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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Polr2a (spascer ID:20020)

Gene summary for Polr2a

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Polr2a
	Gene ID	20020
	Gene name	polymerase (RNA) II (DNA directed) polypeptide A
	Synonyms	220kDa\|Rpb1\|Rpo2-1
	Cytomap	11 B3\|11 42.86 cM
	Type of gene	protein-coding
	Description	DNA-directed RNA polymerase II subunit RPB1DNA-directed RNA polymerase II subunit ADNA-directed RNA polymerase III largest subunitRNA polymerase II 1RNA polymerase II subunit B1
	Modification date	20220424
	UniProtAcc	P08775

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Polr2a	GO:0001055	RNA polymerase II activity	21873635	Function
Polr2a	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635	Function
Polr2a	GO:0005665	RNA polymerase II, core complex	21873635	Component

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Spatial pattern events for Polr2a

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Polr2a	Mouse	Brain	S3	34413515	6.19e-07
Polr2a	Mouse	Brain	S7	34413515	2.75e-08
Polr2a	Mouse	Brain	rep_3	35141374	6.42e-06
Polr2a	Mouse	Embryo	rep_13	33188776	1.35e-08
Polr2a	Mouse	Kidney	CLP	34003797	7.59e-13
Polr2a	Mouse	Kidney	rep_1	34853151	4.86e-10
Polr2a	Mouse	Brain	rep_5	35027729	5.62e-08
Polr2a	Mouse	Intestine	rep_4	35149721	3.54e-06
Polr2a	Mouse	Testicle	rep_4	34731600	1.47e-15
Polr2a	Mouse	Lymph	A1	0	3.29e-15
Polr2a	Mouse	Lymph	B1	0	6.08e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_3_H&E
Kidney_CLP_H&E
Kidney_rep_1_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Polr2a envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Polr2a	GOBP_Rna_Capping	Mouse	Spinal cord	CN80_E1	9.2e-06
Polr2a	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Spinal cord	CN94_E1	8.0e-06
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Spinal cord	CN94_E1	2.7e-06
Polr2a	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	4.4e-07
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Spinal cord	CN94_E1	5.9e-06
Polr2a	GOBP_Regulation_Of_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Spinal cord	CN94_E1	5.5e-06
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Spinal cord	CN94_E1	2.2e-06
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Spinal cord	L7bCN01_D2	3.5e-06
Polr2a	GOBP_Mrna_Processing	Mouse	Spinal cord	L7bCN02_E1	5.5e-06
Polr2a	GOBP_Positive_Regulation_Of_Gene_Expression	Mouse	Spinal cord	L7bCN02_E1	7.5e-06
Polr2a	GOBP_Response_To_Fibroblast_Growth_Factor	Mouse	Spinal cord	L7CN44_C1	6.4e-07
Polr2a	GOBP_Dna_Repair	Mouse	Spinal cord	L7CN45_C1	9.4e-06
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Spinal cord	L7CN45_C1	6.4e-06
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Spinal cord	L7CN45_C1	1.5e-08
Polr2a	GOBP_Dna_Templated_Transcription_Termination	Mouse	Spinal cord	L7CN45_C1	1.4e-07
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	1.9e-08
Polr2a	GOBP_Ncrna_Transcription	Mouse	Spinal cord	L7CN45_C1	9.7e-08
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Polr2a	GOBP_Nucleotide_Excision_Repair	Mouse	Spinal cord	L7CN45_C1	1.1e-09
Polr2a	GOBP_Positive_Regulation_Of_Rna_Splicing	Mouse	Spinal cord	L7CN45_C1	6.0e-07
Polr2a	GOBP_Positive_Regulation_Of_Viral_Process	Mouse	Spinal cord	L7CN45_C1	3.8e-07
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Spinal cord	L7CN45_C1	7.4e-09
Polr2a	GOBP_Response_To_Growth_Factor	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Polr2a	GOBP_Rna_Processing	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Polr2a	GOBP_Rna_Splicing	Mouse	Spinal cord	L7CN45_C1	3.7e-08
Polr2a	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Mouse	Spinal cord	L7CN45_C1	1.8e-09
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Spinal cord	L7CN45_C1	1.3e-06
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Spinal cord	L7CN45_C1	1.3e-08
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Spinal cord	L7CN45_C1	9.0e-07
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Spinal cord	L7CN45_C1	1.3e-08
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	5.7e-08
Polr2a	GOBP_Viral_Gene_Expression	Mouse	Spinal cord	L7CN45_C1	5.3e-10
Polr2a	GOBP_Maintenance_Of_Cell_Number	Mouse	Spinal cord	L7CN47_C1	3.9e-06
Polr2a	GOBP_Regulation_Of_Rna_Splicing	Mouse	Spinal cord	L7CN47_C1	7.2e-06
Polr2a	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Spinal cord	L7CN97_E2	6.8e-06
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Spinal cord	L7CN97_E2	7.4e-08
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Brain	rep_27	1.0e-06
Polr2a	GOBP_Ncrna_Transcription	Mouse	Brain	rep_27	3.8e-05
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Brain	rep_27	4.7e-05
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Brain	rep_27	5.7e-05
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	rep_27	4.7e-08
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	rep_27	1.7e-05
Polr2a	GOBP_Rna_Capping	Mouse	Brain	rep_36	2.6e-07
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Brain	rep_41	4.4e-05
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Brain	rep_1	1.1e-07
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Brain	rep_1	2.3e-11
Polr2a	GOBP_Dna_Templated_Transcription_Termination	Mouse	Brain	rep_1	5.4e-10
Polr2a	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	rep_1	9.9e-07
Polr2a	GOBP_Ncrna_Transcription	Mouse	Brain	rep_1	4.2e-15
Polr2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Polr2a	GOBP_Rna_Capping	Mouse	Brain	rep_1	2.4e-19
Polr2a	GOBP_Snrna_Transcription	Mouse	Brain	rep_1	4.3e-20
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Brain	rep_1	5.3e-15
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	rep_1	4.4e-10
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Brain	rep_1	8.6e-14
Polr2a	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	rep_3	1.9e-146
Polr2a	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	rep_3	5.0e-192
Polr2a	GOBP_Dna_Repair	Mouse	Brain	rep_3	4.0e-216
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Brain	rep_3	5.9e-172
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	rep_3	2.2e-84
Polr2a	GOBP_Maintenance_Of_Cell_Number	Mouse	Brain	rep_3	1.7e-143
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Brain	rep_3	3.9e-221
Polr2a	GOBP_Mrna_Processing	Mouse	Brain	rep_3	4.7e-219
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Brain	rep_3	1.1e-139
Polr2a	GOBP_Nucleotide_Excision_Repair	Mouse	Brain	rep_3	6.1e-152
Polr2a	GOBP_Positive_Regulation_Of_Gene_Expression	Mouse	Brain	rep_3	3.1e-102
Polr2a	GOBP_Positive_Regulation_Of_Rna_Splicing	Mouse	Brain	rep_3	8.7e-166
Polr2a	GOBP_Positive_Regulation_Of_Viral_Process	Mouse	Brain	rep_3	1.5e-168
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Brain	rep_3	8.5e-206
Polr2a	GOBP_Regulation_Of_Rna_Splicing	Mouse	Brain	rep_3	6.3e-171
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Brain	rep_3	6.4e-96
Polr2a	GOBP_Response_To_Fibroblast_Growth_Factor	Mouse	Brain	rep_3	3.5e-73
Polr2a	GOBP_Response_To_Growth_Factor	Mouse	Brain	rep_3	2.7e-45
Polr2a	GOBP_Rna_Processing	Mouse	Brain	rep_3	4.3e-140
Polr2a	GOBP_Rna_Splicing	Mouse	Brain	rep_3	2.2e-224
Polr2a	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Mouse	Brain	rep_3	1.8e-234
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Brain	rep_3	1.9e-145
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	rep_3	1.1e-174
Polr2a	GOBP_Viral_Gene_Expression	Mouse	Brain	rep_3	4.6e-154
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Brain	rep_7	7.6e-18
Polr2a	GOBP_Regulation_Of_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Embryo	rep_6	2.4e-10
Polr2a	GOBP_Response_To_Fibroblast_Growth_Factor	Mouse	Embryo	rep_6	8.0e-12
Polr2a	GOBP_Rna_Capping	Mouse	Embryo	rep_6	1.9e-14
Polr2a	GOBP_Snrna_Transcription	Mouse	Embryo	rep_6	2.0e-10
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Embryo	rep_6	1.9e-07
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Embryo	rep_14	1.0e-14
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Embryo	rep_14	3.3e-18
Polr2a	GOBP_Dna_Templated_Transcription_Termination	Mouse	Embryo	rep_14	1.5e-52
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Embryo	rep_14	4.7e-16
Polr2a	GOBP_Ncrna_Transcription	Mouse	Embryo	rep_14	2.1e-14
Polr2a	GOBP_Nucleotide_Excision_Repair	Mouse	Embryo	rep_14	1.6e-22
Polr2a	GOBP_Positive_Regulation_Of_Rna_Splicing	Mouse	Embryo	rep_14	8.6e-49
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Embryo	rep_14	1.4e-11
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Embryo	rep_14	1.7e-13
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Embryo	rep_14	6.5e-64
Polr2a	GOBP_Rna_Processing	Mouse	Embryo	rep_14	3.5e-14
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Embryo	rep_14	6.6e-08
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Embryo	rep_14	2.0e-22
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Embryo	rep_14	1.9e-16
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Embryo	rep_1	0.0e+00
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Embryo	rep_1	5.8e-21
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Embryo	rep_1	9.4e-07
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Embryo	rep_1	0.0e+00
Polr2a	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Embryo	rep_2	7.4e-121
Polr2a	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Embryo	rep_2	1.4e-08
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Embryo	rep_2	7.2e-216
Polr2a	GOBP_Dna_Repair	Mouse	Embryo	rep_2	1.6e-282
Polr2a	GOBP_Rna_Processing	Mouse	Embryo	rep_2	2.4e-14
Polr2a	GOBP_Viral_Gene_Expression	Mouse	Embryo	rep_2	3.8e-28
Polr2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Embryo	rep_3	2.7e-115
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Embryo	rep_6	2.0e-17
Polr2a	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Polr2a	GOBP_Positive_Regulation_Of_Gene_Expression	Mouse	Kidney	Nep	4.9e-40
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Kidney	Nep	6.3e-23
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Polr2a	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Kidney	rep_2	5.5e-146
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-12
Polr2a	GOBP_Dna_Repair	Mouse	Kidney	rep_2	5.5e-70
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Kidney	rep_2	5.3e-82
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Kidney	rep_2	6.1e-40
Polr2a	GOBP_Dna_Templated_Transcription_Termination	Mouse	Kidney	rep_2	4.1e-111
Polr2a	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	rep_2	1.5e-13
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	8.2e-33
Polr2a	GOBP_Maintenance_Of_Cell_Number	Mouse	Kidney	rep_2	2.5e-69
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Kidney	rep_2	3.1e-08
Polr2a	GOBP_Mrna_Processing	Mouse	Kidney	rep_2	5.0e-53
Polr2a	GOBP_Ncrna_Transcription	Mouse	Kidney	rep_2	4.2e-98
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Kidney	rep_2	1.0e-19
Polr2a	GOBP_Nucleotide_Excision_Repair	Mouse	Kidney	rep_2	3.6e-78
Polr2a	GOBP_Positive_Regulation_Of_Gene_Expression	Mouse	Kidney	rep_2	2.1e-103
Polr2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Polr2a	GOBP_Positive_Regulation_Of_Viral_Process	Mouse	Kidney	rep_2	7.0e-40
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Kidney	rep_2	1.1e-92
Polr2a	GOBP_Regulation_Of_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Kidney	rep_2	2.5e-65
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Kidney	rep_2	4.7e-57
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Kidney	rep_2	1.1e-44
Polr2a	GOBP_Response_To_Fibroblast_Growth_Factor	Mouse	Kidney	rep_2	5.1e-31
Polr2a	GOBP_Response_To_Growth_Factor	Mouse	Kidney	rep_2	4.7e-31
Polr2a	GOBP_Rna_Capping	Mouse	Kidney	rep_2	7.6e-36
Polr2a	GOBP_Rna_Processing	Mouse	Kidney	rep_2	1.1e-71
Polr2a	GOBP_Rna_Splicing	Mouse	Kidney	rep_2	1.1e-33
Polr2a	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Mouse	Kidney	rep_2	8.8e-36
Polr2a	GOBP_Snrna_Transcription	Mouse	Kidney	rep_2	4.9e-17
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Kidney	rep_2	4.4e-34
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Kidney	rep_2	2.5e-67
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Kidney	rep_2	3.3e-51
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Kidney	rep_2	2.1e-58
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Kidney	rep_2	2.5e-32
Polr2a	GOBP_Viral_Gene_Expression	Mouse	Kidney	rep_2	7.6e-94
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Liver	CN16-D2	2.6e-07
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Liver	CN16-D2	6.9e-09
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Liver	CN16-D2	5.2e-07
Polr2a	GOBP_Mrna_Processing	Mouse	Liver	CN16-D2	4.8e-09
Polr2a	GOBP_Positive_Regulation_Of_Viral_Process	Mouse	Liver	CN16-D2	4.2e-07
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Liver	CN16-D2	3.7e-08
Polr2a	GOBP_Rna_Splicing	Mouse	Liver	CN16-D2	2.4e-07
Polr2a	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Mouse	Liver	CN16-D2	2.0e-09
Polr2a	GOBP_Rna_Capping	Mouse	Liver	CN65-C1	1.6e-10
Polr2a	GOBP_Dna_Templated_Transcription_Termination	Mouse	Liver	rep_15	3.9e-07
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Liver	rep_15	6.5e-08
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Liver	rep_16	8.9e-07
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Liver	rep_16	6.0e-09
Polr2a	GOBP_Rna_Capping	Mouse	Liver	rep_16	2.0e-09
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Liver	rep_16	1.2e-37
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Liver	rep_16	2.6e-10
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Liver	rep_16	1.8e-10
Polr2a	GOBP_Snrna_Transcription	Mouse	Brain	rep_1	5.1e-15
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Brain	rep_1	1.1e-13
Polr2a	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Lymph	MS-1	4.6e-18
Polr2a	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Lymph	MS-1	8.5e-13
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Lymph	MS-1	6.8e-10
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Lymph	MS-1	3.5e-13
Polr2a	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Lymph	MS-1	1.6e-14
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	5.7e-10
Polr2a	GOBP_Maintenance_Of_Cell_Number	Mouse	Lymph	MS-1	7.2e-10
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Lymph	MS-1	3.2e-11
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Lymph	MS-1	6.3e-11
Polr2a	GOBP_Nucleotide_Excision_Repair	Mouse	Lymph	MS-1	3.7e-09
Polr2a	GOBP_Positive_Regulation_Of_Gene_Expression	Mouse	Lymph	MS-1	7.3e-12
Polr2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Polr2a	GOBP_Positive_Regulation_Of_Viral_Process	Mouse	Lymph	MS-1	6.7e-22
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Lymph	MS-1	7.1e-09
Polr2a	GOBP_Regulation_Of_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Lymph	MS-1	3.1e-25
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Lymph	MS-1	1.5e-11
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Lymph	MS-1	1.7e-07
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Lymph	MS-1	3.9e-13
Polr2a	GOBP_Response_To_Fibroblast_Growth_Factor	Mouse	Lymph	MS-1	1.5e-12
Polr2a	GOBP_Response_To_Growth_Factor	Mouse	Lymph	MS-1	2.1e-10
Polr2a	GOBP_Rna_Capping	Mouse	Lymph	MS-1	4.8e-14
Polr2a	GOBP_Rna_Processing	Mouse	Lymph	MS-1	2.0e-09
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Lymph	MS-1	1.2e-14
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Lymph	MS-1	2.9e-07
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Lymph	MS-1	8.3e-14
Polr2a	GOBP_Viral_Gene_Expression	Mouse	Lymph	MS-1	1.4e-09
Polr2a	GOBP_Positive_Regulation_Of_Rna_Splicing	Mouse	Lymph	PBS	8.7e-07
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Lymph	PBS	7.7e-07
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Lung	rep_1	4.5e-23
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Lung	rep_1	1.6e-15
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Lung	rep_1	2.0e-30
Polr2a	GOBP_Snrna_Transcription	Mouse	Brain	rep_4	8.3e-08
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Brain	rep_7	7.7e-09
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Brain	rep_7	1.1e-28
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Brain	rep_7	2.2e-16
Polr2a	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Mouse	Brain	HP_ad_rep2	3.4e-13
Polr2a	GOBP_Somatic_Stem_Cell_Population_Maintenance	Mouse	Brain	HP_ad_rep3	3.2e-09
Polr2a	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	HP_ad_rep7	6.8e-10
Polr2a	GOBP_Dna_Metabolic_Process	Mouse	Brain	HP_ad_rep7	3.1e-11
Polr2a	GOBP_Dna_Repair	Mouse	Brain	HP_ad_rep7	2.4e-12
Polr2a	GOBP_Dna_Templated_Transcription_Elongation	Mouse	Brain	HP_ad_rep7	1.4e-14
Polr2a	GOBP_Dna_Templated_Transcription_Termination	Mouse	Brain	HP_ad_rep7	3.0e-07
Polr2a	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	2.5e-10
Polr2a	GOBP_Maintenance_Of_Cell_Number	Mouse	Brain	HP_ad_rep7	1.6e-11
Polr2a	GOBP_Mrna_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.2e-09
Polr2a	GOBP_Mrna_Processing	Mouse	Brain	HP_ad_rep7	2.3e-09
Polr2a	GOBP_Negative_Regulation_Of_Gene_Expression	Mouse	Brain	HP_ad_rep7	2.1e-08
Polr2a	GOBP_Nucleotide_Excision_Repair	Mouse	Brain	HP_ad_rep7	4.3e-08
Polr2a	GOBP_Positive_Regulation_Of_Gene_Expression	Mouse	Brain	HP_ad_rep7	4.4e-07
Polr2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Polr2a	GOBP_Positive_Regulation_Of_Rna_Splicing	Mouse	Brain	HP_ad_rep7	1.3e-18
Polr2a	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Brain	HP_ad_rep7	1.9e-10
Polr2a	GOBP_Regulation_Of_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	HP_ad_rep7	6.6e-21
Polr2a	GOBP_Regulation_Of_Rna_Splicing	Mouse	Brain	HP_ad_rep7	5.9e-11
Polr2a	GOBP_Response_To_Endogenous_Stimulus	Mouse	Brain	HP_ad_rep7	6.3e-10
Polr2a	GOBP_Response_To_Growth_Factor	Mouse	Brain	HP_ad_rep7	3.5e-10
Polr2a	GOBP_Rna_Capping	Mouse	Brain	HP_ad_rep7	1.4e-24
Polr2a	GOBP_Rna_Processing	Mouse	Brain	HP_ad_rep7	2.7e-09
Polr2a	GOBP_Rna_Splicing	Mouse	Brain	HP_ad_rep7	5.3e-10
Polr2a	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Mouse	Brain	HP_ad_rep7	2.3e-11
Polr2a	GOBP_Snrna_Transcription	Mouse	Brain	HP_ad_rep7	9.9e-16
Polr2a	GOBP_Transcription_Elongation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	HP_ad_rep7	9.4e-09
Polr2a	GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter	Mouse	Brain	HP_ad_rep7	6.1e-11
Polr2a	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	9.5e-09
Polr2a	GOBP_Ncrna_Transcription	Mouse	Brain	HP_adpolb_rep1	3.6e-07
Polr2a	GOBP_Positive_Regulation_Of_Viral_Process	Mouse	Brain	HP_adpolb_rep3	6.6e-07
Polr2a	GOBP_Regulation_Of_Viral_Transcription	Mouse	Brain	HP_polb_rep3	2.5e-08
Polr2a	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	HP_polb_rep9	1.1e-12
Polr2a	GOBP_Dna_Templated_Transcription_Initiation	Mouse	Brain	HP_polb_rep9	8.2e-07
Polr2a	GOBP_Fibroblast_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	3.9e-15
Polr2a	GOBP_Response_To_Fibroblast_Growth_Factor	Mouse	Brain	HP_polb_rep9	1.4e-16
Polr2a	GOBP_Viral_Gene_Expression	Mouse	Brain	HP_polb_rep9	1.1e-14
Polr2a	GOBP_Regulation_Of_Gene_Silencing_By_Rna	Mouse	Brain	HP_wt_rep2	1.2e-07

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Polr2a function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Polr2a function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Polr2a envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
POLR2A	Skin	control	Normal_KC_Basal	PKP1,MKNK2,LINC00910, etc.	0.33
POLR2A	Skin	control	Normal_KC_Diff	PKP1,MKNK2,LINC00910, etc.	0.524
POLR2A	Skin	control	Normal_KC_Cyc	PKP1,MKNK2,LINC00910, etc.	0.251
POLR2A	Skin	tumor	Tumor_KC_Diff	IBA57,TBC1D17,DCLRE1A, etc.	0.278
POLR2A	Skin	tumor	Keratinocyte	IBA57,TBC1D17,DCLRE1A, etc.	0.391
POLR2A	Skin	tumor	CD1C	IBA57,TBC1D17,DCLRE1A, etc.	0.29
POLR2A	Skin	tumor	Mac	IBA57,TBC1D17,DCLRE1A, etc.	0.274

Motif information.

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Related Drugs for Polr2a

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Polr2a

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Polr2a	C0232466	Feeding difficulties	1	GENOMICS_ENGLAND
Polr2a	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Polr2a	C1858120	Generalized hypotonia	1	GENOMICS_ENGLAND
Polr2a	C2677504	AUTISM, SUSCEPTIBILITY TO, 15	1	GENOMICS_ENGLAND