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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tbx15 (spascer ID:21384)

Gene summary for Tbx15

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tbx15
	Gene ID	21384
	Gene name	T-box 15
	Synonyms	Tbx14\|Tbx8\|de\|mmTBx8
	Cytomap	3 F2.2\|3 43.03 cM
	Type of gene	protein-coding
	Description	T-box transcription factor TBX15T-box 14T-box protein 14T-box protein 15T-box transcription factor TBX14droopy ear
	Modification date	20220424
	UniProtAcc	O70306

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tbx15	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	21873635	Function
Tbx15	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Tbx15	GO:0001708	cell fate specification	21873635	Process
Tbx15	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process

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Spatial pattern events for Tbx15

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tbx15	Mouse	Embryo	3G	34210887	8.04e-09
Tbx15	Mouse	Embryo	3H	34210887	1.97e-06
Tbx15	Mouse	Embryo	4C	34210887	1.91e-08
Tbx15	Mouse	Embryo	4D	34210887	5.53e-11
Tbx15	Mouse	Testicle	rep_1	34731600	1.71e-11

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)

Singel gene map

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Spatial pattern pathway has Tbx15 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tbx15	GOBP_Animal_Organ_Morphogenesis	Mouse	Spinal cord	CN94_E1	6.6e-06
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	2.5e-06
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Spinal cord	CN94_E1	7.7e-07
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	CN94_E1	2.2e-06
Tbx15	GOBP_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	5.6e-06
Tbx15	GOBP_Cell_Fate_Commitment	Mouse	Spinal cord	L7CN45_C1	5.2e-07
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Spinal cord	L7CN45_C1	3.9e-08
Tbx15	GOBP_Embryo_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Tbx15	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Spinal cord	L7CN45_C1	3.9e-07
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	3.7e-08
Tbx15	GOBP_Embryonic_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Tbx15	GOBP_Embryonic_Organ_Development	Mouse	Spinal cord	L7CN45_C1	5.1e-08
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	2.2e-08
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Spinal cord	L7CN47_C1	3.7e-07
Tbx15	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_27	2.0e-06
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_27	2.8e-05
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Brain	rep_71	2.6e-07
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Brain	rep_1	1.3e-11
Tbx15	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Brain	rep_1	1.0e-08
Tbx15	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_3	5.4e-57
Tbx15	GOBP_Cell_Fate_Commitment	Mouse	Brain	rep_3	8.8e-182
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Brain	rep_3	7.3e-113
Tbx15	GOBP_Embryo_Development	Mouse	Brain	rep_3	1.3e-126
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Brain	rep_3	2.1e-140
Tbx15	GOBP_Embryonic_Morphogenesis	Mouse	Brain	rep_3	5.0e-165
Tbx15	GOBP_Embryonic_Organ_Development	Mouse	Brain	rep_3	4.3e-190
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Brain	rep_3	1.5e-168
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Brain	rep_3	1.0e-111
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Brain	rep_3	1.2e-119
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_3	7.5e-168
Tbx15	GOBP_Skeletal_System_Development	Mouse	Brain	rep_3	3.3e-190
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Brain	rep_3	7.3e-51
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Embryo	rep_6	3.0e-10
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_6	3.8e-12
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Embryo	rep_14	5.2e-63
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Embryo	rep_14	4.3e-57
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Embryo	rep_14	2.2e-13
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Embryo	rep_14	5.5e-53
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_14	2.3e-45
Tbx15	GOBP_Animal_Organ_Morphogenesis	Mouse	Embryo	rep_1	1.7e-10
Tbx15	GOBP_Cell_Fate_Commitment	Mouse	Embryo	rep_1	6.8e-22
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Embryo	rep_1	0.0e+00
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Embryo	rep_3	0.0e+00
Tbx15	GOBP_Embryo_Development	Mouse	Embryo	rep_3	1.2e-173
Tbx15	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Embryo	rep_3	0.0e+00
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Embryo	rep_3	6.1e-174
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Embryo	rep_3	4.4e-129
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_3	0.0e+00
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_3	0.0e+00
Tbx15	GOBP_Skeletal_System_Development	Mouse	Embryo	rep_6	3.1e-59
Tbx15	GOBP_Animal_Organ_Morphogenesis	Mouse	Kidney	rep_2	4.2e-71
Tbx15	GOBP_Cell_Fate_Commitment	Mouse	Kidney	rep_2	1.1e-65
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Kidney	rep_2	1.9e-89
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Kidney	rep_2	2.5e-28
Tbx15	GOBP_Embryo_Development	Mouse	Kidney	rep_2	7.4e-46
Tbx15	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Kidney	rep_2	9.8e-28
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Kidney	rep_2	7.7e-15
Tbx15	GOBP_Embryonic_Morphogenesis	Mouse	Kidney	rep_2	7.3e-66
Tbx15	GOBP_Embryonic_Organ_Development	Mouse	Kidney	rep_2	1.3e-60
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Kidney	rep_2	3.0e-55
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Kidney	rep_2	2.0e-38
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Kidney	rep_2	1.6e-37
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	2.2e-14
Tbx15	GOBP_Skeletal_System_Development	Mouse	Kidney	rep_2	7.5e-46
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Kidney	rep_2	1.2e-20
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Liver	CN16-D2	1.9e-08
Tbx15	GOBP_Skeletal_System_Development	Mouse	Liver	CN73-C1	9.4e-07
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Liver	rep_15	1.4e-09
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Liver	rep_15	2.8e-21
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Liver	rep_15	1.5e-24
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Liver	rep_16	1.6e-10
Tbx15	GOBP_Animal_Organ_Morphogenesis	Mouse	Lymph	MS-1	4.4e-09
Tbx15	GOBP_Cell_Fate_Commitment	Mouse	Lymph	MS-1	2.1e-11
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Lymph	MS-1	7.3e-07
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Lymph	MS-1	2.4e-13
Tbx15	GOBP_Embryo_Development	Mouse	Lymph	MS-1	2.5e-08
Tbx15	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Lymph	MS-1	4.0e-11
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Lymph	MS-1	1.7e-15
Tbx15	GOBP_Embryonic_Morphogenesis	Mouse	Lymph	MS-1	5.6e-07
Tbx15	GOBP_Embryonic_Organ_Development	Mouse	Lymph	MS-1	1.1e-11
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Lymph	MS-1	1.4e-11
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Lymph	MS-1	5.9e-22
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Lymph	MS-1	7.9e-14
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	2.2e-09
Tbx15	GOBP_Skeletal_System_Development	Mouse	Lymph	MS-1	2.6e-12
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Lymph	MS-1	8.7e-13
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Lung	rep_1	4.0e-16
Tbx15	GOBP_Embryonic_Organ_Development	Mouse	Brain	rep_7	7.0e-07
Tbx15	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Brain	rep_7	2.6e-14
Tbx15	GOBP_Cell_Fate_Commitment	Mouse	Brain	HP_ad_rep7	1.5e-09
Tbx15	GOBP_Cell_Fate_Specification	Mouse	Brain	HP_ad_rep7	5.3e-18
Tbx15	GOBP_Cranial_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	4.7e-11
Tbx15	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Brain	HP_ad_rep7	7.5e-07
Tbx15	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Tbx15	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Tbx15	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.1e-13
Tbx15	GOBP_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	3.7e-09
Tbx15	GOBP_Embryonic_Skeletal_System_Development	Mouse	Brain	HP_adpolb_rep1	6.0e-10
Tbx15	GOBP_Embryonic_Cranial_Skeleton_Morphogenesis	Mouse	Brain	HP_adpolb_rep5	6.4e-08
Tbx15	GOBP_Embryo_Development	Mouse	Brain	HP_polb_rep9	1.5e-10
Tbx15	GOBP_Embryonic_Morphogenesis	Mouse	Brain	HP_polb_rep9	3.7e-09
Tbx15	GOBP_Embryonic_Organ_Development	Mouse	Brain	HP_polb_rep9	9.6e-11
Tbx15	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Brain	HP_polb_rep9	3.5e-15
Tbx15	GOBP_Skeletal_System_Morphogenesis	Mouse	Brain	HP_polb_rep9	1.1e-07

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Tbx15 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tbx15 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tbx15 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tbx15

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tbx15

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Tbx15	C1850040	Pelviscapular dysplasia	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tbx15	C0018273	Growth Disorders	1	CTD_human
Tbx15	C0027626	Neoplasm Invasiveness	1	CTD_human
Tbx15	C0376634	Craniofacial Abnormalities	1	CTD_human