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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Pex6 (spascer ID:224824)

Gene summary for Pex6

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Pex6
	Gene ID	224824
	Gene name	peroxisomal biogenesis factor 6
	Synonyms	AI132582\|D130055I09Rik\|PAF-2
	Cytomap	17\|17 C
	Type of gene	protein-coding
	Description	peroxisome assembly factor 2peroxin-6peroxisomal-type ATPase 1
	Modification date	20220424
	UniProtAcc	Q99LC9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Pex6	GO:0005778	peroxisomal membrane	21873635	Component
Pex6	GO:0005829	cytosol	21873635	Component
Pex6	GO:0016558	protein import into peroxisome matrix	21873635	Process
Pex6	GO:0016887	ATP hydrolysis activity	21873635	Function

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Spatial pattern events for Pex6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Pex6	Mouse	Brain	S1	34413515	2.87e-06
Pex6	Mouse	Brain	S6	34413515	9.93e-07
Pex6	Mouse	Kidney	IRI	34003797	2.47e-06
Pex6	Mouse	Intestine	rep_4	35149721	2.30e-15
Pex6	Mouse	Testicle	rep_6	34731600	8.98e-10
Pex6	Mouse	Lymph	B1	0	8.53e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_IRI_H&E

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Spatial pattern pathway has Pex6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Pex6	GOBP_Protein_Import	Mouse	Spinal cord	CN94_E1	5.1e-06
Pex6	GOBP_Regulation_Of_Protein_Stability	Mouse	Spinal cord	CN94_E1	9.3e-07
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Spinal cord	L7CN44_C1	1.3e-07
Pex6	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Pex6	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Pex6	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Pex6	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Pex6	GOBP_Peroxisomal_Transport	Mouse	Spinal cord	L7CN45_C1	2.1e-10
Pex6	GOBP_Protein_Localization_To_Organelle	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Pex6	GOBP_Protein_Stabilization	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Pex6	GOBP_Protein_Targeting	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Pex6	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Spinal cord	L7CN45_C1	1.5e-07
Pex6	GOBP_Protein_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	3.8e-08
Pex6	GOBP_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Pex6	GOBP_Anion_Transmembrane_Transport	Mouse	Spinal cord	L7CN97_E2	6.0e-06
Pex6	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Brain	rep_1	2.0e-13
Pex6	GOBP_Transmembrane_Transport	Mouse	Brain	rep_1	3.1e-23
Pex6	GOBP_Anion_Transmembrane_Transport	Mouse	Brain	rep_3	3.0e-77
Pex6	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Pex6	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	1.2e-180
Pex6	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Pex6	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Pex6	GOBP_Peroxisomal_Transport	Mouse	Brain	rep_3	8.3e-139
Pex6	GOBP_Peroxisome_Organization	Mouse	Brain	rep_3	1.3e-123
Pex6	GOBP_Protein_Import	Mouse	Brain	rep_3	4.9e-170
Pex6	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	6.3e-172
Pex6	GOBP_Protein_Stabilization	Mouse	Brain	rep_3	1.9e-142
Pex6	GOBP_Protein_Targeting	Mouse	Brain	rep_3	2.9e-187
Pex6	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Brain	rep_3	1.1e-203
Pex6	GOBP_Protein_Transmembrane_Transport	Mouse	Brain	rep_3	4.1e-194
Pex6	GOBP_Regulation_Of_Protein_Stability	Mouse	Brain	rep_3	3.1e-136
Pex6	GOBP_Anion_Transmembrane_Transport	Mouse	Embryo	rep_14	5.1e-40
Pex6	GOBP_Peroxisomal_Transport	Mouse	Embryo	rep_14	4.0e-31
Pex6	GOBP_Peroxisome_Organization	Mouse	Embryo	rep_14	3.3e-21
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Embryo	rep_14	2.1e-39
Pex6	GOBP_Protein_Stabilization	Mouse	Embryo	rep_14	3.2e-21
Pex6	GOBP_Protein_Targeting	Mouse	Embryo	rep_14	6.3e-09
Pex6	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Embryo	rep_14	8.4e-89
Pex6	GOBP_Protein_Transmembrane_Transport	Mouse	Embryo	rep_14	1.3e-58
Pex6	GOBP_Regulation_Of_Protein_Stability	Mouse	Embryo	rep_14	4.3e-14
Pex6	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Embryo	rep_1	8.6e-17
Pex6	GOBP_Protein_Import	Mouse	Embryo	rep_1	1.6e-15
Pex6	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Pex6	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Pex6	GOBP_Protein_Stabilization	Mouse	Embryo	rep_5	1.1e-25
Pex6	GOBP_Regulation_Of_Protein_Stability	Mouse	Embryo	rep_5	6.2e-09
Pex6	GOBP_Transmembrane_Transport	Mouse	Kidney	Nep	4.2e-26
Pex6	GOBP_Anion_Transmembrane_Transport	Mouse	Kidney	rep_2	1.0e-56
Pex6	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Pex6	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Pex6	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.3e-19
Pex6	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Pex6	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Pex6	GOBP_Peroxisomal_Transport	Mouse	Kidney	rep_2	9.4e-74
Pex6	GOBP_Peroxisome_Organization	Mouse	Kidney	rep_2	1.7e-39
Pex6	GOBP_Protein_Import	Mouse	Kidney	rep_2	8.2e-25
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Kidney	rep_2	6.5e-136
Pex6	GOBP_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.4e-44
Pex6	GOBP_Protein_Targeting	Mouse	Kidney	rep_2	1.7e-40
Pex6	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Kidney	rep_2	3.6e-33
Pex6	GOBP_Protein_Transmembrane_Transport	Mouse	Kidney	rep_2	4.9e-20
Pex6	GOBP_Transmembrane_Transport	Mouse	Kidney	rep_2	2.7e-23
Pex6	GOBP_Transmembrane_Transport	Mouse	Liver	rep_16	1.4e-13
Pex6	GOBP_Anion_Transmembrane_Transport	Mouse	Lymph	MS-1	7.5e-13
Pex6	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Pex6	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Pex6	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	3.3e-11
Pex6	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Pex6	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Pex6	GOBP_Peroxisomal_Transport	Mouse	Lymph	MS-1	3.4e-10
Pex6	GOBP_Protein_Import	Mouse	Lymph	MS-1	8.2e-11
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Lymph	MS-1	5.7e-09
Pex6	GOBP_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	1.4e-09
Pex6	GOBP_Protein_Stabilization	Mouse	Lymph	MS-1	5.9e-10
Pex6	GOBP_Protein_Targeting	Mouse	Lymph	MS-1	2.1e-09
Pex6	GOBP_Regulation_Of_Protein_Stability	Mouse	Lymph	MS-1	1.0e-14
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Brain	rep_7	1.3e-15
Pex6	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Pex6	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Pex6	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	6.1e-09
Pex6	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Pex6	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Pex6	GOBP_Protein_Import_Into_Peroxisome_Matrix	Mouse	Brain	HP_ad_rep7	1.5e-07
Pex6	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	4.8e-12
Pex6	GOBP_Protein_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	2.7e-07
Pex6	GOBP_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	3.4e-07
Pex6	GOBP_Anion_Transmembrane_Transport	Mouse	Brain	HP_polb_rep9	6.5e-17
Pex6	GOBP_Peroxisomal_Transport	Mouse	Brain	HP_polb_rep9	6.5e-20
Pex6	GOBP_Peroxisome_Organization	Mouse	Brain	HP_polb_rep9	8.3e-16
Pex6	GOBP_Protein_Import	Mouse	Brain	HP_polb_rep9	1.1e-07
Pex6	GOBP_Protein_Targeting	Mouse	Brain	HP_polb_rep9	1.8e-11
Pex6	GOBP_Protein_Transmembrane_Import_Into_Intracellular_Organelle	Mouse	Brain	HP_polb_rep9	1.1e-17
Pex6	GOBP_Regulation_Of_Protein_Stability	Mouse	Brain	HP_polb_rep9	8.6e-09

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Pex6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Pex6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Pex6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Pex6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Pex6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Pex6	C3553936	PEROXISOME BIOGENESIS DISORDER 4A (ZELLWEGER)	10	CTD_human;GENOMICS_ENGLAND;UNIPROT
Pex6	C3553937	PEROXISOME BIOGENESIS DISORDER 4B	5	CTD_human;GENOMICS_ENGLAND
Pex6	C4225267	HEIMLER SYNDROME 2	4	GENOMICS_ENGLAND;UNIPROT
Pex6	C1832200	Peroxisome biogenesis disorders	3	CTD_human;GENOMICS_ENGLAND
Pex6	C0043459	Zellweger Syndrome	2	CTD_human;GENOMICS_ENGLAND
Pex6	C0751594	Zellweger-Like Syndrome	2	CTD_human
Pex6	C3658299	Zellweger Spectrum	2	CTD_human
Pex6	C0020796	Profound Mental Retardation	1	CTD_human
Pex6	C0025363	Mental Retardation, Psychosocial	1	CTD_human
Pex6	C0917816	Mental deficiency	1	CTD_human
Pex6	C1849094	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 3	1	ORPHANET
Pex6	C1856186	Deafness enamel hypoplasia nail defects	1	CTD_human;ORPHANET
Pex6	C3714756	Intellectual Disability	1	CTD_human