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Lymph	MS-1	8.5e-13
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Lymph	MS-1	6.8e-10
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	9.2e-07
Topbp1	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Lymph	MS-1	2.4e-09
Topbp1	GOBP_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	6.4e-09
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Lymph	MS-1	4.1e-08
Topbp1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Topbp1	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Lymph	MS-1	6.9e-07
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Lymph	MS-1	1.0e-13
Topbp1	GOBP_Response_To_Abiotic_Stimulus	Mouse	Lymph	MS-1	1.5e-07
Topbp1	GOBP_Response_To_Ionizing_Radiation	Mouse	Lymph	MS-1	2.5e-12
Topbp1	GOBP_Response_To_Radiation	Mouse	Lymph	MS-1	9.1e-12
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Lymph	MS-1	3.2e-10
Topbp1	GOBP_Mitotic_G2_M_Transition_Checkpoint	Mouse	Lymph	MS-2	3.2e-08
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Lymph	MS-2	1.4e-09
Topbp1	GOBP_Dna_Dependent_Dna_Replication	Mouse	Lymph	PBS	2.2e-07
Topbp1	GOBP_Cell_Cycle	Mouse	Brain	HP_ad_rep7	6.6e-08
Topbp1	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	HP_ad_rep7	3.1e-07
Topbp1	GOBP_Cell_Cycle_Phase_Transition	Mouse	Brain	HP_ad_rep7	4.9e-09
Topbp1	GOBP_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Topbp1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	HP_ad_rep7	6.8e-10
Topbp1	GOBP_Dna_Dependent_Dna_Replication	Mouse	Brain	HP_ad_rep7	1.6e-15
Topbp1	GOBP_Dna_Metabolic_Process	Mouse	Brain	HP_ad_rep7	3.1e-11
Topbp1	GOBP_Dna_Repair	Mouse	Brain	HP_ad_rep7	2.4e-12
Topbp1	GOBP_Dna_Replication	Mouse	Brain	HP_ad_rep7	1.1e-10
Topbp1	GOBP_Dna_Replication_Initiation	Mouse	Brain	HP_ad_rep7	2.9e-08
Topbp1	GOBP_Mitotic_G2_M_Transition_Checkpoint	Mouse	Brain	HP_ad_rep7	7.0e-18
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	9.2e-08
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	HP_ad_rep7	1.9e-16
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Brain	HP_ad_rep7	1.2e-12
Topbp1	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	5.3e-15
Topbp1	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	HP_ad_rep7	5.7e-10
Topbp1	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	1.6e-08
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Mouse	Brain	HP_ad_rep7	7.6e-13
Topbp1	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	9.9e-08
Topbp1	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Mouse	Brain	HP_ad_rep7	3.4e-10
Topbp1	GOBP_Response_To_Abiotic_Stimulus	Mouse	Brain	HP_ad_rep7	4.3e-08
Topbp1	GOBP_Response_To_Ionizing_Radiation	Mouse	Brain	HP_ad_rep7	2.5e-09
Topbp1	GOBP_Response_To_Radiation	Mouse	Brain	HP_ad_rep7	9.1e-09
Topbp1	GOBP_Regulation_Of_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	HP_adpolb_rep1	7.8e-09
Topbp1	GOBP_Regulation_Of_Signal_Transduction_By_P53_Class_Mediator	Mouse	Brain	HP_adpolb_rep1	1.2e-12
Topbp1	GOBP_Signal_Transduction_By_P53_Class_Mediator	Mouse	Brain	HP_adpolb_rep1	5.9e-12
Topbp1	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	HP_polb_rep9	1.6e-10
Topbp1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11

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Topbp1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Topbp1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Topbp1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Topbp1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Topbp1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Topbp1	C0023434	Chronic Lymphocytic Leukemia	1	CTD_human