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Spatial pattern gene: L2hgdh (spascer ID:217666) |
Gene summary for L2hgdh |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | L2hgdh | Gene ID | 217666 |
| Gene name | L-2-hydroxyglutarate dehydrogenase |
| Synonyms | BC016226 |
| Cytomap | 12|12 C2 |
| Type of gene | protein-coding |
| Description | L-2-hydroxyglutarate dehydrogenase, mitochondrialduranin |
| Modification date | 20220424 |
| UniProtAcc | Q91YP0 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| L2hgdh | GO:0003973 | (S)-2-hydroxy-acid oxidase activity | 21873635 | Function |
| L2hgdh | GO:0005739 | mitochondrion | 21873635 | Component |
| L2hgdh | GO:0047545 | 2-hydroxyglutarate dehydrogenase activity | 21873635 | Function |
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Spatial pattern events for L2hgdh |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| L2hgdh | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| L2hgdh | Mouse | Kidney | IRI | 34003797 | 2.29e-15 |
| L2hgdh | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| L2hgdh | Mouse | Kidney | rep_1 | 34853151 | 6.43e-06 |
| L2hgdh | Mouse | Kidney | rep_3 | 34853151 | 1.29e-06 |
| L2hgdh | Mouse | Intestine | rep_4 | 35149721 | 4.51e-12 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_3_H&E  |  |
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Spatial pattern pathway has L2hgdh envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| L2hgdh | GOBP_Organic_Acid_Metabolic_Process | Mouse | Spinal cord | L7bCN02_E1 | 7.1e-06 |
| L2hgdh | GOBP_Small_Molecule_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 1.7e-07 |
| L2hgdh | GOBP_2_Oxoglutarate_Metabolic_Process | Mouse | Spinal cord | L7CN97_E2 | 6.2e-07 |
| L2hgdh | GOBP_Dicarboxylic_Acid_Metabolic_Process | Mouse | Brain | rep_11 | 1.9e-05 |
| L2hgdh | GOBP_2_Oxoglutarate_Metabolic_Process | Mouse | Brain | rep_3 | 1.4e-100 |
| L2hgdh | GOBP_Dicarboxylic_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 1.2e-146 |
| L2hgdh | GOBP_Organic_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 1.5e-154 |
| L2hgdh | GOBP_Small_Molecule_Metabolic_Process | Mouse | Brain | rep_3 | 2.7e-19 |
| L2hgdh | GOBP_Dicarboxylic_Acid_Metabolic_Process | Mouse | Embryo | rep_6 | 7.1e-08 |
| L2hgdh | GOBP_2_Oxoglutarate_Metabolic_Process | Mouse | Embryo | rep_14 | 3.3e-58 |
| L2hgdh | GOBP_Small_Molecule_Metabolic_Process | Mouse | Embryo | rep_1 | 1.4e-55 |
| L2hgdh | GOBP_Organic_Acid_Metabolic_Process | Mouse | Embryo | rep_3 | 1.4e-07 |
| L2hgdh | GOBP_Dicarboxylic_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 8.2e-31 |
| L2hgdh | GOBP_Organic_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 3.8e-62 |
| L2hgdh | GOBP_Small_Molecule_Metabolic_Process | Mouse | Kidney | rep_2 | 1.8e-43 |
| L2hgdh | GOBP_2_Oxoglutarate_Metabolic_Process | Mouse | Liver | CN16-D2 | 2.0e-11 |
| L2hgdh | GOBP_Dicarboxylic_Acid_Metabolic_Process | Mouse | Liver | CN16-E1 | 7.0e-07 |
| L2hgdh | GOBP_Organic_Acid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.3e-15 |
| L2hgdh | GOBP_Small_Molecule_Metabolic_Process | Mouse | Lymph | MS-1 | 2.6e-11 |
| L2hgdh | GOBP_Dicarboxylic_Acid_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 6.2e-09 |
| L2hgdh | GOBP_Organic_Acid_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 4.1e-08 |
| L2hgdh | GOBP_2_Oxoglutarate_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 1.0e-06 |
| L2hgdh | GOBP_Small_Molecule_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 2.0e-09 |
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L2hgdh function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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L2hgdh function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for L2hgdh envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for L2hgdh |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for L2hgdh |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| L2hgdh | C1855995 | L-2-HYDROXYGLUTARIC ACIDURIA | 8 | GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| L2hgdh | C2746066 | Combined D-2- and L-2-hydroxyglutaric aciduria | 3 | CTD_human;GENOMICS_ENGLAND |
| L2hgdh | C0013421 | Dystonia | 1 | GENOMICS_ENGLAND |
| L2hgdh | C0014544 | Epilepsy | 1 | CTD_human |
| L2hgdh | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| L2hgdh | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| L2hgdh | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
| L2hgdh | C0236018 | Aura | 1 | CTD_human |
| L2hgdh | C0265541 | Cranioschisis | 1 | CTD_human |
| L2hgdh | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
| L2hgdh | C0751111 | Awakening Epilepsy | 1 | CTD_human |
| L2hgdh | C0917816 | Mental deficiency | 1 | CTD_human |
| L2hgdh | C3714756 | Intellectual Disability | 1 | CTD_human |
| L2hgdh | C3888081 | L-2-hydroxyglutaric acidemia | 1 | ORPHANET |
