|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
|
Spatial pattern gene: Pepd (spascer ID:18624) |
Gene summary for Pepd |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Pepd | Gene ID | 18624 |
| Gene name | peptidase D |
| Synonyms | Pep-4|Pep4|dal |
| Cytomap | 7 B2|7 20.7 cM |
| Type of gene | protein-coding |
| Description | xaa-Pro dipeptidaseX-pro dipeptidaseimidodipeptidasepeptidase 4prolidaseproline dipeptidase |
| Modification date | 20220515 |
| UniProtAcc | Q11136 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Pepd | GO:0008233 | peptidase activity | 21873635 | Function |
Top |
Spatial pattern events for Pepd |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Pepd | Mouse | Brain | S2 | 34413515 | 1.56e-15 |
| Pepd | Mouse | Brain | S3 | 34413515 | 2.96e-15 |
| Pepd | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Pepd | Mouse | Brain | S6 | 34413515 | 1.46e-15 |
| Pepd | Mouse | Brain | S7 | 34413515 | 1.55e-15 |
| Pepd | Mouse | Brain | 17A | 32637622 | 3.28e-07 |
| Pepd | Mouse | Brain | 21B | 32637622 | 9.97e-12 |
| Pepd | Mouse | Brain | 22A | 32637622 | 6.37e-13 |
| Pepd | Mouse | Brain | 22B | 32637622 | 1.92e-09 |
| Pepd | Mouse | Brain | 28A | 32637622 | 2.36e-06 |
| Pepd | Mouse | Brain | rep_2 | 35141374 | 7.94e-06 |
| Pepd | Mouse | Brain | rep_3 | 35141374 | 1.19e-08 |
| Pepd | Mouse | Brain | rep_4 | 35141374 | 1.11e-09 |
| Pepd | Mouse | Brain | rep_5 | 35141374 | 3.60e-07 |
| Pepd | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| Pepd | Mouse | Kidney | IRI | 34003797 | 2.29e-15 |
| Pepd | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| Pepd | Mouse | Kidney | rep_1 | 34853151 | 2.42e-15 |
| Pepd | Mouse | Kidney | rep_2 | 34853151 | 1.64e-08 |
| Pepd | Mouse | Kidney | rep_3 | 34853151 | 2.94e-15 |
| Pepd | Mouse | Kidney | rep_5 | 34853151 | 3.18e-15 |
| Pepd | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Pepd | Mouse | Liver | rep_20 | 35021063 | 5.10e-06 |
| Pepd | Mouse | Brain | rep_1 | 35027729 | 1.66e-15 |
| Pepd | Mouse | Brain | rep_2 | 35027729 | 1.57e-15 |
| Pepd | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Pepd | Mouse | Brain | rep_4 | 35027729 | 1.76e-15 |
| Pepd | Mouse | Brain | rep_5 | 35027729 | 2.62e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_2_H&E  |  |
Kidney_rep_3_H&E  |  |
Kidney_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Liver_rep_20_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Top |
Spatial pattern pathway has Pepd envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Spinal cord | L7bCN02_E1 | 7.5e-07 |
| Pepd | GOBP_Organic_Acid_Metabolic_Process | Mouse | Spinal cord | L7bCN02_E1 | 7.1e-06 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 5.7e-08 |
| Pepd | GOBP_Collagen_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 1.4e-08 |
| Pepd | GOBP_Proteolysis | Mouse | Spinal cord | L7CN45_C1 | 1.1e-06 |
| Pepd | GOBP_Small_Molecule_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 1.7e-07 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Brain | rep_41 | 1.4e-05 |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 8.5e-191 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Brain | rep_3 | 1.9e-82 |
| Pepd | GOBP_Collagen_Metabolic_Process | Mouse | Brain | rep_3 | 3.6e-88 |
| Pepd | GOBP_Organic_Acid_Metabolic_Process | Mouse | Brain | rep_3 | 1.5e-154 |
| Pepd | GOBP_Proteolysis | Mouse | Brain | rep_3 | 1.8e-168 |
| Pepd | GOBP_Small_Molecule_Metabolic_Process | Mouse | Brain | rep_3 | 2.7e-19 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Embryo | rep_14 | 2.2e-35 |
| Pepd | GOBP_Small_Molecule_Metabolic_Process | Mouse | Embryo | rep_1 | 1.4e-55 |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Embryo | rep_3 | 9.9e-51 |
| Pepd | GOBP_Organic_Acid_Metabolic_Process | Mouse | Embryo | rep_3 | 1.4e-07 |
| Pepd | GOBP_Proteolysis | Mouse | Kidney | Nep | 6.8e-23 |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 3.8e-34 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Kidney | rep_2 | 8.2e-67 |
| Pepd | GOBP_Collagen_Metabolic_Process | Mouse | Kidney | rep_2 | 4.6e-51 |
| Pepd | GOBP_Organic_Acid_Metabolic_Process | Mouse | Kidney | rep_2 | 3.8e-62 |
| Pepd | GOBP_Proteolysis | Mouse | Kidney | rep_2 | 6.0e-106 |
| Pepd | GOBP_Small_Molecule_Metabolic_Process | Mouse | Kidney | rep_2 | 1.8e-43 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Liver | CN16-D1 | 5.5e-09 |
| Pepd | GOBP_Collagen_Metabolic_Process | Mouse | Liver | CN73-C1 | 5.4e-08 |
| Pepd | GOBP_Collagen_Metabolic_Process | Mouse | Liver | rep_16 | 5.0e-31 |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.3e-13 |
| Pepd | GOBP_Organic_Acid_Metabolic_Process | Mouse | Lymph | MS-1 | 1.3e-15 |
| Pepd | GOBP_Proteolysis | Mouse | Lymph | MS-1 | 2.8e-10 |
| Pepd | GOBP_Small_Molecule_Metabolic_Process | Mouse | Lymph | MS-1 | 2.6e-11 |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Brain | rep_4 | 1.9e-21 |
| Pepd | GOBP_Cellular_Amino_Acid_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 1.0e-14 |
| Pepd | GOBP_Organic_Acid_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 4.1e-08 |
| Pepd | GOBP_Proteolysis | Mouse | Brain | HP_ad_rep7 | 3.3e-07 |
| Pepd | GOBP_Collagen_Metabolic_Process | Mouse | Brain | HP_adpolb_rep1 | 3.7e-07 |
| Pepd | GOBP_Collagen_Catabolic_Process | Mouse | Brain | HP_polb_rep9 | 9.1e-16 |
| Pepd | GOBP_Small_Molecule_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 2.0e-09 |
Top |
Pepd function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
Top |
Pepd function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
Top |
Transcription factor for Pepd envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
Top |
Related Drugs for Pepd |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for Pepd |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Pepd | C0268532 | Deficiency of prolidase | 9 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Pepd | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Pepd | C0019209 | Hepatomegaly | 1 | CTD_human |
| Pepd | C0035242 | Respiratory Tract Diseases | 1 | CTD_human |
| Pepd | C0037299 | Skin Ulcer | 1 | CTD_human |
| Pepd | C0038002 | Splenomegaly | 1 | CTD_human |
| Pepd | C0353676 | Organophosphorus Poisoning | 1 | CTD_human |
| Pepd | C0700359 | Organophosphate poisoning | 1 | CTD_human |
| Pepd | C3494247 | Organothiophosphonate Poisoning | 1 | CTD_human |
| Pepd | C3494248 | Organothiophosphate Poisoning | 1 | CTD_human |
| Pepd | C3714514 | Infection | 1 | CTD_human |
