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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Arfgef3 (spascer ID:215821)

Gene summary for Arfgef3

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Arfgef3

Gene ID

215821

Gene nameARFGEF family member 3
Synonyms9630004D11|B930094H20Rik|BIG3|D10Bwg1379e|mKIAA1244
Cytomap10 A3|10 7.79 cM
Type of geneprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 3
Modification date20220424
UniProtAcc

Q3UGY8


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Arfgef3

GO:0030036

actin cytoskeleton organization

21873635

Process

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Spatial pattern events for Arfgef3

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Arfgef3MouseBrainS1 344135152.07e-15
Arfgef3MouseBrainS2 344135151.56e-15
Arfgef3MouseBrainS3 344135151.64e-15
Arfgef3MouseBrainS4 344135151.37e-15
Arfgef3MouseBrainS6 344135151.46e-15
Arfgef3MouseBrainS7 344135151.55e-15
Arfgef3MouseBrainrep_1 351413742.02e-15
Arfgef3MouseBrainrep_2 351413743.67e-13
Arfgef3MouseBrainrep_3 351413741.45e-08
Arfgef3MouseBrainrep_4 351413741.57e-15
Arfgef3MouseBrainrep_5 351413741.47e-15
Arfgef3MouseBrainrep_6 351413745.96e-15
Arfgef3MouseEmbryo1D 342108873.48e-09
Arfgef3MouseEmbryo2G 342108873.39e-07
Arfgef3MouseEmbryo4E 342108874.53e-15
Arfgef3MouseKidneyIRI 340037972.29e-15
Arfgef3MouseBrainrep_1 334690254.15e-13
Arfgef3MouseBrainrep_1 350277293.32e-14
Arfgef3MouseBrainrep_2 350277291.57e-15
Arfgef3MouseBrainrep_3 350277291.32e-15
Arfgef3MouseBrainrep_4 350277294.40e-12
Arfgef3MouseBrainrep_5 350277291.46e-15
Arfgef3MouseBrainN03_D2 327023146.59e-08
Arfgef3MouseLungrep_1 352908012.25e-09
Arfgef3MouseLungrep_2 352908018.45e-09
Arfgef3MouseBrainrep_7 352106244.53e-09

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_rep_6_H&E
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Kidney_IRI_H&E
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Brain_rep_1_H&E
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Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_N03_D2_H&E
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Lung_rep_1_H&E
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Lung_rep_2_H&E
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Spatial pattern pathway has Arfgef3 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Arfgef3GOBP_Regulation_Of_Phosphatase_ActivityMouseSpinal cordCN94_E1 1.6e-06
Arfgef3GOBP_Cytoskeleton_OrganizationMouseSpinal cordL7bCN02_E1 8.3e-06
Arfgef3GOBP_Arf_Protein_Signal_TransductionMouseSpinal cordL7CN45_C1 8.8e-08
Arfgef3GOBP_DephosphorylationMouseSpinal cordL7CN45_C1 3.3e-07
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseSpinal cordL7CN45_C1 1.1e-06
Arfgef3GOBP_Negative_Regulation_Of_DephosphorylationMouseSpinal cordL7CN45_C1 1.6e-07
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseSpinal cordL7CN45_C1 3.2e-07
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseSpinal cordL7CN45_C1 1.1e-06
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseSpinal cordL7CN45_C1 1.1e-06
Arfgef3GOBP_Regulation_Of_DephosphorylationMouseSpinal cordL7CN45_C1 1.4e-06
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseSpinal cordL7CN45_C1 2.3e-07
Arfgef3GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_TransductionMouseSpinal cordL7CN45_C1 5.6e-06
Arfgef3GOBP_Actin_Filament_Based_ProcessMouseSpinal cordL7CN47_C1 3.4e-06
Arfgef3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseSpinal cordL8CN11_C1 3.6e-13
Arfgef3GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseSpinal cordL8CN11_D1 5.6e-09
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseSpinal cordL8CN17_E1 6.9e-06
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseBrainrep_27 8.1e-06
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainrep_27 1.1e-06
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseBrainrep_27 3.9e-05
Arfgef3GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_TransductionMouseBrainrep_27 6.4e-05
Arfgef3GOBP_Actin_Filament_Based_ProcessMouseBrainrep_1 2.1e-24
Arfgef3GOBP_Arf_Protein_Signal_TransductionMouseBrainrep_1 8.6e-91
Arfgef3GOBP_Cytoskeleton_OrganizationMouseBrainrep_1 1.1e-11
Arfgef3GOBP_DephosphorylationMouseBrainrep_1 1.5e-40
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseBrainrep_1 1.0e-08
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainrep_1 1.1e-29
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseBrainrep_1 1.1e-11
Arfgef3GOBP_Regulation_Of_DephosphorylationMouseBrainrep_1 1.4e-28
Arfgef3GOBP_Regulation_Of_Phosphatase_ActivityMouseBrainrep_1 2.0e-14
Arfgef3GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_TransductionMouseBrainrep_1 5.2e-13
Arfgef3GOBP_Small_Gtpase_Mediated_Signal_TransductionMouseBrainrep_1 5.1e-22
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseBrainrep_35.2e-181
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseBrainrep_33.5e-163
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseBrainrep_31.4e-120
Arfgef3GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseBrainrep_31.3e-132
Arfgef3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainrep_3 3.0e-62
Arfgef3GOBP_Regulation_Of_Ras_Protein_Signal_TransductionMouseBrainrep_38.3e-130
Arfgef3GOBP_Arf_Protein_Signal_TransductionMouseEmbryorep_14 7.8e-28
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseEmbryorep_14 4.4e-26
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseEmbryorep_14 8.5e-07
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseEmbryorep_1 2.5e-32
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseEmbryorep_1 4.6e-17
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseEmbryorep_1 6.0e-77
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseEmbryorep_3 5.2e-68
Arfgef3GOBP_Small_Gtpase_Mediated_Signal_TransductionMouseEmbryorep_3 5.2e-68
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseKidneyNep 8.3e-23
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseKidneyNep 1.3e-36
Arfgef3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseKidneyNep 4.6e-22
Arfgef3GOBP_Actin_Filament_Based_ProcessMouseKidneyrep_22.6e-107
Arfgef3GOBP_Arf_Protein_Signal_TransductionMouseKidneyrep_2 3.4e-15
Arfgef3GOBP_Cytoskeleton_OrganizationMouseKidneyrep_2 1.5e-44
Arfgef3GOBP_DephosphorylationMouseKidneyrep_2 1.4e-90
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseKidneyrep_2 5.2e-90
Arfgef3GOBP_Negative_Regulation_Of_DephosphorylationMouseKidneyrep_24.0e-116
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseKidneyrep_2 5.7e-63
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseKidneyrep_2 2.5e-99
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseKidneyrep_2 4.5e-64
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseKidneyrep_2 3.5e-92
Arfgef3GOBP_Regulation_Of_DephosphorylationMouseKidneyrep_2 1.8e-67
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseKidneyrep_2 1.4e-60
Arfgef3GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseKidneyrep_2 1.4e-17
Arfgef3GOBP_Regulation_Of_Phosphatase_ActivityMouseKidneyrep_2 2.5e-75
Arfgef3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseKidneyrep_2 1.3e-41
Arfgef3GOBP_Regulation_Of_Ras_Protein_Signal_TransductionMouseKidneyrep_2 4.4e-65
Arfgef3GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_TransductionMouseKidneyrep_2 1.0e-93
Arfgef3GOBP_Small_Gtpase_Mediated_Signal_TransductionMouseKidneyrep_2 1.2e-75
Arfgef3GOBP_Small_Gtpase_Mediated_Signal_TransductionMouseLiverCN16-D2 1.3e-07
Arfgef3GOBP_Regulation_Of_DephosphorylationMouseLiverCN16-E1 1.3e-11
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseLiverCN73-C1 9.9e-07
Arfgef3GOBP_Actin_Filament_Based_ProcessMouseLymphMS-1 1.4e-10
Arfgef3GOBP_Cytoskeleton_OrganizationMouseLymphMS-1 1.8e-13
Arfgef3GOBP_DephosphorylationMouseLymphMS-1 3.6e-12
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseLymphMS-1 2.2e-13
Arfgef3GOBP_Negative_Regulation_Of_DephosphorylationMouseLymphMS-1 8.1e-13
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseLymphMS-1 4.3e-09
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseLymphMS-1 6.9e-11
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseLymphMS-1 2.2e-13
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseLymphMS-1 1.1e-08
Arfgef3GOBP_Regulation_Of_DephosphorylationMouseLymphMS-1 3.0e-12
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseLymphMS-1 1.9e-08
Arfgef3GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseLymphMS-1 1.0e-14
Arfgef3GOBP_Regulation_Of_Phosphatase_ActivityMouseLymphMS-1 6.8e-12
Arfgef3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseLymphMS-1 5.6e-12
Arfgef3GOBP_Regulation_Of_Ras_Protein_Signal_TransductionMouseLymphMS-1 3.8e-08
Arfgef3GOBP_Small_Gtpase_Mediated_Signal_TransductionMouseLymphMS-1 3.5e-10
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseLungrep_1 6.3e-10
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseLungrep_1 9.4e-15
Arfgef3GOBP_Arf_Protein_Signal_TransductionMouseBrainrep_4 1.2e-17
Arfgef3GOBP_Regulation_Of_Ras_Protein_Signal_TransductionMouseBrainrep_4 1.0e-16
Arfgef3GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_TransductionMouseBrainrep_4 6.8e-16
Arfgef3GOBP_Cytoskeleton_OrganizationMouseBrainHP_ad_rep7 5.3e-08
Arfgef3GOBP_DephosphorylationMouseBrainHP_ad_rep7 3.9e-08
Arfgef3GOBP_Negative_Regulation_Of_Catalytic_ActivityMouseBrainHP_ad_rep7 4.0e-09
Arfgef3GOBP_Negative_Regulation_Of_DephosphorylationMouseBrainHP_ad_rep7 6.7e-10
Arfgef3GOBP_Negative_Regulation_Of_Molecular_FunctionMouseBrainHP_ad_rep7 3.4e-10
Arfgef3GOBP_Negative_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainHP_ad_rep7 9.8e-08
Arfgef3GOBP_Regulation_Of_Phosphatase_ActivityMouseBrainHP_ad_rep7 4.1e-07
Arfgef3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessMouseBrainHP_ad_rep7 1.7e-08
Arfgef3GOBP_Small_Gtpase_Mediated_Signal_TransductionMouseBrainHP_ad_rep7 4.6e-08
Arfgef3GOBP_Actin_Filament_Based_ProcessMouseBrainHP_polb_rep9 3.0e-07
Arfgef3GOBP_Arf_Protein_Signal_TransductionMouseBrainHP_polb_rep9 1.2e-11
Arfgef3GOBP_Negative_Regulation_Of_Hydrolase_ActivityMouseBrainHP_polb_rep9 7.1e-13
Arfgef3GOBP_Ras_Protein_Signal_TransductionMouseBrainHP_polb_rep9 7.2e-09
Arfgef3GOBP_Regulation_Of_Hydrolase_ActivityMouseBrainHP_polb_rep9 6.0e-09
Arfgef3GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseBrainHP_polb_rep9 3.9e-11
Arfgef3GOBP_Regulation_Of_Ras_Protein_Signal_TransductionMouseBrainHP_polb_rep9 4.3e-10
Arfgef3GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_TransductionMouseBrainHP_polb_rep9 5.2e-07

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Arfgef3 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Arfgef3 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Arfgef3 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Arfgef3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Arfgef3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource