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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

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Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Kmt2c (spascer ID:231051)

Gene summary for Kmt2c

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Kmt2c

Gene ID

231051

Gene namelysine (K)-specific methyltransferase 2C
SynonymsE330008K23Rik|HALR|Mll3
Cytomap5|5 B1
Type of geneprotein-coding
Descriptionhistone-lysine N-methyltransferase 2Chistone-lysine N-methyltransferase MLL3myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Modification date20220424
UniProtAcc

Q8BRH4


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Kmt2c

GO:0003713

transcription coactivator activity

21873635

Function
Kmt2c

GO:0042393

histone binding

21873635

Function
Kmt2c

GO:0042800

histone methyltransferase activity (H3-K4 specific)

21873635

Function
Kmt2c

GO:0044666

MLL3/4 complex

21873635

Component
Kmt2c

GO:0045944

positive regulation of transcription by RNA polymerase II

21873635

Process

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Spatial pattern events for Kmt2c

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Kmt2cMouseEmbryorep_4 331887768.11e-06
Kmt2cMouseBrainrep_1 334690251.36e-10
Kmt2cMouseBrainrep_2 350277294.74e-14
Kmt2cMouseBrainrep_3 350277292.09e-10
Kmt2cMouseBrainrep_5 352106245.38e-07

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
boxplot
Brain_rep_2_H&E
boxplot
boxplot
Brain_rep_3_H&E
boxplot
boxplot


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Spatial pattern pathway has Kmt2c envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseSpinal cordCN94_E1 5.2e-06
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseSpinal cordCN94_E1 2.9e-07
Kmt2cGOBP_MethylationMouseSpinal cordCN94_E1 7.7e-06
Kmt2cGOBP_Myeloid_Cell_DifferentiationMouseSpinal cordCN94_E1 2.9e-06
Kmt2cGOBP_Protein_MethylationMouseSpinal cordCN94_E1 2.5e-06
Kmt2cGOBP_Regulation_Of_HemopoiesisMouseSpinal cordCN94_E1 6.5e-06
Kmt2cGOBP_Chromatin_OrganizationMouseSpinal cordL7CN45_C1 3.5e-07
Kmt2cGOBP_Chromosome_OrganizationMouseSpinal cordL7CN45_C1 3.4e-08
Kmt2cGOBP_Histone_H3_K4_MethylationMouseSpinal cordL7CN45_C1 1.0e-07
Kmt2cGOBP_Histone_MethylationMouseSpinal cordL7CN45_C1 5.2e-09
Kmt2cGOBP_Immune_System_DevelopmentMouseSpinal cordL7CN45_C1 8.5e-07
Kmt2cGOBP_Peptidyl_Amino_Acid_ModificationMouseSpinal cordL7CN45_C1 1.6e-07
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseSpinal cordL7CN45_C1 3.5e-08
Kmt2cGOBP_Peptidyl_Lysine_ModificationMouseSpinal cordL7CN45_C1 9.7e-08
Kmt2cGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseSpinal cordL7CN45_C1 1.4e-06
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseSpinal cordL7CN45_C1 8.5e-07
Kmt2cGOBP_Regulation_Of_Immune_System_ProcessMouseSpinal cordL7CN45_C1 4.2e-06
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseSpinal cordL7CN45_C1 8.7e-08
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseSpinal cordL7CN45_C1 4.0e-08
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseSpinal cordL7CN45_C1 1.1e-06
Kmt2cGOBP_Peptidyl_Lysine_ModificationMouseBrainrep_27 4.2e-05
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseBrainrep_41 4.5e-09
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseBrainrep_41 5.2e-09
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseBrainrep_72 1.5e-05
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseBrainrep_75 9.1e-05
Kmt2cGOBP_Chromosome_OrganizationMouseBrainrep_1 3.9e-07
Kmt2cGOBP_Histone_H3_K4_MethylationMouseBrainrep_1 1.9e-19
Kmt2cGOBP_Histone_MethylationMouseBrainrep_1 1.3e-09
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseBrainrep_1 9.3e-27
Kmt2cGOBP_Peptidyl_Amino_Acid_ModificationMouseBrainrep_1 9.0e-07
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseBrainrep_1 3.4e-21
Kmt2cGOBP_Peptidyl_Lysine_ModificationMouseBrainrep_1 1.1e-21
Kmt2cGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseBrainrep_1 2.5e-12
Kmt2cGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseBrainrep_1 1.6e-17
Kmt2cGOBP_Protein_MethylationMouseBrainrep_1 1.8e-08
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseBrainrep_1 2.3e-15
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseBrainrep_1 5.9e-45
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseBrainrep_1 1.8e-19
Kmt2cGOBP_Chromatin_OrganizationMouseBrainrep_35.1e-215
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseBrainrep_31.2e-113
Kmt2cGOBP_Immune_System_DevelopmentMouseBrainrep_3 1.3e-52
Kmt2cGOBP_MethylationMouseBrainrep_33.9e-199
Kmt2cGOBP_Myeloid_Cell_DifferentiationMouseBrainrep_3 1.8e-21
Kmt2cGOBP_Regulation_Of_HemopoiesisMouseBrainrep_32.8e-139
Kmt2cGOBP_Regulation_Of_Immune_System_ProcessMouseBrainrep_36.4e-111
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseBrainrep_3 5.2e-95
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseEmbryorep_6 3.2e-18
Kmt2cGOBP_Regulation_Of_HemopoiesisMouseEmbryorep_6 8.7e-07
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseEmbryorep_6 3.4e-34
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseEmbryorep_14 2.6e-31
Kmt2cGOBP_Myeloid_Cell_DifferentiationMouseEmbryorep_14 1.3e-11
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseEmbryorep_14 1.3e-07
Kmt2cGOBP_Immune_System_DevelopmentMouseEmbryorep_1 0.0e+00
Kmt2cGOBP_Myeloid_Cell_DifferentiationMouseEmbryorep_12.4e-139
Kmt2cGOBP_Regulation_Of_HemopoiesisMouseEmbryorep_1 0.0e+00
Kmt2cGOBP_Regulation_Of_Immune_System_ProcessMouseEmbryorep_19.5e-143
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseEmbryorep_12.8e-203
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseEmbryorep_1 0.0e+00
Kmt2cGOBP_Histone_MethylationMouseEmbryorep_2 5.9e-67
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseEmbryorep_2 3.7e-17
Kmt2cGOBP_Peptidyl_Lysine_ModificationMouseEmbryorep_2 3.3e-11
Kmt2cGOBP_Protein_MethylationMouseEmbryorep_2 2.4e-42
Kmt2cGOBP_Chromatin_OrganizationMouseEmbryorep_3 2.9e-87
Kmt2cGOBP_Chromosome_OrganizationMouseEmbryorep_3 1.4e-57
Kmt2cGOBP_Histone_H3_K4_MethylationMouseEmbryorep_3 0.0e+00
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseEmbryorep_3 3.0e-41
Kmt2cGOBP_MethylationMouseEmbryorep_3 0.0e+00
Kmt2cGOBP_Peptidyl_Amino_Acid_ModificationMouseEmbryorep_3 0.0e+00
Kmt2cGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseEmbryorep_3 0.0e+00
Kmt2cGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseEmbryorep_3 0.0e+00
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseEmbryorep_3 6.3e-72
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseKidneyNep 1.3e-32
Kmt2cGOBP_Chromatin_OrganizationMouseKidneyrep_2 3.0e-63
Kmt2cGOBP_Chromosome_OrganizationMouseKidneyrep_2 1.0e-14
Kmt2cGOBP_Histone_H3_K4_MethylationMouseKidneyrep_2 2.8e-85
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseKidneyrep_2 4.2e-45
Kmt2cGOBP_Histone_MethylationMouseKidneyrep_2 3.8e-43
Kmt2cGOBP_Immune_System_DevelopmentMouseKidneyrep_2 4.6e-22
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseKidneyrep_2 1.2e-34
Kmt2cGOBP_MethylationMouseKidneyrep_2 2.7e-54
Kmt2cGOBP_Peptidyl_Amino_Acid_ModificationMouseKidneyrep_2 6.9e-23
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseKidneyrep_2 4.8e-27
Kmt2cGOBP_Peptidyl_Lysine_ModificationMouseKidneyrep_2 5.8e-39
Kmt2cGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseKidneyrep_2 4.5e-10
Kmt2cGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseKidneyrep_2 8.3e-40
Kmt2cGOBP_Protein_MethylationMouseKidneyrep_2 3.1e-51
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseKidneyrep_2 2.6e-14
Kmt2cGOBP_Regulation_Of_Immune_System_ProcessMouseKidneyrep_2 2.5e-84
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseKidneyrep_2 5.9e-15
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseKidneyrep_28.2e-110
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseLiverCN16-D2 8.7e-07
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseLiverCN16-D2 2.7e-08
Kmt2cGOBP_Immune_System_DevelopmentMouseLiverCN73-C1 2.2e-07
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseLiverrep_15 1.6e-15
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseLiverrep_15 8.2e-08
Kmt2cGOBP_Immune_System_DevelopmentMouseLiverrep_16 5.3e-11
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseLiverrep_16 3.6e-08
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseBrainrep_1 9.6e-06
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseBrainrep_1 4.2e-31
Kmt2cGOBP_Chromatin_OrganizationMouseLymphMS-1 9.1e-11
Kmt2cGOBP_Chromosome_OrganizationMouseLymphMS-1 3.5e-09
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseLymphMS-1 4.8e-08
Kmt2cGOBP_Immune_System_DevelopmentMouseLymphMS-1 1.2e-13
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseLymphMS-1 3.8e-10
Kmt2cGOBP_MethylationMouseLymphMS-1 2.5e-08
Kmt2cGOBP_Myeloid_Cell_DifferentiationMouseLymphMS-1 1.9e-13
Kmt2cGOBP_Peptidyl_Amino_Acid_ModificationMouseLymphMS-1 1.2e-13
Kmt2cGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseLymphMS-1 4.4e-12
Kmt2cGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseLymphMS-1 1.7e-12
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseLymphMS-1 1.3e-14
Kmt2cGOBP_Regulation_Of_HemopoiesisMouseLymphMS-1 1.7e-14
Kmt2cGOBP_Regulation_Of_Immune_System_ProcessMouseLymphMS-1 2.2e-14
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseLymphMS-1 7.2e-15
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseLymphMS-1 4.7e-18
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseLymphMS-2 1.7e-07
Kmt2cGOBP_Protein_MethylationMouseLymphMS-2 1.6e-07
Kmt2cGOBP_Histone_MethylationMouseBrainrep_4 1.7e-07
Kmt2cGOBP_Peptidyl_Lysine_MethylationMouseBrainrep_4 1.0e-13
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseBrainrep_7 1.0e-41
Kmt2cGOBP_MethylationMouseBrainrep_7 1.2e-08
Kmt2cGOBP_Chromatin_OrganizationMouseBrainHP_ad_rep7 7.6e-11
Kmt2cGOBP_Chromosome_OrganizationMouseBrainHP_ad_rep7 2.9e-10
Kmt2cGOBP_Histone_H3_K4_MethylationMouseBrainHP_ad_rep7 1.0e-08
Kmt2cGOBP_Histone_MethylationMouseBrainHP_ad_rep7 2.4e-09
Kmt2cGOBP_Immune_System_DevelopmentMouseBrainHP_ad_rep7 8.3e-09
Kmt2cGOBP_MethylationMouseBrainHP_ad_rep7 1.4e-10
Kmt2cGOBP_Myeloid_Cell_DifferentiationMouseBrainHP_ad_rep7 1.2e-09
Kmt2cGOBP_Peptidyl_Amino_Acid_ModificationMouseBrainHP_ad_rep7 3.2e-08
Kmt2cGOBP_Peptidyl_Lysine_ModificationMouseBrainHP_ad_rep7 1.7e-10
Kmt2cGOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseBrainHP_ad_rep7 2.8e-11
Kmt2cGOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_IiMouseBrainHP_ad_rep7 7.3e-11
Kmt2cGOBP_Protein_MethylationMouseBrainHP_ad_rep7 6.9e-09
Kmt2cGOBP_Regulation_Of_HemopoiesisMouseBrainHP_ad_rep7 2.0e-08
Kmt2cGOBP_Regulation_Of_Immune_System_ProcessMouseBrainHP_ad_rep7 1.8e-09
Kmt2cGOBP_Regulation_Of_Multicellular_Organismal_DevelopmentMouseBrainHP_ad_rep7 1.1e-08
Kmt2cGOBP_Regulation_Of_Myeloid_Cell_DifferentiationMouseBrainHP_ad_rep7 4.4e-11
Kmt2cGOBP_Regulation_Of_Megakaryocyte_DifferentiationMouseBrainHP_adpolb_rep3 7.7e-08
Kmt2cGOBP_Histone_H3_K4_MonomethylationMouseBrainHP_adpolb_rep5 1.9e-08
Kmt2cGOBP_Megakaryocyte_DifferentiationMouseBrainHP_adpolb_rep5 2.4e-07
Kmt2cGOBP_Regulation_Of_Cell_DifferentiationMouseBrainHP_polb_rep9 6.5e-09

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Kmt2c function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Kmt2c function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Kmt2c envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Kmt2c

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Kmt2c

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Kmt2cC3714756Intellectual Disability2GENOMICS_ENGLAND
Kmt2cC4540395KLEEFSTRA SYNDROME 22GENOMICS_ENGLAND
Kmt2cC0001418Adenocarcinoma1CTD_human
Kmt2cC0005684Malignant neoplasm of urinary bladder1CTD_human
Kmt2cC0005695Bladder Neoplasm1CTD_human
Kmt2cC0007138Carcinoma, Transitional Cell1CTD_human
Kmt2cC0010606Adenoid Cystic Carcinoma1CTD_human
Kmt2cC0023467Leukemia, Myelocytic, Acute1CTD_human
Kmt2cC0023897Liver Diseases, Parasitic1CTD_human
Kmt2cC0024623Malignant neoplasm of stomach1CTD_human
Kmt2cC0026998Acute Myeloid Leukemia, M11CTD_human
Kmt2cC0033578Prostatic Neoplasms1CTD_human
Kmt2cC0036920Sezary Syndrome1CTD_human
Kmt2cC0038356Stomach Neoplasms1CTD_human
Kmt2cC0205641Adenocarcinoma, Basal Cell1CTD_human
Kmt2cC0205642Adenocarcinoma, Oxyphilic1CTD_human
Kmt2cC0205643Carcinoma, Cribriform1CTD_human
Kmt2cC0205644Carcinoma, Granular Cell1CTD_human
Kmt2cC0205645Adenocarcinoma, Tubular1CTD_human
Kmt2cC0206698Cholangiocarcinoma1CTD_human
Kmt2cC0279626Squamous cell carcinoma of esophagus1CTD_human
Kmt2cC0345905Intrahepatic Cholangiocarcinoma1CTD_human
Kmt2cC0376358Malignant neoplasm of prostate1CTD_human
Kmt2cC1535926Neurodevelopmental Disorders1CTD_human
Kmt2cC1708349Hereditary Diffuse Gastric Cancer1CTD_human
Kmt2cC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
Kmt2cC2239176Liver carcinoma1CTD_human
Kmt2cC3805278Extrahepatic Cholangiocarcinoma1CTD_human