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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Phf2 (spascer ID:18676)

Gene summary for Phf2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Phf2
	Gene ID	18676
	Gene name	PHD finger protein 2
	Synonyms	GRC5
	Cytomap	13 A5\|13 24.96 cM
	Type of gene	protein-coding
	Description	lysine-specific demethylase PHF2
	Modification date	20220424
	UniProtAcc	Q9WTU0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Phf2	GO:0003712	transcription coregulator activity	21873635	Function
Phf2	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
Phf2	GO:0006482	protein demethylation	21873635	Process
Phf2	GO:0032452	histone demethylase activity	21873635	Function

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Spatial pattern events for Phf2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Phf2	Mouse	Brain	S4	34413515	1.99e-08
Phf2	Mouse	Kidney	CLP	34003797	1.67e-10
Phf2	Mouse	Kidney	Sham	34003797	2.11e-12
Phf2	Mouse	Kidney	rep_1	34853151	1.19e-08
Phf2	Mouse	Brain	rep_1	33469025	5.26e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Phf2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Phf2	GOBP_Demethylation	Mouse	Spinal cord	CN94_E1	9.5e-06
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Phf2	GOBP_Negative_Regulation_Of_Chromatin_Organization	Mouse	Spinal cord	CN94_E1	1.0e-06
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Phf2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Spinal cord	CN94_E1	4.2e-06
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Spinal cord	CN94_E1	1.6e-06
Phf2	GOBP_Regulation_Of_Chromosome_Organization	Mouse	Spinal cord	CN94_E1	9.3e-06
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Spinal cord	L7bCN02_E1	2.9e-06
Phf2	GOBP_Histone_H3_K9_Demethylation	Mouse	Spinal cord	L7CN30_D2	8.0e-07
Phf2	GOBP_Chromatin_Assembly_Or_Disassembly	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Phf2	GOBP_Chromatin_Organization	Mouse	Spinal cord	L7CN45_C1	3.5e-07
Phf2	GOBP_Chromatin_Remodeling	Mouse	Spinal cord	L7CN45_C1	4.5e-06
Phf2	GOBP_Chromosome_Organization	Mouse	Spinal cord	L7CN45_C1	3.4e-08
Phf2	GOBP_Dna_Conformation_Change	Mouse	Spinal cord	L7CN45_C1	8.1e-07
Phf2	GOBP_Dna_Packaging	Mouse	Spinal cord	L7CN45_C1	7.6e-07
Phf2	GOBP_Heterochromatin_Organization	Mouse	Spinal cord	L7CN45_C1	4.0e-09
Phf2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Mouse	Spinal cord	L7CN45_C1	7.1e-07
Phf2	GOBP_Protein_Demethylation	Mouse	Spinal cord	L7CN45_C1	3.4e-06
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Spinal cord	L7CN45_C1	7.9e-07
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Spinal cord	L7CN45_C1	1.5e-06
Phf2	GOBP_Negative_Regulation_Of_Chromosome_Organization	Mouse	Spinal cord	L7CN47_C1	3.8e-07
Phf2	GOBP_Dna_Conformation_Change	Mouse	Brain	rep_11	3.6e-05
Phf2	GOBP_Chromatin_Assembly_Or_Disassembly	Mouse	Brain	rep_19	1.5e-05
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Phf2	GOBP_Heterochromatin_Organization	Mouse	Brain	rep_41	6.9e-05
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Brain	rep_41	4.7e-07
Phf2	GOBP_Chromosome_Organization	Mouse	Brain	rep_1	3.9e-07
Phf2	GOBP_Demethylation	Mouse	Brain	rep_1	8.3e-26
Phf2	GOBP_Gland_Development	Mouse	Brain	rep_1	4.1e-23
Phf2	GOBP_Histone_H3_K9_Demethylation	Mouse	Brain	rep_1	1.9e-13
Phf2	GOBP_Negative_Regulation_Of_Organelle_Organization	Mouse	Brain	rep_1	8.5e-21
Phf2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Phf2	GOBP_Protein_Demethylation	Mouse	Brain	rep_1	7.4e-45
Phf2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	rep_1	1.3e-27
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Brain	rep_1	2.4e-11
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Brain	rep_1	7.7e-10
Phf2	GOBP_Regulation_Of_Organelle_Organization	Mouse	Brain	rep_1	7.9e-20
Phf2	GOBP_Chromatin_Assembly_Or_Disassembly	Mouse	Brain	rep_3	1.7e-35
Phf2	GOBP_Chromatin_Organization	Mouse	Brain	rep_3	5.1e-215
Phf2	GOBP_Chromatin_Remodeling	Mouse	Brain	rep_3	4.4e-194
Phf2	GOBP_Dna_Conformation_Change	Mouse	Brain	rep_3	7.4e-54
Phf2	GOBP_Dna_Packaging	Mouse	Brain	rep_3	3.0e-32
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Brain	rep_3	4.1e-188
Phf2	GOBP_Heterochromatin_Organization	Mouse	Brain	rep_3	2.4e-164
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Phf2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Mouse	Brain	rep_3	4.4e-113
Phf2	GOBP_Negative_Regulation_Of_Chromosome_Organization	Mouse	Brain	rep_3	3.0e-138
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Brain	rep_3	5.6e-166
Phf2	GOBP_Regulation_Of_Chromosome_Organization	Mouse	Brain	rep_3	4.6e-162
Phf2	GOBP_Negative_Regulation_Of_Chromatin_Organization	Mouse	Brain	rep_4	1.3e-31
Phf2	GOBP_Demethylation	Mouse	Embryo	rep_14	6.1e-43
Phf2	GOBP_Dna_Conformation_Change	Mouse	Embryo	rep_14	2.1e-08
Phf2	GOBP_Dna_Packaging	Mouse	Embryo	rep_14	2.5e-08
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Embryo	rep_14	7.2e-30
Phf2	GOBP_Heterochromatin_Organization	Mouse	Embryo	rep_14	2.5e-32
Phf2	GOBP_Histone_H3_K9_Demethylation	Mouse	Embryo	rep_14	1.1e-65
Phf2	GOBP_Negative_Regulation_Of_Chromatin_Organization	Mouse	Embryo	rep_14	8.0e-34
Phf2	GOBP_Protein_Demethylation	Mouse	Embryo	rep_14	6.1e-58
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Embryo	rep_14	3.0e-25
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Embryo	rep_14	3.1e-30
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Embryo	rep_14	3.0e-17
Phf2	GOBP_Heterochromatin_Organization	Mouse	Embryo	rep_1	2.8e-41
Phf2	GOBP_Regulation_Of_Chromosome_Organization	Mouse	Embryo	rep_1	2.4e-207
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Embryo	rep_2	0.0e+00
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Phf2	GOBP_Chromatin_Assembly_Or_Disassembly	Mouse	Embryo	rep_3	4.5e-65
Phf2	GOBP_Chromatin_Organization	Mouse	Embryo	rep_3	2.9e-87
Phf2	GOBP_Chromosome_Organization	Mouse	Embryo	rep_3	1.4e-57
Phf2	GOBP_Dna_Conformation_Change	Mouse	Embryo	rep_3	1.5e-48
Phf2	GOBP_Dna_Packaging	Mouse	Embryo	rep_3	1.5e-48
Phf2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Mouse	Embryo	rep_3	2.7e-07
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Phf2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Phf2	GOBP_Regulation_Of_Organelle_Organization	Mouse	Embryo	rep_3	1.3e-27
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Embryo	rep_6	4.7e-14
Phf2	GOBP_Chromatin_Assembly_Or_Disassembly	Mouse	Kidney	rep_2	1.1e-38
Phf2	GOBP_Chromatin_Organization	Mouse	Kidney	rep_2	3.0e-63
Phf2	GOBP_Chromosome_Organization	Mouse	Kidney	rep_2	1.0e-14
Phf2	GOBP_Demethylation	Mouse	Kidney	rep_2	2.8e-10
Phf2	GOBP_Dna_Conformation_Change	Mouse	Kidney	rep_2	1.4e-38
Phf2	GOBP_Dna_Packaging	Mouse	Kidney	rep_2	8.1e-32
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Kidney	rep_2	1.3e-24
Phf2	GOBP_Heterochromatin_Organization	Mouse	Kidney	rep_2	1.4e-20
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Phf2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Mouse	Kidney	rep_2	8.7e-59
Phf2	GOBP_Negative_Regulation_Of_Chromosome_Organization	Mouse	Kidney	rep_2	1.5e-15
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Phf2	GOBP_Negative_Regulation_Of_Organelle_Organization	Mouse	Kidney	rep_2	1.5e-119
Phf2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Phf2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Kidney	rep_2	8.3e-40
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Kidney	rep_2	8.6e-16
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Kidney	rep_2	2.3e-08
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Kidney	rep_2	9.5e-17
Phf2	GOBP_Regulation_Of_Chromosome_Organization	Mouse	Kidney	rep_2	7.4e-43
Phf2	GOBP_Regulation_Of_Organelle_Organization	Mouse	Kidney	rep_2	6.7e-77
Phf2	GOBP_Protein_Demethylation	Mouse	Liver	CN16-D2	9.4e-07
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Liver	CN16-D2	3.3e-11
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Liver	CN16-D2	1.0e-09
Phf2	GOBP_Heterochromatin_Organization	Mouse	Liver	CN65-C1	2.7e-10
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Liver	CN65-C1	7.3e-09
Phf2	GOBP_Negative_Regulation_Of_Chromatin_Organization	Mouse	Liver	CN73-C1	2.2e-09
Phf2	GOBP_Histone_H3_K9_Demethylation	Mouse	Liver	rep_14	5.8e-10
Phf2	GOBP_Negative_Regulation_Of_Chromatin_Organization	Mouse	Liver	rep_14	1.3e-11
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Liver	rep_15	5.7e-07
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Liver	rep_15	3.9e-08
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Liver	rep_16	7.0e-09
Phf2	GOBP_Protein_Demethylation	Mouse	Liver	rep_16	1.6e-11
Phf2	GOBP_Demethylation	Mouse	Liver	rep_23	9.3e-09
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Intestine	rep_2	1.2e-12
Phf2	GOBP_Chromatin_Organization	Mouse	Lymph	MS-1	9.1e-11
Phf2	GOBP_Chromosome_Organization	Mouse	Lymph	MS-1	3.5e-09
Phf2	GOBP_Demethylation	Mouse	Lymph	MS-1	1.5e-08
Phf2	GOBP_Gland_Development	Mouse	Lymph	MS-1	1.7e-10
Phf2	GOBP_Heterochromatin_Organization	Mouse	Lymph	MS-1	8.4e-11
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Phf2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Mouse	Lymph	MS-1	3.7e-11
Phf2	GOBP_Negative_Regulation_Of_Chromosome_Organization	Mouse	Lymph	MS-1	9.2e-11
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Phf2	GOBP_Negative_Regulation_Of_Organelle_Organization	Mouse	Lymph	MS-1	4.9e-09
Phf2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Phf2	GOBP_Protein_Demethylation	Mouse	Lymph	MS-1	7.0e-07
Phf2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Lymph	MS-1	2.2e-09
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Lymph	MS-1	1.4e-11
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Lymph	MS-1	3.0e-08
Phf2	GOBP_Regulation_Of_Chromosome_Organization	Mouse	Lymph	MS-1	5.6e-07
Phf2	GOBP_Regulation_Of_Organelle_Organization	Mouse	Lymph	MS-1	1.4e-10
Phf2	GOBP_Histone_H3_K9_Demethylation	Mouse	Lymph	MS-2	6.4e-07
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Brain	rep_4	3.0e-07
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Brain	rep_7	1.6e-23
Phf2	GOBP_Negative_Regulation_Of_Chromatin_Organization	Mouse	Brain	HP_ad_rep2	4.7e-18
Phf2	GOBP_Chromatin_Assembly_Or_Disassembly	Mouse	Brain	HP_ad_rep7	6.7e-07
Phf2	GOBP_Chromatin_Organization	Mouse	Brain	HP_ad_rep7	7.6e-11
Phf2	GOBP_Chromatin_Remodeling	Mouse	Brain	HP_ad_rep7	5.3e-11
Phf2	GOBP_Chromosome_Organization	Mouse	Brain	HP_ad_rep7	2.9e-10
Phf2	GOBP_Demethylation	Mouse	Brain	HP_ad_rep7	3.1e-11
Phf2	GOBP_Dna_Conformation_Change	Mouse	Brain	HP_ad_rep7	1.3e-13
Phf2	GOBP_Dna_Packaging	Mouse	Brain	HP_ad_rep7	8.5e-11
Phf2	GOBP_Gland_Development	Mouse	Brain	HP_ad_rep7	3.2e-13
Phf2	GOBP_Hepaticobiliary_System_Development	Mouse	Brain	HP_ad_rep7	4.6e-18
Phf2	GOBP_Heterochromatin_Organization	Mouse	Brain	HP_ad_rep7	1.3e-15
Phf2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Phf2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Mouse	Brain	HP_ad_rep7	2.6e-08
Phf2	GOBP_Negative_Regulation_Of_Chromosome_Organization	Mouse	Brain	HP_ad_rep7	1.9e-18
Phf2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Phf2	GOBP_Negative_Regulation_Of_Organelle_Organization	Mouse	Brain	HP_ad_rep7	6.1e-08
Phf2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Phf2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Mouse	Brain	HP_ad_rep7	6.5e-10
Phf2	GOBP_Regulation_Of_Chromatin_Assembly	Mouse	Brain	HP_ad_rep7	1.4e-07
Phf2	GOBP_Regulation_Of_Chromatin_Assembly_Or_Disassembly	Mouse	Brain	HP_ad_rep7	7.5e-09
Phf2	GOBP_Regulation_Of_Chromosome_Organization	Mouse	Brain	HP_ad_rep7	1.4e-11
Phf2	GOBP_Regulation_Of_Organelle_Organization	Mouse	Brain	HP_ad_rep7	8.1e-07
Phf2	GOBP_Regulation_Of_Chromatin_Organization	Mouse	Brain	HP_adpolb_rep1	8.5e-09
Phf2	GOBP_Histone_H3_K9_Demethylation	Mouse	Brain	HP_polb_rep9	9.2e-10
Phf2	GOBP_Protein_Demethylation	Mouse	Brain	HP_polb_rep9	1.0e-08

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Phf2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Phf2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Phf2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Phf2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Phf2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Phf2	C1535926	Neurodevelopmental Disorders	1	CTD_human