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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tle2 (spascer ID:21886)

Gene summary for Tle2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tle2
	Gene ID	21886
	Gene name	transducin-like enhancer of split 2
	Synonyms	Grg2\|mKIAA4188
	Cytomap	10\|10 C1
	Type of gene	protein-coding
	Description	transducin-like enhancer protein 2groucho-related proteintransducin-like enhancer of split 2, homolog of Drosophila E(spl)
	Modification date	20220424
	UniProtAcc	Q9WVB2

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tle2	GO:0003714	transcription corepressor activity	21873635	Function
Tle2	GO:0005634	nucleus	21873635	Component
Tle2	GO:0005667	transcription regulator complex	21873635	Component
Tle2	GO:0090090	negative regulation of canonical Wnt signaling pathway	21873635	Process

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Spatial pattern events for Tle2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tle2	Mouse	Brain	S3	34413515	1.85e-07
Tle2	Mouse	Brain	S4	34413515	1.37e-15
Tle2	Mouse	Brain	S6	34413515	1.81e-06
Tle2	Mouse	Kidney	rep_3	34853151	4.93e-15
Tle2	Mouse	Brain	rep_1	33469025	1.30e-15
Tle2	Mouse	Testicle	rep_1	34731600	4.92e-06
Tle2	Mouse	Lymph	A1	0	1.65e-12
Tle2	Mouse	Lymph	B1	0	1.11e-14
Tle2	Mouse	Brain	rep_1	35210624	2.09e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_rep_3_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Tle2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tle2	GOBP_Animal_Organ_Morphogenesis	Mouse	Spinal cord	CN94_E1	6.6e-06
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Tle2	GOBP_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Tle2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	5.6e-07
Tle2	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	4.8e-06
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	4.8e-06
Tle2	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.2e-06
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Spinal cord	L8CN17_E1	1.6e-07
Tle2	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Spinal cord	L8CN17_E1	3.7e-07
Tle2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Spinal cord	L8CN17_E1	8.3e-06
Tle2	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_27	2.0e-06
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Tle2	GOBP_Cell_Cell_Signaling	Mouse	Brain	rep_1	5.1e-48
Tle2	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_3	5.4e-57
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	5.3e-174
Tle2	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Brain	rep_3	2.0e-124
Tle2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Brain	rep_3	3.3e-46
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Tle2	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	2.3e-180
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Tle2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Tle2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	rep_3	7.8e-106
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	4.4e-159
Tle2	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	1.7e-164
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_14	1.1e-07
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Embryo	rep_14	5.8e-09
Tle2	GOBP_Animal_Organ_Morphogenesis	Mouse	Embryo	rep_1	1.7e-10
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	2.6e-12
Tle2	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	6.8e-306
Tle2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Tle2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Embryo	rep_1	5.6e-10
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	2.0e-10
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Tle2	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Embryo	rep_6	1.7e-33
Tle2	GOBP_Animal_Organ_Morphogenesis	Mouse	Kidney	rep_2	4.2e-71
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	2.0e-101
Tle2	GOBP_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.2e-72
Tle2	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Kidney	rep_2	2.1e-78
Tle2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.7e-89
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Tle2	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	1.3e-49
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Tle2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Tle2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Kidney	rep_2	4.0e-40
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	2.4e-65
Tle2	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	5.2e-90
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Liver	CN16-E1	1.5e-08
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Liver	rep_16	3.3e-07
Tle2	GOBP_Animal_Organ_Morphogenesis	Mouse	Lymph	MS-1	4.4e-09
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	8.5e-09
Tle2	GOBP_Cell_Cell_Signaling	Mouse	Lymph	MS-1	9.7e-11
Tle2	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Lymph	MS-1	7.3e-10
Tle2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Lymph	MS-1	1.6e-11
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Tle2	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	9.4e-09
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Tle2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Tle2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Lymph	MS-1	1.0e-14
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	9.3e-09
Tle2	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	6.2e-07
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Tle2	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	1.2e-07
Tle2	GOBP_Cell_Cell_Signaling	Mouse	Brain	HP_ad_rep7	1.6e-08
Tle2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Tle2	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	4.0e-07
Tle2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Tle2	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	3.8e-08
Tle2	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Brain	HP_polb_rep9	1.7e-14
Tle2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Brain	HP_polb_rep9	1.2e-14
Tle2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Tle2	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.4e-11
Tle2	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.7e-20

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Tle2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tle2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tle2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tle2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tle2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source