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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Themis2 (spascer ID:230787)

Gene summary for Themis2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Themis2
	Gene ID	230787
	Gene name	thymocyte selection associated family member 2
	Synonyms	ICB-1
	Cytomap	4\|4 D2.3
	Type of gene	protein-coding
	Description	protein THEMIS2basement membrane-induced proteininduced by contact to basement membrane 1 proteinprotein ICB-1thymocyte-expressed molecule involved in selection protein 2
	Modification date	20220424
	UniProtAcc	Q91YX0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Themis2	GO:0005634	nucleus	21873635	Component
Themis2	GO:0005737	cytoplasm	21873635	Component
Themis2	GO:0050852	T cell receptor signaling pathway	21873635	Process

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Spatial pattern events for Themis2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Themis2	Mouse	Kidney	rep_1	34853151	3.08e-14
Themis2	Mouse	Liver	rep_20	35021063	2.78e-10
Themis2	Mouse	Testicle	rep_4	34731600	1.14e-15
Themis2	Mouse	Lymph	MS-1	0	4.91e-10
Themis2	Mouse	Lymph	MS-2	0	3.09e-09
Themis2	Mouse	Lymph	PBS	0	3.34e-14
Themis2	Mouse	Lymph	A1	0	3.29e-15
Themis2	Mouse	Lymph	B1	0	1.11e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_rep_1_H&E
Liver_rep_20_H&E

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Spatial pattern pathway has Themis2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Themis2	GOBP_Inflammatory_Response	Mouse	Spinal cord	CN94_E1	8.2e-06
Themis2	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Spinal cord	CN94_E1	6.6e-06
Themis2	GOBP_Activation_Of_Immune_Response	Mouse	Spinal cord	L7CN45_C1	7.8e-08
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	9.5e-08
Themis2	GOBP_Biological_Adhesion	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Spinal cord	L7CN45_C1	8.7e-09
Themis2	GOBP_Regulation_Of_Immune_System_Process	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Themis2	GOBP_T_Cell_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	1.8e-06
Themis2	GOBP_Defense_Response	Mouse	Spinal cord	L8CN11_C1	3.3e-17
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Spinal cord	L8CN11_C1	4.7e-22
Themis2	GOBP_Immune_Response_Regulating_Signaling_Pathway	Mouse	Spinal cord	L8CN17_E1	2.8e-06
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	rep_27	7.5e-06
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Brain	rep_1	1.5e-17
Themis2	GOBP_Immune_Response_Regulating_Signaling_Pathway	Mouse	Brain	rep_1	8.1e-27
Themis2	GOBP_Activation_Of_Immune_Response	Mouse	Brain	rep_3	6.5e-108
Themis2	GOBP_Biological_Adhesion	Mouse	Brain	rep_3	4.3e-106
Themis2	GOBP_Defense_Response	Mouse	Brain	rep_3	8.7e-77
Themis2	GOBP_Inflammatory_Response	Mouse	Brain	rep_3	4.1e-53
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Brain	rep_3	7.6e-125
Themis2	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Brain	rep_3	6.9e-97
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	rep_3	1.1e-86
Themis2	GOBP_Regulation_Of_Immune_System_Process	Mouse	Brain	rep_3	6.4e-111
Themis2	GOBP_T_Cell_Receptor_Signaling_Pathway	Mouse	Brain	rep_3	1.2e-157
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Embryo	rep_14	3.2e-28
Themis2	GOBP_Immune_Response_Regulating_Signaling_Pathway	Mouse	Embryo	rep_14	5.3e-08
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Embryo	rep_14	9.6e-07
Themis2	GOBP_T_Cell_Receptor_Signaling_Pathway	Mouse	Embryo	rep_14	4.2e-46
Themis2	GOBP_Biological_Adhesion	Mouse	Embryo	rep_1	2.2e-19
Themis2	GOBP_Defense_Response	Mouse	Embryo	rep_1	5.2e-63
Themis2	GOBP_Inflammatory_Response	Mouse	Embryo	rep_1	1.1e-20
Themis2	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Embryo	rep_1	7.3e-23
Themis2	GOBP_Regulation_Of_Immune_System_Process	Mouse	Embryo	rep_1	9.5e-143
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Kidney	IRI	8.3e-08
Themis2	GOBP_Inflammatory_Response	Mouse	Kidney	Nep	6.5e-32
Themis2	GOBP_Activation_Of_Immune_Response	Mouse	Kidney	rep_2	5.4e-134
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Kidney	rep_2	2.1e-119
Themis2	GOBP_Biological_Adhesion	Mouse	Kidney	rep_2	1.3e-48
Themis2	GOBP_Defense_Response	Mouse	Kidney	rep_2	6.8e-127
Themis2	GOBP_Inflammatory_Response	Mouse	Kidney	rep_2	8.2e-77
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Kidney	rep_2	8.3e-94
Themis2	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Kidney	rep_2	1.2e-85
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Kidney	rep_2	1.3e-91
Themis2	GOBP_Regulation_Of_Immune_System_Process	Mouse	Kidney	rep_2	2.5e-84
Themis2	GOBP_T_Cell_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	2.2e-102
Themis2	GOBP_Activation_Of_Immune_Response	Mouse	Liver	rep_16	5.6e-12
Themis2	GOBP_Biological_Adhesion	Mouse	Liver	rep_16	2.1e-07
Themis2	GOBP_Defense_Response	Mouse	Liver	rep_16	8.0e-16
Themis2	GOBP_Inflammatory_Response	Mouse	Liver	rep_16	3.5e-14
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Liver	rep_16	2.3e-11
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Liver	rep_16	2.5e-16
Themis2	GOBP_Activation_Of_Immune_Response	Mouse	Lymph	MS-1	2.3e-23
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Lymph	MS-1	8.7e-25
Themis2	GOBP_Biological_Adhesion	Mouse	Lymph	MS-1	8.0e-14
Themis2	GOBP_Defense_Response	Mouse	Lymph	MS-1	8.6e-18
Themis2	GOBP_Immune_Response_Regulating_Signaling_Pathway	Mouse	Lymph	MS-1	2.3e-23
Themis2	GOBP_Inflammatory_Response	Mouse	Lymph	MS-1	1.2e-12
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Lymph	MS-1	1.0e-21
Themis2	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Lymph	MS-1	1.6e-18
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Lymph	MS-1	2.3e-21
Themis2	GOBP_Regulation_Of_Immune_System_Process	Mouse	Lymph	MS-1	2.2e-14
Themis2	GOBP_T_Cell_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	2.7e-15
Themis2	GOBP_Biological_Adhesion	Mouse	Lung	rep_1	3.0e-22
Themis2	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	2.3e-09
Themis2	GOBP_Defense_Response	Mouse	Brain	HP_ad_rep7	5.6e-10
Themis2	GOBP_Immune_Response_Regulating_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	3.3e-10
Themis2	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Brain	HP_ad_rep7	4.6e-07
Themis2	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Brain	HP_ad_rep7	5.5e-07
Themis2	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	HP_ad_rep7	2.1e-11
Themis2	GOBP_Regulation_Of_Immune_System_Process	Mouse	Brain	HP_ad_rep7	1.8e-09
Themis2	GOBP_Activation_Of_Immune_Response	Mouse	Brain	HP_polb_rep9	2.1e-07
Themis2	GOBP_Biological_Adhesion	Mouse	Brain	HP_polb_rep9	1.5e-07
Themis2	GOBP_Inflammatory_Response	Mouse	Brain	HP_polb_rep9	2.0e-10
Themis2	GOBP_T_Cell_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	2.2e-08

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Themis2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Themis2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Themis2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Themis2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Themis2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Themis2	C0006142	Malignant neoplasm of breast	1	CTD_human
Themis2	C0678222	Breast Carcinoma	1	CTD_human
Themis2	C1257931	Mammary Neoplasms, Human	1	CTD_human
Themis2	C1458155	Mammary Neoplasms	1	CTD_human
Themis2	C4704874	Mammary Carcinoma, Human	1	CTD_human