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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tle4 (spascer ID:21888)

Gene summary for Tle4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tle4
	Gene ID	21888
	Gene name	transducin-like enhancer of split 4
	Synonyms	5730411M05Rik\|AA792082\|Bce-1\|Bce1\|ESTM13\|ESTM14\|Grg4\|X83332\|X83333\|grg-4
	Cytomap	19 A\|19 9.11 cM
	Type of gene	protein-coding
	Description	transducin-like enhancer protein 4B lymphocyte gene 1groucho-related protein 4transducin-like enhancer of split 4, homolog of Drosophila E(spl)
	Modification date	20220424
	UniProtAcc	Q62441

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tle4	GO:0003714	transcription corepressor activity	21873635	Function
Tle4	GO:0005634	nucleus	21873635	Component
Tle4	GO:0005667	transcription regulator complex	21873635	Component
Tle4	GO:0090090	negative regulation of canonical Wnt signaling pathway	21873635	Process

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Spatial pattern events for Tle4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tle4	Mouse	Brain	S1	34413515	2.07e-15
Tle4	Mouse	Brain	S2	34413515	1.56e-15
Tle4	Mouse	Brain	S3	34413515	3.90e-14
Tle4	Mouse	Brain	S4	34413515	1.37e-15
Tle4	Mouse	Brain	S6	34413515	1.46e-15
Tle4	Mouse	Brain	S7	34413515	1.55e-15
Tle4	Mouse	Brain	02A	32637622	6.13e-07
Tle4	Mouse	Brain	04B	32637622	1.02e-08
Tle4	Mouse	Brain	05B	32637622	1.73e-06
Tle4	Mouse	Brain	06B	32637622	1.42e-09
Tle4	Mouse	Brain	07A	32637622	1.84e-07
Tle4	Mouse	Brain	07B	32637622	6.07e-12
Tle4	Mouse	Brain	08A	32637622	8.60e-06
Tle4	Mouse	Brain	12B	32637622	1.23e-08
Tle4	Mouse	Brain	17A	32637622	2.13e-07
Tle4	Mouse	Brain	20A	32637622	1.52e-07
Tle4	Mouse	Brain	22A	32637622	6.97e-11
Tle4	Mouse	Brain	28A	32637622	2.66e-06
Tle4	Mouse	Brain	33A	32637622	2.59e-14
Tle4	Mouse	Brain	33B	32637622	1.94e-14
Tle4	Mouse	Brain	34A	32637622	2.50e-14
Tle4	Mouse	Brain	34B	32637622	1.79e-10
Tle4	Mouse	Brain	rep_1	35141374	2.02e-15
Tle4	Mouse	Brain	rep_2	35141374	1.69e-15
Tle4	Mouse	Brain	rep_3	35141374	1.64e-15
Tle4	Mouse	Brain	rep_4	35141374	1.28e-11
Tle4	Mouse	Brain	rep_5	35141374	3.16e-12
Tle4	Mouse	Brain	rep_6	35141374	9.43e-06
Tle4	Mouse	Embryo	4E	34210887	5.67e-08
Tle4	Mouse	Embryo	rep_2	33188776	3.50e-14
Tle4	Mouse	Embryo	rep_3	33188776	1.13e-14
Tle4	Mouse	Embryo	rep_5	33188776	4.08e-09
Tle4	Mouse	Embryo	rep_7	33188776	1.53e-13
Tle4	Mouse	Embryo	rep_13	33188776	3.05e-09
Tle4	Mouse	Kidney	Sham	34003797	1.37e-06
Tle4	Mouse	Brain	rep_1	33469025	1.30e-15
Tle4	Mouse	Brain	rep_1	35027729	1.66e-15
Tle4	Mouse	Brain	rep_2	35027729	1.57e-15
Tle4	Mouse	Brain	rep_3	35027729	1.32e-15
Tle4	Mouse	Brain	rep_4	35027729	1.76e-15
Tle4	Mouse	Brain	rep_5	35027729	1.46e-15
Tle4	Mouse	Intestine	rep_1	35149721	6.08e-15
Tle4	Mouse	Intestine	rep_2	35149721	2.66e-08
Tle4	Mouse	Intestine	rep_3	35149721	1.37e-11
Tle4	Mouse	Brain	rep_1	35210624	1.74e-15
Tle4	Mouse	Brain	rep_2	35210624	1.74e-15
Tle4	Mouse	Brain	rep_3	35210624	1.82e-15
Tle4	Mouse	Brain	rep_4	35210624	7.35e-14
Tle4	Mouse	Brain	rep_5	35210624	2.60e-09
Tle4	Mouse	Brain	rep_6	35210624	2.05e-15
Tle4	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_Sham_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Tle4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Tle4	GOBP_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Tle4	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	5.6e-07
Tle4	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	4.8e-06
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	4.8e-06
Tle4	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.2e-06
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Spinal cord	L8CN17_E1	1.6e-07
Tle4	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Spinal cord	L8CN17_E1	3.7e-07
Tle4	GOBP_Negative_Regulation_Of_Signaling	Mouse	Spinal cord	L8CN17_E1	8.3e-06
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Tle4	GOBP_Cell_Cell_Signaling	Mouse	Brain	rep_1	5.1e-48
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	5.3e-174
Tle4	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Brain	rep_3	2.0e-124
Tle4	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Brain	rep_3	3.3e-46
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Tle4	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	2.3e-180
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Tle4	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Tle4	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	rep_3	7.8e-106
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	4.4e-159
Tle4	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	1.7e-164
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_14	1.1e-07
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Embryo	rep_14	5.8e-09
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	2.6e-12
Tle4	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	6.8e-306
Tle4	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Tle4	GOBP_Negative_Regulation_Of_Signaling	Mouse	Embryo	rep_1	5.6e-10
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	2.0e-10
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Tle4	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Embryo	rep_6	1.7e-33
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	2.0e-101
Tle4	GOBP_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.2e-72
Tle4	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Kidney	rep_2	2.1e-78
Tle4	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.7e-89
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Tle4	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	1.3e-49
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Tle4	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Tle4	GOBP_Negative_Regulation_Of_Signaling	Mouse	Kidney	rep_2	4.0e-40
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	2.4e-65
Tle4	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	5.2e-90
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Liver	CN16-E1	1.5e-08
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Liver	rep_16	3.3e-07
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	8.5e-09
Tle4	GOBP_Cell_Cell_Signaling	Mouse	Lymph	MS-1	9.7e-11
Tle4	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Lymph	MS-1	7.3e-10
Tle4	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Lymph	MS-1	1.6e-11
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Tle4	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	9.4e-09
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Tle4	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Tle4	GOBP_Negative_Regulation_Of_Signaling	Mouse	Lymph	MS-1	1.0e-14
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	9.3e-09
Tle4	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	6.2e-07
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Tle4	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	1.2e-07
Tle4	GOBP_Cell_Cell_Signaling	Mouse	Brain	HP_ad_rep7	1.6e-08
Tle4	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Tle4	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	4.0e-07
Tle4	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Tle4	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	3.8e-08
Tle4	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Brain	HP_polb_rep9	1.7e-14
Tle4	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Brain	HP_polb_rep9	1.2e-14
Tle4	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Tle4	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.4e-11
Tle4	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.7e-20

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Tle4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tle4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tle4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tle4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tle4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Tle4	C0007097	Carcinoma	1	CTD_human
Tle4	C0024667	Animal Mammary Neoplasms	1	CTD_human
Tle4	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tle4	C0151744	Myocardial Ischemia	1	CTD_human
Tle4	C0205696	Anaplastic carcinoma	1	CTD_human
Tle4	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tle4	C0205698	Undifferentiated carcinoma	1	CTD_human
Tle4	C0205699	Carcinomatosis	1	CTD_human
Tle4	C1257925	Mammary Carcinoma, Animal	1	CTD_human